Information on EC 1.5.1.31 - berberine reductase

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The expected taxonomic range for this enzyme is: Corydalis cava

EC NUMBER
COMMENTARY hide
1.5.1.31
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RECOMMENDED NAME
GeneOntology No.
berberine reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Isoquinoline alkaloid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(R)-tetrahydroberberine:NADP+ oxidoreductase
Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC 1.3.3.8 tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
7,8-dihydroberberine + NADPH
canadine + NADP+
show the reaction diagram
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at 64% of the activity with palmatine and NADPH
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r
berberine + NADH
canadine + NAD+
show the reaction diagram
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at 59% of the activity with palmatine. At 15% of the activity with berberine and NADPH
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r
berberine + NADPH
canadine + NADP+
show the reaction diagram
columbamine + NADPH
? + NADP+
show the reaction diagram
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at 39% of the activity with palmatine and NADPH
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r
coptisine + NADPH
? + NADP+
show the reaction diagram
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at 47% of the activity with palmatine and NADPH
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r
dehydroscoulerine + NADPH
? + NADP+
show the reaction diagram
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at 5% of the activity with palmatine and NADPH
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-
r
dihydrosinactine + NADPH
? + NADP+
show the reaction diagram
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at 52% of the activity with palmatine and NADPH
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r
jatrorrhizine + NADPH
? + NADP+
show the reaction diagram
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at 25% of the activity with palmatine and NADPH
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r
palmatine + NADPH
? + NADP+
show the reaction diagram
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r
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
berberine + NADPH
canadine + NADP+
show the reaction diagram
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(R)-tetrahydroberberines are formed from protoberberines by a highly stereoselective reduction system
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r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
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at 15% of the activity with NADPH
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE