Information on EC 1.8.4.3 - glutathione-CoA-glutathione transhydrogenase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
1.8.4.3
-
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RECOMMENDED NAME
GeneOntology No.
glutathione-CoA-glutathione transhydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CoA + glutathione disulfide = CoA-glutathione + glutathione
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
-
-
Glutathione metabolism
-
-
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SYSTEMATIC NAME
IUBMB Comments
CoA:glutathione-disulfide oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37256-48-7
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CoA-glutathione + GSH
CoA + GSSG
show the reaction diagram
cysteine-glutathione + GSH
cysteine + GSSG
show the reaction diagram
pantetheine-glutathione + GSH
pantetheine + GSSG
show the reaction diagram
-
-
-
-
?
thiolethanolamine-glutathione + GSH
thioethanolamine + GSSG
show the reaction diagram
-
-
-
-
?
additional information
?
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CoA-glutathione + GSH
CoA + GSSG
show the reaction diagram
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.045
CoA-glutathione
-
-
0.33
GSH
-
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.513
-
-
12000
-
transhydrogenase of normal rat
13300
-
transhydrogenase of diabetic rat
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.2
-
-
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 9
-
pH 7: about 30% of activity maximum, pH 9: about 75% of activity maximum
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
low activity
Manually annotated by BRENDA team
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
120000
-
gel filtration
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
inactivation during storage is largely reversed by glutathione
-
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-12°C, 6 weeks, stable
-
-12°C, 7 months, 70% loss of activity
-
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.8.4.3)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)