Information on EC 1.3.99.14 - cyclohexanone dehydrogenase

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The expected taxonomic range for this enzyme is: Pseudomonas sp.

EC NUMBER
COMMENTARY hide
1.3.99.14
-
RECOMMENDED NAME
GeneOntology No.
cyclohexanone dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cyclohexanone + acceptor = cyclohex-2-enone + reduced acceptor
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
cyclohexanone:acceptor 2-oxidoreductase
2,6-Dichloroindophenol can act as acceptor. The corresponding ketones of cyclopentane and cycloheptane cannot act as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
123516-43-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
denitrifying species
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cyclohex-2-enone + 2,6-dichlorophenol indophenol
phenol + reduced 2,6-dichlorophenol indophenol
show the reaction diagram
-
about 30% of the activity with cyclohexanone
-
-
cyclohexanone + 2,6-dichlorophenol indophenol
cyclohex-2-enone + reduced 2,6-dichlorophenol indophenol
show the reaction diagram
-
no activity as acceptor: NAD+, NADP+, methylene blue
-
-
Cyclohexanone + acceptor
?
show the reaction diagram
-
the enzyme is involved in anaerobic degradation of cyclohexanol
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Cyclohexanone + acceptor
?
show the reaction diagram
-
the enzyme is involved in anaerobic degradation of cyclohexanol
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-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-cyclohexenone
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
anaerobically or aerobically
Manually annotated by BRENDA team