Information on EC 1.2.7.B3 - aldehyde oxidoreductase WOR5

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The expected taxonomic range for this enzyme is: Pyrococcus furiosus

EC NUMBER
COMMENTARY hide
1.2.7.B3
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
aldehyde oxidoreductase WOR5
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hexanal + H2O + 2 oxidized ferredoxin = hexanoate + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
hexanal:ferredoxin oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
E7FHH1: alpha-subunit, Q8U0V2: electron-transfer beta-subunit
E7FHH1 and Q8U0V2
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-ethylhexanal + H2O + oxidized benzyl viologen
2-ethylhexanoate + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 56% compared to the value for hexanal
-
-
?
2-methylbutyraldehyde + H2O + oxidized benzyl viologen
2-methylbutyrate + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 20% compared to the value for hexanal
-
-
?
2-methylvaleraldehyde + H2O + oxidized benzyl viologen
2-methylvalerate + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 54% compared to the value for hexanal
-
-
?
2-naphthaldehyde + H2O + oxidized benzyl viologen
2-naphthoate + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 6.7% compared to the value for hexanal
-
-
?
3-phenylbutyraldehyde + H2O + oxidized benzyl viologen
3-phenylbutyrate + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 11% compared to the value for hexanal
-
-
?
cinnamaldehyde + H2O + oxidized benzyl viologen
cinnamate + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 5.3% compared to the value for hexanal
-
-
?
hexanal + H2O + 2 oxidized ferredoxin
hexanoate + 2 reduced ferredoxin + 2 H+
show the reaction diagram
E7FHH1 and Q8U0V2
-
-
-
?
hexanal + H2O + oxidized methyl viologen
hexanoate + reduced methyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
-
-
-
?
hydratropaldehyde + H2O + oxidized benzyl viologen
? + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 89% compared to the value for hexanal
-
-
?
isobutyraldehyde + H2O + oxidized benzyl viologen
isobutyrate + reduced benzyl viologen + H+
show the reaction diagram
E7FHH1 and Q8U0V2
Vmax/Km is 17% compared to the value for hexanal
-
-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
E7FHH1 and Q8U0V2
ferredoxin can be the physiological electron acceptor
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Iron
-
contains one [4Fe-4S] cluster per subunit
Tungsten
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
15.6
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pH 8.4, 60°C
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
67000
-
2 * 67000, SDS-PAGE
135000
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non-denaturing PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
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2 * 67000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
for prolonged cold-shock (5 h) the mRNA level of WOR5 is up-regulated 4.2 fold compared to normal growth conditions
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