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(R,S)-2,3-Diaminopropionic acid + pyruvate + NADH
?
-
9.67% of the activity with S: (S)-norvaline
-
-
?
(R,S)-3-Aminobutanoate + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(R,S)-3-aminobutanoate + NAD+
-
0.68% of the activity with (S)-norvaline
-
-
?
(S)-2-aminobutyric acid + pyruvate + NADH
N-[1-(R)-(carboxy)ethyl]-(S)-2-aminobutyric acid + NAD+
(S)-Norleucine + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-norleucine + NAD+
(S)-Norvaline + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-norvaline + NAD+
(S)-Phenylalaninol + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-phenylalaninol + NAD+
-
0.63% of the activity with (S)-norvaline
-
-
?
(S)-Phenylglycine + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-phenylglycine + NAD+
-
4.4% of the activity with (S)-norvaline
-
-
?
amino acid + pyruvate + NADH + H+
opine + NAD+ + H2O
beta-Chloro-(S)-Ala + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-beta-chloroalanine + NAD+
Gly + pyruvate + NADH
N-(carboxymethyl)-D-alanine + NAD+
-
5.3% of the activity with L-Met
-
-
r
L-Ala + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ala + NAD+
L-Asp + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Asp + NAD+
-
1.2% of the activity with L-Met
-
-
r
L-Cys + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Cys + NAD+
-
39% of the activity with L-Met
-
-
r
L-Ile + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ile + NAD+
L-Leu + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Leu + NAD+
L-Met + 2-oxobutanoate + NADH
?
-
11% of the activity with pyruvate
-
-
r
L-Met + 2-oxohexanoate + NADH
?
-
2.1% of the activity with pyruvate
-
-
r
L-Met + glyoxylate + NADH
?
-
11% of the activity with pyruvate
-
-
r
L-Met + hydroxypyruvate + NADH
?
-
6.1% of the activity with pyruvate
-
-
r
L-Met + oxaloacetate + NADH
?
-
30% of the activity with pyruvate
-
-
r
L-Met + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Met + NAD+
L-Phe + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Phe + NAD+
L-Ser + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ser + NAD+
-
39% of the activity with L-Met
-
-
r
L-Thr + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Thr + NAD+
-
50% of the activity with L-Met
-
-
r
L-Val + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Val + NAD+
O-Acetyl-(S)-Ser + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-O-acetyl-Ser + NAD+
O-phospho-(S)-Ser + pyruvate + NADH + H+
N-[1-(R)-(carboxy)ethyl]-(S)-O-phospho-Ser + NAD+
-
-
-
-
r
p-Phospho-(S)-Tyr + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(R,S)-p-phospho-(S)-Tyr + NAD+
-
0.64% of the activity with (S)-norvaline
-
-
?
phospho-(S)-Ser + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-phospho-Ser + NAD+
-
15.8% of the activity with (S)-norvaline
-
-
?
additional information
?
-
(S)-2-aminobutyric acid + pyruvate + NADH
N-[1-(R)-(carboxy)ethyl]-(S)-2-aminobutyric acid + NAD+
-
83.7% of the activity with (S)-norvaline
-
-
?
(S)-2-aminobutyric acid + pyruvate + NADH
N-[1-(R)-(carboxy)ethyl]-(S)-2-aminobutyric acid + NAD+
-
83.7% of the activity with (S)-norvaline
-
-
?
(S)-Norleucine + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-norleucine + NAD+
-
72.5% of the activity with (S)-norvaline
-
-
?
(S)-Norleucine + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-norleucine + NAD+
-
72.5% of the activity with (S)-norvaline
-
-
?
(S)-Norvaline + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-norvaline + NAD+
-
-
-
-
?
(S)-Norvaline + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-norvaline + NAD+
-
-
-
-
?
amino acid + pyruvate + NADH + H+
opine + NAD+ + H2O
-
-
-
-
?
amino acid + pyruvate + NADH + H+
opine + NAD+ + H2O
-
-
-
-
?
beta-Chloro-(S)-Ala + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-beta-chloroalanine + NAD+
-
53.1% of the activity with (S)-norvaline
-
-
?
beta-Chloro-(S)-Ala + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-beta-chloroalanine + NAD+
-
53.1% of the activity with (S)-norvaline
-
-
?
L-Ala + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ala + NAD+
-
16.0% of the activity with (S)-norvaline
-
-
?
L-Ala + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ala + NAD+
-
67% of the activity with L-Met
-
-
r
L-Ile + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ile + NAD+
-
22.3% of the activity with (S)-norvaline
-
-
?
L-Ile + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ile + NAD+
-
94% of the activity with L-Met
-
-
r
L-Ile + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Ile + NAD+
-
94% of the activity with L-Met
-
-
r
L-Leu + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Leu + NAD+
-
21.2% of the activity with (S)-norvaline
-
-
?
L-Leu + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Leu + NAD+
-
89% of the activity with L-Met
-
-
r
L-Leu + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Leu + NAD+
-
89% of the activity with L-Met
-
-
r
L-Met + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Met + NAD+
-
-
-
-
r
L-Met + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Met + NAD+
-
23.9% of the activity with (S)-norvaline
-
-
?
L-Met + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Met + NAD+
-
-
-
-
r
L-Phe + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Phe + NAD+
-
21.7% of the activity with (S)-norvaline
-
-
?
L-Phe + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Phe + NAD+
-
91% of the activity with L-Met
-
?
L-Phe + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Phe + NAD+
-
91% of the activity with L-Met
-
?
L-Val + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Val + NAD+
-
21.9% of the activity with (S)-norvaline
-
-
?
L-Val + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Val + NAD+
-
92% of the activity with L-Met
-
-
r
L-Val + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-Val + NAD+
-
92% of the activity with L-Met
-
-
r
O-Acetyl-(S)-Ser + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-O-acetyl-Ser + NAD+
-
35.8% of the activity with (S)-norvaline
-
-
?
O-Acetyl-(S)-Ser + pyruvate + NADH
N-[1-(R)-(Carboxy)ethyl]-(S)-O-acetyl-Ser + NAD+
-
35.8% of the activity with (S)-norvaline
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
the physiological role of this enzyme may be the degradation of opines of plant origin to yield NADH rather than the synthesis of the opines. The products 2-keto acid and L-amino acid can support the growth of the microorganism
-
-
?
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Britton, K.L.; Rogers, H.F.; Asano, Y.; Dairi, T.; Kato, Y.; Stillman, T.J.
Crystallization of Arthrobacter sp. strain 1C N-(1-D-carboxyethyl)-L-norvaline dehydrogenase and its complex with NAD+
Acta Crystallogr. Sect. D
54
124-126
1998
Arthrobacter sp., Arthrobacter sp. 1C
brenda
Asano, Y.; Yamaguchi, K.; Kondo, K.
A new NAD+-dependent opine dehydrogenase from Arthrobacter sp. strain 1C
J. Bacteriol.
171
4466-4471
1989
Arthrobacter sp., Arthrobacter sp. 1C
brenda
Kato, Y.; Yamada, H.; Asano, Y.
Stereoselective synthesis of opine-type secondary amine carboxylic acids by a new enzyme opine dehydrogenase. Use of recombinant enzymes
J. Mol. Catal. , B Enzym.
1
151-160
1996
Arthrobacter sp., Arthrobacter sp. 1C
-
brenda
Asano, Y.
A japanese screening approach: selection of an opine dehydrogenase and alkaline D-peptidase
Stud. Org. Chem.
53
19-28
1998
Arthrobacter sp.
-
brenda
Dairi, T.; Asano, Y.
Cloning, nucleotide sequencing, and expression of an opine dehydrogenase gene from Arthrobacter sp. strain 1C
Appl. Environ. Microbiol.
61
3169-3171
1995
Arthrobacter sp.
brenda
Vazquez-Dorado, S.; de Carlos, A.; Comesana, A.S.; Sanjuan, A.
Phylogenetic comparison of opine dehydrogenase sequences from marine invertebrates
Biochem. Genet.
51
154-165
2013
Mytilus galloprovincialis
brenda
Harcet, M.; Perina, D.; Plese, B.
Opine dehydrogenases in marine invertebrates
Biochem. Genet.
51
666-676
2013
Monosiga brevicollis, no activity in Amphimedon queenslandica, Nematostella vectensis
brenda