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Disease on EC 1.4.3.3 - D-amino-acid oxidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Some aspects of proximal tubular sodium chloride reabsorption in Necturus kidney.
Alzheimer Disease
Benzoate, a D-Amino Acid Oxidase Inhibitor, for the Treatment of Early-Phase Alzheimer Disease: A Randomized, Double-Blind, Placebo-Controlled Trial.
Brain Activity of Benzoate, a D-Amino Acid Oxidase Inhibitor, in Patients With Mild Cognitive Impairment in a Randomized, Double-Blind, Placebo Controlled Clinical Trial.
Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial.
Precision Medicine of Sodium Benzoate for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD).
Sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD): A randomized, double-blind, placebo-controlled, 6-week trial.
Amyotrophic Lateral Sclerosis
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
Insights into the role of d-amino acid oxidase mutations in amyotrophic lateral sclerosis.
Mechanistic insights into the loss-of-function mechanisms of rare human D-amino acid oxidase variants implicated in amyotrophic lateral sclerosis.
Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.
Anemia
Rat liver D-amino acid oxidase activity in iron deficiency anemia.
Anemia, Iron-Deficiency
Rat liver D-amino acid oxidase activity in iron deficiency anemia.
Ataxia
Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801.
Bone Neoplasms
Contributions of spinal D-amino acid oxidase to bone cancer pain.
Down-regulation of spinal D-amino acid oxidase expression blocks formalin-induced tonic pain.
Brain Neoplasms
Induction of cytotoxic oxidative stress by D-alanine in brain tumor cells expressing Rhodotorula gracilis D-amino acid oxidase: a cancer gene therapy strategy.
Carcinoma
Peroxisomal enzymes in normal and tumoral human breast.
Carcinoma, Hepatocellular
Functional interactions between oxidative stress, membrane Na(+) permeability, and cell volume in rat hepatoma cells.
[Distribution, after differential centrifugation, of acid hydrolases, catalase, D-amino acid oxidase and urate oxidase in various Morris hepatomas]
Cardiomyopathy, Dilated
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction.
Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress.
d-amino-acid oxidase deficiency
d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats.
Dementia
A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia.
Diabetes Mellitus, Experimental
Influence of insulin status on extra-mitochondrial oxygen metabolism in the rat.
Xanthine oxidase and D-amino-acid oxidase in fatty liver and alloxan diabetes.
Diabetic Retinopathy
Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.
Fatty Liver
Xanthine oxidase and D-amino-acid oxidase in fatty liver and alloxan diabetes.
Foot-and-Mouth Disease
Active protein aggregates induced by terminally attached self-assembling peptide ELK16 in Escherichia coli.
Glioblastoma
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.
Identification of DNA-binding proteins that interact with the 5'-flanking region of the human d-amino acid oxidase gene by pull-down assay coupled with two-dimensional gel electrophoresis and mass spectrometry.
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility.
Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargeting.
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.
Glioma
D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate.
D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).
Granulomatous Disease, Chronic
PEGylated D-amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite.
Heart Failure
Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress.
Hyperalgesia
Contributions of spinal D-amino acid oxidase to chronic morphine-induced hyperalgesia.
Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived d-serine.
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
WITHDRAWN: Spinal d-amino acid oxidase contributes to the pathogenesis of hyperalgesia in the rat formalin test.
Hyperoxaluria, Primary
Enzymological characterization of a feline analogue of primary hyperoxaluria type 2: a model for the human disease.
Hyperpigmentation
Evaluation of In Vitro Function by Subcellular Distribution of Lysosomal and Peroxisomal Protein in Saccharomyces cerevisiae.
Hypersensitivity
Benzoate and Sorbate Salts: A Systematic Review of the Potential Hazards of These Invaluable Preservatives and the Expanding Spectrum of Clinical Uses for Sodium Benzoate.
Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat.
Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat.
Hyperthyroidism
The effects of postnatal hyper- and hypothyroidism on the development of D-amino acid oxidase in rat cerebellum and brain stem.
Hypokinesia
Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway.
Hypothyroidism
The effects of postnatal hyper- and hypothyroidism on the development of D-amino acid oxidase in rat cerebellum and brain stem.
Infections
Protective Role of D-Amino Acid Oxidase Against Staphylococcus aureus infection.
Salmonella evades D-amino acid oxidase to promote infection in neutrophils.
Malnutrition
Hepatic and renal D-amino acid oxidase activities in the growing rat after ten days of protein undernutrition and refeeding.
Neoplasms
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin.
D-Aminoacid oxidase and homogentisate oxygenase activities in the tumor bearing rats.
Determination of D-amino acid oxidase activity in tumour cells.
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
Induction of cytotoxic oxidative stress by D-alanine in brain tumor cells expressing Rhodotorula gracilis D-amino acid oxidase: a cancer gene therapy strategy.
Optimization of D-amino acid oxidase for low substrate concentrations--towards a cancer enzyme therapy.
Oxidoreductase activities in normal rat liver, tumor-bearing rat liver, and hepatoma HC-252.
Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase.
PEG-DAAO conjugate: A promising tool for cancer therapy optimized by protein engineering.
Peroxisomes in human colon carcinomas. A cytochemical and biochemical study.
Preparation of enzymatically highly active pegylated-D-amino acid oxidase and its application to antitumor therapy.
THE DETERMINATION OF THE TOTAL D-AMINO ACID CONTENT OF HUMAN TUMORS AND NORMAL TISSUES BY MEANS OF D-AMINO ACID OXIDASE.
Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization.
Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide.
Nervous System Diseases
Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.
Neuralgia
An integrated review on new targets in the treatment of neuropathic pain.
Binding Residence Time through Scaled Molecular Dynamics: A Prospective Application to hDAAO Inhibitors.
Down-regulation of spinal D-amino acid oxidase expression blocks formalin-induced tonic pain.
Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives.
PHARMACODYNAMIC EFFECTS OF A D-AMINO ACID OXIDASE INHIBITOR INDICATE A SPINAL SITE OF ACTION IN RAT MODELS OF NEUROPATHIC PAIN.
Spinal D-Amino Acid Oxidase Contributes to Neuropathic Pain in Rats.
Neurobehavioral Manifestations
D-amino Acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.
Drug discovery strategies and the preclinical development of D-amino-acid oxidase inhibitors as antipsychotic therapies.
Lack of Effect of Sodium Benzoate at Reported Clinical Therapeutic Concentration on d-Alanine Metabolism in Dogs.
Neurodegenerative Diseases
P219L substitution in human D-amino acid oxidase impacts the ligand binding and catalytic efficiency.
The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS).
Peroxisomal Disorders
Pipecolic acid is oxidized by renal and hepatic peroxisomes. Implications for Zellweger's cerebro-hepato-renal syndrome (CHRS).
Polyuria
D-amino-acid oxidase is involved in D-serine-induced nephrotoxicity.
Renal Aminoacidurias
Lack of D-amino-acid oxidase activity causes a specific renal aminoaciduria in the mouse.
Renal Insufficiency
D-Amino acids in chronic renal failure and the effects of dialysis and urinary losses.
Reperfusion Injury
Production of hydrogen sulfide from d-cysteine and its therapeutic potential.
Sarcoma 180
Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase.
Sleep Deprivation
Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat.
Spinocerebellar Ataxias
Localization of the candidate gene D-amino acid oxidase outside the refined I-cM region of spinocerebellar ataxia 2.
Staphylococcal Infections
Protective Role of D-Amino Acid Oxidase Against Staphylococcus aureus infection.
Starvation
Dynamics of D-amino acid oxidase in kidney epithelial cells under amino acid starvation.
Stomach Neoplasms
D-amino acid oxidase (DAO) rare genetic missense variant p.Pro103Leu and gastric cancer.
Thymoma
An update on the genetics of schizophrenia.
Tuberculosis
Knockout of MRA_1916 in Mycobacterium tuberculosis H37Ra affects its growth, biofilm formation, survival in macrophages and in mice.
The Mycobacterium tuberculosis H37Ra gene MRA_1916 causes growth defects upon down-regulation.
Urinary Bladder, Overactive
Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy.
Zellweger Syndrome
Histochemistry of peroxisomal enzyme activities: a tool in the diagnosis of Zellweger syndrome.
The human L-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than D-amino acid oxidases.