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2,6-diaminopimelate + O2 + H2O
?
-
22% activity compared to L-lysine
-
-
?
5-hydroxy-DL-lysine + O2 + H2O
6-amino-5-hydroxy-2-oxohexanoate + NH3 + H2O2
-
5% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
L-histidine + O2 + H2O
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
L-leucine + O2 + H2O
4-methyl-2-oxopentanoate + NH3 + H2O2
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
L-lysine + semicarbazide + ?
4-methyl-2-oxopentanoate + ?
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
L-tyrosine + O2 + H2O
3-(4-hydroxyphenyl)pyruvate + NH3 + H2O2
-
-
-
?
L-tyrosine + O2 + H2O
4-hydroxyphenylpyruvate + NH3 + H2O2
-
1.4% activity compared to L-lysine
-
-
?
additional information
?
-
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
-
5.8% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
8.3% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
8.3% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
12.8% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
6.3% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-arginine + O2 + H2O
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
6.3% activity compared to L-lysine
-
-
?
L-histidine + O2 + H2O
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
?
L-histidine + O2 + H2O
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
?
L-histidine + O2 + H2O
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
only 1% in comparison with L-lysine
-
?
L-leucine + O2 + H2O
4-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-leucine + O2 + H2O
4-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-leucine + O2 + H2O
4-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
the mechanistic features are reported that are important for allowing the single active site of L-LOX/MOG to catalyze the two reactions of apparent monooxygenation and the oxidation of the flavoprotein oxidase
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma aureoviride Rifai VKM F-4268D
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
the stereospecific enzyme oxidizes almost exclusively L-lysine
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
the stereospecific enzyme oxidizes almost exclusively L-lysine
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
most favored substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
also other alpha,omega-diaminomonocarboxylates and L-lysine hydroxamate are oxidized
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
lysine metabolism
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
lysine metabolism
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
the molecular mechanism of the strict specificity for L-lysine is explained
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
100% activity
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
enzymes with dual activities in a single active site: L-lysine oxidase and L-lysine monooxygenase
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
5.8% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
5.8% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
the mechanistic features are reported that are important for allowing the single active site of L-LOX/MOG to catalyze the two reactions of apparent monooxygenation and the oxidation of the flavoprotein oxidase
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
6% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
8.3% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
18.3% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoic acid + NH3 + H2O2
-
18.3% activity compared to L-lysine
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
-
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
16% in comparison to L-lysine
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
1.7% activity compared to L-lysine
-
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
16% in comparison to L-lysine
-
?
L-phenylalanine + O2 + H2O
phenylpyruvate + NH3 + H2O2
-
1.7% activity compared to L-lysine
-
-
?
additional information
?
-
-
the enzyme shows no activity with L-histidine, L-aspartic acid, glycine, L-phenylalanine, L-alanine, L-arginine, L-glutamic acid, L-isoleucine, L-leucine, L-serine, L-proline, L-threonine, L-glutamine, L-asparagine, L-threonine, L-tryptophan, L-tyrosine, L-valine, L-methionine, L-cysteine and D-lysine
-
-
?
additional information
?
-
-
very low activity with DL-phenylalanine, L-histidine, L-arginine, DL-methionine and L-glycine
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
no activity with N-2-trifluoroacetyl-L-lysine, 6-aminocaproic acid, 1,4-diaminobutane, L-alanine, L-leucine, L-glutamic acid, L-2,7-diamino heptanoic acid, L-glutamine, and D-lysine
-
-
?
additional information
?
-
Trichoderma cf. aureoviride
-
no activity with The L-isomers of leucine, phenylalanine, citrulline, alanine, asparagine, histidine, ornithine, glutamine, threonine, tyrosine, isoleucine, valine, as well as glycine and D-lysine
-
-
?
additional information
?
-
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
no activity with The L-isomers of leucine, phenylalanine, citrulline, alanine, asparagine, histidine, ornithine, glutamine, threonine, tyrosine, isoleucine, valine, as well as glycine and D-lysine
-
-
?
additional information
?
-
-
very low activity with DL-phenylalanine and DL-methionine
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
very low activity with several other amino acids
-
-
?
additional information
?
-
-
several amino acids, amino acid derivatives and other substances that are assumed to be possible substrates are tested
-
-
?
additional information
?
-
-
no activity with L-cysteine, L-asparagine-NH2, DL-serine, DL-asparagine and DL-glutamic acid
-
-
?
additional information
?
-
-
commercially manufactured LyOx is generally not highly selective for L-Lys among amino acids
-
-
?
additional information
?
-
-
several amino acids, amino acid derivatives and other substances that are assumed to be possible substrates are tested
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
additional information
?
-
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
8.3% activity compared to L-lysine
-
-
?
L-arginine + O2 + H2O
5-carbamidamido-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
8.3% activity compared to L-lysine
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
the stereospecific enzyme oxidizes almost exclusively L-lysine
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
the stereospecific enzyme oxidizes almost exclusively L-lysine
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
most favored substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
also other alpha,omega-diaminomonocarboxylates and L-lysine hydroxamate are oxidized
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
lysine metabolism
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
lysine metabolism
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
preferred substrate
-
?
L-lysine + O2 + H2O
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride
-
5.8% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-amino-2-oxopentanoate + NH3 + H2O2
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
5.8% activity compared to L-lysine
-
-
?
additional information
?
-
Trichoderma cf. aureoviride
-
no activity with The L-isomers of leucine, phenylalanine, citrulline, alanine, asparagine, histidine, ornithine, glutamine, threonine, tyrosine, isoleucine, valine, as well as glycine and D-lysine
-
-
?
additional information
?
-
Trichoderma cf. aureoviride Rifai VKM F-4268D
-
no activity with The L-isomers of leucine, phenylalanine, citrulline, alanine, asparagine, histidine, ornithine, glutamine, threonine, tyrosine, isoleucine, valine, as well as glycine and D-lysine
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Anemia
BAG-1 inhibits p53-induced but not apoptin-induced apoptosis.
Anemia
Proteins selectively killing tumor cells.
Anisakiasis
Purification and cloning of an apoptosis-inducing protein derived from fish infected with Anisakis simplex, a causative nematode of human anisakiasis.
Autoimmune Diseases
Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.
Breast Neoplasms
Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway.
Burkitt Lymphoma
[Effect of L-lysine-alpha-oxidase on the cell cycle kinetics of cultured Burkitt's lymphoma cells]
Carcinoma
[Antimetastatic effect of L-lysine-alpha oxidase]
Carcinoma
[Comparative study of the effect of L-lysine-L-oxidase from Trichoderma harzianum Rifai and Trichoderma viride on nucleic acid synthesis in human tumor cells in vitro]
Carcinoma
[Cytostatic effect of L-lysine-alpha-oxidase from Trichoderma harzianum Rifai and Trichoderma viride]
Carcinoma
[Effect of L-lysine-alpha-oxidase on skin carcinoma induced by methylcholanthrene in mice]
Carcinoma, Hepatocellular
TT virus-derived apoptosis-inducing protein induces apoptosis preferentially in hepatocellular carcinoma-derived cells.
Carcinoma, Lewis Lung
[Antimetastatic effect of L-lysine-alpha oxidase]
Diabetic Retinopathy
Elevation of the vitreous body concentrations of oxidative stress-responsive apoptosis-inducing protein (ORAIP) in proliferative diabetic retinopathy.
Glioblastoma
Unravelling the role of Humanin.
Glioma
Soluble Fas-ligand (sFasL) in human astrocytoma cyst fluid is cytotoxic to T-cells: another potential means of immune evasion.
Hearing Loss
The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein.
Herpes Simplex
[Effect of L-lysine-a-oxidase on reproduction of herpes simplex type I virus in vitro]
Herpes Simplex
[Effect of L-lysine-alpha-oxidase gel on development of ophthalmic herpes and herpetic skin lesions in rabbit]
HIV Infections
[Effect of L-lysine-alpha-oxidase on the synthesis of cell proteins, targets of autoimmune pathology in HIV infection]
Hyperlipoproteinemia Type II
Oxidative stress-responsive apoptosis-inducing protein in patients with heterozygous familial hypercholesterolemia.
Hypertension
Haemodynamic and endocrinological changes during anti-hypertensive treatment with a new vasodilator substance (L6150) and propranolol.
Infections
[Effect of L-lysine-A-oxidase on development of herpetic genital infection in guinea pigs]
Leukemia
The use of an enzyme single fiber reactor in the study of leukemic cell proliferation: in vitro experiments and computer simulation.
Leukemia, Lymphocytic, Chronic, B-Cell
DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.
Melanoma
Proteins selectively killing tumor cells.
Neoplasm Metastasis
Lysyl oxidase: a potential target for cancer therapy.
Neoplasm Metastasis
[Antimetastatic effect of L-lysine-alpha oxidase]
Neoplasms
A Different Path for Harnessing TRAIL.
Neoplasms
AAV-mediated TRAIL gene expression driven by hTERT promoter suppressed human hepatocellular carcinoma growth in mice.
Neoplasms
Apoptin specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: a review.
Neoplasms
Autoimmune lymphoproliferative syndrome: etiology, diagnosis, and management.
Neoplasms
Combination of apoptin with photodynamic therapy induces nasopharyngeal carcinoma cell death in vitro and in vivo.
Neoplasms
Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53.
Neoplasms
Defective apoptosis due to a point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease.
Neoplasms
Engineering of double recombinant vaccinia virus with enhanced oncolytic potential for solid tumor virotherapy.
Neoplasms
Gene expression profiling of metastatic brain cancer.
Neoplasms
Hepatitis C Virus Core Protein Subverts the Anti-Viral Activities of Human Kupffer Cells.
Neoplasms
Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells.
Neoplasms
Induction of Cancer Cell Death by Hyaluronic Acid-Mediated Uptake of Cytochrome C.
Neoplasms
Lysyl oxidase: a potential target for cancer therapy.
Neoplasms
Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway.
Neoplasms
Proteins selectively killing tumor cells.
Neoplasms
Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, l-Lysine ?-oxidase from Trichoderma viride.
Neoplasms
Targeted knockdown of Bcl2 in tumor cells using a synthetic TRAIL 3'-UTR microRNA.
Neoplasms
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
Neoplasms
The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein.
Neoplasms
Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk.
Neoplasms
Tumor counterattack: fact or fiction?
Neoplasms
Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs.
Neoplasms
[Anti-invasive and anti-metastatic effect of lysine oxidase from Trichoderma sp. in vitro and in vivo]
Neoplasms
[Antimetastatic effect of L-lysine-alpha oxidase]
Neoplasms
[Antitumor enzyme L-lyzine-alpha-oxidase from Trichoderma harzianum Rifai F-180 and investigation of its action on L-lysine oxidation by capillar electrophoresis].
Neoplasms
[Biosynthesis of L-lysine-alpha-oxidase, an antitumor enzyme, by Trichoderma spp]
Neoplasms
[Cytotoxic effect of conjugates of L-lysine-alpha-oxidase with monoclonal antibodies on human tumor cells in vitro]
Neoplasms
[Experimental evaluation of synergism of cisplatin with L-lysine-alpha-oxidase].
Pheochromocytoma
[Effect of L-lysine alpha-oxidase from Trichoderma cf. aureoviride Rifai ???F-4268D on pheochromocytoma PC12 cell line].
Prostatic Neoplasms
Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk.
Prostatic Neoplasms
Use of the probasin promoter ARR2PB to express Bax in androgen receptor-positive prostate cancer cells.
Prostatic Neoplasms
[Effect of p53-regulated apoptosis-inducing protein 1 transfection on the biological characteristics of PC-3M human prostate cancer cells].
Urinary Bladder Neoplasms
Apoptin induces apoptosis in human bladder cancer EJ and BIU-87 cells.
Urinary Bladder Neoplasms
Histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells.
Urinary Bladder Neoplasms
Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist.
Virus Diseases
Association of RNase?L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line.
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Smirnova, I.P.; Berezov, T.T.
Substrate specificity of L-amino acid oxidases of certain strains of the genus Trichoderma
Mikrobiologiya
58
49-53
1989
Trichoderma aureoviride, Trichoderma harzianum, Trichoderma viride, Trichoderma longibrachiatum
-
brenda
Kusakabe, H.; Midorikawa, Y.; Kuninaka, A.; Yoshino, H.
Distribution of extracellular oxygen related enzymes in molds
Agric. Biol. Chem.
47
1385-1387
1983
no activity in Aspergillus, no activity in Fusarium, no activity in Mucor, no activity in Penicillium, no activity in Rhizopus, Trichoderma viride
-
brenda
Kusakabe, H.; Kodama, K.; Kuninaka, A.; Yoshino, H.; Misono, H.; Soda, K.
A new antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride. Purification and enzymological properties
J. Biol. Chem.
255
976-981
1980
Trichoderma viride
brenda
Kusakabe, H.; Kodama, K.; Kuninaka, A.; Yoshino, H.; Soda, K.
Extracellular production of L-lysine alpha-oxidase in wheat bran culture of a strain of Trichoderma viride
Agric. Biol. Chem.
43
2531-2535
1979
Trichoderma viride
-
brenda
Kusakabe, H.; Kodama, K.; Machida, H.; Midorikawa, Y.; Kuninaka, A.; Misono, H.; Soda, K.
Occurence of a novel enzyme, L-lysine oxidase with antitumor activity in culture of Trichoderma viride
Agric. Biol. Chem.
43
337-343
1979
Trichoderma viride
-
brenda
Hu, H.M.; Cheng, S.W.; Huang, M.C.; Tang, S.J.; Chang, M.C.; Tsai, Y.C.
Purification and characterization of L-lysine oxidase from Trichoderma pseudokonigii and its effect on growth of mouse erythroleukemia cells
Zhongguo Nongye Huaxue Huizhi
32
361-371
1994
Trichoderma pseudokoningii
-
brenda
Treshalina, H.M.; Lukasheva, E.V.; Sedakova, L.A.; Firsova, G.A.; Guerassimova, G.K.; Gogichaeva, N.V.; Berezov, T.T.
Anticancer enzyme L-lysine alpha-oxidase: properties and application perspectives
Appl. Biochem. Biotechnol.
88
267-273
2000
Trichoderma harzianum, Trichoderma harzianum Rifai
-
brenda
Weber, E.; Tonder, K.; Reinbothe, C.; Unverhau, K.; Weide, H.; Aurich, H.
L-Lysine alpha-oxidase from Trichoderma viride i4. Purification and characterization
J. Basic Microbiol.
34
265-276
1994
Trichoderma viride, Trichoderma viride i4
-
brenda
Murthy, S.N.; Janardanasarma, M.K.
Identification of L-amino acid/L-lysine alpha-amino oxidase in mouse brain
Mol. Cell. Biochem.
197
13-23
1999
Mus musculus, Trichoderma viride
brenda
Smirnova, I.P.; Alekseev, S.B.; Diorditsa, S.V.; Vesa, V.S.; Zaitsev, I.Z.
Effect of L-lysine-alpha-oxidase on the development of genital herpes infection in guinea pigs
Bull. Exp. Biol. Med.
128
1226-1228
2000
Trichoderma harzianum, Trichoderma harzianum Rifai
-
brenda
Danson, J.W.; Trawick, M.L.; Cooper, A.J.
Spectrophotometric assays for L-lysine alpha-oxidase and gamma-glutamylamine cyclotransferase
Anal. Biochem.
303
120-130
2002
Trichoderma viride
brenda
Lucas-Elio, P.; Gomez, D.; Solano, F.; Sanchez-Amat, A.
The antimicrobial activity of marinocine, synthesized by Marinomonas mediterranea, is due to hydrogen peroxide generated by its lysine oxidase activity
J. Bacteriol.
188
2493-2501
2006
Marinomonas mediterranea
brenda
Endo, H.; Hayashi, Y.; Kitani, Y.; Ren, H.; Hayashi, T.; Nagashima, Y.
Optical enzyme sensor for determining L-lysine content using L-lysine oxidase from the rockfish Sebastes schlegeli
Anal. Bioanal. Chem.
391
1255-1261
2008
Trichoderma viride, Sebastes schlegelii
brenda
Guerrieri, A.; Cataldi, T.R.; Ciriello, R.
The kinetic and analytical behaviours of an L-lysine amperometric biosensor based on lysine oxidase immobilized onto a platinum electrode by co-crosslinking
Sens. Actuators B Chem.
B126
424-430
2007
Trichoderma viride
-
brenda
Chen, W.; Lin, C.; Sheu, S.
Investigating antimicrobial activity in Rheinheimera sp. due to hydrogen peroxide generated by L-lysine oxidase activity
Enzyme Microb. Technol.
46
487-493
2010
Rheinheimera sp., Rheinheimera sp. GR5
brenda
Arinbasarova, A.; Ashin, V.; Makrushin, K.; Medentsev, A.; Lukasheva, E.; Berezov, T.
Isolation and properties of L-lysine-alpha-oxidase from the fungus Trichoderma cf. aureoviride RIFAI VKM F-4268D
Microbiology
81
549-554
2012
Trichoderma cf. aureoviride, Trichoderma cf. aureoviride Rifai VKM F-4268D
brenda
Arinbasarova, A.; Makrushin, K.; Medentsev, A.; Lukasheva, E.; Berezov, T.
Production of extracellular hydrogen peroxide and L-lysine-alpha-oxidase in the process of deep culturing of fungus Trichoderma cf. aureoviride rifai BKM F-4268D under salt stress
Microbiology
81
684-687
2012
Trichoderma cf. aureoviride, Trichoderma cf. aureoviride Rifai VKM F-4268D
brenda
Pokrovsky, V.S.; Treshalina, H.M.; Lukasheva, E.V.; Sedakova, L.A.; Medentzev, A.G.; Arinbasarova, A.Y.; Berezov, T.T.
Enzymatic properties and anticancer activity of L-lysine alpha-oxidase from Trichoderma cf. aureoviride Rifai BKMF-4268D
Anticancer Drugs
24
846-851
2013
Trichoderma aureoviride
brenda
Krupyanko, V.; Medentsev, A.; Lukasheva, E.; Arinbasarova, A.
Kinetic characteristics of L-lysine alpha-oxidase from Trichoderma cf. aureoviride Rifai VKM F-4268D Substrate specificity and allosteric effects
Biochem. Biophys. Rep.
9
9-12
2017
Trichoderma aureoviride
-
brenda
Lukasheva, E.; Ribakova, Y.; Fedorova, T.; Makletsova, M.; Arinbasarova, A.; Medentzev, A.; Berezov, T.
The effect of L-Lysine alpha-oxidase from Trichoderma cf. aureoviride Rifai VKM F-4268D on the rat pheochromocytoma PC12 cell line
Biochemistry (Moscow)
8
130-133
2014
Trichoderma aureoviride
-
brenda
Shneider, Y.A.; Smirnova, I.P.; Karimova, E.V.
Inhibition of Tobacco ringspot virus by the culture fluid of L-lysine-alpha-oxidase producing strain
Bull. Exp. Biol. Med.
162
79-81
2016
Trichoderma harzianum, Trichoderma harzianum Rifai F-180
brenda
Tani, Y.; Omatsu, K.; Saito, S.; Miyake, R.; Kawabata, H.; Ueda, M.; Mihara, H.
Heterologous expression of l-lysine alpha-oxidase from Scomber japonicus in Pichia pastoris and functional characterization of the recombinant enzyme
J. Biochem.
157
201-210
2015
Scomber japonicus
brenda
Amano, M.; Mizuguchi, H.; Sano, T.; Kondo, H.; Shinyashiki, K.; Inagaki, J.; Tamura, T.; Kawaguchi, T.; Kusakabe, H.; Imada, K.; Inagaki, K.
Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, L-lysine alpha-oxidase from Trichoderma viride
J. Biochem.
157
549-559
2015
Trichoderma viride, Trichoderma viride Y244-2
brenda
Pokrovsky, V.S.; Lukashev, A.N.; Babayeva, G.; Karshieva, S.S.; Arinbasarova, A.Y.; Medentzev, A.G.; Komarova, M.V.; Lukasheva, E.V.
Plasma pharmacokinetics and tissue distribution of L-lysine alpha-oxidase from Trichoderma cf. aureoviride RIFAI VKM F- 4268D in mice
Amino Acids
53
111-118
2021
Trichoderma aureoviride, Trichoderma aureoviride Rifai VKM F-4268D
brenda
Guerrieri, A.; Ciriello, R.; Bianco, G.; De Gennaro, F.; Frascaro, S.
Allosteric enzyme-based biosensors-kinetic behaviours of immobilised L-lysine-alpha-oxidase from Trichoderma viride pH influence and allosteric properties
Biosensors
10
145
2020
Trichoderma viride
brenda
Smirnova, I.P.; Karimova, E.V.; Shneider, Y.A.
Antibacterial activity of L-lysine-alpha-oxidase from the Trichoderma
Bull. Exp. Biol. Med.
163
777-779
2017
Trichoderma harzianum, Trichoderma harzianum Rifai F-180
brenda
Smirnova, I.P.; Karimova, E.V.; Shneider, Y.A.; Volina, E.G.
L-Lysine-alpha-oxidase Acidovorax citrulli bacterium inhibitor
Bull. Exp. Biol. Med.
164
459-461
2018
Trichoderma harzianum, Trichoderma harzianum Rifai F-180
brenda
Senyagin, A.N.; Larichev, A.F.; Smirnova, I.P.; Podoprigora, I.V.
A novel express method to determine activity of antitumor enzyme L-lysine-alpha-oxidase of Trichoderma harzianum Rifai F-180
Bull. Exp. Biol. Med.
169
119-121
2020
Trichoderma harzianum, Trichoderma harzianum Rifai F-180
brenda
Trisrivirat, D.; Lawan, N.; Chenprakhon, P.; Matsui, D.; Asano, Y.; Chaiyen, P.
Mechanistic insights into the dual activities of the single active site of L-lysine oxidase/monooxygenase from Pseudomonas sp. AIU 813
J. Biol. Chem.
295
11246-11261
2020
Pseudomonas sp. AIU 813, Pseudomonas sp. AIU 813 (W6JQJ6)
brenda
Kitagawa, M.; Ito, N.; Matsumoto, Y.; Saito, M.; Tamura, T.; Kusakabe, H.; Inagaki, K.; Imada, K.
Structural basis of enzyme activity regulation by the propeptide of l-lysine alpha-oxidase precursor from Trichoderma viride
J. Struct. Biol.
5
100044
2021
Trichoderma viride (A0A0G4DCU0), Trichoderma viride
brenda
Lukasheva, E.V.; Makletsova, M.G.; Lukashev, A.N.; Babayeva, G.; Arinbasarova, A.Y.; Medentsev, A.G.
Fungal enzyme L-lysine alpha-oxidase affects the amino acid metabolism in the brain and decreases the polyamine level
Pharmaceuticals
13
398
2020
Trichoderma aureoviride, Trichoderma aureoviride Rifai VKM F-4268D
brenda
Kondo, H.; Kitagawa, M.; Matsumoto, Y.; Saito, M.; Amano, M.; Sugiyama, S.; Tamura, T.; Kusakabe, H.; Inagaki, K.; Imada, K.
Structural basis of strict substrate recognition of l-lysine alpha-oxidase from Trichoderma viride
Protein Sci.
29
2213-2225
2020
Trichoderma viride (A0A0J9X1X3), Trichoderma viride
brenda