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(2E)-3-[2-fluoro-4-(trifluoromethyl)phenyl]-2-methylprop-2-en-1-ol
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(2E)-N-ethyl-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
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(2E)-N-[(1H-indol-7-yl)methyl]-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
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(2E)-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
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(2E)-N-[(1H-indol-7-yl)methyl]-N-(propan-2-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
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(2E)-N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-methyl-3-(4-methylphenyl)prop-2-en-1-amine
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(2E,4E)-5-(2-fluoro-4-(trifluoromethyl)phenyl)penta-2,4-dien-1-ol
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(2E,4E)-5-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpenta-2,4-dien-1-amine
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(2E,4E)-N-((1H-indol-7-yl)methyl)-5-([1,1'-biphenyl]-4-yl)-N-methylpenta-2,4-dien-1-amine
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(2E,4E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylpenta-2,4-dien-1-amine
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(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N,2-dimethylprop-2-en-1-amine
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(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-en-1-amine
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(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylprop-2-en-1-amine
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(E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
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(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
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(E)-4-(3-((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
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(E)-4-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylbut-3-en-1-amine
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(E)-methyl 4-(3-((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzoate
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(E)-N-((1H-indol-2-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-3-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-4-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-5-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-6-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N,2-dimethylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-4-([1,1'-biphenyl]-4-yl)-N-methylbut-3-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-1-yl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-2-yl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-phenylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methylbut-2-en-1-amine
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(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-ethyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-isopropyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2,4-dichlorophenyl)-Nmethylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methyprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methyprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
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(E)-N-(benzofuran-7-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)-phenyl)prop-2-en-1-amine
inhibits the pigment production of S. aureus Newman and three MRSA strains, without any impact on the survival of four strains. Compound shows good oral bioavailability and safety profiles. IC50 value for growth of Staphylococcus aureus 3.9 nM
(E)-N-(benzo[b]thiophen-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[b]thiophen-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N,2-dimethylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-isopropylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-ethyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(4-nitrophenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(thiophen-2-yl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylbut-2-en-1-amine
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1-(benzo[d][1,3]dioxol-5-yl)-N-(((1R,2R)-2-(2-fluoro-4-(trifluoromethyl)phenyl)cyclopropyl)methyl)-N-methylmethanamine
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3-(2-fluoro-4-(trifluoromethyl)phenyl)prop-2-yn-1-ol
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3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-yn-1-amine
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3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpropan-1-amine
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ethyl (2E,4E)-5-(2-fluoro-4-(trifluoromethyl)phenyl)penta-2,4-dienoate
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ethyl (E)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methylacrylate
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methyl (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzoate
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methyl (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
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methyl(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
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N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-yn-1-amine
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N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylpropan-1-amine
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N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-yn-1-amine
vivo effects of (2E,4E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylpenta-2,4-dien-1-amine on attenuating the virulence of Newman, Mu50 and NRS271
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N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylpropan-1-amine
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naftifine
blocks biosynthesis of carotenoid pigment at nanomolar concentrations by competitive inhibition of diapophytoene desaturase CrtN. Naftifine attenuates the virulence of strain Newman and of a variety of clinical Staphylocuus aureus isolates, in mouse infection models
additional information
piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, overview
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additional information
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piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, overview
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additional information
synthesis of a series of CrtN inhibitors with other scaffolds, method overview. The compounds show excellent activity against different MRSA in in vitro and in vivo at a lower dosage but also overcome the disadvantages of hERG inhibition. Linezolid and vancomycin, the last-resort antimicrobial agents, are introduced as positive control drugs into a murine model of Staphylococcus aureus abscess formation to evaluate the effectiveness of the analogues. Diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, in vivo cytotoxicity IC50 values and pigment inhibition activity IC50 values, overview
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0.000118
(2E)-N-ethyl-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(2E)-N-[(1H-indol-7-yl)methyl]-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine, (2E)-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine, (2E)-N-[(1H-indol-7-yl)methyl]-N-(propan-2-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000157
(2E)-N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-methyl-3-(4-methylphenyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(2E,4E)-5-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpenta-2,4-dien-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000194
(2E,4E)-N-((1H-indol-7-yl)methyl)-5-([1,1'-biphenyl]-4-yl)-N-methylpenta-2,4-dien-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N,2-dimethylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000002
(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000039
(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0007847
(E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000801
(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000125
(E)-4-(3-((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-4-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylbut-3-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000079
(E)-methyl 4-(3-((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzoate
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0002796
(E)-N-((1H-indol-7-yl)methyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-((1H-indol-7-yl)methyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000484
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000731
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000435
(E)-N-((1H-indol-7-yl)methyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0007
(E)-N-((1H-indol-7-yl)methyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000838
(E)-N-((1H-indol-7-yl)methyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0001426
(E)-N-((1H-indol-7-yl)methyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000648
(E)-N-((1H-indol-7-yl)methyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-((1H-indol-7-yl)methyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000167
(E)-N-((1H-indol-7-yl)methyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-((1H-indol-7-yl)methyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N,2-dimethylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000033
(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-((1H-indol-7-yl)methyl)-3-cyclohexyl-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-3-cyclopentyl-N-methylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-4-([1,1'-biphenyl]-4-yl)-N-methylbut-3-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-1-yl)-prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0001318
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-2-yl)-prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000199
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-phenylprop-2-en-1-amine, (E)-N-((1H-indol-7-yl)methyl)-N-methylbut-2-en-1-amine, (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine, (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-ethyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine, (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-isopropyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000062
(E)-N-(benzofuran-3-ylmethyl)-3-(2,4-dichlorophenyl)-Nmethylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0003598
(E)-N-(benzofuran-3-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000092
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000864
(E)-N-(benzofuran-3-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000741
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000064
(E)-N-(benzofuran-3-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000025 - 0.0000158
(E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
-
0.0000049
(E)-N-(benzofuran-3-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000741
(E)-N-(benzofuran-3-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0003973
(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000913
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000095
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000064
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000099
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine, (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000339
(E)-N-(benzofuran-7-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)-phenyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C
0.0000176
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000018
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000038
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000121
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000576
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000057
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000112
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000412
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000041
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000052
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000046
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000042
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine, (E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000042
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
-
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000584
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000091
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine, (E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
Staphylococcus aureus
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000288
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000523
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000035
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000826
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(4-nitrophenyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000372
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.000004
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine, (E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(thiophen-2-yl)prop-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(thiophen-2-yl)prop-2-en-1-amine
Staphylococcus aureus
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine, (E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylbut-2-en-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylbut-2-en-1-amine
Staphylococcus aureus
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-yn-1-amine, 3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpropan-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.02
Diphenylamine
Staphylococcus aureus
pH 6.6, 30°C
0.0000878
methyl (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzoate
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000095
methyl (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0001018
N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-yn-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.001
N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylpropan-1-amine
Staphylococcus aureus
above, pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000025
(E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
0.0000158
(E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
Staphylococcus aureus
pH 7.5, 37°C, recombinant His-tagged enzyme
-
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Takaichi, S.; Inoue, K.; Akaike, M.; Kobayashi, M.; Oh-oka, H.; Madigan, M.T.
The major carotenoid in all known species of heliobacteria is the C30 carotenoid 4,4'-diaponeurosporene, not neurosporene
Arch. Microbiol.
168
277-281
1997
Heliomicrobium gestii, Heliobacterium chlorum, Heliomicrobium modesticaldum, Heliobacterium mobile, Heliophilum fasciatum
brenda
Raisig, A.; Sandmann, G.
Functional properties of diapophytoene and related desaturases of C30 to C40 carotenoid biosynthetic pathways
Biochim. Biophys. Acta
1533
164-170
2001
Anabaena sp., Pantoea ananatis, Staphylococcus aureus (O07855), Staphylococcus aureus
brenda
Yoshida, K.; Ueda, S.; Maeda, I.
Carotenoid production in Bacillus subtilis achieved by metabolic engineering
Biotechnol. Lett.
31
1789-1793
2009
Staphylococcus aureus (O07855)
brenda
Wieland, B.; Feil, C.; Gloria-Maercker, E.; Thumm, G.; Lechner, M.; Bravo, J.M.; Poralla, K.; Gotz, F.
Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus
J. Bacteriol.
176
7719-7726
1994
Staphylococcus aureus (O07855), Staphylococcus aureus
brenda
Raisig, A.; Sandmann, G.
4,4'-diapophytoene desaturase: catalytic properties of an enzyme from the C30 carotenoid pathway of Staphylococcus aureus
J. Bacteriol.
181
6184-6187
1999
Staphylococcus aureus (O07855)
brenda
Pelz, A.; Wieland, K.P.; Putzbach, K.; Hentschel, P.; Albert, K.; Gtz, F.
Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus
J. Biol. Chem.
280
32493-32498
2005
Staphylococcus aureus (O07855), Staphylococcus aureus
brenda
Maeda, I.
Genetic modification in Bacillus subtilis for production of C30 carotenoids
Methods Mol. Biol.
892
197-205
2012
Staphylococcus aureus
brenda
Wang, Y.; Chen, F.; Di, H.; Xu, Y.; Xiao, Q.; Wang, X.; Wei, H.; Lu, Y.; Zhang, L.; Zhu, J.; Sheng, C.; Lan, L.; Li, J.
Discovery of potent benzofuran-derived diapophytoene desaturase (CrtN) inhibitors with enhanced oral bioavailability for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections
J. Med. Chem.
59
3215-3230
2016
Staphylococcus aureus (O07855), Staphylococcus aureus, Staphylococcus aureus Newman (O07855)
brenda
Chen, F.; Di, H.; Wang, Y.; Cao, Q.; Xu, B.; Zhang, X.; Yang, N.; Liu, G.; Yang, C.G.; Xu, Y.; Jiang, H.; Lian, F.; Zhang, N.; Li, J.; Lan, L.
Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence
Nat. Chem. Biol.
12
174-179
2016
Staphylococcus aureus (O07855), Staphylococcus aureus, Staphylococcus aureus Newman (O07855)
brenda
Wei, H.; Mao, F.; Ni, S.; Chen, F.; Li, B.; Qiu, X.; Hu, L.; Wang, M.; Zheng, X.; Zhu, J.; Lan, L.; Li, J.
Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections
Eur. J. Med. Chem.
145
235-251
2018
Staphylococcus aureus (O07855), Staphylococcus aureus, Staphylococcus aureus Newman (O07855)
brenda
Li, B.; Ni, S.; Mao, F.; Chen, F.; Liu, Y.; Wei, H.; Chen, W.; Zhu, J.; Lan, L.; Li, J.
Novel terminal biphenyl-based diapophytoene desaturases (CrtN) inhibitors as anti-MRSA/VISR/LRSA agents with reduced hERG activity
J. Med. Chem.
61
224-250
2018
Staphylococcus aureus (O07855), Staphylococcus aureus Newman (O07855)
brenda