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Enzyme Nomenclature
Information on EC 1.5.1.17 - alanopine dehydrogenase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.5.1.17
-
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RECOMMENDED NAME
GeneOntology No.
alanopine dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH + H+
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
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-
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reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)
In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22 strombine dehydrogenase).
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CAS REGISTRY NUMBER
COMMENTARY
71343-07-2
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Busycotypus canaliculatum
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Gly + pyruvate + NADH
Strombine + NAD+ + H2O
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at 161.5% of the activity with L-Ala
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Gly + pyruvate + NADH
Strombine + NAD+ + H2O
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at 69% of the activity with L-Ala
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-
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Gly + pyruvate + NADH
Strombine + NAD+ + H2O
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at 9% of the activity with L-Ala
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-
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L-2-Aminobutyrate + pyruvate + NADH
?
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at 60% of the activity with L-Ala
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-
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L-2-Aminobutyrate + pyruvate + NADH
?
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at 94% of the activity with L-Ala
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-
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L-Ala + 2-oxobutanoate + NADH
?
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at 21% of the activity with pyruvate
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-
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L-Ala + 2-oxobutanoate + NADH
?
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at 68% of the activity with pyruvate
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-
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L-Ala + 2-oxobutanoate + NADH
?
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at 22% the activity with pyruvate
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-
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L-Ala + 2-oxopentanoate + NADH
?
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at 25.6% of the activity with pyruvate
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-
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L-Ala + 2-oxopentanoate + NADH
?
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at 58% of the activity with pyruvate
-
-
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L-Ala + hydroxypyruvate + NADH
?
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at 12.8% of the activity with pyruvate
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-
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L-Ala + hydroxypyruvate + NADH
?
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at 3.3% of the activity with pyruvate
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-
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L-Ala + oxaloacetate + NADH
?
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at 106.6% of the activity with pyruvate
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-
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L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
Busycotypus canaliculatum
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-
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L-Ala + pyruvate + NADH
2,2'-Iminodipropanoate + NAD+ + H2O
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-
-
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additional information
?
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Busycotypus canaliculatum
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the enzyme from hepatopancreas is involved in alanopine oxidation
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-
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additional information
?
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Busycotypus canaliculatum
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muscle enzyme is involved in anaerobic glycolysis
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-
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additional information
?
-
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enzyme catalyzes the terminal step of anaerobic glycolysis during muscle anoxia associated with locomotion
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-
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additional information
?
-
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the enzyme probably functions in the maintenance of a redox balance during anaerobiosis in the adductor muscle and heart of the oyster
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-
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additional information
?
-
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the enzyme functions in cytoplasmic redox balance during anoxia stress
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additional information
?
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the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
Busycotypus canaliculatum
-
the enzyme from hepatopancreas is involved in alanopine oxidation
-
-
-
additional information
?
-
Busycotypus canaliculatum
-
muscle enzyme is involved in anaerobic glycolysis
-
-
-
additional information
?
-
-
enzyme catalyzes the terminal step of anaerobic glycolysis during muscle anoxia associated with locomotion
-
-
-
additional information
?
-
-
the enzyme probably functions in the maintenance of a redox balance during anaerobiosis in the adductor muscle and heart of the oyster
-
-
-
additional information
?
-
-
the enzyme functions in cytoplasmic redox balance during anoxia stress
-
-
-
additional information
?
-
-
the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia
-
-
-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
Busycotypus canaliculatum
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Km-values for the 3 isoenzymes at pH 6.5 and at pH 7.5
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5
7.1
Busycotypus canaliculatum
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with 50 mM L-Ala and 2 mM pyruvate as substrates, foot muscle enzyme
8.1
Busycotypus canaliculatum
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with 15 mM meso-alanopine and 1.2 mM NAD+ as substrates, enzyme from hepatopancreas
8.5
8.6
Busycotypus canaliculatum
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with 15 mM meso-alanopine and 1.2 mM NAD+ as substrates, enzyme from gill
6.5
Busycotypus canaliculatum
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with 35 mM L-Ala and 1.4 mM pyruvate as substrate, foot muscle enzyme
8.5
Busycotypus canaliculatum
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with 15 mM meso-alanopine and 1.2 mM NAD+ as substrates, foot muscle enzyme
9
Busycotypus canaliculatum
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with 40 mM meso-alanopine and 2 mM NAD+ as substrates, all three isoenzymes
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
42000
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
analysis
analysis
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a nonfluorescent negative stain to visualize the alanopine dehydrogenase isoenzyme pattern in crude-tissue homogenates from very small worms
analysis
Polydora commensalis
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a nonfluorescent negative stain to visualize the alanopine dehydrogenase isoenzyme pattern in crude-tissue homogenates from very small worms
analysis
Polydora glycymerica
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a nonfluorescent negative stain to visualize the alanopine dehydrogenase isoenzyme pattern in crude-tissue homogenates from very small worms
analysis
-
a nonfluorescent negative stain to visualize the alanopine dehydrogenase isoenzyme pattern in crude-tissue homogenates from very small worms
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LINKS TO OTHER DATABASES (specific for EC-Number 1.5.1.17)
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