Information on EC 1.3.1.40 - 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase

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The expected taxonomic range for this enzyme is: Pseudomonas cruciviae

EC NUMBER
COMMENTARY hide
1.3.1.40
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RECOMMENDED NAME
GeneOntology No.
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H+
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
-
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redox reaction
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-
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reduction
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SYSTEMATIC NAME
IUBMB Comments
2,6-dioxo-6-phenylhexanoate:NADP+ DELTA2-oxidoreductase
Broad specificity; reduces a number of compounds produced by Pseudomonas from aromatic hydrocarbons by ring fission.
CAS REGISTRY NUMBER
COMMENTARY hide
104645-83-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate + NADPH
2,6-dioxo-6-phenylhexanoate + NADP+
show the reaction diagram
2-methoxy-6-oxo-6-phenylhexa-2,3-dienoic acid methyl ester + NADPH
2-methoxy-6-oxo-6-phenylhexa-2-enoic acid methyl ester + NADP+
show the reaction diagram
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enzymes I and II
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?
2-methoxy-6-oxo-6-phenylhexa-2,4-dienoic acid methyl ester + NADPH
2-methoxy-6-oxo-6-phenylhexa-2-enoic acid methyl ester + NADP+
show the reaction diagram
ring fission product of 3-methoxycatechol + NADPH
?
show the reaction diagram
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enzymes I and II
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-
?
ring fission products from 3-isopropylcatechol + NADPH
?
show the reaction diagram
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enzymes I, II and III
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-
?
ring fission products from 3-methylcatechol + NADPH
?
show the reaction diagram
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enzymes I, II and III
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-
?
ring fission products from biphenyl-2,3-diol + NADPH
?
show the reaction diagram
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enzymes I, II and III
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?
ring fission products of catechol + NADPH
?
show the reaction diagram
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enzymes I and II
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
monoiodoacetate
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p-chloromercuribenzoate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.013
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activity of reducing enzyme III in cells grown on glucose
0.049
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activity of reducing enzyme III in cells grown on biphenyl
2.5
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2-hydroxy-6-oxo-phenylhexa-2,4-dienoate reducing enzyme III
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6
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2-hydroxy-6-oxo-phenylhexa-2,4-dienoate reducing enzyme III
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
170000
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 7
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390769
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, dialyzate
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate reducing enzyme III
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