Reference on EC 1.21.99.3 - thyroxine 5-deiodinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koehrle, J.; Auf'mkolk, M.; Rokos, H.; Hesch, R.D.; Cody, V.
Rat liver iodothyronine monodeiodinase. Evaluation of the iodothyronine ligand-binding site
J. Biol. Chem.
261
11613-11622
1986
Rattus norvegicus
Auf'mkolk, M.; Koehrle, J.; Hesch, R.D.; Cody, V.
Inhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site
J. Biol. Chem.
261
11623-11630
1986
Rattus norvegicus
Santini, F.; Chopra, I.J.; Hurd, R.E.; Solomon, D.H.; Chua Teco, G.N.
A study of the characteristics of the rat placental iodothyronine 5'-monodeiodinase: evidence that it is distinct from the rat hepatic iodothyronine 5'-monoiodinase
Endocrinology
130
2325-2332
1992
Rattus norvegicus
Auf dem Brinke, D.; Kohrle, J.; Kodding, R.; Hesch, R.D.
Subcellular localization of thyroxine-5-deiodinase in rat liver
J. Endocrinol. Invest.
3
73-76
1980
Rattus norvegicus
Fekkes, D.; Hennemann, G.; Visser, T.J.
Properties of detergent-dispersed iodothyronine 5- and 5'-deiodinase activities from rat liver
Biochim. Biophys. Acta
742
324-333
1983
Rattus norvegicus
Galton, V.A.; Hiebert, A.
Hepatic iodothyronine 5-deiodinase activity in Rana catesbeiana tadpoles at different stages of the life cycle
Endocrinology
121
42-47
1987
Lithobates catesbeianus
Darras, V.M.; Berghman, L.R.; Vanderpooten, A.; Kuhn, E.R.
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver
FEBS Lett.
310
5-8
1992
Gallus gallus
Tanaka, K.; Shimatsu, A.; Imura, H.
Iodothyronine 5-deiodinase in rat posterior pituitary
Biochem. Biophys. Res. Commun.
188
272-277
1992
Rattus norvegicus
Visser, T.J.; Schoenmakers, C.H.
Characteristics of type III iodothyronine deiodinase
Acta Med. Austriaca
19 Suppl 1
18-21
1992
Gallus gallus, Homo sapiens, Platyrrhini, Lithobates catesbeianus, Rattus norvegicus
Mori, K.; Yoshida, K.; Kayama, T.; Kaise, N.; Fukazawa, H.; Kiso, Y.; Kikuchi, K.; Aizawa, Y.; Abe, K.
Thyroxine 5-deiodinase in human brain tumors
J. Clin. Endocrinol. Metab.
77
1198-1202
1993
Homo sapiens
Mori, K.; Yoshida, K.; Fukazawa, H.; Kiso, Y.; Sayama, N.; Kikuchi, K.; Aizawa, Y.; Abe, K.
Thyroid hormone regulates rat placental type III iodothyronine deiodinase activity by inducing kinetic changes different from those in the same isozyme in rat brain
Endocr. J.
42
753-760
1995
Rattus norvegicus
Hernandez, A.; Obregon, M.J.
Presence of growth factors-induced type III iodothyronine 5-deiodinase in cultured rat brown adipocytes
Endocrinology
136
4543-4550
1995
Rattus norvegicus
Croteau, W.; Whittemore, S.L.; Schneider, M.J.; St Germain, D.L.
Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase
J. Biol. Chem.
270
16569-16575
1995
Rattus norvegicus (P49897)
Ramauge, M.; Pallud, S.; Esfandiari, A.; Gavaret, J.; Lennon, A.; Pierre, M.; Courtin, F.
Evidence that type III iodothyronine deiodinase in rat astrocyte is a selenoprotein
Endocrinology
137
3021-3025
1996
Rattus norvegicus
Sanders, J.P.; Van der Geyten, S.; Kaptein, E.; Darras, V.M.; Kuhn, E.R.; Leonard, J.L.; Visser, T.J.
Cloning and characterization of type III iodothyronine deiodinase from the fish Oreochromis niloticus
Endocrinology
140
3666-3673
1999
Oreochromis niloticus (Q9I966), Oreochromis niloticus
Bates, J.M.; Spate, V.L.; Morris, J.S.; St.Germain, D.L.; Galton, V.A.
Effects of selenium deficiency on tissue selenium content, deiodinase activity, and thyroid hormone economy in the rat during development
Endocrinology
141
2490-2500
2000
Rattus norvegicus
Santini, F.; Pinchera, A.; Ceccarini, G.; Castagna, M.; Rosellini, V.; Mammoli, C.; Montanelli, L.; Zucchi, V.; Chopra, I.J.; Chiovato, L.
Evidence for a role of the type III-iodothyronine deiodinase in the regulation of 3,5,3'-triiodothyronine content in the human central nervous system
Eur. J. Endocrinol.
144
577-583
2001
Homo sapiens
Shintani, N.; Nohira, T.; Hikosaka, A.; Kawahara, A.
Tissue-specific regulation of type III iodothyronine 5-deiodinase gene expression mediates the effects of prolactin and growth hormone in Xenopus metamorphosis
Dev. Growth Differ.
44
327-335
2002
Xenopus laevis, Xenopus laevis (Q90Z53)
Koehrle, J.
Iodothyronine deiodinases
Methods Enzymol.
347
125-167
2002
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, vertebrata
Verhoelst, C.H.; Vandenborne, K.; Severi, T.; Bakker, O.; Zandieh Doulabi, B.; Leonard, J.L.; Kuhn, E.R.; van der Geyten, S.; Darras, V.M.
Specific detection of type III iodothyronine deiodinase protein in chicken cerebellar purkinje cells
Endocrinology
143
2700-2707
2002
Gallus gallus, Gallus gallus Hybro
Kuiper, G.G.; Klootwijk, W.; Visser, T.J.
Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference
Endocrinology
144
2505-2513
2003
Homo sapiens (P55073), Homo sapiens
Schoenmakers, C.H.; Pigmans, I.G.; Kaptein, E.; Darras, V.M.; Visser, T.J.
Reaction of the type III iodothyronine deiodinase with the affinity label N-bromoacetyl-triiodothyronine
FEBS Lett.
335
104-108
1993
Gallus gallus, Rattus norvegicus
Curcio-Morelli, C.; Gereben, B.; Zavacki, A.M.; Kim, B.W.; Huang, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases
Endocrinology
144
937-946
2003
Homo sapiens
Huang, S.A.; Dorfman, D.M.; Genest, D.R.; Salvatore, D.; Larsen, P.R.
Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium
J. Clin. Endocrinol. Metab.
88
1384-1388
2003
Homo sapiens
Verhoelst, C.H.; Van Der Geyten, S.; Darras, V.M.
Renal and hepatic distribution of type I and type III iodothyronine deiodinase protein in chicken
J. Endocrinol.
181
85-90
2004
Gallus gallus (O42412), Gallus gallus
Olivares, E.L.; Marassi, M.P.; Fortunato, R.S.; da Silva, A.C.; Costa-e-Sousa, R.H.; Araujo, I.G.; Mattos, E.C.; Masuda, M.O.; Mulcahey, M.A.; Huang, S.A.; Bianco, A.C.; Carvalho, D.P.
Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study
Endocrinology
148
4786-4792
2007
Rattus norvegicus
Martinez, L.M.; Orozco, A.; Villalobos, P.; Valverde-R, C.
Cloning and characterization of a type 3 iodothyronine deiodinase (D3) in the liver of the chondrichtyan Chiloscyllium punctatum
Gen. Comp. Endocrinol.
156
464-469
2008
Chiloscyllium punctatum (A9QW70), Chiloscyllium punctatum
Dentice, M.; Luongo, C.; Huang, S.; Ambrosio, R.; Elefante, A.; Mirebeau-Prunier, D.; Zavacki, A.M.; Fenzi, G.; Grachtchouk, M.; Hutchin, M.; Dlugosz, A.A.; Bianco, A.C.; Missero, C.; Larsen, P.R.; Salvatore, D.
Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes
Proc. Natl. Acad. Sci. USA
104
14466-14471
2007
Homo sapiens, Mus musculus
Ng, L.; Hernandez, A.; He, W.; Ren, T.; Srinivas, M.; Ma, M.; Galton, V.A.; St Germain, D.L.; Forrest, D.
A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function
Endocrinology
150
1952-1960
2009
Mus musculus (Q91ZI8)
Boelen, A.; Kwakkel, J.; Wieland, C.W.; St Germain, D.L.; Fliers, E.; Hernandez, A.
Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae
Endocrinology
150
1984-1990
2009
Mus musculus
Aerts, G.; Arrojo E Drigo, R.; Van Herck, S.L.; Sammels, E.; Mirebeau-Prunier, D.; Gereben, B.; Zeoeld, A.; Harney, J.W.; Huang, S.A.; Mulcahey, M.A.; Van der Geyten, S.; Van den Bergh, G.; Arckens, L.; Darras, V.M.; Zavacki, A.M.
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells
Endocrinology
150
5171-5180
2009
Homo sapiens
Bessho, K.; Etani, Y.; Ichimori, H.; Miyoshi, Y.; Namba, N.; Yoneda, A.; Ooue, T.; Chihara, T.; Morii, E.; Aoki, T.; Murakami, M.; Mushiake, S.; Ozono, K.
Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism
Eur. J. Pediatr.
169
215-221
2009
Homo sapiens
Boelen, A.; Mikita, J.; Boiziau, C.; Chassande, O.; Fliers, E.; Petry, K.G.
Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis
Thyroid
19
1401-1406
2009
Rattus norvegicus
Bouzaffour, M.; Rampon, C.; Ramauge, M.; Courtin, F.; Vriz, S.
Implication of type 3 deiodinase induction in zebrafish fin regeneration
Gen. Comp. Endocrinol.
168
88-94
2010
Danio rerio (D3Y4D3)
Villalobos, P.; Orozco, A.; Valverde-R, C.
Molecular cloning and characterization of a type 3 iodothyronine deiodinase in the pine snake Pituophis deppei
Gen. Comp. Endocrinol.
169
167-173
2010
Pituophis deppei (D2J363), Pituophis deppei
Ng, L.; Lyubarsky, A.; Nikonov, S.S.; Ma, M.; Srinivas, M.; Kefas, B.; St Germain, D.L.; Hernandez, A.; Pugh, E.N.; Forrest, D.
Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors
J. Neurosci.
30
3347-3357
2010
Mus musculus
Pavelka, S.
Radiometric enzyme assays: development of methods for extremely sensitive determination of types 1, 2 and 3 iodothyronine deiodinase enzyme activities
J. Radioanal. Nucl. Chem.
286
861-865
2010
Rattus norvegicus
-
Piehl, S.; Heberer, T.; Balizs, G.; Scanlan, T.S.; Kohrle, J.
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates
Rapid Commun. Mass Spectrom.
22
3286-3296
2008
Homo sapiens, Mus musculus
Heijlen, M.; Houbrechts, A.M.; Bagci, E.; Van Herck, S.L.; Kersseboom, S.; Esguerra, C.V.; Blust, R.; Visser, T.J.; Knapen, D.; Darras, V.M.
Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish
Endocrinology
155
1547-1559
2014
Danio rerio, Danio rerio (A0A3G0ZGD9)
Galton, V.A.; Hernandez, A.; St Germain, D.L.
The 5-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone
Endocrinology
155
3172-3181
2014
Mus musculus (Q91ZI8)
Luongo, C.; Trivisano, L.; Alfano, F.; Salvatore, D.
Type 3 deiodinase and consumptive hypothyroidism: a common mechanism for a rare disease
Front. Endocrinol. (Lausanne)
4
115
2013
Homo sapiens (P55073)
Akiyama, S.; Ogiwara, T.; Aoki, T.; Tsunekawa, K.; Araki, O.; Murakami, M.
Glucagon-like peptide-1 stimulates type 3 iodothyronine deiodinase expression in a mouse insulinoma cell line
Life Sci.
115
22-28
2014
Mus musculus (Q91ZI8), Mus musculus
Schweizer, U.; Schlicker, C.; Braun, D.; Khrle, J.; Steegborn, C.
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
Proc. Natl. Acad. Sci. USA
111
10526-10531
2014
Mus musculus (Q91ZI8), Mus musculus
Stevenson, T.; Onishi, K.; Bradley, S.; Prendergast, B.
Cell-autonomous iodothyronine deiodinase expression mediates seasonal plasticity in immune function
Brain Behav. Immun.
36
61-70
2014
Phodopus sungorus
Fortino, M.; Marino, T.; Russo, N.; Sicilia, E.
Mechanism of thyroxine deiodination by naphthyl-based iodothyronine deiodinase mimics and the halogen bonding role a DFT investigation
Chemistry
21
8554-8560
2015
Homo sapiens
Wu, Z.; Martinez, M.E.; St Germain, D.L.; Hernandez, A.
Type 3 deiodinase role on central thyroid hormone action affects the leptin-melanocortin system and circadian activity
Endocrinology
158
419-430
2017
Mus musculus
Schweizerulrich U, S.U.; Steegborn C, S.C.
New insights into the structure and mechanism of iodothyronine deiodinases
J. Mol. Endocrinol.
55
T37-T52
2015
Mus musculus
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