Information on EC 1.4.3.8 - ethanolamine oxidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.4.3.8
-
RECOMMENDED NAME
GeneOntology No.
ethanolamine oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
oxidative deamination
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ethanolamine:oxygen oxidoreductase (deaminating)
A cobamide-protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9013-00-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
blowfly
-
-
Manually annotated by BRENDA team
Bacterium ATCC 13796, Arthrobacter sp.
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-amino-2-propanol + H2O + O2
2-hydroxy-propionic aldehyde + NH3 + H2O2
show the reaction diagram
3-amino-1-propanol + H2O + O2
3-hydroxy-propionic aldehyde + NH3 + H2O2
show the reaction diagram
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
show the reaction diagram
-
aerobic catabolism of ethanolamine
-
-
ir
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
activates the dialyzed enzyme, regeneration of 50% of the initial activity
Ni2+
-
slight stimulation
Zn2+
-
activates the dialyzed enzyme, regeneration of 50% of initial activity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
cysteine
Dibenzylamine
-
-
glutathione
hydrazine
hydroxylamine
Iproniazide
-
-
isoniazide
Quinacrine
Semicarbazide
Sodium azide
-
-
Sodium bisulfite
sodium-diethyldithiocarbamate
-
-
additional information
-
not: 8-hydroxyquinoline
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.16 - 5
ethanolamine
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00026
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 8.2
-
pH 7.0: about 50% of activity maximum, pH 8.2: 37% of activity maximum
7 - 9.8
-
half-maximal activities at pH 7 and pH 9.8
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
26 - 48
-
half-maximal activities at 26°C and 48°C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
low activity
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
additional information
-
enzyme more active in larvae than in adults
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
-
no activity in mitochondria
-
Manually annotated by BRENDA team
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
dialysis causes inactivation, activity cannot be restored by addition of pyridoxal phosphate, FAD, NAD+, NADP+ alone or in combination with divalent cations
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-5°C, 6 months, stable
-
more unstable, cannot be stored
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE