Information on EC 1.4.1.10 - glycine dehydrogenase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.4.1.10
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RECOMMENDED NAME
GeneOntology No.
glycine dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
glycine + H2O + NAD+ = glyoxylate + NH3 + NADH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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SYSTEMATIC NAME
IUBMB Comments
glycine:NAD+ oxidoreductase (deaminating)
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CAS REGISTRY NUMBER
COMMENTARY hide
37255-40-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Blastobacter aminovorus
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
ATCC 607
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Manually annotated by BRENDA team
no activity in Arthrobacter globiformis
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-
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Manually annotated by BRENDA team
no activity in Methylomonas methylovora
M8-5, M12-4
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-
Manually annotated by BRENDA team
no activity in Methylomonas methylovora M8-5 M12-4
M8-5, M12-4
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Manually annotated by BRENDA team
no activity in Methylophilus methanolovorus
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-
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Manually annotated by BRENDA team
Pseudomonas methylica
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-
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Manually annotated by BRENDA team
AM1
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Manually annotated by BRENDA team
AM1
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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the rs10975641 single nucleotide polymorphism in the glycine dehydrogenase gene is associated with selective serotonin reuptake inhibitors treatment outcome phenotypes, overview. Selective serotonin reuptake inhibitors are used in teatment of major depressive disorder (MDD), a common psychiatric disease
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glyoxylate + NH3 + NADH
glycine + H2O + NAD+
show the reaction diagram
glyoxylate + NH3 + NADH + H+
glycine + H2O + NAD+
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
glyoxylate + NH3 + NADH
glycine + H2O + NAD+
show the reaction diagram
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alternate pathway for formation of glycine in absence of transamination
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r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
oxygen
serine
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non-competitive
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.22 - 5.5
glyoxylate
0.0087
NADH
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anaerobic resting bacilli - RB
120
NH3
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anaerobic resting bacilli - RB
additional information
additional information
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
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no enzyme detected in the extracellular medium
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Manually annotated by BRENDA team
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-17°C, 72 h, 30-50% loss of activity
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37°C, 12 d under microaerophilic conditions
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATCC 607, partial from microaerophilic adapted cultures
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H37Ra strain, partial
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recombinant His-tagged enzyme from Escherichia coli strain ER2566 by nickel affinity chromatography, native enzyme by anion exchange and hydrophobic interaction chromatography, followed by ultrafiltration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, genotyping and isolation of rs10975641 single nucleotide polymorphism
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gene ald, quantitative real-time PCR expression analysis, expression in Escherichia coli strain ER2566
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
transcription of ald is induced when alanine is the sole nitrogen source
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information