Information on EC 1.3.1.11 - 2-coumarate reductase

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The expected taxonomic range for this enzyme is: Arthrobacter sp.

EC NUMBER
COMMENTARY hide
1.3.1.11
-
RECOMMENDED NAME
GeneOntology No.
2-coumarate reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-(2-hydroxyphenyl)propanoate + NAD+ = 2-coumarate + NADH + H+
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Microbial metabolism in diverse environments
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Phenylalanine metabolism
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-
SYSTEMATIC NAME
IUBMB Comments
3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37251-10-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-dihydroxycinnamic acid + NADH
?
show the reaction diagram
-
1.6% of activity with 2-coumarate
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-
?
2-coumarate + NADH
melilotate + NAD+
show the reaction diagram
-
-
-
ir
4-coumarate + NADH
?
show the reaction diagram
-
1.4% of activity with 2-coumarate
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-coumarate + NADH
melilotate + NAD+
show the reaction diagram
-
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
iodoacetate
-
3.3 mM, 29% inhibition
N-ethylmaleimide
-
3.0 mM, 63% inhibition
p-chloromercuribenzoate
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3.0 mM, 100% inhibition, 0.33 mM, 37% inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0173
o-coumarate
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 8.5
-
o-coumarate + NADH
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
1 week, -20°C
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially
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