Information on EC 1.4.1.19 - tryptophan dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.4.1.19
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RECOMMENDED NAME
GeneOntology No.
tryptophan dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-tryptophan + NAD(P)+ + H2O = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amination
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Deamination
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-
-
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oxidation
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-
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redox reaction
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reduction
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SYSTEMATIC NAME
IUBMB Comments
L-tryptophan:NAD(P)+ oxidoreductase (deaminating)
Activated by Ca2+.
CAS REGISTRY NUMBER
COMMENTARY hide
94047-13-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
normal and crown-gall tumor tissue cultures, tissue transformed by Agrobacterium tumefaciens
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-
Manually annotated by BRENDA team
no activity in Brassica oleracea
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Manually annotated by BRENDA team
tomato
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Manually annotated by BRENDA team
spinach
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-
Manually annotated by BRENDA team
maize
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-tryptophan + NAD(P)+
indol-3-yl-pyruvate + NH3 + NAD(P)H
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-tryptophan + NAD(P)+
indol-3-yl-pyruvate + NH3 + NAD(P)H
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD(P)+
NAD(P)H
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mn2+
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activation
additional information
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absence of heavy metal ions in active centre
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
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reactivation by Ca2+ and Mn2+
additional information
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presence of a carbonyl group in the active centre, less sensitive to SH-inhibitors than glutamate dehydrogenase
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.36 - 1.46
NADH
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.014
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activity in organelles, cofactor NAD+, deamination of L-tryptophan
0.0155
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activity in organelles, cofactor NADP+, deamination of L-tryptophan
0.0359
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activity in organelles, cofactor NADH, amination of L-tryptophan
0.648
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activity in organelles, cofactor NADPH, amination of L-tryptophan
0.87
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cofactor NADH, activity in normal BV-N strain
1.22
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cofactor NADPH, activity in normal BV-N strain
1.24
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cofactor NADH or NADPH, activity in tumor tobacco tissue strains T-24
1.57
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cofactor NADH, activity in tumor tobacco tissue strain C-58
1.59
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cofactor NADPH, activity in tumor tobacco tissue strain C-58
6
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activity in shoots, cofactor NADH
9
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activity in shoots, cofactor NADPH
14
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activity in the apical part of the epicotyl in five-day-old etiolated seedlings 48 h after root excision
18
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activity in the apical part of the epicotyl in five-day-old etiolated seedlings immidiately after root excision
22
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activity in roots, cofactor NADH
23
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activity in the apical part of the epicotyl in five-day-old etiolated seedlings 12 h after root excision
28
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activity in shoots, cofactor NADH
30
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activity in roots, cofactor NADPH
39
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activity in shoots, cofactor NADPH
45
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activity in shoots, cofactor NADH
52
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activity in shoots, cofactor NADH
64
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activity in shoots, cofactor NADPH
70
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activity in shoots, cofactor NADPH
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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normal and crown-gall tumor tissue cultures, tissue transformed by Agrobacterium tumefaciens
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
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enzyme occurs in cytoplasm, chloroplast and pellet of remaining organelles sedimenting at 97000 * g
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Manually annotated by BRENDA team