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Information on EC 1.8.4.3 - glutathione-CoA-glutathione transhydrogenase Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The enzyme appears in viruses and cellular organisms
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glutathione-CoA-glutathione transhydrogenase
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CoA + glutathione disulfide = CoA-glutathione + glutathione
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Cysteine and methionine metabolism
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Glutathione metabolism
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CoA:glutathione-disulfide oxidoreductase
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glutathione coenzyme A-glutathione transhydrogenase
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glutathione-coenzyme A glutathione disulfide transhydrogenase
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glutathione:coenzyme A-glutathione transhydrogenase
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transhydrogenase, glutathione-coenzyme A glutathione disulfide
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CoA-glutathione + GSH
CoA + GSSG
cysteine-glutathione + GSH
cysteine + GSSG
pantetheine-glutathione + GSH
pantetheine + GSSG
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thiolethanolamine-glutathione + GSH
thioethanolamine + GSSG
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CoA-glutathione + GSH
CoA + GSSG
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CoA-glutathione + GSH
CoA + GSSG
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cysteine-glutathione + GSH
cysteine + GSSG
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cysteine-glutathione + GSH
cysteine + GSSG
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possible functions: 1. salvage of the coenzyme form of pantothenic acid which might be lost to the cell as CoA-glutathione, 2. maintenance of the free CoA-SH at cellular level
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catalyzes GSH-GSSG exchange reaction
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possible functions: 1. salvage of the coenzyme form of pantothenic acid which might be lost to the cell as CoA-glutathione, 2. maintenance of the free CoA-SH at cellular level
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catalyzes GSH-GSSG exchange reaction
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CoA-glutathione + GSH
CoA + GSSG
CoA-glutathione + GSH
CoA + GSSG
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CoA-glutathione + GSH
CoA + GSSG
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0.045
CoA-glutathione
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12000
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transhydrogenase of normal rat
13300
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transhydrogenase of diabetic rat
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7 - 9
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pH 7: about 30% of activity maximum, pH 9: about 75% of activity maximum
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25
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assay at
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low activity
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inactivation during storage is largely reversed by glutathione
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-12°C, 7 months, 70% loss of activity
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Chang, S.H.; Wilken, D.R.
Participation of the unsymmetrical disulfide of coenzyme A and glutathione in an enzymatic sulfhydryl-disulfide interchange
J. Biol. Chem.
241
4251-4260
1966
Bos taurus, Rattus norvegicus
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Dyar, R.E.; Wilken, D.R.
Rat liver levels of coenzyme A-glutathione and of enzymes in its metabolism
Arch. Biochem. Biophys.
153
619-626
1972
Rattus norvegicus
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