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N-methyl-L-alanine + acceptor + H2O
L-alanine + formaldehyde + reduced acceptor
N-methyl-L-leucine + acceptor + H2O
L-leucine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue, meldola blue, nile blue, potassium ferricyanide
-
?
N-methyl-L-valine + acceptor + H2O
L-valine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue, meldola blue, nile blue, potassium ferricyanide
-
?
N-methylglycine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue, meldola blue, nile blue, potassium ferricyanide
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
sarcosine + H2O + electron-transfer flavoprotein
glycine + formaldehyde + reduced electron-transfer flavoprotein
-
-
-
-
?
sarcosine + H2O + phenazine methosulfate
glycine + formaldehyde + reduced phenazine methosulfate
-
-
-
-
r
sarcosine + H2O + potassium ferricyanide
glycine + formaldehyde + potassium ferrocyanide
-
-
-
-
r
sarcosine + oxidized 1-methoxy-5-methylphenazinium methylsulfate
glycine + formaldehyde + reduced 1-methoxy-5-methylphenazinium methylsulfate
-
quantification with nitroblue tetrazolium chloride, i.e. NBT or 2,2'-bis(4-nitrophenyl)-5,5'-diphenyl-3,3'-(3,3'-dimethoxy-4,4'-diphenylene)ditetrazolium chloride, giving NBT-formazan in reaction with reduced 1-methoxy-5-methylphenazinium methylsulfate, overview
-
-
?
N-methyl-L-alanine + acceptor + H2O
L-alanine + formaldehyde + reduced acceptor
-
-
-
-
?
N-methyl-L-alanine + acceptor + H2O
L-alanine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue, meldola blue, nile blue, potassium ferricyanide
-
?
N-methyl-L-alanine + acceptor + H2O
L-alanine + formaldehyde + reduced acceptor
-
-
-
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
-
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
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sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
sarcosine + H2O + electron-transfer flavoprotein
glycine + formaldehyde + reduced electron-transfer flavoprotein
-
-
-
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
-
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
sarcosine + acceptor + H2O
glycine + formaldehyde + reduced acceptor
-
acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate
-
?
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Brain Neoplasms
Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.
Breast Neoplasms
Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.
Breast Neoplasms
Implications of differences in expression of sarcosine metabolism-related proteins according to the molecular subtype of breast cancer.
Carcinoma
DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.
Carcinoma, Renal Cell
DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.
Cardiomyopathy, Dilated
Anti-mitochondrial antibodies in patients with dilated cardiomyopathy (anti-M7) are directed against flavoenzymes with covalently bound FAD.
Colorectal Neoplasms
Alteration of the tumour suppressor SARDH in sporadic colorectal cancer: a functional and transcriptome profiling-based study.
Heart Diseases
Anti-mitochondrial antibodies (anti-M7) in heart diseases recognize epitopes on bacterial and mammalian sarcosine dehydrogenase.
Liver Neoplasms
Alteration of the tumour suppressor SARDH in sporadic colorectal cancer: a functional and transcriptome profiling-based study.
Lung Neoplasms
Alteration of the tumour suppressor SARDH in sporadic colorectal cancer: a functional and transcriptome profiling-based study.
Myocarditis
Anti-mitochondrial antibodies in patients with dilated cardiomyopathy (anti-M7) are directed against flavoenzymes with covalently bound FAD.
Neoplasm Metastasis
DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.
Neoplasm Metastasis
Expression of sarcosine metabolism-related proteins according to metastatic site in breast cancer.
Neoplasms
Alteration of the tumour suppressor SARDH in sporadic colorectal cancer: a functional and transcriptome profiling-based study.
Neoplasms
DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.
Neoplasms
Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer.
Neoplasms
The role of sarcosine metabolism in prostate cancer progression.
Neoplasms
The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels.
Neoplasms
TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells.
Pancreatic Neoplasms
Alteration of the tumour suppressor SARDH in sporadic colorectal cancer: a functional and transcriptome profiling-based study.
Prostatic Neoplasms
TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells.
Respiratory Insufficiency
A young adult with sarcosinemia. No benefit from long duration treatment with memantine.
sarcosine dehydrogenase deficiency
Sarcosine dehydrogenase deficiency, the enzyme defect in hypersarcosinemia.
sarcosine dehydrogenase deficiency
[Sarcosine dehydrogenase deficiency]
Spinal Dysraphism
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
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Tsuru, D.; Oka, I.; Yoshimoto, T.
Creatinine decomposing enzymes in Pseudomonas putida
Agric. Biol. Chem.
40
1011-1018
1976
Pseudomonas putida
-
brenda
Yamada, H.; Shimizu, S.; Kim, J.M.; Shinmen, Y.; Sakai, T.
A novel metabolic pathway for creatinine degradation in Pseudomonas putida 77
FEMS Microbiol. Lett.
30
337-340
1985
Pseudomonas putida
-
brenda
Bater, A.J.; Venables, W.A.
The characterisation of inducible dehydrogenases specific for the oxidation of D-alanine, allohydroxy-D-proline, choline and sarcosine as peripheral membrane proteins in Pseudomonas aeruginosa
Biochim. Biophys. Acta
468
209-226
1977
Pseudomonas aeruginosa, Pseudomonas reptilivorous
brenda
Smith, L.T.; Pocard, J.A.; Bernard, T.; LeRudulier, D.
Osmotic control of glycine betaine biosynthesis and degradation in Rhizobium meliloti
J. Bacteriol.
170
3142-3149
1988
Sinorhizobium meliloti
brenda
Cook, R.J.; Wagner, C.
Dimethylglycine dehydrogenase and sarcosine dehydrogenase: mitochondrial folate-binding proteins from rat liver
Methods Enzymol.
122
255-260
1986
Rattus norvegicus
brenda
Porter, D.H.; Cook, R.J.; Wagner, C.
Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver
Arch. Biochem. Biophys.
243
396-407
1985
Rattus norvegicus
brenda
Cook, R.J.; Misono, K.S.; Wagner, C.
The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria
J. Biol. Chem.
260
12998-13002
1985
Rattus norvegicus
brenda
Steenkamp, D.J.; Husain, M.
The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases
Biochem. J.
203
707-715
1982
Sus scrofa
brenda
Wittwer, A.J.; Wagner, C.
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins
J. Biol. Chem.
256
4109-4115
1981
Rattus norvegicus
brenda
Wittwer, A.J.; Wagner, C.
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics
J. Biol. Chem.
256
4102-4108
1981
Rattus norvegicus
brenda
Cook, R.J.; Misono, K.S.; Wagner, C.
Identification of the covalently bound flavin of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria
J. Biol. Chem.
259
12475-12480
1980
Rattus norvegicus
brenda
Oka, I.; Yoshimoto, T.; Rikitake, K.; Ogushi, S.; Tsur, D.
Sarcosine dehydrogenase from Pseudomonas putida: purification and some properties
Agric. Biol. Chem.
43
1197-1203
1979
Corynebacterium sp., Pseudomonas putida
-
brenda
Pinto, J.T.; Frisell, W.R.
Characterization of the peptide-bound flavin of a bacterial sarcosine dehydrogenase
Arch. Biochem. Biophys.
169
483-491
1975
Pseudomonas sp.
brenda
Patek, D.R.; Frisell, W.R.
Purification and characterization of the flavin prosthetic group of sarcosine dehydrogenase
Arch. Biochem. Biophys.
150
347-354
1972
Rattus norvegicus
brenda
Frisell, W.R.; Mackenzie, C.G.
Sarcosine dehydrogenase and dimethylglycine dehydrogenase (rat liver, monkey liver)
Methods Enzymol.
17A
976-981
1970
Macaca mulatta, Rattus norvegicus
-
brenda
Frisell, W.R.; Mackenzie, C.G.
Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase
J. Biol. Chem.
237
94-98
1962
Rattus norvegicus
brenda
Eschenbrenner, M.; Schuman Jorns, M.
Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia
Genomics
59
300-308
1999
Homo sapiens
brenda
Tang, T.Y.; Jong, J.G.; Liu, W.H.
Purification and some properties of sarcosine dehydrogenase from Pseudomonas putida RS65
Food Sci. Agric. Chem.
3
36-41
2001
Pseudomonas putida, Pseudomonas putida RS65
brenda
Bergeron, F.; Otto, A.; Blache, P.; Day, R.; Denoroy, L.; Brandsch, R.; Bataille, D.
Molecular cloning and tissue distribution of rat sarcosine dehydrogenase
Eur. J. Biochem.
257
556-561
1998
Rattus norvegicus
brenda
Kato, K.; Walde, P.; Mitsui, H.; Higashi, N.
Enzymatic activity and stability of D-fructose dehydrogenase and sarcosine dehydrogenase immobilized onto giant vesicles
Biotechnol. Bioeng.
84
415-423
2003
Pseudomonas putida
brenda
Chen, X.; Overcash, R.; Green, T.; Hoffman, D.; Asch, A.S.; Ruiz-Echevarria, M.J.
The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels
J. Biol. Chem.
286
16091-16100
2011
Homo sapiens
brenda
Umair, S.; Ria, C.; Knight, J.S.; Bland, R.J.; Simpson, H.V.
Sarcosine metabolism in Haemonchus contortus and Teladorsagia circumcincta
Exp. Parasitol.
134
1-6
2013
no activity in Haemonchus contortus, no activity in Teladorsagia circumcincta
brenda
Kim, H.; Lee, Y.; Koo, J.
Expression of sarcosine-metabolizing enzymes in thyroid cancer
Int. J. Clin. Exp. Pathol.
9
7132-7139
2016
Homo sapiens
-
brenda
Heger, Z.; Merlos Rodrigo, M.A.; Michalek, P.; Polanska, H.; Masarik, M.; Vit, V.; Plevova, M.; Pacik, D.; Eckschlager, T.; Stiborova, M.; Adam, V.
Sarcosine up-regulates expression of genes involved in cell cycle progression of metastatic models of prostate cancer
PLoS ONE
11
e0165830
2016
Homo sapiens
brenda
Green, T.; Chen, X.; Ryan, S.; Asch, A.S.; Ruiz-Echevarria, M.J.
TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells
Prostate
73
1561-1575
2013
Homo sapiens
brenda
Mazdak, M.; Tezval, H.; Callauch, J.C.; Dubrowinskaja, N.; Peters, I.; Bokemeyer, C.; Hennenlotter, J.; Stenzl, A.; Kuczyk, M.A.; Serth, J.
DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma
Oncol. Rep.
42
2159-2168
2019
Homo sapiens (Q9UL12), Homo sapiens
brenda