Information on EC 1.5.99.3 - L-pipecolate dehydrogenase

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The expected taxonomic range for this enzyme is: Pseudomonas putida

EC NUMBER
COMMENTARY hide
1.5.99.3
-
RECOMMENDED NAME
GeneOntology No.
L-pipecolate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-pipecolate + acceptor = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Lysine degradation
-
-
Metabolic pathways
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-
SYSTEMATIC NAME
IUBMB Comments
L-pipecolate:acceptor 1,6-oxidoreductase
The product reacts with water to form (S)-2-amino-6-oxohexanoate.
CAS REGISTRY NUMBER
COMMENTARY hide
9076-63-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
P2 ATCC 25571
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-pipecolate + acceptor
2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor
show the reaction diagram
-
acceptors: 2,6-dichlorophenolindophenol, redox dyes
product reacts with H2O to form 2-aminoadipate 6-semialdehyde, i.e. 2-amino-6-oxohexanoate
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome b
-
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
-
0.03 mM, 65% inhibition, 0.1 mM, 90% inhibition, 1 mM, 100% inhibition
iodoacetamide
-
-
p-chloromercuribenzoate
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17
L-pipecolate
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
pipecolate + 2,6-dichlorophenolindophenol
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE