Information on EC 1.3.1.17 - 3-methyleneoxindole reductase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.3.1.17
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RECOMMENDED NAME
GeneOntology No.
3-methyleneoxindole reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-methyl-1,3-dihydroindol-2-one + NADP+ = 3-methylene-1,3-dihydro-2H-indol-2-one + NADPH + H+
show the reaction diagram
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
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-
-
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reduction
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-
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SYSTEMATIC NAME
IUBMB Comments
3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37255-29-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
oat
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-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
lentil
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
wheat
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-
Manually annotated by BRENDA team
ROXB. var. mungo
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-methyleneoxindole + NADPH
3-methyloxindole + NADP+
show the reaction diagram
menadione + NADPH
?
show the reaction diagram
-
low activity
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
10% of activity with NADPH
NADPH
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-Naphthaleneacetic acid
2,4-Dichlorophenoxyacetic acid
indole-3-acetic acid
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-
Indole-3-aldehyde
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4
1-naphtaleneacetic acid
-
-
12
2,4-Dichlorophenoxyacetic acid
-
-
2.7
indole-3-acetic acid
-
-
1.9
Indole-3-aldehyde
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.5 - 6.5
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 7
-
50% of maximum activity at pH 4.0 and pH 7.0
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
reductase A is labile
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4-8°C, at least 1 month
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE