Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 1.3.8.6 - glutaryl-CoA dehydrogenase (ETF)

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gomes, B.; Fendrich, G.; Abeles, R.H.
Mechanism of action of glutaryl-CoA and butyryl-CoA dehydrogenases. Purification of glutaryl-CoA dehydrogenase
Biochemistry
20
1481-1490
1981
Pseudomonas fluorescens
Manually annotated by BRENDA team
Byron, C.M.; Stankovich, M.T.; Husain, M.
Spectral and electrochemical properties of glutaryl-CoA dehydrogenase from Paracoccus denitrificans
Biochemistry
29
3691-3700
1990
Paracoccus denitrificans
Manually annotated by BRENDA team
McMillan, T.A.; Gibson, K.M.; Sweetman, L.; Meyers, G.S.; Green, R.
Conservation of central nervous system glutaryl-coenzyme A dehydrogenase in fruit-eating bats with glutaric aciduria and deficient hepatic glutaryl-coenzyme A dehydrogenase
J. Biol. Chem.
263
17258-17261
1988
Rousettus aegyptiacus
Manually annotated by BRENDA team
Lenich, A.C.; Goodman, S.I.
The purification and characterization of glutaryl-coenzyme A dehydrogenase from porcine and human liver
J. Biol. Chem.
261
4090-4096
1986
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Husain, M.; Steenkamp, D.J.
Partial purification and characterization of glutaryl-coenzyme A dehydrogenase, electron transfer flavoprotein, and electron transfer flavoprotein-Q oxidoreductase from Paracoccus denitrificans
J. Bacteriol.
163
709-715
1985
Paracoccus denitrificans
Manually annotated by BRENDA team
Vamecq, J.; van Hoof, F.
Implication of a peroxisomal enzyme in the catabolism of glutaryl-CoA
Biochem. J.
221
203-211
1984
Mus musculus
Manually annotated by BRENDA team
Besrat, A.; Polan, C.E.; Henderson, L.M.
Mammalian metabolism of glutaric acid
J. Biol. Chem.
244
1461-1467
1969
Bos taurus
Manually annotated by BRENDA team
Liesert, M.; Zschocke, J.; Hoffmann, G.F.; Muhlhauser, N.; Buckel, W.
Biochemistry of glutaric aciduria type I: activities of in vitro expressed wild-type and mutant cDNA encoding human glutaryl-CoA dehydrogenase
J. Inherit. Metab. Dis.
22
256-258
1999
Homo sapiens
Manually annotated by BRENDA team
Goodman, S.I.; Kratz, L.E.; DiGiulio, K.A.; Biery, B.J.; Goodman, K.E.; Isaya, G.; Frerman, F.E.
Cloning of glutaryl-CoA dehydrogenase cDNA, and expression of wild type and mutant enzymes in Escherichia coli
Hum. Mol. Genet.
4
1493-1498
1995
Homo sapiens
Manually annotated by BRENDA team
Goodman, S.I.; Stein, D.E.; Schlesinger, S.; Christensen, E.; Schwartz, M.; Greenberg, C.R.; Elpeleg, O.N.
Glutaryl-CoA dehydrogenase mutations in glutaric acidemia (type I): Review and report of thirty novel mutations
Hum. Mutat.
12
141-144
1998
Homo sapiens
Manually annotated by BRENDA team
Haertel, U.; Eckel, E.; Koch, J.; Fuchs, G.; Linder, D.; Buckel, W.
Purification of glutaryl-CoA dehydrogenase from Pseudomonas sp., an enzyme involved in the anaerobic degradation of benzoate
Arch. Microbiol.
159
174-181
1993
Pseudomonas sp.
Manually annotated by BRENDA team
Dwyer, T.M.; Rao, K.S.; Goodman, S.I.; Frerman, F.E.
Proton abstraction reaction, steady-state kinetics, and oxidation-reduction potential of human glutaryl-CoA dehydrogenase
Biochemistry
39
11488-11499
2000
Homo sapiens
Manually annotated by BRENDA team
Westover, J.B.; Goodman, S.I.; Frerman, F.E.
Binding, hydration, and decarboxylation of the reaction intermediate glutaconyl-Coenzyme A by human Glutaryl-CoA dehydrogenase
Biochemistry
40
14106-14114
2001
Homo sapiens
Manually annotated by BRENDA team
Rao, K.S.; Vander Velde, D.; Dwyer, T.M.; Goodman, S.I.; Frerman, F.E.
Alternate substrates of human glutaryl-CoA dehydrogenase: Structure and reactivity of substrates, and identification of a novel 2-enoyl-CoA product
Biochemistry
41
1274-1284
2002
Homo sapiens
Manually annotated by BRENDA team
Dwyer, T.M.; Rao, K.S.; Westover, J.B.; Kim, J.J.P.; Frerman, F.E.
The function of Arg-94 in the oxidation and decarboxylation of glutaryl-CoA by human glutaryl-CoA dehydrogenase
J. Biol. Chem.
276
133-138
2001
Homo sapiens
Manually annotated by BRENDA team
Woontner, M.; Crnic, L.S.; Koeller, D.M.
Analysis of the expression of murine glutaryl-CoA dehydrogenase: in vitro and in vivo studies
Mol. Genet. Metab.
69
116-122
2000
Mus musculus
Manually annotated by BRENDA team
Vamecq, J.; de Hoffmann, E.; van Hoff, F.
Mitochondrial and peroxisomal metabolism of glutaryl-CoA
Eur. J. Biochem.
146
663-669
1985
Mus musculus
Manually annotated by BRENDA team
Fu, Z.; Wang, M.; Paschke, R.; Rao, K.S.; Frerman, F.E.; Kim, J.J.
Crystal structures of human glutaryl-CoA dehydrogenase with and without an alternate substrate: structural bases of dehydrogenation and decarboxylation reactions
Biochemistry
43
9674-9684
2004
Homo sapiens (Q92947), Homo sapiens
Manually annotated by BRENDA team
Rao, K.S.; Albro, M.; Vockley, J.; Frerman, F.E.
Mechanism-based inactivation of human glutaryl-CoA dehydrogenase by 2-pentynoyl-CoA: rationale for enhanced reactivity
J. Biol. Chem.
278
26342-26350
2003
Homo sapiens (Q92947), Homo sapiens
Manually annotated by BRENDA team
Muehlhausen, C.; Christensen, E.; Schwartz, M.; Muschol, N.; Ullrich, K.; Lukacs, Z.
Severe phenotype despite high residual glutaryl-CoA dehydrogenase activity: a novel mutation in a Turkish patient with glutaric aciduria type I
J. Inherit. Metab. Dis.
26
713-714
2003
Homo sapiens
Manually annotated by BRENDA team
Treacy, E.P.; Lee-Chong, A.; Roche, G.; Lynch, B.; Ryan, S.; Goodman, S.
Profound neurological presentation resulting from homozygosity for a mild glutaryl-CoA dehydrogenase mutation with a minimal biochemical phenotype
J. Inherit. Metab. Dis.
26
72-74
2003
Homo sapiens
Manually annotated by BRENDA team
Westover, J.B.; Goodman, S.I.; Frerman, F.E.
Pathogenic mutations in the carboxyl-terminal domain of glutaryl-CoA dehydrogenase: effects on catalytic activity and the stability of the tetramer
Mol. Genet. Metab.
79
245-256
2003
Homo sapiens
Manually annotated by BRENDA team
Rao, K.S.; Albro, M.; Zirrolli, J.A.; Vander Velde, D.; Jones, D.N.M.; Frerman, F.E.
Protonation of crotonyl-CoA dienolate by human glutaryl-CoA dehydrogenase occurs by solvent-derived protons
Biochemistry
44
13932-13940
2005
Homo sapiens
Manually annotated by BRENDA team
Rao, K.S.; Albro, M.; Dwyer, T.M.; Frerman, F.E.
Kinetic mechanism of glutaryl-CoA dehydrogenase
Biochemistry
45
15853-15861
2006
Homo sapiens (Q92947)
Manually annotated by BRENDA team
Yeh, C.S.; Wang, J.Y.; Cheng, T.L.; Juan, C.H.; Wu, C.H.; Lin, S.R.
Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis
Cancer Lett.
233
297-308
2006
Homo sapiens
Manually annotated by BRENDA team
Rao, K.S.; Fu, Z.; Albro, M.; Narayanan, B.; Baddam, S.; Lee, H.J.; Kim, J.J.; Frerman, F.E.
The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate
Biochemistry
46
14468-14477
2007
Homo sapiens (Q92947)
Manually annotated by BRENDA team
Strauss, K.A.; Lazovic, J.; Wintermark, M.; Morton, D.H.
Multimodal imaging of striatal degeneration in Amish patients with glutaryl-CoA dehydrogenase deficiency
Brain
130
1905-1920
2007
Homo sapiens
Manually annotated by BRENDA team
Blazquez, B.; Carmona, M.; Garcia, J.L.; Diaz, E.
Identification and analysis of a glutaryl-CoA dehydrogenase-encoding gene and its cognate transcriptional regulator from Azoarcus sp. CIB
Environ. Microbiol.
10
474-482
2008
Pseudomonas putida, Azoarcus sp. (B0EVL5), Pseudomonas putida KT 2240
Manually annotated by BRENDA team
Koelker, S.; Christensen, E.; Leonard, J.V.; Greenberg, C.R.; Burlina, A.B.; Burlina, A.P.; Dixon, M.; Duran, M.; Goodman, S.I.; Koeller, D.M.; Mueller, E.; Naughten, E.R.; Neumaier-Probst, E.; Okun, J.G.; Kyllerman, M.; Surtees, R.A.; Wilcken, B.; Hoffmann, G.F.; Burgard, P.
Guideline for the diagnosis and management of glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I)
J. Inherit. Metab. Dis.
30
5-22
2007
Homo sapiens
Manually annotated by BRENDA team
Sauer, S.W.
Biochemistry and bioenergetics of glutaryl-CoA dehydrogenase deficiency
J. Inherit. Metab. Dis.
30
673-680
2007
Homo sapiens
Manually annotated by BRENDA team
Lopez-Laso, E.; Garcia-Villoria, J.; Martin, E.; Duque, P.; Cano, A.; Ribes, A.
Classic and late-onset neurological disease in two siblings with glutaryl-CoA dehydrogenase deficiency
J. Inherit. Metab. Dis.
30
979
2007
Homo sapiens
Manually annotated by BRENDA team
McClelland Verity , M.V.; Gissen Pau, G.P.; Hendriksz Chri, H.C.; Chakrapani Anupa, C.A.
Glutaryl-CoA dehydrogenase deficiency
Pediatr. Res.
61
134-135
2007
Homo sapiens
-
Manually annotated by BRENDA team
Koelker, S.; Garbade, S.F.; Boy, N.; Maier, E.M.; Meissner, T.; Muehlhausen, C.; Hennermann, J.B.; Luecke, T.; Haeberle, J.; Baumkoetter, J.; Haller, W.; Muller, E.; Zschocke, J.; Burgard, P.; Hoffmann, G.F.
Decline of acute encephalopathic crises in children with glutaryl-CoA dehydrogenase deficiency identified by newborn screening in Germany
Pediatr. Res.
62
357-363
2007
Homo sapiens
Manually annotated by BRENDA team
Keyser, B.; Glatzel, M.; Stellmer, F.; Kortmann, B.; Lukacs, Z.; Koelker, S.; Sauer, S.W.; Muschol, N.; Herdering, W.; Thiem, J.; Goodman, S.I.; Koeller, D.M.; Ullrich, K.; Braulke, T.; Muehlhausen, C.
Transport and distribution of 3-hydroxyglutaric acid before and during induced encephalopathic crises in a mouse model of glutaric aciduria type 1
Biochim. Biophys. Acta
1782
385-390
2008
Mus musculus (Q60759), Mus musculus
Manually annotated by BRENDA team
Wischgoll, S.; Demmer, U.; Warkentin, E.; Guenther, R.; Boll, M.; Ermler, U.
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme A dehydrogenases
Biochemistry
49
5350-5357
2010
Homo sapiens (Q92947)
Manually annotated by BRENDA team
Strauss, K.A.; Donnelly, P.; Wintermark, M.
Cerebral haemodynamics in patients with glutaryl-coenzyme A dehydrogenase deficiency
Brain
133
76-92
2010
Homo sapiens
Manually annotated by BRENDA team
Wischgoll, S.; Taubert, M.; Peters, F.; Jehmlich, N.; von Bergen, M.; Boll, M.
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria
J. Bacteriol.
191
4401-4409
2009
Geobacter metallireducens
Manually annotated by BRENDA team
van der Watt, G.; Owen, E.P.; Berman, P.; Meldau, S.; Watermeyer, N.; Olpin, S.E.; Manning, N.J.; Baumgarten, I.; Leisegang, F.; Henderson, H.
Glutaric aciduria type 1 in South Africa-high incidence of glutaryl-CoA dehydrogenase deficiency in black South Africans
Mol. Genet. Metab.
101
178-182
2010
Homo sapiens
Manually annotated by BRENDA team
Begley, D.W.; Davies, D.R.; Hartley, R.C.; Hewitt, S.N.; Rychel, A.L.; Myler, P.J.; Van Voorhis, W.C.; Staker, B.L.; Stewart, L.J.
Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
Acta Crystallogr. Sect. F
67
1060-1069
2011
Homo sapiens, Burkholderia pseudomallei (Q3JP94), Burkholderia pseudomallei, Burkholderia pseudomallei 1710b (Q3JP94)
Manually annotated by BRENDA team
Wu, L.; Qiao, Y.; Gao, J.; Deng, G.; Yu, W.; Chen, G.; Li, D.
Functional characterization of rat glutaryl-CoA dehydrogenase and its comparison with straight-chain acyl-CoA dehydrogenase
Bioorg. Med. Chem. Lett.
21
6667-6673
2011
Rattus norvegicus
Manually annotated by BRENDA team
Gao, J.; Zhang, C.; Fu, X.; Yi, Q.; Tian, F.; Ning, Q.; Luo, X.
Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons
PLoS ONE
8
e63084
2013
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Schmiesing, J.; Lohmoeller, B.; Schweizer, M.; Tidow, H.; Gersting, S.W.; Muntau, A.C.; Braulke, T.; Muehlhausen, C.
Disease-causing mutations affecting surface residues of mitochondrial glutaryl-CoA dehydrogenase impair stability, heteromeric complex formation and mitochondria architecture
Hum. Mol. Genet.
26
538-551
2017
Homo sapiens (Q92947), Homo sapiens
Manually annotated by BRENDA team
Braissant, O.; Jafari, P.; Remacle, N.; Cudre-Cung, H.P.; Do Vale Pereira, S.; Ballhausen, D.
Immunolocalization of glutaryl-CoA dehydrogenase (GCDH) in adult and embryonic rat brain and peripheral tissues
Neuroscience
343
355-363
2017
Rattus norvegicus
Manually annotated by BRENDA team
Schmiesing, J.; Schlueter, H.; Ullrich, K.; Braulke, T.; Muehlhausen, C.
Interaction of glutaric aciduria type 1-related glutaryl-CoA dehydrogenase with mitochondrial matrix proteins
PLoS ONE
9
e87715
2014
Homo sapiens (Q92947), Homo sapiens
Manually annotated by BRENDA team
Ribeiro, J.; Lucas, T.; Bross, P.; Gomes, C.; Henriques, B.
Potential complementation effects of two disease-associated mutations in tetrameric glutaryl-CoA dehydrogenase is due to inter subunit stability-activity counterbalance
Biochim. Biophys. Acta
1868
140269
2020
Homo sapiens (Q92947), Homo sapiens
Manually annotated by BRENDA team