Information on EC 2.1.1.108 - 6-hydroxymellein O-methyltransferase

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The expected taxonomic range for this enzyme is: Daucus carota

EC NUMBER
COMMENTARY hide
2.1.1.108
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RECOMMENDED NAME
GeneOntology No.
6-hydroxymellein O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 6-hydroxymellein = S-adenosyl-L-homocysteine + 6-methoxymellein
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
6-methoxymellein biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase
3,4-Dehydro-6-hydroxymellein can also act as acceptor. 6-Methoxymellein is a phytoalexin produced by carrot tissue.
CAS REGISTRY NUMBER
COMMENTARY hide
124149-02-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 3,4-dehydro-6-hydroxymellein
S-adenosyl-L-homocysteine + 3,4-dehydro-6-methoxymellein
show the reaction diagram
S-adenosyl-L-methionine + 6-hydroxymellein
S-adenosyl-L-homocysteine + 6-methoxymellein
show the reaction diagram
S-adenosyl-L-methionine + 6-hydroxymellein + 3,4-dehydro-6-hydroxymellein
S-adenosyl-L-homocysteine + 6-methoxymellein + 3,4-dehydro-6-methoxymellein
show the reaction diagram
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-
-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 6-hydroxymellein
S-adenosyl-L-homocysteine + 6-methoxymellein
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-methoxymellein
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iodoacetoamide
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p-chloromercuribenzoate
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S-adenosyl-L-homocysteine
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sulfhydryl reagents
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-Chloroethylphosphonic acid
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elicitor, the activity increases after a 2 day lag period and attains a maximum 3 days after the addition, then decreases gradually
Fusarium moniliforme endo-polygalacturonsae
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elicitor, the enzyme activity reaches a maximum 40 h after the addition, then decreased graduelly
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Phythophthora megasperma cell wall fraction
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elicitor, the enzyme activity reaches a maximum 50 h after the addition
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uronide
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elicitor
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.047
6-methoxymellein
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-
0.026
S-adenosyl-L-homocysteine
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5 - 8
-
pI: 5.7
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
76000
-
gel filtration
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 7 d, complete loss of activity
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frozen overnight, complete loss of activity
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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