Reference on EC 1.3.1.24 - biliverdin reductase
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Kohchi, T.; Mukougawa, K.; Frankenberg, N.; Masuda, M.; Yokota, A.; Lagarias, J.C.
The Arabidopsis hy2 gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase
Plant Cell
13
425-436
2001
Arabidopsis sp.
Singleton, J.W.; Laster, L.
Biliverdin reductase of guinea pig liver
J. Biol. Chem.
240
4780-4789
1965
Cavia porcellus, Homo sapiens
Noguchi, M.; Yoshida, T.; Kikuchi, G.
Purification and properties of biliverdin reductases from pig spleen and rat liver
J. Biochem.
86
833-848
1979
Rattus norvegicus, Sus scrofa
Kutty, R.K.; Maines, M.D.
Purification and characterization of biliverdin reductase from rat liver
J. Biol. Chem.
256
3956-3962
1981
Rattus norvegicus
Frydman, J.; Tomaro, M.L.; Rosenfeld, J.; Frydman, R.B.
Identification of the amino acid residues essential for the activity and the interconversion of the molecular forms of biliverdin reductase
Biochim. Biophys. Acta
1040
119-129
1990
Rattus norvegicus
Huang, T.J.; Trakshel, G.M.; Maines, M.D.
Detection of 10 variants of biliverdin reductase in rat liver by two-dimensional gel electrophoresis
J. Biol. Chem.
264
7844-7849
1989
Rattus norvegicus
Rigney, E.M.; Mantle, T.J.
The reaction mechanism of bovine kidney biliverdin reductase
Biochim. Biophys. Acta
957
237-242
1988
Bos taurus
Huang, T.J.; Trakshel, G.M.; Maines, M.D.
Multiple forms of biliverdin reductase: modification of the pattern of expression in rat liver by bromobenzene
Arch. Biochem. Biophys.
270
513-520
1989
Rattus norvegicus
Cascone, O.; Frydman, R.B.; Ferrara, P.; Tomaro, M.L.; Rosenfeld, J.
Molecular differences between rat-liver and rat-kidney biliverdin reductase. Implications for their in vivo regulation
Eur. J. Biochem.
179
123-130
1989
Rattus norvegicus
Rigney, E.M.; Phillips, O.; Mantle, T.J.
Some physical and immunological properties of ox kidney biliverdin reductase
Biochem. J.
255
431-435
1988
Bos taurus, Mus musculus, Rattus norvegicus
Bell, J.E.; Maines, M.D.
Kinetic properties and regulation of biliverdin reductase
Arch. Biochem. Biophys.
263
1-9
1988
Rattus norvegicus
Frydman, R.B.; Tomaro, M.L.; Rosenfeld, J.; Awruch, J.; Sambrotta, L.; Valasinas, A.; Frydman, B.
Biliverdin reductase: substrate specificity and kinetics
Biochim. Biophys. Acta
916
500-511
1987
Rattus norvegicus
Rigney, E.M.; Mantle, T.J.
Nucleotide binding to ox kidney biliverdin reductase
Biochem. Soc. Trans.
13
502
1985
Bos taurus, Mus musculus
-
Tomaro, M.L.; Frydman, R.B.; Awruch, J.; Valasinas, A.; Frydman, B.; Pandey, R.K.; Smith, K.M.
The specificity of biliverdin reductase. A study with different biliverdin types
Biochim. Biophys. Acta
791
350-356
1984
Rattus norvegicus
Awruch, J.; Tomaro, M.L.; Frydman, R.B.; Frydman, B.
The specificity of biliverdin reductase. The reduction of biliverdin XIII isomers
Biochim. Biophys. Acta
787
146-151
1984
Rattus norvegicus
Kumar, M.A.; Dastur, N.N.; Ganguli, N.C.
Biliverdin reductase-like activity in buffalo mammary tissues
Experientia
39
1010-1011
1983
Syncerus sp.
-
Yoshinaga, T.; Sassa, S.; Kappas, A.
The occurrence of molecular interactions among NADPH-cytochrome c reductase, heme oxygenase, and biliverdin reductase in heme degradation
J. Biol. Chem.
257
7786-7793
1982
Bos taurus
Frydman, R.B.; Tomaro, M.L.; Awruch, J.; Frydman, B.
Molecular forms of biliverdin reductase from rat liver with different reduction rates for biliverdin-IX
Biochem. Biophys. Res. Commun.
105
752-758
1982
Rattus norvegicus
Phillips, O.; Mantle, T.J.
Some kinetic and physical properties of biliverdin reductase
Biochem. Soc. Trans.
9
275-278
1981
Bos taurus
McDonagh, A.F.; Palma, L.A.; Schmid, R.
Reduction of biliverdin and placental transfer of bilirubin and biliverdin in the pregnant guinea pig
Biochem. J.
194
273-282
1981
Cavia porcellus
Watt, J.; O'Carra, P.
Affinity chromatography of biliverdin reductase
Biochem. Soc. Trans.
4
866-868
1976
Bos taurus
O'Carra, P.; Colleran, E.
Properties and kinetics of biliverdin reductase
Biochem. J.
125
110P-111 P
1971
Cavia porcellus
Tenhunen, R.; Ross, M.E.; Marver, H.S.; Schmid, R.
Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization
Biochemistry
9
298-303
1970
Cavia porcellus
Salim, M.; Brown-Kipphut, B.A.; Maines, M.D.
Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation
J. Biol. Chem.
276
10929-10934
2001
Homo sapiens
Schluchter, W.M.; Glazer, A.N.
Characterization of cyanobacterial biliverdin reductase. Conversion of biliverdin to bilirubin is important for normal phycobiliprotein biosynthesis
J. Biol. Chem.
272
13562-13569
1997
Synechocystis sp.
Cunningham, O.; Dunne, A.; Sabido, P.; Lightner, D.; Mantle, T.J.
Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites
J. Biol. Chem.
275
19009-19017
2000
Homo sapiens
Ahmad, Z.; Salim, M.; Maines, M.D.
Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress
J. Biol. Chem.
277
9226-9232
2002
Homo sapiens
Lagarias, D.M.; Crepeau, M.W.; Maines, M.D.; Lagarias, J.C.
Regulation of photomorphogenesis by expression of mammalian biliverdin reductase in transgenic Arabidopsis plants
Plant Cell
9
675-688
1997
Rattus norvegicus
Sun, D.; Sato, M.; Yoshida, T.; Shimizu, H.; Miyatake, H.; Adachi, S.; Shiro, Y.; Kikuchi, A.
Crystallization and preliminary X-ray diffraction analysis of a rat biliverdin reductase
Acta Crystallogr. Sect. D
56
1180-1182
2000
Rattus norvegicus
Kikuchi, A.; Park, S.Y.; Miyatake, H.; Sun, D.; Sato, M.; Yoshida, T.; Shiro, Y.
Crystal structure of rat biliverdin reductase
Nat. Struct. Biol.
8
221-225
2001
Rattus norvegicus
Ewing, J.F.; Maines, M.D.
Immunohistochemical localization of biliverdin reductase in rat brain: age related expression of protein and transcript
Brain Res.
672
29-41
1995
Rattus norvegicus
Panahian, N.; Huang, T.; Maines, M.D.
Enhanced neuronal expression of the oxidoreductase, biliverdin reductase, after permanent focal cerebral ischemia
Brain Res.
850
1-13
1999
Mus musculus
Ding, Z.; Xu, Y.
Purification and properties of cow splenic biliverdin reductase
Prep. Biochem.
24
193-201
1994
Bos taurus
Ennis, O.M.; Mantle, T.
Expression of rat biliverdin reductase as a glutathione-S-transferase fusion protein
Biochem. Soc. Trans.
23
443S
1995
Rattus norvegicus
Maines, M.D.; Trakshel, G.M.
Purification and characterization of human biliverdin reductase
Arch. Biochem. Biophys.
300
320-326
1993
Homo sapiens, Rattus norvegicus
Ewing, J.F.; Weber, C.M.; Maines, M.D.
Biliverdin reductase is heat resistant and coexpressed with constitutive and heat shock forms of heme oxygenase in brain
J. Neurochem.
61
1015-1023
1993
Rattus norvegicus
Maines, M.D.; Mayer, R.D.; Erturk, E.; Huang, T.J.; Disantagnese, A.
The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma - pH and cofactor-specific increase in activity
J. Urol.
162
1467-1472
1999
Homo sapiens
McCoubrey, W.K., Jr.; Maines, M.D.
Site-directed mutagenesis of cysteine residues in biliverdin reductase. Roles in substrate and cofactor binding
Eur. J. Biochem.
222
597-603
1994
Rattus norvegicus
Xu, Y.Q.; Ding, Z.K.
Biliverdin reductase from the liver of Atlantic salmon (Salmo salar)
Biochemistry
68
639-643
2003
Salmo salar
Colpaert, E.E.; Timmermans, J.P.; Lefebvre, R.A.
Immunohistochemical localization of the antioxidant enzymes biliverdin reductase and heme oxygenase-2 in human and pig gastric fundus
Free Radic. Biol. Med.
32
630-637
2002
Homo sapiens, Sus scrofa
Wang, J.; de Montellano, P.R.
The binding sites on human heme oxygenase-1 for cytochrome p450 reductase and biliverdin reductase
J. Biol. Chem.
278
20069-20076
2003
Rattus norvegicus
Kravets, A.; Hu, Z.; Miralem, T.; Torno, M.D.; Maines, M.D.
Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1
J. Biol. Chem.
279
19916-19923
2004
Homo sapiens
Miralem, T.; Hu, Z.; Torno, M.D.; Lelli, K.M.; Maines, M.D.
siRNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells
J. Biol. Chem.
280
17084-17092
2005
Homo sapiens
Whitby, F.G.; Phillips, J.D.; Hill, C.P.; McCoubrey, W.; Maines, M.D.
Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex
J. Mol. Biol.
319
1199-1210
2002
Rattus norvegicus (P46844)
Franklin, K.A.; Linley, P.J.; Montgomery, B.L.; Lagarias, J.C.; Thomas, B.; Jackson, S.D.; Terry, M.J.
Misregulation of tetrapyrrole biosynthesis in transgenic tobacco seedlings expressing mammalian biliverdin reductase
Plant J.
35
717-728
2003
Rattus norvegicus
Baranano, D.E.; Rao, M.; Ferris, C.D.; Snyder, S.H.
Biliverdin reductase: a major physiologic cytoprotectant
Proc. Natl. Acad. Sci. USA
99
16093-16098
2002
Homo sapiens
Lerner-Marmarosh, N.; Shen, J.; Torno, M.D.; Kravets, A.; Hu, Z.; Maines, M.D.
Human biliverdin reductase: A member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity
Proc. Natl. Acad. Sci. USA
102
7109-7114
2005
Homo sapiens
Liu, Y.; Liu, J.; Tetzlaff, W.; Paty, D.W.; Cynader, M.S.
Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis
Free Radic. Biol. Med.
40
960-967
2006
Rattus norvegicus
Maines, M.D.; Miralem, T.; Lerner-Marmarosh, N.; Shen, J.; Gibbs, P.E.
Human biliverdin reductase - a previously unknown activator of protein kinase C beta II
J. Biol. Chem.
282
8110-8122
2007
Homo sapiens
Maines, M.D.
New insights into biliverdin reductase functions: linking heme metabolism to cell signaling
Physiology
20
382-389
2005
Arabidopsis sp., Canis lupus familiaris, Cavia porcellus, Gallus gallus, Cyanidium caldarium, Homo sapiens, Mus musculus, Pan troglodytes, Rattus norvegicus, Sus scrofa, Takifugu rubripes, Xenopus sp.
Maines, M.D.
Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways
Antioxid. Redox Signal.
9
2187-2195
2007
Homo sapiens
Tudor, C.; Lerner-Marmarosh, N.; Engelborghs, Y.; Gibbs, P.E.; Maines, M.D.
Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin
Biochem. J.
413
405-416
2008
Homo sapiens
De Backer, O.; Lefebvre, R.A.
Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum
Eur. J. Pharmacol.
590
369-376
2008
Mus musculus
Lerner-Marmarosh, N.; Miralem, T.; Gibbs, P.E.; Maines, M.D.
Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase
FASEB J.
21
3949-3962
2007
Homo sapiens
Gibbs, P.E.; Maines, M.D.
Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase
Int. J. Cancer
121
2567-2574
2007
Homo sapiens
Zeng, R.; Yao, Y.; Han, M.; Zhao, X.; Liu, X.C.; Wei, J.; Luo, Y.; Zhang, J.; Zhou, J.; Wang, S.; Ma, D.; Xu, G.
Biliverdin reductase mediates hypoxia-induced EMT via PI3-kinase and Akt
J. Am. Soc. Nephrol.
19
380-387
2008
Pachori, A.S.; Smith, A.; McDonald, P.; Zhang, L.; Dzau, V.J.; Melo, L.G.
Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway
J. Mol. Cell. Cardiol.
43
580-592
2007
Mus musculus
Wu, B.; Liu, X.; Shen, J.
Old biliverdin reductase: links to insulin resistance and may be a novel therapeutic target
Med. Hypotheses
71
73-76
2008
Homo sapiens
Florczyk, U.M.; Jozkowicz, A.; Dulak, J.
Biliverdin reductase: new features of an old enzyme and its potential therapeutic significance
Pharmacol. Rep.
60
38-48
2008
Rattus norvegicus, Rattus norvegicus (P46844), Homo sapiens (P30043), Homo sapiens (P53004)
Lerner-Marmarosh, N.; Miralem, T.; Gibbs, P.E.; Maines, M.D.
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
Proc. Natl. Acad. Sci. USA
105
6870-6875
2008
Homo sapiens
Young, S.C.; Storm, M.V.; Speed, J.S.; Kelsen, S.; Tiller, C.V.; Vera, T.; Drummond, H.A.; Stec, D.E.
Inhibition of biliverdin reductase increases angiotensin II-dependent superoxide levels in cultured renal tubular epithelial cells
Am. J. Physiol. Regul. Integr. Comp. Physiol.
297
R1546-R1553
2009
Mus musculus
Wegiel, B.; Baty, C.J.; Gallo, D.; Csizmadia, E.; Scott, J.R.; Akhavan, A.; Chin, B.Y.; Kaczmarek, E.; Alam, J.; Bach, F.H.; Zuckerbraun, B.S.; Otterbein, L.E.
Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt
J. Biol. Chem.
284
21369-21378
2009
Homo sapiens, Mus musculus
Maghzal, G.J.; Leck, M.C.; Collinson, E.; Li, C.; Stocker, R.
Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase
J. Biol. Chem.
284
29251-29259
2009
Homo sapiens
Gafvels, M.; Holmstroem, P.; Somell, A.; Sjoevall, F.; Svensson, J.O.; Stahle, L.; Broome, U.; Stal, P.
A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice)
Liver Int.
29
1116-1124
2009
Homo sapiens
Warnasooriya, S.N.; Montgomery, B.L.
Detection of spatial-specific phytochrome responses using targeted expression of biliverdin reductase in Arabidopsis
Plant Physiol.
149
424-433
2009
Rattus norvegicus (P46844)
Perez, M.J.; Castano, B.; Jimenez, S.; Serrano, M.A.; Gonzalez-Buitrago, J.M.; Marin, J.J.
Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy
Toxicol. Appl. Pharmacol.
232
327-336
2008
Homo sapiens (P53004), Homo sapiens, Rattus norvegicus
Kapitulnik, J.; Maines, M.D.
Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin
Trends Pharmacol. Sci.
30
129-137
2009
Homo sapiens
Florczyk, U.; Golda, S.; Zieba, A.; Cisowski, J.; Jozkowicz, A.; Dulak, J.
Overexpression of biliverdin reductase enhances resistance to chemotherapeutics
Cancer Lett.
300
40-47
2010
Homo sapiens (P53004)
Mancuso, C.; Barone, E.
The heme oxygenase/biliverdin reductase pathway in drug research and development
Curr. Drug Metab.
10
579-594
2009
Homo sapiens, Rattus norvegicus
Maines, M.D.
Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings
Curr. Drug Targets
11
1586-1594
2010
Homo sapiens
Ding, B.; Gibbs, P.E.; Brookes, P.S.; Maines, M.D.
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction
FASEB J.
25
301-313
2010
Homo sapiens, Rattus norvegicus
Jansen, T.; Hortmann, M.; Oelze, M.; Opitz, B.; Steven, S.; Schell, R.; Knorr, M.; Karbach, S.; Schuhmacher, S.; Wenzel, P.; Muenzel, T.; Daiber, A.
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin
J. Mol. Cell. Cardiol.
49
186-195
2010
Homo sapiens
Goven, D.; Boutten, A.; Lecon-Malas, V.; Marchal-Somme, J.; Soler, P.; Boczkowski, J.; Bonay, M.
Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha
PLoS ONE
5
e10886
2010
Homo sapiens
Watanabe, A.; Hirata, K.; Hagiwara, Y.; Yutani, Y.; Sugishima, M.; Yamamoto, M.; Fukuyama, K.; Wada, K.
Expression, purification and preliminary X-ray crystallographic analysis of cyanobacterial biliverdin reductase
Acta Crystallogr. Sect. F
67
313-317
2011
Synechocystis sp.
Barone, E.; Di Domenico, F.; Cenini, G.; Sultana, R.; Cini, C.; Preziosi, P.; Perluigi, M.; Mancuso, C.; Butterfield, D.A.
Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment
Biochim. Biophys. Acta
1812
480-487
2011
Homo sapiens
Reed, J.R.; Huber, W.J.; Backes, W.L.
Human heme oxygenase-1 efficiently catabolizes heme in the absence of biliverdin reductase
Drug Metab. Dispos.
38
2060-2066
2010
Homo sapiens
Song, S.; Wang, S.; Ma, J.; Yao, L.; Xing, H.; Zhang, L.; Liao, L.; Zhu, D.
Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway
Exp. Cell Res.
319
1973-1987
2013
Rattus norvegicus
Kim, S.Y.; Kang, H.T.; Choi, H.R.; Park, S.C.
Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
Exp. Mol. Med.
43
15-23
2011
Homo sapiens
Gibbs, P.E.; Miralem, T.; Maines, M.D.
Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB
FASEB J.
24
3239-3254
2010
Homo sapiens
Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Tudor, C.; Hagen, F.K.; Maines, M.D.
The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C
J. Biol. Chem.
287
24698-24712
2012
Homo sapiens
Barone, E.; Mancuso, C.; Di Domenico, F.; Sultana, R.; Murphy, M.P.; Head, E.; Butterfield, D.A.
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease
J. Neurochem.
120
135-146
2012
Canis lupus familiaris
Fu, G.; Liu, H.; Doerksen, R.J.
Molecular modeling to provide insight into the substrate binding and catalytic mechanism of human biliverdin-IXalpha reductase
J. Phys. Chem. B
116
9580-9594
2012
Homo sapiens
Franklin, E.; Mantle, T.; Dunne, A.
Activation of human biliverdin-IXalpha reductase by urea: generation of kinetically distinct forms during the unfolding pathway
Biochim. Biophys. Acta
1834
2573-2578
2013
Homo sapiens (P53004)
Huan, L.; Bao, C.; Chen, D.; Li, Y.; Lian, J.; Ding, J.; Huang, S.; Liang, L.; He, X.
MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-kappaB pathway to suppress cell growth in hepatocellular carcinoma cells
Cancer Sci.
107
258-266
2016
Homo sapiens
Lee, S.J.; Kang, H.K.; Eum, W.S.; Park, J.; Choi, S.Y.; Kwon, H.Y.
Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress
Cell Biol. Int.
41
514-524
2017
Homo sapiens (P53004), Homo sapiens
Chu, W.T.; Nesbitt, N.M.; Gnatenko, D.V.; Li, Z.; Zhang, B.; Seeliger, M.A.; Browne, S.; Mantle, T.J.; Bahou, W.F.; Wang, J.
Enzymatic activity and thermodynamic stability of biliverdin IXbeta reductase are maintained by an active site serine
Chemistry
23
1891-1900
2017
Homo sapiens (P30043), Homo sapiens
Zhang, M.; Song, S.; Yi, Z.; Zhao, X.; Fu, L.; Wang, L.; Ma, C.; Mao, M.; Xing, Y.; Zhu, D.
Human biliverdin reductase promotes EMT through the ERK1/2 signal pathway in breast cancer
Eur. J. Pharmacol.
788
45-53
2016
Homo sapiens
Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Jenkins, J.L.; Heimiller, C.; Maines, M.D.
Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation
FASEB J.
30
2926-2944
2016
Homo sapiens (P53004), Homo sapiens
Gibbs, P.E.; Miralem, T.; Maines, M.D.
Biliverdin reductase: a target for cancer therapy?
Front. Pharmacol.
6
119
2015
Homo sapiens
Hu, Z.; Pei, G.; Wang, P.; Yang, J.; Zhu, F.; Guo, Y.; Wang, M.; Yao, Y.; Zeng, R.; Liao, W.; Xu, G.
Biliverdin reductase A (BVRA) mediates macrophage expression of interleukin-10 in injured kidney
Int. J. Mol. Sci.
16
22621-22635
2015
Mus musculus (Q9CY64), Mus musculus
Spencer, A.L.; Bagai, I.; Becker, D.F.; Zuiderweg, E.R.; Ragsdale, S.W.
Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase
J. Biol. Chem.
289
29836-29858
2014
Homo sapiens
D'Amours, O.; Frenette, G.; Caron, P.; Belleannee, C.; Guillemette, C.; Sullivan, R.
Evidences of biological functions of biliverdin reductase A in the bovine epididymis
J. Cell. Physiol.
231
1077-1089
2016
Bos taurus
Pallua, J.D.; Schaefer, G.; Seifarth, C.; Becker, M.; Meding, S.; Rauser, S.; Walch, A.; Handler, M.; Netzer, M.; Popovscaia, M.; Osl, M.; Baumgartner, C.; Lindner, H.; Kremser, L.; Sarg, B.; Bartsch, G.; Huck, C.W.; Bonn, G.K.; Klocker, H.
MALDI-MS tissue imaging identification of biliverdin reductase B overexpression in prostate cancer
J. Proteomics
91
500-514
2013
Homo sapiens (P30043)
Takao, H.; Hirabayashi, K.; Nishigaya, Y.; Kouriki, H.; Nakaniwa, T.; Hagiwara, Y.; Harada, J.; Sato, H.; Yamazaki, T.; Sakakibara, Y.; Suiko, M.; Asada, Y.; Takahashi, Y.; Yamamoto, K.; Fukuyama, K.; Sugishima, M.; Wada, K.
A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity
Nat. Commun.
8
14397
2017
Rattus norvegicus (P06762), Homo sapiens (P53004), Synechocystis sp. PCC 6803 (P72782)
Subhanova, I.; Muchova, L.; Lenicek, M.; Vreman, H.J.; Luksan, O.; Kubickova, K.; Kreidlova, M.; Zima, T.; Vitek, L.; Urbanek, P.
Expression of biliverdin reductase A in peripheral blood leukocytes is associated with treatment response in HCV-infected patients
PLoS ONE
8
e57555
2013
Homo sapiens (P53004), Homo sapiens
Ahmed, F.H.; Mohamed, A.E.; Carr, P.D.; Lee, B.M.; Condic-Jurkic, K.; O'Mara, M.L.; Jackson, C.J.
Rv2074 is a novel F420H2-dependent biliverdin reductase in Mycobacterium tuberculosis
Protein Sci.
25
1692-1709
2016
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
O'Brien, L.; Hosick, P.A.; John, K.; Stec, D.E.; Hinds, T.D.
Biliverdin reductase isozymes in metabolism
Trends Endocrinol. Metab.
26
212-220
2015
Homo sapiens (P30043), Homo sapiens (P53004)
Gordon, D.M.; Adeosun, S.O.; Ngwudike, S.I.; Anderson, C.D.; Hall, J.E.; Hinds, T.D.; Stec, D.E.
CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation
Arch. Biochem. Biophys.
672
108072
2019
Mus musculus (Q9CY64), Mus musculus
Mancuso, C.
Biliverdin reductase as a target in drug research and development Facts and hypotheses
Free Radic. Biol. Med.
172
521-529
2021
Homo sapiens (P53004), Homo sapiens
Solar, P.; Brazda, V.; Levin, S.; Zamani, A.; Jancalek, R.; Dubovy, P.; Joukal, M.
Subarachnoid hemorrhage increases level of heme oxygenase-1 and biliverdin reductase in the choroid plexus
Front. Cell. Neurosci.
14
593305
2020
Rattus norvegicus (P46844)
Kim, S.J.; Shin, M.J.; Kim, D.W.; Yeo, H.J.; Yeo, E.J.; Choi, Y.J.; Sohn, E.J.; Han, K.H.; Park, J.; Lee, K.W.; Park, J.K.; Cho, Y.J.; Kim, D.S.; Eum, W.S.; Choi, S.Y.
Tat-Biliverdin reductase A exerts a protective role in oxidative stress-induced hippocampal neuronal cell damage by regulating the apoptosis and MAPK signaling
Int. J. Mol. Sci.
21
2672
2020
Mus musculus (Q9CY64)
Zhang, M.; Xin, W.; Yi, Z.; Li, Y.; Liu, Y.; Zhang, H.; Chen, H.; Chen, X.; Tan, S.; Zhu, D.
Human biliverdin reductase regulates the molecular mechanism underlying cancer development
J. Cell. Biochem.
119
1337-1345
2018
Homo sapiens (P53004), Homo sapiens
Zhang, Y.; Ding, Y.; Lu, T.; Zhang, Y.; Xu, N.; McBride, D.W.; Tang, J.; Zhang, J.H.
Biliverdin reductase-A attenuated GMH-induced inflammatory response in the spleen by inhibiting toll-like receptor-4 through eNOS/NO pathway
J. Neuroinflammation
15
118
2018
Rattus norvegicus (P46844)
Barone, E.; Tramutola, A.; Triani, F.; Calcagnini, S.; Di Domenico, F.; Ripoli, C.; Gaetani, S.; Grassi, C.; Butterfield, D.A.; Cassano, T.; Perluigi, M.
Biliverdin reductase-A mediates the beneficial effects of intranasal insulin in Alzheimer Disease
Mol. Neurobiol.
56
2922-2943
2019
Mus musculus (Q9CY64)
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