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Gly + pyruvate + NADH
Strombine + NAD+ + H2O
L-2-Aminobutyrate + pyruvate + NADH
?
L-Ala + 2-oxobutanoate + NADH
?
L-Ala + 2-oxopentanoate + NADH
?
L-Ala + glyoxylate + NADH
?
L-Ala + hydroxypyruvate + NADH
?
L-Ala + oxaloacetate + NADH
?
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
L-Cys + pyruvate + NADH
?
L-Ser + pyruvate + NADH
?
L-Thr + pyruvate + NADH
?
L-Val + pyruvate + NADH
?
additional information
?
-
Gly + pyruvate + NADH

Strombine + NAD+ + H2O
-
r
-
-
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
at 161.5% of the activity with L-Ala
-
-
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
Busycotypus canaliculatum
-
-
-
-
-
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
no activity
-
-
-
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
-
-
-
-
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
-
-
-
-
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
at 69% of the activity with L-Ala
-
-
-
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
-
at 9% of the activity with L-Ala
-
-
-
L-2-Aminobutyrate + pyruvate + NADH

?
-
at 60% of the activity with L-Ala
-
-
-
L-2-Aminobutyrate + pyruvate + NADH
?
-
-
-
-
-
L-2-Aminobutyrate + pyruvate + NADH
?
-
-
-
-
-
L-2-Aminobutyrate + pyruvate + NADH
?
-
at 94% of the activity with L-Ala
-
-
-
L-Ala + 2-oxobutanoate + NADH

?
-
at 21% of the activity with pyruvate
-
-
-
L-Ala + 2-oxobutanoate + NADH
?
-
at 68% of the activity with pyruvate
-
-
-
L-Ala + 2-oxobutanoate + NADH
?
-
-
-
-
-
L-Ala + 2-oxobutanoate + NADH
?
-
at 22% the activity with pyruvate
-
-
-
L-Ala + 2-oxobutanoate + NADH
?
-
at 14% of the activity with pyruvate
-
-
-
L-Ala + 2-oxopentanoate + NADH

?
-
at 25.6% of the activity with pyruvate
-
-
-
L-Ala + 2-oxopentanoate + NADH
?
-
at 58% of the activity with pyruvate
-
-
-
L-Ala + glyoxylate + NADH

?
-
at 10.5% of the activity with pyruvate
-
-
-
L-Ala + glyoxylate + NADH
?
-
-
-
-
-
L-Ala + glyoxylate + NADH
?
-
at 44% the activity with pyruvate
-
-
-
L-Ala + hydroxypyruvate + NADH

?
-
at 12.8% of the activity with pyruvate
-
-
-
L-Ala + hydroxypyruvate + NADH
?
-
at 3.3% of the activity with pyruvate
-
-
-
L-Ala + oxaloacetate + NADH

?
-
at 106.6% of the activity with pyruvate
-
-
-
L-Ala + oxaloacetate + NADH
?
-
-
-
-
-
L-Ala + oxaloacetate + NADH
?
-
as effective as pyruvate
-
-
-
L-Ala + pyruvate + NADH

2,2'-Iminodipropanoate + NAD+ + H2O
-
r
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Busycotypus canaliculatum
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
r
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
r
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
r
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Nucula nitida
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Polydora commensalis
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Polydora glycymerica
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Scolelepis fuliginosa
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
-
-
-
-
-
L-Cys + pyruvate + NADH

?
-
at 130.8% of the activity with L-Ala
-
-
-
L-Cys + pyruvate + NADH
?
-
-
-
-
-
L-Cys + pyruvate + NADH
?
-
at 90% of the activity with L-Ala
-
-
-
L-Cys + pyruvate + NADH
?
-
at 110% of the activity with L-Ala
-
-
-
L-Ser + pyruvate + NADH

?
-
at 150.8% of the activity with L-Ala
-
-
-
L-Ser + pyruvate + NADH
?
-
-
-
-
-
L-Ser + pyruvate + NADH
?
-
-
-
-
-
L-Ser + pyruvate + NADH
?
-
-
-
-
-
L-Ser + pyruvate + NADH
?
-
at 90% of the activity with L-Ala
-
-
-
L-Ser + pyruvate + NADH
?
-
at 67% of the activity with L-Ala
-
-
-
L-Thr + pyruvate + NADH

?
-
as effective as L-Ala
-
-
-
L-Thr + pyruvate + NADH
?
-
at 62% of the activity with L-Ala
-
-
-
L-Val + pyruvate + NADH

?
-
at 71.5% of the activity with L-Ala
-
-
-
L-Val + pyruvate + NADH
?
-
at 65% of the activity with L-Ala
-
-
-
additional information

?
-
Busycotypus canaliculatum
-
the enzyme from hepatopancreas is involved in alanopine oxidation
-
-
-
additional information
?
-
Busycotypus canaliculatum
-
muscle enzyme is involved in anaerobic glycolysis
-
-
-
additional information
?
-
-
enzyme catalyzes the terminal step of anaerobic glycolysis during muscle anoxia associated with locomotion
-
-
-
additional information
?
-
-
the enzyme probably functions in the maintenance of a redox balance during anaerobiosis in the adductor muscle and heart of the oyster
-
-
-
additional information
?
-
-
D-strombine is not oxidized
-
-
-
additional information
?
-
-
the enzyme functions in cytoplasmic redox balance during anoxia stress
-
-
-
additional information
?
-
-
the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia
-
-
-
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6.5 - 7
-
with L-Ala and pyruvate as substrates
7.1
Busycotypus canaliculatum
-
with 50 mM L-Ala and 2 mM pyruvate as substrates, foot muscle enzyme
7.5
-
with 130 mM L-Ala, 0.1 mM NADH and 1.3 mM pyruvate as substrates
8.1
Busycotypus canaliculatum
-
with 15 mM meso-alanopine and 1.2 mM NAD+ as substrates, enzyme from hepatopancreas
8.6
Busycotypus canaliculatum
-
with 15 mM meso-alanopine and 1.2 mM NAD+ as substrates, enzyme from gill
9.2
-
with 50 mM meso-alanopine as substrate
6.5

Busycotypus canaliculatum
-
with 35 mM L-Ala and 1.4 mM pyruvate as substrate, foot muscle enzyme
6.5
-
with 100 mM L-Ala, 0.1 mM NADH and 1 mM pyruvate as substrates
7

-
with Ala and pyruvate as substrates
7
-
with L-Ala and pyruvate as substrates
7
-
with Ala and pyruvate as substrates
8.5

Busycotypus canaliculatum
-
with 15 mM meso-alanopine and 1.2 mM NAD+ as substrates, foot muscle enzyme
8.5
-
with meso-alanopine as substrate
8.5
-
with 10 mM meso-alanopine as substrate
9

-
with meso-alanopine as substrate
9
Busycotypus canaliculatum
-
with 40 mM meso-alanopine and 2 mM NAD+ as substrates, all three isoenzymes
9
-
with meso-alanopine as substrate
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Carvajal, N.; Vega, E.; Erices, A.; Bustos, D.; Torres, C.
Lactate dehydrogenase, alanopine dehydrogenase and octopine dehydrogenase from heart of Concholepas concholepas (gastropoda: muricidae)
Comp. Biochem. Physiol. B
108
543-550
1994
Concholepas concholepas
-
brenda
Sato, M.; Takeuchi, M.; Kanno, N.; Nagahisa, E.; Sato, Y.
Distribution of opine dehydrogenases and lactate dehydrogenase activities in marine animals
Comp. Biochem. Physiol. B
106
955-960
1993
Anthopleura japonica, Anthopleura nigrescens, Buccinum isaotakii, Cellana grata, Chlamys farreri nipponensis, Chlorostoma lischkei, Crassostrea gigas, Fusitriton oregonensis, Haliotis discus hannai, Liolophura japonica, Littorina brevicula, Loligo bleekeri, Meretrix lusoria, Mesocentrotus nudus, Mizuhopecten yessoensis, Mytilus edulis, Neptunea arthritica, no activity in Aplysia juliana, no activity in Aplysia kurodai, no activity in Asterias amurensis, no activity in Asterina pectinifera, no activity in Aurelia aurita, no activity in Balanus cariosus, no activity in Halichondria japonica, no activity in Halocynthia roretzi, no activity in Hemigrapsus sanguineus, no activity in Hexagrammos otakii, no activity in Octopus membranaceus, no activity in Oncorhynchus keta, no activity in Pagurus samuelis, no activity in Pollicipes mitella, no activity in Pugettia quadridens, no activity in Solaster paxillatus, no activity in Stichopus japonicus, Octopus vulgaris, Perinereis nuntia, Pseudocardium sachalinense, Pseudopotamilla occelata, Reishia clavigera, Ruditapes philippinarum, Scapharca broughtonii, Todarodes pacificus, Tugali gigas
-
brenda
Blackstock, J.; Burdass, M.C.
Pyruvate oxidoreductase in some sublittoral polychaetes
Biochem. Soc. Trans.
15
383-384
1987
Capitella capitata, Glycera alba, Scolelepis fuliginosa
-
brenda
Fields, J.H.A.; Storey, K.B.
Tissue-specific alanopine dehydrogenase from the gill and strombine dehydrogenase from the foot muscle of the cherrystone clam Mercenaria mercenaria
J. Exp. Mar. Biol. Ecol.
105
175-185
1987
Mercenaria mercenaria
-
brenda
Manchenko, G.P.
Nonfluorescent negative stain for alanopine dehydrogemase activity on starch gels
Anal. Biochem.
145
308-310
1985
Polydora ciliata, Polydora commensalis, Polydora glycymerica, Pseudopolydora paucibranchiata
brenda
Fields, J.H.A.; Eng, A.K.; Ramsden, W.D.; Hochachka, P.W.; Weinstein, B.
Alanopine and strombine are novel imino acids produced by a dehydrogenase found in the adductor muscle of the oyster, Crassostrea gigas
Arch. Biochem. Biophys.
201
110-114
1980
Crassostrea gigas
brenda
Siegmund, B.; Grieshaber, M.K.
Determination of meso-alanopine and D-strombine by high pressure liquid chromatography in extracts from marine invertebrates
Hoppe-Seyler's Z. Physiol. Chem.
364
807-812
1983
Arenicola marina, Crassostrea angulata, Mytilus edulis, Nucula nitida
brenda
Dando, P.R.
Strombine [N-(carboxymethyl)-D-alanine]dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine]dehydrogenase from the mussel Mytilus edulis L.
Biochem. Soc. Trans.
9
297-298
1981
Mytilus edulis
-
brenda
Fields, J.H.A.; Hochachka, P.W.
Purification and properties of alanopine dehydrogenase from the adductur muscle of the oyster, Crassostrea gigas (mollusca, bivalvia)
Eur. J. Biochem.
114
615-621
1981
Crassostrea gigas
brenda
Plaxton, W.C.; Storey, K.B.
Tissue specific isozymes of alanopine dehydrogenase in the channeled whelk Busycotypus canaliculatum
Can. J. Zool.
60
1568-1572
1982
Busycotypus canaliculatum
-
brenda
Plaxton, W.C.; Storey, K.B.
Purification and properties of alanopine dehydrogenase isozymes from the channeled whelk, Busycotypus canaliculatum
Comp. Biochem. Physiol. B
76
321-326
1983
Busycotypus canaliculatum
-
brenda
Storey, K.B.
Tissue-specific alanopine dehydrogenase and strombine dehydrogenase from the sea mouse, Aphrodite aculeata (polychaeta)
J. Exp. Zool.
225
369-378
1983
Aphrodita aculeata
-
brenda
Plaxton, W.C.; Storey, K.B.
Alanopine dehydrogenase: purification and characterization of the enzyme from Littorina littorea foot muscle
J. Comp. Physiol.
149
57-65
1982
Littorina littorea
-
brenda
Baldwin, J.; England, W.R.
The properties and functions of alanopine dehydrogenase and octopine dehydrogenase from the pedal retractor muscle of strombidae (class gastropoda)
Pac. Sci.
36
381-394
1982
Bursa sp., Cantharus undosus, Conomurex luhuanus, Conus arenatus, Cymatium pileare, Cypraea tigris, Cypraecassis rufa, Lambis lambis, Lambis millepeda, Lambis scorpius, Menathais tuberosa, Mitra eremitarum, Nassarius coronatus, Nassarius glans particeps, Nerita atramentosa, Strombus aurisdianae, Strombus canarium, Strombus gibberulus, Strombus labiatus, Strombus lentiginosus, Strombus sinuatus, Tibia martinii, Xenophora crispa
-
brenda