Information on EC 2.1.1.120 - 12-hydroxydihydrochelirubine 12-O-methyltransferase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
2.1.1.120
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RECOMMENDED NAME
GeneOntology No.
12-hydroxydihydrochelirubine 12-O-methyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Isoquinoline alkaloid biosynthesis
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Metabolic pathways
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sanguinarine and macarpine biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase
This reaction is part of the pathway for synthesis of benzophenanthridine alkaloid macarpine in plants.
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CAS REGISTRY NUMBER
COMMENTARY hide
158736-40-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Thalictrum bulgaricum
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-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine
?
show the reaction diagram
Thalictrum bulgaricum
-
involved in biosynthesis of macarpine, the most highly oxidized benzophenanthridine alkaloid, not significantly affected by elicitation
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-
-
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine
S-adenosyl-L-homocysteine + dihydromacarpine
show the reaction diagram
Thalictrum bulgaricum
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-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine
?
show the reaction diagram
Thalictrum bulgaricum
-
involved in biosynthesis of macarpine, the most highly oxidized benzophenanthridine alkaloid, not significantly affected by elicitation
-
-
-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
Thalictrum bulgaricum
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-
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
Thalictrum bulgaricum
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-
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Thalictrum bulgaricum
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-
Manually annotated by BRENDA team
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
-
Thalictrum bulgaricum
-
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LINKS TO OTHER DATABASES (specific for EC-Number 2.1.1.120)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)