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2,3-dihydro-2,3-dehydroxybiphenyl-2,3-dehydrogenase
2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase
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2,3-dihydroxy-4-phenylhexa-4,6-diene dehydrogenase
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biphenyl dihydrodiol dehydrogenase
Biphenyl-2,3-dihydro-2,3-diol dehydrogenase
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biphenyl-2,3-dihydrodiol 2,3-dehydrogenase
biphenyl-2,3-dihydrodiol-2,3-dehydrogenase
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Biphenyl-cis-diol dehydrogenase
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cis-2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase
cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase
NAD-dependent cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
2,3-dihydro-2,3-dehydroxybiphenyl-2,3-dehydrogenase
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-
2,3-dihydro-2,3-dehydroxybiphenyl-2,3-dehydrogenase
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2,3-dihydro-2,3-dehydroxybiphenyl-2,3-dehydrogenase
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biphenyl dihydrodiol dehydrogenase
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biphenyl dihydrodiol dehydrogenase
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biphenyl-2,3-dihydrodiol 2,3-dehydrogenase
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biphenyl-2,3-dihydrodiol 2,3-dehydrogenase
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biphenyl-2,3-dihydrodiol 2,3-dehydrogenase
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BphB
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BphBB356
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cis-2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase
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cis-2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase
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cis-2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase
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cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase
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cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase
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cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase
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NAD-dependent cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
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NAD-dependent cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
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additional information
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enzyme belongs to the short-chain alcohol dehydrogenase/reductase family
additional information
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enzyme belongs to the short-chain alcohol dehydrogenase/reductase family
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additional information
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enzyme belongs to the short-chain alcohol dehydrogenase/reductase family
additional information
the enzyme belongs to the short-chain alcohol dehydrogenase/reductase, SDR, family
additional information
the enzyme belongs to the short-chain alcohol dehydrogenase/reductase, SDR, family
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2,2',5,5'-tetrachlorobiphenyl + NAD+
2,2',5,5'-tetrachloro-3,4-dihydroxybiphenyl + NADH
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
7,2',3'-trihydroxy-8-methyl-2',3'-dihydro-isoflavone + NAD+
7,2',3'-trihydroxy-8-methylisoflavone + NADH
7,3',4'-trihydroxy-3',4'-dihydro-isoflavone + NAD+
7,3',4'-trihydroxyisoflavone + NADH
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recombinant enzyme
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?
7-hydroxy-8-methylisoflavone + 2 NAD+ + 2 H2O
7,2',3'-trihydroxy-8-methylisoflavone + 2 NADH + 2 H+
7-hydroxyisoflavone + 2 NAD+ + 2 H2O
7,3',4'-trihydroxyisoflavone + 2 NADH + 2 H+
cis-1,2-dihydro-1,2-dihydroxynaphthalene + NAD+
? + NADH
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-
?
cis-2,3-dihydro-2,3-dihydroxy-4,4'-dichlorobiphenyl + NAD+
?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD(P)+
2,3-dihydroxybiphenyl + NAD(P)H
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH + H+
cis-indole-2,3-dihydrodiol + NAD+
2,3-dihydroxyindole + NADH
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isatin can be formed by spontaneously isomerization of 2,3-dihydroxyindole, which is formed from cis-indole-2,3-dihydrodiol catalyzed by BphB
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?
additional information
?
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2,2',5,5'-tetrachlorobiphenyl + NAD+
2,2',5,5'-tetrachloro-3,4-dihydroxybiphenyl + NADH
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?
2,2',5,5'-tetrachlorobiphenyl + NAD+
2,2',5,5'-tetrachloro-3,4-dihydroxybiphenyl + NADH
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-
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?
2,2',5,5'-tetrachlorobiphenyl + NAD+
2,2',5,5'-tetrachloro-3,4-dihydroxybiphenyl + NADH
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?
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
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-
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?
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
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-
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?
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
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-
?
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
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-
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?
7,2',3'-trihydroxy-8-methyl-2',3'-dihydro-isoflavone + NAD+
7,2',3'-trihydroxy-8-methylisoflavone + NADH
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recombinant enzyme
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?
7,2',3'-trihydroxy-8-methyl-2',3'-dihydro-isoflavone + NAD+
7,2',3'-trihydroxy-8-methylisoflavone + NADH
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recombinant enzyme
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?
7-hydroxy-8-methylisoflavone + 2 NAD+ + 2 H2O
7,2',3'-trihydroxy-8-methylisoflavone + 2 NADH + 2 H+
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2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
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-
?
7-hydroxy-8-methylisoflavone + 2 NAD+ + 2 H2O
7,2',3'-trihydroxy-8-methylisoflavone + 2 NADH + 2 H+
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2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
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?
7-hydroxyisoflavone + 2 NAD+ + 2 H2O
7,3',4'-trihydroxyisoflavone + 2 NADH + 2 H+
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2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
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?
7-hydroxyisoflavone + 2 NAD+ + 2 H2O
7,3',4'-trihydroxyisoflavone + 2 NADH + 2 H+
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2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
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?
cis-2,3-dihydro-2,3-dihydroxy-4,4'-dichlorobiphenyl + NAD+
?
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?
cis-2,3-dihydro-2,3-dihydroxy-4,4'-dichlorobiphenyl + NAD+
?
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
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polychlorobiphenyl catabolic pathway
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
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polychlorobiphenyl catabolic pathway
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD(P)+
2,3-dihydroxybiphenyl + NAD(P)H
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD(P)+
2,3-dihydroxybiphenyl + NAD(P)H
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second step of the metabolic pathway for the bacterial degradation of biphenyl
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
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-
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
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biphenyl degradation pathway
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
biphenyl degradation pathway
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
?
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
?
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?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
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?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
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-
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?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
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?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH + H+
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?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH + H+
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?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH + H+
modeling studies indicate that the substrate is bound in a deep hydrophobic cleft close to the nicotinamide moiety of the NAD+ cofactor. These studies further suggest that Asn143 is a key determinant of substrate specificity
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?
additional information
?
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biotransformation of natural and synthetic isoflavonoids by the recombinant enzyme, overview
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?
additional information
?
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enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview
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?
additional information
?
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enzyme shows a broad substrate specificity
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?
additional information
?
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enzyme shows a broad substrate specificity
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?
additional information
?
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biotransformation of natural and synthetic isoflavonoids by the recombinant enzyme, overview
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?
additional information
?
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enzyme shows a broad substrate specificity
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?
additional information
?
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enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview
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?
additional information
?
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enzyme shows a broad substrate specificity
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?
additional information
?
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enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview
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?
additional information
?
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enzyme shows a broad substrate specificity
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?
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3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
7-hydroxy-8-methylisoflavone + 2 NAD+ + 2 H2O
7,2',3'-trihydroxy-8-methylisoflavone + 2 NADH + 2 H+
7-hydroxyisoflavone + 2 NAD+ + 2 H2O
7,3',4'-trihydroxyisoflavone + 2 NADH + 2 H+
cis-1,2-dihydro-1,2-dihydroxynaphthalene + NAD+
? + NADH
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-
?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD(P)+
2,3-dihydroxybiphenyl + NAD(P)H
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second step of the metabolic pathway for the bacterial degradation of biphenyl
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH + H+
additional information
?
-
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
-
-
-
?
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
-
-
-
?
3,4-dihydro-3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NAD+
3,4-dihydroxy-2,2',5,5'-tetrachlorobiphenyl + NADH
-
-
?
7-hydroxy-8-methylisoflavone + 2 NAD+ + 2 H2O
7,2',3'-trihydroxy-8-methylisoflavone + 2 NADH + 2 H+
-
2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
-
-
?
7-hydroxy-8-methylisoflavone + 2 NAD+ + 2 H2O
7,2',3'-trihydroxy-8-methylisoflavone + 2 NADH + 2 H+
-
2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
-
-
?
7-hydroxyisoflavone + 2 NAD+ + 2 H2O
7,3',4'-trihydroxyisoflavone + 2 NADH + 2 H+
-
2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
-
-
?
7-hydroxyisoflavone + 2 NAD+ + 2 H2O
7,3',4'-trihydroxyisoflavone + 2 NADH + 2 H+
-
2-step biotransformation in cooperation with biphenyl-2,3-dioxygenase, BphA, catalyzing the first step and BphB the second step, recombinant enzymes in Escherichia coli cells
-
-
?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
-
polychlorobiphenyl catabolic pathway
-
?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + ?
2,3-dihydroxybiphenyl + ?
-
polychlorobiphenyl catabolic pathway
-
?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
-
biphenyl degradation pathway
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?
cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD+
2,3-dihydroxybiphenyl + NADH
biphenyl degradation pathway
-
?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
-
-
-
-
?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
-
-
-
-
?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH
-
-
-
-
?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH + H+
-
-
-
-
?
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+
biphenyl-2,3-diol + NADH + H+
-
-
-
-
?
additional information
?
-
-
biotransformation of natural and synthetic isoflavonoids by the recombinant enzyme, overview
-
-
?
additional information
?
-
-
enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview
-
-
?
additional information
?
-
-
biotransformation of natural and synthetic isoflavonoids by the recombinant enzyme, overview
-
-
?
additional information
?
-
-
enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview
-
-
?
additional information
?
-
-
enzyme catalyzes the second step in the biphenyl catabolic degradation pathway, substrate spectrum of the organism in vivo, overview
-
-
?
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Vedadi, M.; Barriault, D.; Sylvestre, M; Powlowski, J.
Active site residues of cis-2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni strain B-356
Biochemistry
39
5028-5034
2000
Comamonas testosteroni
brenda
Sylvestre, M.; Hurtubise, Y.; Barriault, D.; Bergeron, J.; Ahmad, D.
Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB)
Appl. Environ. Microbiol.
62
2710-2715
1996
Comamonas testosteroni
brenda
Barriault, D.; Vedadi, M.; Powlowski, J.; Sylvestre, M.
cis-2,3-Dihydro-2,3-dihydroxybiphenyl dehydrogenase and cis-1,2-dihydro-1,2-dihydroxynaphathalene dehydrogenase catalyze dehydrogenation of the same range of substrates
Biochem. Biophys. Res. Commun.
260
181-187
1999
Burkholderia cepacia, Comamonas testosteroni (Q46381), Comamonas testosteroni, Burkholderia cepacia LB400
brenda
Seeger, M.; Timmis, K.N.; Hofer, B.
Degradation of chlorobiphenyls catalyzed by the bph-encoded biphenyl-2,3-dioxygenase and biphenyl-2,3-dihydrodiol-2,3-dehydrogenase of Pseudomonas sp. LB400
FEMS Microbiol. Lett.
133
259-264
1995
Pseudomonas sp., Pseudomonas sp. LB400
brenda
Seeger, M.; Gonzalez, M.; Camara, B.; Munoz, L.; Ponce, E.; Mejias, L.; Mascayano, C.; Vasquez, Y.; Sepulveda-Boza, S.
Biotransformation of natural and synthetic isoflavonoids by two recombinant microbial enzymes
Appl. Environ. Microbiol.
69
5045-5050
2003
Burkholderia sp., Burkholderia sp. LB400
brenda
Sylvestre, M.
Genetically modified organisms to remediate polychlorinated biphenyls. Where do we stand?
Int. Biodeter. Biodegrad.
54
153-162
2004
Burkholderia sp., Burkholderia sp. LB400, Comamonas testosteroni
-
brenda
Patil, D.N.; Tomar, S.; Sylvestre, M.; Kumar, P.
Expression, purification, crystallization and preliminary crystallographic studies of cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase from Pandoraea pnomenusa B-356
Acta Crystallogr. Sect. F
66
1517-1520
2010
Comamonas testosteroni (Q46381), Comamonas testosteroni B-356 (Q46381)
brenda
Qu, Y.; Xu, B.; Zhang, X.; Ma, Q.; Zhou, H.; Kong, C.; Zhang, Z.; Zhou, J.
Biotransformation of indole by whole cells of recombinant biphenyl dioxygenase and biphenyl-2,3-dihydrodiol-2,3-dehydrogenase
Biochem. Eng. J.
72
54-60
2013
Dyella ginsengisoli
-
brenda
Dhindwal, S.; Patil, D.N.; Mohammadi, M.; Sylvestre, M.; Tomar, S.; Kumar, P.
Biochemical studies and ligand-bound structures of biphenyl dehydrogenase from Pandoraea pnomenusa strain B-356 reveal a basis for broad specificity of the enzyme
J. Biol. Chem.
286
37011-37022
2011
Comamonas testosteroni (Q46381)
brenda
Hlsmeyer, M.; Hecht, H.J.; Niefind, K.; Hofer, B.; Eltis, L.D.; Timmis, K.N.; Schomburg, D.
Crystal structure of cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase from a PCB degrader at 2.0 A resolution
Protein Sci.
7
1286-1293
1998
Pseudomonas sp. (P47227)
brenda
Piccoli, S.; Musiani, F.; Giorgetti, A.
Dynamic characterization and substrate binding of cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase - an enzyme used in bioremediation
J. Mol. Model.
20
2531
2014
Pandoraea pnomenusa, Pandoraea pnomenusa B-356
brenda
Zhang, R.; Shi, X.; Sun, Y.; Zhang, Q.; Wang, W.
Insights into the catalytic mechanism of dehydrogenase BphB A quantum mechanics/molecular mechanics study
Chemosphere
208
69-76
2018
Pandoraea pnomenusa, Pandoraea pnomenusa B-356
brenda