Reference on EC 1.8.1.9 - thioredoxin-disulfide reductase
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Williams, C.H.
Flavin-containing dehydrogenases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
13
89-173
1976
Escherichia coli
-
Pigiet, V.P.; Conley, R.R.
Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography
J. Biol. Chem.
252
6367-6372
1977
Escherichia coli
Lundstrm, J.; Holmgren, A.
Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity
J. Biol. Chem.
265
9114-9120
1990
Bos taurus, Escherichia coli
Gleason, F.K.; Lim, C.J.; Gerami-Nejad, M.; Fuchs, J.A.
Characterization of Escherichia coli thioredoxins with altered active site residues
Biochemistry
29
3701-3709
1990
Escherichia coli
Schallreuter, K.U.; Wood, J.M.
Calcium regulates thioredoxin reductase in human metastatic melanoma
Biochim. Biophys. Acta
997
242-247
1989
Homo sapiens
McFarlan, S.C.; Hogenkamp, H.P.C.; Eccleston, E.D.; Howard, J.B.; Fuchs, J.A.
Purification, characterization and revised amino acid sequence of a second thioredoxin from Corynebacterium nephridii [published erratum appears in Eur J Biochem 1989 Apr 1;180(3):603]
Eur. J. Biochem.
179
389-398
1989
Corynebacterium nephridii
Schallreuter, K.U.; Pittelkow, M.R.; Wood, J.M.
EF-Hands calcium binding regulates the thioredoxin reductase/thioredoxin electron transfer in human keratinocytes
Biochem. Biophys. Res. Commun.
162
1311-1316
1989
Escherichia coli, Homo sapiens
Schallreuter, K.U.; Wood, J.M.
The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid
Biochem. Biophys. Res. Commun.
160
573-579
1989
Homo sapiens
Prongay, A.J.; Engelke, D.R.; Williams, C.H.
Characterization of two active site mutations of thioredoxin reductase from Escherichia coli [published erratum appears in J Biol Chem 1989 Jul 15;264(20):12113]
J. Biol. Chem.
264
2656-2664
1989
Escherichia coli
Schallreuter, K.U.; Wood, J.M.
The activity and purification of membrane-associated thioredoxin reductase from human metastatic melanotic melanoma
Biochim. Biophys. Acta
967
103-109
1988
Homo sapiens
Florencio, F.J.; Yee, B.C.; Johnson, T.C.; Buchanan, B.
An NADP/thioredoxin system in leaves: purification and characterization of NADP-thioredoxin reductase and thioredoxin h from spinach
Arch. Biochem. Biophys.
266
496-507
1988
Spinacia oleracea
Russel, M.; Model, P.
Direct cloning of the trxB gene that encodes thioredoxin reductase
J. Bacteriol.
163
238-242
1985
Escherichia coli
Johnson, T.C.; Cao, R.Q.; Kung, J.E.; Buchanan, B.B.
Thioredoxin and NADP-thioredoxin reductase from cultured carrot cells
Planta
171
321-331
1987
Daucus carota
Clement-Metral, J.D.; Hg, J.O.; Holmgren, A.
Characterization of the thioredoxin system in the facultative phototroph Rhodobacter sphaeroides Y [published erratum appears in Eur J Biochem 1987 May 4;164(3):713]
Eur. J. Biochem.
161
119-126
1986
Cereibacter sphaeroides, Cereibacter sphaeroides Y
Schallreuter, K.U.; Wood, J.M.
The role of thioredoxin reductase in the reduction of free radicals at the surface of the epidermis
Biochem. Biophys. Res. Commun.
136
630-637
1986
Cavia porcellus, Homo sapiens
O'Donnell, M.E.; Williams, C.H.
Reaction of both active site thiols of reduced thioredoxin reductase with N-ethylmaleimide
Biochemistry
24
7617-7621
1985
Escherichia coli
Gibson, R.M.; Large, P.J.
The involvement of thioredoxin and thioredoxin reductase in the dimethyl sulphoxide reductase system of Saccharomyces cerevisiae
FEMS Microbiol. Lett.
26
89-94
1985
Saccharomyces cerevisiae
-
Johnson, T.C.; Crawford, N.A.; Buchanan, B.B.
Thioredoxin system of the photosynthetic anaerobe Chromatium vinosum
J. Bacteriol.
158
1061-1069
1984
Allochromatium vinosum
Luthman, M.; Holmgren, A.
Rat liver thioredoxin and thioredoxin reductase: purification and characterization
Biochemistry
21
6628-6633
1982
Rattus norvegicus
Grankvist, K.; Holmgren, A.; Luthman, M.; Tljedal, I.B.
Thioredoxin and thioredoxin reductase in pancreatic islets may participate in diabetogenic free-radical production
Biochem. Biophys. Res. Commun.
107
1412-1418
1982
Bos taurus, Escherichia coli, Mus musculus
Lik-Shing Tsang, M.; Weatherbee, J.A.
Thioredoxin, glutaredoxin, and thioredoxin reductase from cultured HeLa cells
Proc. Natl. Acad. Sci. USA
78
7478-7482
1981
Homo sapiens
Holmgren, A.; Lyckeborg, C.
Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase
Proc. Natl. Acad. Sci. USA
77
5149-5152
1980
Bos taurus
Suske, G.; Wagner, W.; Follmann, H.
NADPH-dependent thioredoxin reductase and a new thioredoxinn from wheat
Z. Naturforsch. C
34
214-221
1979
Triticum aestivum
-
Munavalli, S.; Parker, D.V.; Hamilton, F.D.
Identification of NADPH-thioredoxin reductase system in Euglena gracillis
Proc. Natl. Acad. Sci. USA
72
4233-4237
1975
Euglena gracilis
Berglund, O.; Holmgren, A.
Thioredoxin reductase-mediated hydrogen transfer from Escherichia coli thioredoxin-(SH)2 to phage T4 thioredoxin-S2
J. Biol. Chem.
250
2778-2782
1975
Escherichia coli
Speranza, M.L.; Ronchi, S.; Minchiotti, L.
Purification and characterization of yeast thioredoxin reductase
Biochim. Biophys. Acta
327
274-281
1973
Saccharomyces cerevisiae
Larsson, A.
Thioredoxin reductase from rat liver
Eur. J. Biochem.
35
346-349
1973
Rattus norvegicus
Moore, E.C.; Reichard, P.; Thelander, L.
Enzymatic synthesis of desoxyribonucleotides. V. Purification and properties of thioredoxin reductase from Escherichia coli B
J. Biol. Chem.
239
3445-3452
1964
Escherichia coli
Jacquot, J.P.; Rivera-Madrid, R.; Marinho, P.; Kollarova, M.; Le Marechal, P.; Miginiac-Maslow, M.; Meyer, Y.
Arabidopsis thaliana NADPH thioredoxin reductase. cDNA characterization and expression of the recombinant protein in Escherichia coli
J. Mol. Biol.
235
1357-1363
1994
Arabidopsis thaliana
Lennon, B.W.; Williams, C.H., Jr.
Enzyme-monitored turnover of Escherichia coli thioredoxin reductase: insights for catalysis
Biochemistry
35
4704-4712
1996
Escherichia coli
Oblong, J.E.; Gasdaska, P.Y.; Sherrill, K.; Powis, G.
Purification of human thioredoxin reductase: properties and characterization by absorption and circular dichroism spectroscopy
Biochemistry
32
7271-7277
1993
Homo sapiens
Wang, P.F.; Veine, D.M.; Ahn, S.H.; Williams, C.H., Jr.
A stable mixed disulfide between thioredoxin reductase and its substrate, thioredoxin: preparation and characterization
Biochemistry
35
4812-4819
1996
Escherichia coli
Martinez-Galisteo, E.; Padilla, C.A.; Holmgren, A.; Barcena, J.A.
Characterization of mammalian thioredoxin reductase, thioredoxin and glutaredoxin by immunochemical methods
Comp. Biochem. Physiol. B
111
17-25
1995
Bos taurus
Serrato, A.J.; Perez-Ruiz, J.M.; Cejudo, F.J.
Cloning of thioredoxin h reductase and characterization of the thioredoxin reductase-thioredoxin h system from wheat
Biochem. J.
367
491-497
2002
Triticum aestivum (Q8VX47), Triticum aestivum
Krnajski, Z.; Gilberger, T.W.; Walter, R.D.; Muller, S.
Intersubunit interactions in Plasmodium falciparum thioredoxin reductase
J. Biol. Chem.
275
40874-40878
2000
Plasmodium falciparum
Liu, S.Y.; Stadtman, T.
Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells
Proc. Natl. Acad. Sci. USA
94
6138-6141
1997
Homo sapiens
Tamura, T.; Stadtman, T.C.
A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity
Proc. Natl. Acad. Sci. USA
93
1006-1011
1996
Homo sapiens
Arner, E.S.J.; Bjoernstedt, M.; Holmgren, A.
1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity
J. Biol. Chem.
270
3479-3482
1995
Homo sapiens
Zhong, L.; Holmgren, A.
Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations
J. Biol. Chem.
275
18121-18128
2000
Rattus norvegicus
Gilberger, T.W.; Walter, R.D.; Muller, S.
Identification and characterization of the functional amino acids at the active site of the large thioredoxin reductase from Plasmodium falciparum
J. Biol. Chem.
272
29584-29589
1997
Plasmodium falciparum
Nordberg, J.; Zhong, L.; Holmgren, A.; Arner, E.S.J.
Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue
J. Biol. Chem.
273
10835-10842
1998
Bos taurus, Homo sapiens
Sun, Q.A.; Zappacosta, F.; Factor, V.M.; Wirth, P.J.; Hatfield, D.L.; Gladyshev, V.N.
Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing
J. Biol. Chem.
276
3106-3114
2001
Drosophila melanogaster, Drosophila melanogaster (P91938), Homo sapiens, Homo sapiens (Q9NNW7), Mus musculus, Mus musculus (Q9JMH6), Rattus norvegicus
Veine, D.M.; Mulrooney, S.B.; Wang, P.F.; Williams, C.H., Jr.
Formation and properties of mixed disulfides between thioredoxin reductase from Escherichia coli and thioredoxin: evidence that cysteine-138 functions to initiate dithiol-disulfide interchange and to accept the reducing equivalent from reduced flavin
Protein Sci.
7
1441-1450
1998
Escherichia coli
Gromer, S.; Gross, J.H.
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase: implications for the antitumor effects of selenium
J. Biol. Chem.
277
9701-9706
2002
Drosophila melanogaster, Homo sapiens, Mus musculus, Plasmodium falciparum
Van den Berg, P.A.W.; Mulrooney, S.B.; Gobets, B.; van Stokkum, I.H.M.; van Hoek, A.; Williams, C.H., Jr.; Visser, A.J.W.G.
Exploring the conformational equilibrium of E. coli thioredoxin reductase: characterization of two catalytically important states by ultrafast flavin fluorescence spectroscopy
Protein Sci.
10
2037-2049
2001
Escherichia coli
Missirlis, F.; Ulschmid, J.K.; Hirosawa-Takamori, M.; Gronke, S.; Schafer, U.; Becker, K.; Phillips, J.P.; Jackle, H.
Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability
J. Biol. Chem.
277
11521-11526
2002
Drosophila melanogaster
Reynolds, C.M.; Poole, L.B.
Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity
Biochemistry
39
8859-8869
2000
Escherichia coli
Lundstroem-Ljung, J.; Birnbach, U.; Rupp, K.; Soeling, H.D.; Holmgren, A.
Two resident ER-proteins, CaBP1 and CaBP2, with thioredoxin domains, are substrates for thioredoxin reductase: comparison with protein disulfide isomerase
FEBS Lett.
357
305-308
1995
Escherichia coli
Watabe, S.; Makino, Y.; Ogawa, K.; Hiroi, T.; Yamamoto, Y.; Takahashi, S.Y.
Mitochondrial thioredoxin reductase in bovine adrenal cortex its purification, properties, nucleotide/amino acid sequences, and identification of selenocysteine
Eur. J. Biochem.
264
74-84
1999
Bos taurus, Escherichia coli
Wang, P.F.; Marcinkeviciene, J.; Williams, C.H., Jr.; Blanchard, J.S.
Thioredoxin Reductase-Thioredoxin Fusion Enzyme from Mycobacterium leprae: Comparison with the Separately Expressed Thioredoxin Reductase
Biochemistry
37
16378-16389
1998
Escherichia coli, Mycobacterium leprae
Gorlatov, S.N.; Stadtman, T.C.
Human selenium-dependent thioredoxin reductase from HeLa cells: properties of forms with differing heparin affinities
Arch. Biochem. Biophys.
369
133-142
1999
Homo sapiens
Jeon, S.J.; Ishikawa, K.
Identification and characterization of thioredoxin and thioredoxin reductase from Aeropyrum pernix K1
Eur. J. Biochem.
269
5423-5430
2002
Aeropyrum pernix
Bauer, H.; Gromer, S.; Urbani, A.; Schnlzer, M.; Schirmer, R.H.; Mller, H.M.
Thioredoxin reductase from the malaria mosquito Anopheles gambiae
Eur. J. Biochem.
270
4272-4281
2003
Anopheles gambiae
Reichheld, J.P.; Meyer, E.; Khafif, M.; Bonnard, G.; Meyer, Y.
AtNTRB is the major mitochondrial thioredoxin reductase in Arabidopsis thaliana
FEBS Lett.
579
337-342
2005
Arabidopsis thaliana (Q39242), Arabidopsis thaliana (Q39243), Arabidopsis thaliana
Jacob, J.; Schirmer, R.H.; Gromer, S.
The conserved histidine 106 of large thioredoxin reductases is likely to have a structural role but not a base catalyst function
FEBS Lett.
579
745-748
2005
Drosophila melanogaster (P91938), Drosophila melanogaster
Nalvarte, I.; Damdimopoulos, A.E.; Spyrou, G.
Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition
Free Radic. Biol. Med.
36
1270-1278
2004
Homo sapiens (Q16881), Homo sapiens (Q9NNW7), Homo sapiens
Rundlof, A.K.; Janard, M.; Miranda-Vizuete, A.; Arner, E.S.J.
Evidence for intriguingly complex transcription of human thioredoxin reductase 1
Free Radic. Biol. Med.
36
641-656
2004
Homo sapiens
Xia, L.; Nordman, T.; Olsson, J.M.; Damdimopoulos, A.; Bjorkhem-Bergman, L.; Nalvarte, I.; Eriksson, L.C.; Arner, E.S.; Spyrou, G.; Bjornstedt, M.
The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress
J. Biol. Chem.
278
2141-2146
2003
Bos taurus, Escherichia coli, Homo sapiens, Rattus norvegicus
Bauer, H.; Massey, V.; Arscott, L.D.; Schirmer, R.H.; Ballou, D.P.; Williams, C.H., Jr.
The mechanism of high Mr thioredoxin reductase from Drosophila melanogaster
J. Biol. Chem.
278
33020-33028
2003
Drosophila melanogaster
Serrato, A.J.; Perez-Ruiz, J.M.; Spinola, M.C.; Cejudo, F.J.
A novel NADPH thioredoxin reductase, localized in the chloroplast, which deficiency causes hypersensitivity to abiotic stress in Arabidopsis thaliana
J. Biol. Chem.
279
43821-43827
2004
Oryza sativa (Q70G58), Oryza sativa
Fernandes, A.P.; Fladvad, M.; Berndt, C.; Andresen, C.; Lillig, C.H.; Neubauer, P.; Sunnerhagen, M.; Holmgren, A.; Vlamis-Gardikas, A.
A novel monothiol glutaredoxin (GRX4) from Escherichia coli can serve as a substrate for thioredoxin reductase
J. Biol. Chem.
280
24544-24552
2005
Escherichia coli
Maggioli, G.; Piacenza, L.; Carambula, B.; Carmona, C.
Purification, characterization, and immunolocalization of a thioredoxin reductase from adult
J. Parasitol.
90
205-211
2004
Fasciola hepatica
Rendon, J.L.; del Arenal, I.P.; Guevara-Flores, A.; Uribe, A.; Plancarte, A.; Mendoza-Hernandez, G.
Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci)
Mol. Biochem. Parasitol.
133
61-69
2004
Taenia crassiceps
Tanaka, R.; Kosugi, K.; Mizukami, M.; Ishibashi, M.; Tokunaga, H.; Tokunaga, M.
Expression and purification of thioredoxin (TrxA) and thioredoxin reductase (TrxB) from Brevibacillus choshinensis
Protein Expr. Purif.
37
385-391
2004
Brevibacillus choshinensis (Q5KTZ6), Brevibacillus choshinensis
Akif, M.; Suhre, K.; Verma, C.; Mande, S.C.
Conformational flexibility of Mycobacterium tuberculosis thioredoxin reductase: crystal structure and normal-mode analysis
Acta Crystallogr. Sect. D
D61
1603-1611
2005
Mycobacterium tuberculosis
Oliveira, M.A.; Discola, K.F.; Alves, S.V.; Barbosa, J.A.; Medrano, F.J.; Netto, L.E.; Guimaraes, B.G.
Crystallization and preliminary X-ray diffraction analysis of NADPH-dependent thioredoxin reductase I from Saccharomyces cerevisiae
Acta Crystallogr. Sect. F
61
387-390
2005
Saccharomyces cerevisiae
Ruggiero, A.; Ruocco, M.R.; Grimaldi, P.; Arcari, P.; Masullo, M.; Zagari, A.; Vitagliano, L.
Crystallization and preliminary X-ray crystallographic analysis of Sulfolobus solfataricus thioredoxin reductase
Acta Crystallogr. Sect. F
61
906-909
2005
Saccharolobus solfataricus
Obiero, J.; Bonderoff, S.A.; Goertzen, M.M.; Sanders, D.A.
Expression, purification, crystallization and preliminary X-ray crystallographic studies of Deinococcus radiodurans thioredoxin reductase
Acta Crystallogr. Sect. F
62
757-760
2006
Deinococcus radiodurans
Lacey, B.M.; Hondal, R.J.
Characterization of mitochondrial thioredoxin reductase from C. elegans
Biochem. Biophys. Res. Commun.
346
629-636
2006
Caenorhabditis elegans
Eckenroth, B.; Harris, K.; Turanov, A.A.; Gladyshev, V.N.; Raines, R.T.; Hondal, R.J.
Semisynthesis and characterization of mammalian thioredoxin reductase
Biochemistry
45
5158-5170
2006
Mus musculus (Q9JLT4), Mus musculus
Andricopulo, A.D.; Akoachere, M.B.; Krogh, R.; Nickel, C.; McLeish, M.J.; Kenyon, G.L.; Arscott, L.D.; Williams, C.H.; Davioud-Charvet, E.; Becker, K.
Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents
Bioorg. Med. Chem. Lett.
16
2283-2292
2006
Homo sapiens, Plasmodium falciparum
Lu, J.; Papp, L.V.; Fang, J.; Rodriguez-Nieto, S.; Zhivotovsky, B.; Holmgren, A.
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity
Cancer Res.
66
4410-4418
2006
Rattus norvegicus
Cassidy, P.B.; Edes, K.; Nelson, C.C.; Parsawar, K.; Fitzpatrick, F.A.; Moos, P.J.
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles
Carcinogenesis
27
2538-2549
2006
Rattus norvegicus
Kato, M.; Yamamoto, H.; Okamura, T.A.; Maoka, N.; Masui, R.; Kuramitsu, S.; Ueyama, N.
Inhibition of Thermus thermophilus HB8 thioredoxin activity by platinum(II)
Dalton Trans.
2005
1023-1026
2005
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Urig, S.; Lieske, J.; Fritz-Wolf, K.; Irmler, A.; Becker, K.
Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity
FEBS Lett.
580
3595-3600
2006
Homo sapiens
Johansson, L.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.; Arner, E.S.
Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme
Free Radic. Biol. Med.
41
649-656
2006
Rattus norvegicus (O89049)
Walters, E.M.; Garcia-Serres, R.; Jameson, G.N.; Glauser, D.A.; Bourquin, F.; Manieri, W.; Schuermann, P.; Johnson, M.K.; Huynh, B.H.
Spectroscopic characterization of site-specific [Fe(4)S(4)] cluster chemistry in ferredoxin:thioredoxin reductase: implications for the catalytic mechanism
J. Am. Chem. Soc.
127
9612-9624
2005
Synechocystis sp.
Fang, J.; Holmgren, A.
Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo
J. Am. Chem. Soc.
128
1879-1885
2006
Rattus norvegicus
Fang, J.; Lu, J.; Holmgren, A.
Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity
J. Biol. Chem.
280
25284-25290
2005
Homo sapiens, Rattus norvegicus
Turanov, A.A.; Su, D.; Gladyshev, V.N.
Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase
J. Biol. Chem.
281
22953-22963
2006
Homo sapiens, Mus musculus
Gray, J.P.; Heck, D.E.; Mishin, V.; Smith, P.J.; Hong, J.Y.; Thiruchelvam, M.; Cory-Slechta, D.A.; Laskin, D.L.; Laskin, J.D.
Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H: paraquat oxidoreductase: Identification of the enzyme as thioredoxin reductase
J. Biol. Chem.
282
7939-7949
2007
Mus musculus
Alkhalfioui, F.; Renard, M.; Montrichard, F.
Unique properties of NADP-thioredoxin reductase C in legumes
J. Exp. Bot.
58
969-978
2006
Medicago truncatula, Medicago truncatula (A6XJ27)
Karunasinghe, N.; Ferguson, L.R.; Tuckey, J.; Masters, J.
Hemolysate thioredoxin reductase and glutathione peroxidase activities correlate with serum selenium in a group of New Zealand men at high prostate cancer risk
J. Nutr.
136
2232-2235
2006
Homo sapiens
Matsuzaka, Y.; Okamoto, K.; Mabuchi, T.; Iizuka, M.; Ozawa, A.; Oka, A.; Tamiya, G.; Kulski, J.K.; Inoko, H.
Identification and characterization of novel variants of the thioredoxin reductase 3 new transcript 1 TXNRD3NT1
Mamm. Genome
16
41-49
2005
Homo sapiens (Q86VQ6), Homo sapiens
Powis, G.; Wipf, P.; Lynch, S.M.; Birmingham, A.; Kirkpatrick, D.L.
Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase
Mol. Cancer Ther.
5
630-636
2006
Homo sapiens
Kang, H.J.; Hong, S.M.; Kim, B.C.; Park, E.H.; Ahn, K.; Lim, C.J.
Effects of heterologous expression of thioredoxin reductase on the level of reactive oxygen species in COS-7 cells
Mol. Cell
22
113-118
2006
Chlorocebus aethiops
Biterova, E.I.; Turanov, A.A.; Gladyshev, V.N.; Barycki, J.J.
Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism
Proc. Natl. Acad. Sci. USA
102
15018-15023
2005
Mus musculus (Q9JLT4), Mus musculus
Wang, X.; Zhang, J.; Xu, T.
Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo
Toxicol. Appl. Pharmacol.
218
88-95
2007
Mus musculus
Omata, Y.; Folan, M.; Shaw, M.; Messer, R.L.; Lockwood, P.E.; Hobbs, D.; Bouillaguet, S.; Sano, H.; Lewis, J.B.; Wataha, J.C.
Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1)
Toxicol. In Vitro
20
882-890
2006
Rattus norvegicus
Ruocco, M.R.; Ruggiero, A.; Masullo, L.; Arcari, P.; Masullo, M.
A 35 kDa NAD(P)H oxidase previously isolated from the archaeon Sulfolobus solfataricus is instead a thioredoxin reductase.
Biochimie
86
883-892
2004
Saccharolobus solfataricus (Q97W27), Saccharolobus solfataricus
Gustafsson, T.N.; Sandalova, T.; Lu, J.; Holmgren, A.; Schneider, G.
High-resolution structures of oxidized and reduced thioredoxin reductase from Helicobacter pylori
Acta Crystallogr. Sect. D
63
833-843
2007
Helicobacter pylori
Kaakoush, N.O.; Sterzenbach, T.; Miller, W.G.; Suerbaum, S.; Mendz, G.L.
Identification of disulfide reductases in Campylobacterales: a bioinformatics investigation
Antonie van Leeuwenhoek
92
429-441
2007
Aliarcobacter butzleri, Aliarcobacter butzleri RM4018, Helicobacter pylori
Crosley, L.K.; Meplan, C.; Nicol, F.; Rundloef, A.K.; Arner, E.S.; Hesketh, J.E.; Arthur, J.R.
Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney
Arch. Biochem. Biophys.
459
178-188
2007
Rattus norvegicus (O89049), Rattus norvegicus Rowett (O89049)
Conterato, G.M.; Augusti, P.R.; Somacal, S.; Einsfeld, L.; Sobieski, R.; Torres, J.R.; Emanuelli, T.
Effect of lead acetate on cytosolic thioredoxin reductase activity and oxidative stress parameters in rat kidneys
Basic Clin. Pharmacol. Toxicol.
101
96-100
2007
Rattus norvegicus (O89049)
Sohn, K.C.; Jang, S.; Choi, D.K.; Lee, Y.S.; Yoon, T.J.; Jeon, E.K.; Kim, K.H.; Seo, Y.J.; Lee, J.H.; Park, J.K.; Kim, C.D.
Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells
Biochem. Biophys. Res. Commun.
356
810-815
2007
Homo sapiens (Q16881), Homo sapiens
Seyfried, J.; Wuellner, U.
Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway
Biochem. Biophys. Res. Commun.
359
759-764
2007
Rattus norvegicus
Kabuyama, Y.; Kitamura, T.; Yamaki, J.; Homma, M.K.; Kikuchi, S.; Homma, Y.
Involvement of thioredoxin reductase 1 in the regulation of redox balance and viability of rheumatoid synovial cells
Biochem. Biophys. Res. Commun.
367
491-496
2008
Homo sapiens (Q16881), Homo sapiens
Watson, W.H.; Heilman, J.M.; Hughes, L.L.; Spielberger, J.C.
Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation
Biochem. Biophys. Res. Commun.
368
832-836
2008
Homo sapiens (Q16881)
Inarrea, P.; Moini, H.; Han, D.; Rettori, D.; Aguilo, I.; Alava, M.A.; Iturralde, M.; Cadenas, E.
Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis
Biochem. J.
405
173-179
2007
Rattus norvegicus (O89049)
Thandavarayan, R.A.; Watanabe, K.; Ma, M.; Veeraveedu, P.T.; Gurusamy, N.; Palaniyandi, S.S.; Zhang, S.; Muslin, A.J.; Kodama, M.; Aizawa, Y.
14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy
Biochem. Pharmacol.
75
1797-1806
2008
Mus musculus
Selenius, M.; Fernandes, A.P.; Brodin, O.; Bjoernstedt, M.; Rundloef, A.K.
Treatment of lung cancer cells with cytotoxic levels of sodium selenite: effects on the thioredoxin system
Biochem. Pharmacol.
75
2092-2099
2008
Homo sapiens (Q16881), Homo sapiens
Eckenroth, B.E.; Rould, M.A.; Hondal, R.J.; Everse, S.J.
Structural and biochemical studies reveal differences in the catalytic mechanisms of mammalian and Drosophila melanogaster thioredoxin reductases
Biochemistry
46
4694-4705
2007
Drosophila melanogaster (P91938), Drosophila melanogaster, Mus musculus (Q8BTW3), Mus musculus
Cheng, Z.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.
The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila
Biochemistry
46
7875-7885
2007
Drosophila melanogaster
Eckenroth, B.E.; Lacey, B.M.; Lothrop, A.P.; Harris, K.M.; Hondal, R.J.
Investigation of the C-terminal redox center of high-Mr thioredoxin reductase by protein engineering and semisynthesis
Biochemistry
46
9472-9483
2007
Caenorhabditis elegans, Drosophila melanogaster, Mus musculus (Q8BTW3), Mus musculus
Hernandez, H.H.; Jaquez, O.A.; Hamill, M.J.; Elliott, S.J.; Drennan, C.L.
Thioredoxin Reductase from Thermoplasma acidophilum: A New Twist on Redox Regulation
Biochemistry
47
9728-9737
2008
Thermoplasma acidophilum
Hamill, M.J.; Chobot, S.E.; Hernandez, H.H.; Drennan, C.L.; Elliott, S.J.
Direct electrochemical analyses of a thermophilic thioredoxin reductase: interplay between conformational change and redox chemistry
Biochemistry
47
9738-9746
2008
Thermoplasma acidophilum
Sroka, J.; Antosik, A.; Czyz, J.; Nalvarte, I.; Olsson, J.M.; Spyrou, G.; Madeja, Z.
Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells
Biol. Cell
99
677-687
2007
Homo sapiens (Q16881)
Hu, Y.; Urig, S.; Koncarevic, S.; Wu, X.; Fischer, M.; Rahlfs, S.; Mersch-Sundermann, V.; Becker, K.
Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents
Biol. Chem.
388
1069-1081
2007
Homo sapiens
Geisberger, R.; Kiermayer, C.; Hoemig, C.; Conrad, M.; Schmidt, J.; Zimber-Strobl, U.; Brielmeier, M.
B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance
Biol. Chem.
388
1083-1090
2007
Mus musculus (Q9JLT4), Mus musculus
Kiermayer, C.; Michalke, B.; Schmidt, J.; Brielmeier, M.
Effect of selenium on thioredoxin reductase activity in Txnrd1 or Txnrd2 hemizygous mice
Biol. Chem.
388
1091-1097
2007
Mus musculus (Q9JLT4), Mus musculus (Q9JMH6)
Qiu, X.; Liu, Z.; Shao, W.Y.; Liu, X.; Jing, D.P.; Yu, Y.J.; An, L.K.; Huang, S.L.; Bu, X.Z.; Huang, Z.S.; Gu, L.Q.
Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
Bioorg. Med. Chem.
16
8035-8041
2008
Homo sapiens
Liu, Z.; Du, Z.Y.; Huang, Z.S.; Lee, K.S.; Gu, L.Q.
Inhibition of thioredoxin reductase by curcumin analogs
Biosci. Biotechnol. Biochem.
72
2214-2218
2008
Sus scrofa
Zhang, J.; Wang, X.; Lu, H.
Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase
Cancer Lett.
260
127-136
2008
Mus musculus
Park, S.M.; Jung, J.S.; Jang, M.S.; Kang, K.S.; Kang, S.K.
Transforming growth factor-beta1 regulates the fate of cultured spinal cord-derived neural progenitor cells
Cell Prolif.
41
248-264
2008
Rattus norvegicus (O89049)
Zhang, Y.; Shen, X.
Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity
Clin. Cancer Res.
13
2855-2864
2007
Mus musculus
Yan, H.; Harding, J.J.; Xing, K.; Lou, M.F.
Revival of glutathione reductase in human cataractous and clear lens extracts by thioredoxin and thioredoxin reductase, in conjunction with alpha-crystallin or thioltransferase
Curr. Eye Res.
32
455-463
2007
Homo sapiens
Rundloef, A.; Fernandes, A.P.; Selenius, M.; Babic, M.; Shariatgorji, M.; Nilsonne, G.; Ilag, L.L.; Dobra, K.; Bjoernstedt, M.
Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells
Differentiation
75
123-132
2007
Homo sapiens (Q16881), Homo sapiens
Mentel, M.; Zimorski, V.; Haferkamp, P.; Martin, W.; Henze, K.
Protein import into hydrogenosomes of Trichomonas vaginalis involves both N-terminal and internal targeting signals - a case study of thioredoxin reductases
Eukaryot. Cell
7
1750-1757
2008
Trichomonas vaginalis
Wang, X.; Zhang, J.; Xu, T.
Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy
Eur. J. Pharmacol.
579
66-73
2008
Mus musculus
Meplan, C.; Crosley, L.K.; Nicol, F.; Beckett, G.J.; Howie, A.F.; Hill, K.E.; Horgan, G.; Mathers, J.C.; Arthur, J.R.; Hesketh, J.E.
Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study)
FASEB J.
21
3063-3074
2007
Homo sapiens
Chew, E.H.; Lu, J.; Bradshaw, T.D.; Holmgren, A.
Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity
FASEB J.
22
2072-2083
2008
Rattus norvegicus
Stenbaek, A.; Hansson, A.; Wulff, R.P.; Hansson, M.; Dietz, K.J.; Jensen, P.E.
NADPH-dependent thioredoxin reductase and 2-Cys peroxiredoxins are needed for the protection of Mg-protoporphyrin monomethyl ester cyclase
FEBS Lett.
582
2773-2778
2008
Arabidopsis sp.
Arias, D.G.; Gutierrez, C.E.; Iglesias, A.A.; Guerrero, S.A.
Thioredoxin-linked metabolism in Entamoeba histolytica
Free Radic. Biol. Med.
42
1496-1505
2007
Entamoeba histolytica
Marzano, C.; Gandin, V.; Folda, A.; Scutari, G.; Bindoli, A.; Rigobello, M.P.
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
Free Radic. Biol. Med.
42
872-881
2007
Homo sapiens
Bondareva, A.A.; Capecchi, M.R.; Iverson, S.V.; Li, Y.; Lopez, N.I.; Lucas, O.; Merrill, G.F.; Prigge, J.R.; Siders, A.M.; Wakamiya, M.; Wallin, S.L.; Schmidt, E.E.
Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome
Free Radic. Biol. Med.
43
911-923
2007
Mus musculus (Q9JMH6), Mus musculus
Arias, D.G.; Carranza, P.G.; Lujan, H.D.; Iglesias, A.A.; Guerrero, S.A.
Immunolocalization and enzymatic functional characterization of the thioredoxin system in Entamoeba histolytica
Free Radic. Biol. Med.
45
32-39
2008
Entamoeba histolytica
Moskovitz, J.
Prolonged selenium-deficient diet in MsrA knockout mice causes enhanced oxidative modification to proteins and affects the levels of antioxidant enzymes in a tissue-specific manner
Free Radic. Res.
41
162-171
2007
Mus musculus
Lemarechal, H.; Anract, P.; Beaudeux, J.L.; Bonnefont-Rousselot, D.; Ekindjian, O.G.; Borderie, D.
Impairment of thioredoxin reductase activity by oxidative stress in human rheumatoid synoviocytes
Free Radic. Res.
41
688-698
2007
Homo sapiens
Trandafir, F.; Hoogewijs, D.; Altieri, F.; Rivetti di Val Cervo, P.; Ramser, K.; Van Doorslaer, S.; Vanfleteren, J.R.; Moens, L.; Dewilde, S.
Neuroglobin and cytoglobin as potential enzyme or substrate
Gene
398
103-113
2007
Rattus norvegicus
Cunnea, P.; Fernandes, A.P.; Capitanio, A.; Eken, S.; Spyrou, G.; Bjoernstedt, M.
Increased expression of specific thioredoxin family proteins; a pilot immunohistochemical study on human hepatocellular carcinoma
Int. J. Immunopathol. Pharmacol.
20
17-24
2007
Homo sapiens (Q16881), Homo sapiens
Bacon, J.R.; Plumb, G.W.; Howie, A.F.; Beckett, G.J.; Wang, W.; Bao, Y.
Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells
J. Agric. Food Chem.
55
1170-1176
2007
Homo sapiens
Rocha, E.R.; Tzianabos, A.O.; Smith, C.J.
Thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilis
J. Bacteriol.
189
8015-8023
2007
Bacteroides fragilis
Takahata, M.; Tamura, T.; Abe, K.; Mihara, H.; Kurokawa, S.; Yamamoto, Y.; Nakano, R.; Esaki, N.; Inagaki, K.
Selenite assimilation into formate dehydrogenase H depends on thioredoxin reductase in Escherichia coli
J. Biochem.
143
467-473
2008
Escherichia coli
Cumming, R.C.; Dargusch, R.; Fischer, W.H.; Schubert, D.
Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells
J. Biol. Chem.
282
30523-30534
2007
Rattus norvegicus
Hintze, K.J.; Katoh, Y.; Igarashi, K.; Theil, E.C.
Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin, and NADP(H) quinone (oxido) reductase1
J. Biol. Chem.
282
34365-34371
2007
Mus musculus (Q9JMH6)
Dammeyer, P.; Damdimopoulos, A.E.; Nordman, T.; Jimenez, A.; Miranda-Vizuete, A.; Arner, E.S.
Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1
J. Biol. Chem.
283
2814-2821
2008
Homo sapiens (Q16881), Homo sapiens
Sordillo, L.M.; OBoyle, N.; Gandy, J.C.; Corl, C.M.; Hamilton, E.
Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle
J. Dairy Sci.
90
1186-1192
2007
Bos taurus
Mura, P.; Camalli, M.; Bindoli, A.; Sorrentino, F.; Casini, A.; Gabbiani, C.; Corsini, M.; Zanello, P.; Rigobello, M.P.; Messori, L.
Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound
J. Med. Chem.
50
5871-5874
2007
Rattus norvegicus (O89049)
Fritz-Wolf, K.; Urig, S.; Becker, K.
The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis
J. Mol. Biol.
370
116-127
2007
Homo sapiens (Q16881), Homo sapiens
Cao, Z.; Bhella, D.; Lindsay, J.G.
Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state
J. Mol. Biol.
372
1022-1033
2007
Homo sapiens
Flemer, S.; Lacey, B.M.; Hondal, R.J.
Synthesis of peptide substrates for mammalian thioredoxin reductase
J. Pept. Sci.
14
637-647
2008
Mus musculus
Arbones-Mainar, J.M.; Ross, K.; Rucklidge, G.J.; Reid, M.; Duncan, G.; Arthur, J.R.; Horgan, G.W.; Navarro, M.A.; Carnicer, R.; Arnal, C.; Osada, J.; de Roos, B.
Extra virgin olive oils increase hepatic fat accumulation and hepatic antioxidant protein levels in APOE-/- mice
J. Proteome Res.
6
4041-4054
2007
Mus musculus
Peng, Z.F.; Lan, L.X.; Zhao, F.; Li, J.; Tan, Q.; Yin, H.W.; Zeng, H.H.
A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells
J. Zhejiang Univ. Sci. B
9
16-21
2008
Homo sapiens
Serrano, L.M.; Molenaar, D.; Wels, M.; Teusink, B.; Bron, P.A.; de Vos, W.M.; Smid, E.J.
Thioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1
Microb. Cell Fact.
6
29
2007
Lactiplantibacillus plantarum
Huber, K.; Patel, P.; Zhang, L.; Evans, H.; Westwell, A.D.; Fischer, P.M.; Chan, S.; Martin, S.
2-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation
Mol. Cancer Ther.
7
143-151
2008
Homo sapiens
Reyes, D.Y.; Zuber, P.
Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation
Mol. Microbiol.
69
765-779
2008
Rattus norvegicus (O89049), Homo sapiens (Q16881)
Zamudio, S.; Kovalenko, O.; Vanderlelie, J.; Illsley, N.P.; Heller, D.; Belliappa, S.; Perkins, A.V.
Chronic hypoxia in vivo reduces placental oxidative stress
Placenta
28
846-853
2007
Homo sapiens
Reichheld, J.P.; Khafif, M.; Riondet, C.; Droux, M.; Bonnard, G.; Meyer, Y.
Inactivation of thioredoxin reductases reveals a complex interplay between thioredoxin and glutathione pathways in Arabidopsis development
Plant Cell
19
1851-1865
2007
Arabidopsis thaliana
Hishiya, S.; Hatakeyama, W.; Mizota, Y.; Hosoya-Matsuda, N.; Motohashi, K.; Ikeuchi, M.; Hisabori, T.
Binary reducing equivalent pathways using NADPH-thioredoxin reductase and ferredoxin-thioredoxin reductase in the cyanobacterium Synechocystis sp. strain PCC 6803
Plant Cell Physiol.
49
11-18
2008
Synechocystis sp.
Shahpiri, A.; Svensson, B.; Finnie, C.
The NADPH-dependent thioredoxin reductase/thioredoxin system in germinating barley seeds: gene expression, protein profiles, and interactions between isoforms of thioredoxin h and thioredoxin reductase
Plant Physiol.
146
789-799
2008
Hordeum vulgare
Leitsch, D.; Kolarich, D.; Wilson, I.B.; Altmann, F.; Duchene, M.
Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase
PLoS Biol.
5
e211
2007
Entamoeba histolytica
Yoo, M.H.; Xu, X.M.; Carlson, B.A.; Patterson, A.D.; Gladyshev, V.N.; Hatfield, D.L.
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication
PLoS ONE
2
e1112
2007
Homo sapiens (Q16881), Mus musculus (Q9JMH6), Mus musculus
Soerensen, J.; Jakupoglu, C.; Beck, H.; Foerster, H.; Schmidt, J.; Schmahl, W.; Schweizer, U.; Conrad, M.; Brielmeier, M.
The role of thioredoxin reductases in brain development
PLoS ONE
3
e1813
2008
Mus musculus (Q9JLT4), Mus musculus (Q9JMH6)
Anestal, K.; Prast-Nielsen, S.; Cenas, N.; Arner, E.S.
Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells
PLoS ONE
3
e1846
2008
Homo sapiens, Rattus norvegicus (O89049)
Lu, J.; Chew, E.H.; Holmgren, A.
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
Proc. Natl. Acad. Sci. USA
104
12288-12293
2007
Homo sapiens
Angelucci, F.; Miele, A.E.; Boumis, G.; Dimastrogiovanni, D.; Brunori, M.; Bellelli, A.
Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase
Proteins
72
936-945
2008
Schistosoma mansoni
Zhang, J.; Wang, H.; Peng, D.; Taylor, E.W.
Further insight into the impact of sodium selenite on selenoenzymes: high-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury
Toxicol. Lett.
176
223-229
2008
Mus musculus (Q9JMH6)
Kirkensgaard, K.G.; Haegglund, P.; Finnie, C.; Svensson, B.; Henriksen, A.
Structure of Hordeum vulgare NADPH-dependent thioredoxin reductase 2. Unwinding the reaction mechanism
Acta Crystallogr. Sect. D
65
932-941
2009
Hordeum vulgare (A9LN30), Hordeum vulgare
Sueoka, K.; Yamazaki, T.; Hiyama, T.; Nakamoto, H.
The NADPH thioredoxin reductase C functions as an electron donor to 2-Cys peroxiredoxin in a thermophilic cyanobacterium Thermosynechococcus elongatus BP-1
Biochem. Biophys. Res. Commun.
380
520-524
2009
Thermosynechococcus vestitus
Huang, H.H.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.
Function of Glu-469 in the acid-base catalysis of thioredoxin reductase from Drosophila melanogaster
Biochemistry
47
12769-12776
2008
Drosophila melanogaster
Lacey, B.M.; Eckenroth, B.E.; Flemer, S.; Hondal, R.J.
Selenium in thioredoxin reductase: a mechanistic perspective
Biochemistry
47
12810-12821
2008
Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus
Conrad, M.
Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4
Biochim. Biophys. Acta
1790
1575-1585
2009
Mus musculus
Arner, E.S.
Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions
Biochim. Biophys. Acta
1790
495-526
2009
Homo sapiens, Mus musculus (Q9JLT4), Mus musculus (Q9JMH6), Mus musculus
Zhang, Z.; Bao, R.; Zhang, Y.; Yu, J.; Zhou, C.Z.; Chen, Y.
Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin
Biochim. Biophys. Acta
1794
124-128
2009
Saccharomyces cerevisiae (P29509), Saccharomyces cerevisiae
Ruggiero, A.; Masullo, M.; Ruocco, M.R.; Grimaldi, P.; Lanzotti, M.A.; Arcari, P.; Zagari, A.; Vitagliano, L.
Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: a thermostable protein with two functions
Biochim. Biophys. Acta
1794
554-562
2009
Saccharolobus solfataricus (Q97W27), Saccharolobus solfataricus
Du, Y.; Wu, Y.; Cao, X.; Cui, W.; Zhang, H.; Tian, W.; Ji, M.; Holmgren, A.; Zhong, L.
Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions
Biochimie
91
434-444
2009
Bos taurus (O62768), Homo sapiens (Q16881)
Wang, Y.; Zhang, X.; Liu, Q.; Ai, C.; Mo, H.; Zeng, J.
Expression, purification and molecular structure modeling of thioredoxin (Trx) and thioredoxin reductase (TrxR) from Acidithiobacillus ferrooxidans
Curr. Microbiol.
59
35-41
2009
Acidithiobacillus ferrooxidans
Volonte, D.; Galbiati, F.
Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence
EMBO Rep.
10
1334-1340
2009
Mus musculus, Homo sapiens (Q16881)
Perez-Ruiz, J.M.; Cejudo, F.J.
A proposed reaction mechanism for rice NADPH thioredoxin reductase C, an enzyme with protein disulfide reductase activity
FEBS Lett.
583
1399-1402
2009
Oryza sativa (Q70G58), Oryza sativa
Hishinuma, S.; Ohtsu, I.; Fujimura, M.; Fukumori, F.
OxyR is involved in the expression of thioredoxin reductase TrxB in Pseudomonas putida
FEMS Microbiol. Lett.
289
138-145
2008
Pseudomonas putida, Pseudomonas putida KT 2442
Rengby, O.; Cheng, Q.; Vahter, M.; Joernvall, H.; Arner, E.S.
Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1
Free Radic. Biol. Med.
46
893-904
2009
Rattus norvegicus (O89049)
Eriksson, S.E.; Prast-Nielsen, S.; Flaberg, E.; Szekely, L.; Arner, E.S.
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
Free Radic. Biol. Med.
47
1661-1671
2009
Rattus norvegicus (O89049), Homo sapiens (Q16881), Homo sapiens
Chew, E.H.; Nagle, A.A.; Zhang, Y.; Scarmagnani, S.; Palaniappan, P.; Bradshaw, T.D.; Holmgren, A.; Westwell, A.D.
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention
Free Radic. Biol. Med.
48
98-111
2010
Escherichia coli, Homo sapiens, Rattus norvegicus
Ballal, A.; Manna, A.C.
Control of thioredoxin reductase (trxB) transcription by SarA in Staphylococcus aureus
J. Bacteriol.
192
336-345
2010
Staphylococcus aureus
Araie, H.; Suzuki, I.; Shiraiwa, Y.
Identification and characterization of a selenoprotein, thioredoxin reductase, in a unicellular marine haptophyte alga, Emiliania huxleyi
J. Biol. Chem.
283
35329-35336
2008
Emiliania huxleyi (B9A1H3), Emiliania huxleyi
Cheng, Q.; Sandalova, T.; Lindqvist, Y.; Arner, E.S.
Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1
J. Biol. Chem.
284
3998-4008
2009
Rattus norvegicus (O89049)
Potter, A.J.; Kidd, S.P.; Edwards, J.L.; Falsetta, M.L.; Apicella, M.A.; Jennings, M.P.; McEwan, A.G.
Thioredoxin reductase is essential for protection of Neisseria gonorrhoeae against killing by nitric oxide and for bacterial growth during interaction with cervical epithelial cells
J. Infect. Dis.
199
227-235
2009
Neisseria gonorrhoeae, Neisseria gonorrhoeae 1291
Banerjee, A.K.; Arora, N.; Murty, U.S.
Structural model of the Plasmodium falciparum thioredoxin reductase: a novel target for antimalarial drugs
J. Vector Borne Dis.
46
171-183
2009
Plasmodium falciparum
Greetham, D.; Grant, C.M.
Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo
Mol. Cell. Biol.
29
3229-3240
2009
Saccharomyces cerevisiae
Kirchsteiger, K.; Pulido, P.; Gonzalez, M.; Cejudo, F.J.
NADPH thioredoxin reductase C controls the redox status of chloroplast 2-Cys peroxiredoxins in Arabidopsis thaliana
Mol. Plant
2
298-307
2009
Arabidopsis thaliana
Perez-Ruiz, J.M.; Gonzalez, M.; Spinola, M.C.; Sandalio, L.M.; Cejudo, F.J.
The quaternary structure of NADPH thioredoxin reductase C is redox-sensitive
Mol. Plant
2
457-467
2009
Arabidopsis thaliana
Singh, S.S.; Li, Y.; Ford, O.H.; Wrzosek, C.S.; Mehedint, D.C.; Titus, M.A.; Mohler, J.L.
Thioredoxin reductase 1 expression and castration-recurrent growth of prostate cancer
Transl. Oncol.
1
153-157
2008
Mus musculus (Q9JMH6)
Hondal, R.J.; Ruggles, E.L.
Differing views of the role of selenium in thioredoxin reductase
Amino Acids
41
73-89
2011
Mus musculus, Rattus norvegicus
Tibodeau, J.; Benson, L.; Isham, C.; Owen, W.; Bible, K.
The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase
Antioxid. Redox Signal.
11
1097-1106
2009
Homo sapiens
Liu, Z.B.; Shen, X.
Thioredoxin reductase 1 upregulates MCP-1 release in human endothelial cells
Biochem. Biophys. Res. Commun.
386
703-708
2009
Homo sapiens
Holmgren, A.; Lu, J.
Thioredoxin and thioredoxin reductase: current research with special reference to human disease
Biochem. Biophys. Res. Commun.
396
120-124
2010
Rattus norvegicus
Turanov, A.A.; Kehr, S.; Marino, S.M.; Yoo, M.H.; Carlson, B.A.; Hatfield, D.L.; Gladyshev, V.N.
Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets
Biochem. J.
430
285-293
2010
Mus musculus, Rattus norvegicus (O89049), Homo sapiens (Q16881)
Stoner, C.S.; Pearson, G.D.; Koc, A.; Merwin, J.R.; Lopez, N.I.; Merrill, G.F.
Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast
Biochemistry
48
9156-9169
2009
Saccharomyces cerevisiae, Saccharomyces cerevisiae W303-1A
Damdimopoulou, P.E.; Miranda-Vizuete, A.; Arner, E.S.; Gustafsson, J.A.; Damdimopoulos, A.E.
The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia
Biochim. Biophys. Acta
1793
1588-1596
2009
Homo sapiens
Singh, D.V.; Misra, K.
Curcuminoids as inhibitors of thioredoxin reductase: a receptor based pharmacophore study with distance mapping of the active site
Bioinformation
4
187-192
2009
Rattus norvegicus
Wagner, C.; Sudati, J.H.; Nogueira, C.W.; Rocha, J.B.
In vivo and in vitro inhibition of mice thioredoxin reductase by methylmercury
Biometals
23
1171-1177
2010
Mus musculus
Sorrentino, F.; Karioti, A.; Gratteri, P.; Rigobello, M.P.; Scutari, G.; Messori, L.; Bindoli, A.; Chioccioli, M.; Gabbiani, C.; Bergonzi, M.C.; Bilia, A.R.
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones
Bioorg. Med. Chem.
19
631-641
2011
Rattus norvegicus (O89049), Rattus norvegicus (Q9Z0J5)
Machida, T.; Kato, E.; Ishibashi, A.; Sato, J.; Kawasaki, S.; Niimura, Y.; Honjoh, K.; Miyamoto, T.
Expression pattern of a chloroplast NADPH-dependent thioredoxin reductase in Chlorella vulgaris during hardening and its interaction with 2-Cys peroxiredoxin
Biosci. Biotechnol. Biochem.
73
695-701
2009
Chlorella vulgaris (B9ZYY5), Chlorella vulgaris, Chlorella vulgaris Beijerinck IAM C-27 (B9ZYY5)
Javvadi, P.; Hertan, L.; Kosoff, R.; Datta, T.; Kolev, J.; Mick, R.; Tuttle, S.W.; Koumenis, C.
Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells
Cancer Res.
70
1941-1950
2010
Homo sapiens
Vergara, E.; Casini, A.; Sorrentino, F.; Zava, O.; Cerrada, E.; Rigobello, M.P.; Bindoli, A.; Laguna, M.; Dyson, P.J.
Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity, and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands
ChemMedChem
5
96-102
2010
Homo sapiens
Yang, H.; Kang, M.; Guo, X.; Xu, B.
Cloning, structural features, and expression analysis of the gene encoding thioredoxin reductase 1 from Apis cerana cerana
Comp. Biochem. Physiol. B
156
229-236
2010
Apis cerana cerana (D7PBZ6), Apis cerana cerana
Carvalho, C.M.; Lu, J.; Zhang, X.; Arner, E.S.; Holmgren, A.
Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning
FASEB J.
25
370-381
2011
Homo sapiens, Rattus norvegicus
Myers, J.M.; Myers, C.R.
The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells
Free Radic. Biol. Med.
47
1477-1485
2009
Homo sapiens
Prast-Nielsen, S.; Cebula, M.; Pader, I.; Arner, E.S.
Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin
Free Radic. Biol. Med.
49
1765-1778
2010
Homo sapiens, Rattus norvegicus
Mandal, P.K.; Seiler, A.; Perisic, T.; Koelle, P.; Banjac Canak, A.; Foerster, H.; Weiss, N.; Kremmer, E.; Lieberman, M.W.; Bannai, S.; Kuhlencordt, P.; Sato, H.; Bornkamm, G.W.; Conrad, M.
System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency
J. Biol. Chem.
285
22244-22253
2010
Rattus norvegicus
Angelucci, F.; Dimastrogiovanni, D.; Boumis, G.; Brunori, M.; Miele, A.E.; Saccoccia, F.; Bellelli, A.
Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography
J. Biol. Chem.
285
32557-32567
2010
Schistosoma mansoni (Q962Y6)
Lo, Y.C.; Ko, T.P.; Su, W.C.; Su, T.L.; Wang, A.H.
Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1
J. Inorg. Biochem.
103
1082-1092
2009
Homo sapiens (Q16881), Homo sapiens
Kapoor, G.; Banyal, H.S.
Glutathione reductase and thioredoxin reductase: novel antioxidant enzymes from Plasmodium berghei
Korean J. Parasitol.
47
421-424
2009
Plasmodium berghei
Rigobello, M.P.; Bindoli, A.
Mitochondrial thioredoxin reductase purification, inhibitor studies, and role in cell signaling
Methods Enzymol.
474
109-122
2010
Rattus norvegicus
Turanov, A.A.; Hatfield, D.L.; Gladyshev, V.N.
Characterization of protein targets of mammalian thioredoxin reductases
Methods Enzymol.
474
245-254
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Yan, C.; Shieh, B.; Reigan, P.; Zhang, Z.; Colucci, M.A.; Chilloux, A.; Newsome, J.J.; Siegel, D.; Chan, D.; Moody, C.J.; Ross, D.
Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target
Mol. Pharmacol.
76
163-172
2009
Homo sapiens, Rattus norvegicus
Hudson, A.L.; Sotirchos, I.M.; Davey, M.W.
Substrate specificity of the mitochondrial thioredoxin reductase of the parasitic nematode Haemonchus contortus
Parasitol. Res.
107
487-493
2010
Haemonchus contortus
Lepistoe, A.; Kangasjaervi, S.; Luomala, E.M.; Brader, G.; Sipari, N.; Keraenen, M.; Keinaenen, M.; Rintamaeki, E.
Chloroplast NADPH-thioredoxin reductase interacts with photoperiodic development in Arabidopsis
Plant Physiol.
149
1261-1276
2009
Arabidopsis thaliana, Arabidopsis thaliana ecotype Col-0
Negri, A.; Rodriguez-Larrea, D.; Marco, E.; Jimenez-Ruiz, A.; Sanchez-Ruiz, J.; Gago, F.
Protein-protein interactions at an enzyme-substrate interface: Characterization of transient reaction intermediates throughout a full catalytic cycle of Escherichia coli thioredoxin reductase
Proteins Struct. Funct. Bioinform.
78
36-51
2010
Escherichia coli (P0A9P4), Escherichia coli
Jacquot, J.P.; Eklund, H.; Rouhier, N.; Schuermann, P.
Structural and evolutionary aspects of thioredoxin reductases in photosynthetic organisms
Trends Plant Sci.
14
336-343
2009
Arabidopsis thaliana
Kapoor, G.; Banyal, H.
Purification and characterization of Plasmodium berghei thioredoxin reductase
Asian-australas. J. Anim. Sci.
5
145-152
2011
Plasmodium berghei
-
Snider, G.; Grout, L.; Ruggles, E.L.; Hondal, R.J.
Methaneseleninic acid is a substrate for truncated mammalian thioredoxin reductase: implications for the catalytic mechanism and redox signaling
Biochemistry
49
10329-10338
2010
Mus musculus
Oliveira, M.A.; Discola, K.F.; Alves, S.V.; Medrano, F.J.; Guimaraes, B.G.; Netto, L.E.
Insights into the specificity of thioredoxin reductase-thioredoxin interactions. A structural and functional investigation of the yeast thioredoxin system
Biochemistry
49
3317-3326
2010
Saccharomyces cerevisiae
Wulff, R.P.; Lundqvist, J.; Rutsdottir, G.; Hansson, A.; Stenbaek, A.; Elmlund, D.; Elmlund, H.; Jensen, P.E.; Hansson, M.
The activity of barley NADPH-dependent thioredoxin reductase C is independent of the oligomeric state of the protein: tetrameric structure determined by cryo-electron microscopy
Biochemistry
50
3713-3723
2011
Hordeum vulgare (B0FXK2), Hordeum vulgare
Arias, D.G.; Regner, E.L.; Iglesias, A.A.; Guerrero, S.A.
Entamoeba histolytica thioredoxin reductase: molecular and functional characterization of its atypical properties
Biochim. Biophys. Acta
1820
1859-1866
2012
Entamoeba histolytica
Dai, C.; Wang, M.H.
Isolation and characterization of thioredoxin and NADPH-dependent thioredoxin reductase from tomato (Solanum lycopersicum)
BMB Rep.
44
692-697
2011
Solanum lycopersicum
Yuan, L.; Kim, H.
Characterization of human cytosolic thioredoxin reductase by site-specific mutagenesis
Bull. Korean Chem. Soc.
31
3515-3516
2010
Homo sapiens
-
Nair, P.M.; Choi, J.
Characterization and transcriptional regulation of thioredoxin reductase 1 on exposure to oxidative stress inducing environmental pollutants in Chironomus riparius
Comp. Biochem. Physiol. B
161
134-139
2012
Chironomus riparius (G5DA76), Chironomus riparius
Rackham, O.; Shearwood, A.M.; Thyer, R.; McNamara, E.; Davies, S.M.; Callus, B.A.; Miranda-Vizuete, A.; Berners-Price, S.J.; Cheng, Q.; Arner, E.S.; Filipovska, A.
Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors
Free Radic. Biol. Med.
50
689-699
2011
Homo sapiens
Yang, X.; Ma, K.
Characterization of a thioredoxin-thioredoxin reductase system from the hyperthermophilic bacterium Thermotoga maritima
J. Bacteriol.
192
1370-1376
2010
Thermotoga maritima, Thermotoga maritima DSM 3109
Seo, H.J.; Lee, Y.N.
Characterization of Deinococcus radiophilus thioredoxin reductase active with both NADH and NADPH
J. Microbiol.
48
637-643
2010
Deinococcus radiophilus, Deinococcus radiophilus ATCC 27603
de Freitas, A.S.; Rocha, J.B.
Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects
Neurosci. Lett.
503
1-5
2011
Rattus norvegicus
McCarver, A.C.; Lessner, D.J.
Molecular characterization of the thioredoxin system from Methanosarcina acetivorans
FEBS J.
281
4598-7611
2014
Methanosarcina acetivorans
Moon, J.C.; Lee, S.; Shin, S.Y.; Chae, H.B.; Jung, Y.J.; Jung, H.S.; Lee, K.O.; Lee, J.R.; Lee, S.Y.
Overexpression of Arabidopsis NADPH-dependent thioredoxin reductase C (AtNTRC) confers freezing and cold shock tolerance to plants
Biochem. Biophys. Res. Commun.
463
1225-1229
2015
Arabidopsis thaliana (O22229), Arabidopsis thaliana
Qin, H.; Liang, W.; Xu, Z.; Ye, F.; Li, X.; Zhong, L.
Mechanistic insights into the inhibitory effects of palmitoylation on cytosolic thioredoxin reductase and thioredoxin
Biochimie
110
25-35
2015
Homo sapiens (Q16881), Homo sapiens
Regner, E.L.; Thompson, C.S.; Iglesias, A.A.; Guerrero, S.A.; Arias, D.G.
Biochemical characterization of thioredoxin reductase from Babesia bovis
Biochimie
99
44-53
2014
Babesia bovis (A7AW73), Babesia bovis
Parrilha, G.L.; Ferraz, K.S.; Lessa, J.A.; de Oliveira, K.N.; Rodrigues, B.L.; Ramos, J.P.; Souza-Fagundes, E.M.; Ott, I.; Beraldo, H.
Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase
Eur. J. Med. Chem.
84
537-544
2014
Rattus norvegicus
Lu, J.; Vlamis-Gardikas, A.; Kandasamy, K.; Zhao, R.; Gustafsson, T.; Engstrand, L.; Hoffner, S.; Engman, L.; Holmgren, A.
Inhibition of bacterial thioredoxin reductase An antibiotic mechanism targeting bacteria lacking glutathione
FASEB J.
27
1394-1403
2013
Escherichia coli, Haemonchus contortus
Pirazzini, M.; Bordin, F.; Rossetto, O.; Shone, C.; Binz, T.; Montecucco, C.
The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals
FEBS Lett.
587
150-155
2013
Rattus norvegicus
Bernal-Bayard, P.; Ojeda, V.; Hervas, M.; Cejudo, F.J.; Navarro, J.A.; Velazquez-Campoy, A.; Perez-Ruiz, J.M.
Molecular recognition in the interaction of chloroplast 2-Cys peroxiredoxin with NADPH-thioredoxin reductase C (NTRC) and thioredoxin x
FEBS Lett.
588
4342-4347
2014
Nicotiana benthamiana
Sasoni, N.; Iglesias, A.A.; Guerrero, S.A.; Arias, D.G.
Functional thioredoxin reductase from pathogenic and free-living Leptospira spp.
Free Radic. Biol. Med.
97
1-13
2016
Leptospira biflexa serovar Patoc (B0SKV7), Leptospira biflexa serovar Patoc ATCC 23582 (B0SKV7), Leptospira interrogans serovar Copenhageni (Q72SB4), Leptospira interrogans serovar Copenhageni Fiocruz L1-130 (Q72SB4)
Sanchez-Riego, A.M.; Mata-Cabana, A.; Galmozzi, C.V.; Florencio, F.J.
NADPH-thioredoxin reductase C mediates the response to oxidative stress and thermotolerance in the cyanobacterium Anabaena sp. PCC7120
Front. Microbiol.
7
1283
2016
Nostoc sp. PCC 7120 = FACHB-418 (Q8YYV6)
Toivola, J.; Nikkanen, L.; Dahlstroem, K.M.; Salminen, T.A.; Lepistoe, A.; Vignols, H.F.; Rintamaeki, E.
Overexpression of chloroplast NADPH-dependent thioredoxin reductase in Arabidopsis enhances leaf growth and elucidates in vivo function of reductase and thioredoxin domains
Front. Plant Sci.
4
389
2013
Arabidopsis thaliana (O22229)
Wang, P.; Wu, Y.; Li, X.; Ma, X.; Zhong, L.
Thioredoxin and thioredoxin reductase control tissue factor activity by thiol redox-dependent mechanism
J. Biol. Chem.
288
3346-3358
2013
Homo sapiens (Q16881)
-
Puerto-Galan, L.; Perez-Ruiz, J.M.; Guinea, M.; Cejudo, F.J.
The contribution of NADPH thioredoxin reductase C (NTRC) and sulfiredoxin to 2-Cys peroxiredoxin overoxidation in Arabidopsis thaliana chloroplasts
J. Exp. Bot.
66
2957-2966
2015
Arabidopsis thaliana (O22229), Arabidopsis thaliana
Choi, A.R.; Kim, M.S.; Kang, S.G.; Lee, H.S.
Dimethyl sulfoxide reduction by a hyperhermophilic archaeon Thermococcus onnurineus NA1 via a cysteine-cystine redox shuttle
J. Microbiol.
54
31-38
2016
Thermococcus onnurineus (B6YUA8)
Kim, M.; Khaleda, L.; Jung, I.; Kim, J.; Lee, S.; Cha, J.; Kim, W.
Overexpression of chloroplast-localized NADPH-dependent thioredoxin reductase C (NTRC) enhances tolerance to photo-oxidative and drought stresses in Arabidopsis thaliana
J. Plant Biol.
60
175-180
2017
Arabidopsis thaliana (O22229)
-
Smiri, M.; Jelali, N.; El Ghoul, J.
Cadmium affects the NADP-thioredoxin reductase/thioredoxin system in germinating pea seeds
J. Plant Interact.
8
125-133
2013
Pisum sativum
-
Perez-Ruiz, J.; Guinea, M.; Puerto-Galan, L.; Cejudo, F.
NADPH thioredoxin reductase C is involved in redox regulation of the Mg-chelatase I subunit in Arabidopsis thaliana chloroplasts
Mol. Plant
7
1252-1255
2014
Arabidopsis thaliana (O22229), Arabidopsis thaliana
Ishiga, Y.; Ishiga, T.; Ikeda, Y.; Matsuura, T.; Mysore, K.
NADPH-dependent thioredoxin reductase C plays a role in nonhost disease resistance against Pseudomonas syringae pathogens by regulating chloroplast-generated reactive oxygen species
PeerJ
4
e1938
2016
Arabidopsis thaliana (O22229)
Naranjo, B.; Mignee, C.; Krieger-Liszkay, A.; Hornero-Mendez, D.; Gallardo-Guerrero, L.; Cejudo, F.J.; Lindahl, M.
The chloroplast NADPH thioredoxin reductase C, NTRC, controls non-photochemical quenching of light energy and photosynthetic electron transport in Arabidopsis
Plant Cell Environ.
39
804-822
2016
Arabidopsis thaliana (O22229), Arabidopsis thaliana
Richter, A.S.; Peter, E.; Rothbart, M.; Schlicke, H.; Toivola, J.; Rintamaeki, E.; Grimm, B.
Posttranslational influence of NADPH-dependent thioredoxin reductase C on enzymes in tetrapyrrole synthesis
Plant Physiol.
162
63-73
2013
Arabidopsis thaliana (O22229)
Ojeda, V.; Perez-Ruiz, J.M.; Gonzalez, M.; Najera, V.A.; Sahrawy, M.; Serrato, A.J.; Geigenberger, P.; Cejudo, F.J.
NADPH thioredoxin reductase C and thioredoxins act concertedly in seedling development
Plant Physiol.
174
1436-1448
2017
Arabidopsis thaliana (O22229)
Tamaki, S.; Maruta, T.; Sawa, Y.; Shigeoka, S.; Ishikawa, T.
Biochemical and physiological analyses of NADPH-dependent thioredoxin reductase isozymes in Euglena gracilis
Plant Sci.
236
29-36
2015
Euglena gracilis (W8VNN5), Euglena gracilis (W8VVL6), Euglena gracilis (W8VZ54), Euglena gracilis
Najera, V.A.; Gonzalez, M.C.; Perez-Ruiz, J.M.; Cejudo, F.J.
An event of alternative splicing affects the expression of the NTRC gene, encoding NADPH-thioredoxin reductase C, in seed plants
Plant Sci.
258
21-28
2017
Solanum lycopersicum, Brachypodium distachyon (A0A0Q3NCX3), Arabidopsis thaliana (O22229)
Fernandez, J.; Wilson, R.
Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease
PLoS ONE
9
e87300
2014
Pyricularia oryzae
Kirkensgaard, K.; Hagglund, P.; Shahpiri, A.; Finnie, C.; Henriksen, A.; Svensson, B.
A novel twist on molecular interactions between thioredoxin and nicotinamide adenine dinucleotide phosphate-dependent thioredoxin reductase
Proteins
82
607-619
2014
Hordeum vulgare subsp. vulgare (A9LN30), Arabidopsis thaliana (Q39243), Arabidopsis thaliana
Temel, Y.; Kufrevioglu, .; Ciftci, M.
Investigation of the effects of purification and characterization of turkey (Meleagris gallopavo) liver mitochondrial thioredoxin reductase enzyme and some metal ions on enzyme activity
Turk. J. Chem.
41
48-60
2017
Meleagris gallopavo
-
Kashima, Y.; Ishikawa, K.
A hyperthermostable novel protein-disulfide oxidoreductase is reduced by thioredoxin reductase from hyperthermophilic archaeon Pyrococcus horikoshii
Arch. Biochem. Biophys.
418
179-185
2003
Pyrococcus horikoshii (O50134), Pyrococcus horikoshii, Pyrococcus furiosus (O57917), Pyrococcus furiosus, Pyrococcus horikoshii DSM 12428 (O50134), Pyrococcus furiosus OT-3 (O57917)
Buey, R.M.; Schmitz, R.A.; Buchanan, B.B.; Balsera, M.
Crystal structure of the apo-form of NADPH-dependent thioredoxin reductase from a methane-producing archaeon
Antioxidants (Basel)
7
166
2018
Methanosarcina mazei (Q8PUI1), Methanosarcina mazei, Methanosarcina mazei ATCC BAA-159 (Q8PUI1)
Jung, H.-C.; Lim , J.K.; Yang, T.-J.; Kang, S.G.; Lee, H.S.
Direct electron transfer between the frhAGB-encoded hydrogenase and thioredoxin reductase in the nonmethanogenic archaeon Thermococcus onnurineus NA1
Appl. Environ. Microbiol.
86
e02630-19
2020
Thermococcus onnurineus (B6YUA8)
Poet, G.J.; Oka, O.B.; van Lith, M.; Cao, Z.; Robinson, P.J.; Pringle, M.A.; Arner, E.S.; Bulleid, N.J.
Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER
EMBO J.
36
693-702
2017
Oryctolagus cuniculus
Shoor, M.; Gudim, I.; Hersleth, H.P.; Hammerstad, M.
Thioredoxin reductase from Bacillus cereus exhibits distinct reduction and NADPH-binding properties
FEBS open bio
11
3019-3031
2021
Bacillus cereus (Q815J1), Bacillus cereus, Bacillus cereus ATCC 14579 (Q815J1)
Ren, X.; Zou, L.; Lu, J.; Holmgren, A.
Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic
Free Radic. Biol. Med.
127
238-247
2018
Escherichia coli, Homo sapiens (Q86VQ6), Homo sapiens (Q9NNW7)
Liao, X.; Yang, F.; Li, H.; So, P.K.; Yao, Z.; Xia, W.; Sun, H.
Targeting the thioredoxin reductase-thioredoxin system from Staphylococcus aureus by silver ions
Inorg. Chem.
56
14823-14830
2017
Staphylococcus aureus, Staphylococcus aureus Newman
Deschoenmaeker, F.; Mihara, S.; Niwa, T.; Taguchi, H.; Wakabayashi, K.I.; Toyoshima, M.; Shimizu, H.; Hisabori, T.
Thioredoxin pathway in Anabaena sp. PCC 7120 activity of NADPH-thioredoxin reductase C
J. Biochem.
169
709-719
2021
Nostoc sp. PCC 7120 = FACHB-418
Cao, X.; Lilla, S.; Cao, Z.; Pringle, M.A.; Oka, O.B.V.; Robinson, P.J.; Szmaja, T.; van Lith, M.; Zanivan, S.; Bulleid, N.J.
The mammalian cytosolic thioredoxin reductase pathway acts via a membrane protein to reduce ER-localised proteins
J. Cell Sci.
133
jcs241976
2020
Homo sapiens (Q16881)
Gonzalez, M.; Delgado-Requerey, V.; Ferrandez, J.; Serna, A.; Cejudo, F.J.
Insights into the function of NADPH thioredoxin reductase C (NTRC) based on identification of NTRC-interacting proteins in vivo
J. Exp. Bot.
70
5787-5798
2019
Arabidopsis thaliana (O22229), Arabidopsis thaliana
Mikheyeva, I.; Thomas, J.; Kolar, S.; Corvaglia, A.; Gaia, N.; Leo, S.; Francois, P.; Liu, G.; Rawat, M.; Cheung, A.
YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus
Mol. Microbiol.
111
1039-1056
2019
Staphylococcus aureus (Q2FYF3), Staphylococcus aureus, Staphylococcus aureus NCTC 8325 (Q2FYF3), Staphylococcus aureus PS 47 (Q2FYF3)
Nikkanen, L.; Guinea Diaz, M.; Toivola, J.; Tiwari, A.; Rintamaeki, E.
Multilevel regulation of non-photochemical quenching andstate transitions by chloroplast NADPH-dependent thioredoxin reductase
Physiol. Plant.
166
211-225
2019
Arabidopsis thaliana (O22229)
Nikkanen, L.; Toivola, J.; Trotta, A.; Diaz, M.G.; Tikkanen, M.; Aro, E.M.; Rintamaeki, E.
Regulation of cyclic electron flow by chloroplast NADPH-dependent thioredoxin system
Plant Direct
2
e00093
2018
Arabidopsis thaliana (O22229)
Da, Q.; Wang, P.; Wang, M.; Sun, T.; Jin, H.; Liu, B.; Wang, J.; Grimm, B.; Wang, H.B.
Thioredoxin and NADPH-dependent thioredoxin reductase C regulation of tetrapyrrole biosynthesis
Plant Physiol.
175
652-666
2017
Arabidopsis thaliana
Cejudo, F.J.; Gonzalez, M.C.; Perez-Ruiz, J.M.
Redox regulation of chloroplast metabolism
Plant Physiol.
186
9-21
2021
Arabidopsis thaliana (O22229)
Kameritsch, P.; Singer, M.; Nuernbergk, C.; Rios, N.; Reyes, A.M.; Schmidt, K.; Kirsch, J.; Schneider, H.; Mueller, S.; Pogoda, K.; Cui, R.; Kirchner, T.; de Wit, C.; Lange-Sperandio, B.; Pohl, U.; Conrad, M.; Radi, R.; Beck, H.
The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity
Proc. Natl. Acad. Sci. USA
118
e1921828118
2021
Mus musculus (Q9JLT4)
Gaballa, A.; Su, T.; Helmann, J.
The Bacillus subtilis monothiol bacilliredoxin BrxC (YtxJ) and the Bdr (YpdA) disulfide reductase reduce S-bacillithiolated proteins
Redox Biol.
42
101935
2021
Bacillus subtilis (P50736), Bacillus subtilis, Bacillus subtilis 168 (P50736)
Picazo, C.; Matallana, E.; Aranda, A.
Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes
Sci. Rep.
8
16500
2018
Saccharomyces cerevisiae
Montrichard, F.; Frendo, P.; Rey, P.; Buchanan, B.
Role of thioredoxins and NADP-thioredoxin reductases in legume seeds and seedlings
The Model Legume Medicago truncatula (ed. de Bruijn F.)
2019
80-91
2019
Medicago truncatula (A0A072VJM3)
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