Information on EC 1.21.3.5 - sulochrin oxidase [(-)-bisdechlorogeodin-forming]

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.21.3.5
-
RECOMMENDED NAME
GeneOntology No.
sulochrin oxidase [(-)-bisdechlorogeodin-forming]
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 sulochrin + O2 = 2 (-)-bisdechlorogeodin + 2 H2O
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
asterrate biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)
Also acts on several diphenols and phenylenediamines, but has low affinity for these substrates. Involved in the biosynthesis of mould metabolites related to the antibiotic griseofulvin.
CAS REGISTRY NUMBER
COMMENTARY hide
82469-87-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Oospora sulphurea-ochracea
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hydroquinone + O2
?
show the reaction diagram
Oospora sulphurea-ochracea
-
-
-
-
?
N,N,N',N'-tetramethyl-p-phenylenediamine + O2
?
show the reaction diagram
Oospora sulphurea-ochracea
-
-
-
-
?
sulochrin + O2
(-)-bisdechlorogeodin + H2O
show the reaction diagram
Oospora sulphurea-ochracea
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
copper
Oospora sulphurea-ochracea
-
6 copper atoms per molecule
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Sodium diethyldithiocarbamate
Oospora sulphurea-ochracea
-
0.1 mM, 66% inhibition, 1 mM, complete inhibition
additional information
Oospora sulphurea-ochracea
-
not inhibited by 2 mM, neocuproin, 5 mM potassium cyanide or 10 mM EDTA
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
53
hydroquinone
Oospora sulphurea-ochracea
-
-
1.5
N,N,N',N'-tetramethyl-p-phenylenediamine
Oospora sulphurea-ochracea
-
-
0.0085
sulochrin
Oospora sulphurea-ochracea
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.2
Oospora sulphurea-ochracea
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.8
Oospora sulphurea-ochracea
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.5 - 7
Oospora sulphurea-ochracea
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
Oospora sulphurea-ochracea
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Oospora sulphurea-ochracea
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Oospora sulphurea-ochracea
-
no extracellular activity
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
128000
Oospora sulphurea-ochracea
-
gel filtration
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
Oospora sulphurea-ochracea
-
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, pH 5.8, citrate-phosphate buffer, several months, no loss in activity
Oospora sulphurea-ochracea
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
-
Oospora sulphurea-ochracea
-