Information on EC 1.3.99.25 - carvone reductase

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The expected taxonomic range for this enzyme is: Rhodococcus erythropolis

EC NUMBER
COMMENTARY hide
1.3.99.25
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RECOMMENDED NAME
GeneOntology No.
carvone reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(+)-dihydrocarvone + acceptor = (-)-carvone + reduced acceptor
show the reaction diagram
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(-)-isodihydrocarvone + acceptor = (+)-carvone + reduced acceptor
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(4R)-carveol and (4R)-dihydrocarveol degradation
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(4S)-carveol and (4S)-dihydrocarveol degradation
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Limonene and pinene degradation
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SYSTEMATIC NAME
IUBMB Comments
(+)-dihydrocarvone:acceptor 1,6-oxidoreductase
This enzyme participates in the carveol and dihydrocarveol degradation pathway of the Gram-positive bacterium Rhodococcus erythropolis DCL14. The enzyme has not been purified, and requires an unknown cofactor, which is different from NAD+, NADP+ or a flavin.
CAS REGISTRY NUMBER
COMMENTARY hide
287177-53-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
DCL14
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(4R)-carvone + reduced acceptor
?
show the reaction diagram
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transient accumulation of (1R,4R)-dihydrocarvone is observed. Upon longer incubation, this compound is converted mainly into (1R,2R,4R)-dihydrocarveol and traces of (1R,2S,4R)-neo-dihydrocarveol
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?
(4S)-carvone + reduced acceptor
(1R,4S)-iso-dihydrocarvone + acceptor
show the reaction diagram
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under aerobic conditions, only traces of (iso-)dihydrocarvone accumulate. Under anaerobic conditions much larger quantities of these compounds accumulate. The enzyme requires an unknown cofactor, which is different from NAD+, NADP+ or a flavin
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
dialysis results in a complete loss of carvone reductase activity
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