Information on EC 2.1.1.119 - 10-hydroxydihydrosanguinarine 10-O-methyltransferase

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The expected taxonomic range for this enzyme is: Eschscholzia californica

EC NUMBER
COMMENTARY hide
2.1.1.119
-
RECOMMENDED NAME
GeneOntology No.
10-hydroxydihydrosanguinarine 10-O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
sanguinarine and macarpine biosynthesis
-
-
Isoquinoline alkaloid biosynthesis
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
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-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase
This reaction is part of the pathway for synthesis of benzophenanthridine alkaloids in plants.
CAS REGISTRY NUMBER
COMMENTARY hide
144388-39-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine
S-adenosyl-L-homocysteine + dihydrochelirubine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine
S-adenosyl-L-homocysteine + dihydrochelirubine
show the reaction diagram
-
the enzyme is involved in benzophenanthridine alkaloid biosynthesis
-
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.01
10-Hydroxydihydrosanguinarine
-
-
0.003
S-adenosyl-L-methionine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
49000
-
gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE