Information on EC 1.2.3.8 - pyridoxal oxidase

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The expected taxonomic range for this enzyme is: Drosophila melanogaster

EC NUMBER
COMMENTARY hide
1.2.3.8
-
RECOMMENDED NAME
GeneOntology No.
pyridoxal oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyridoxal + H2O + O2 = 4-pyridoxate + (?)
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Metabolic pathways
-
-
Microbial metabolism in diverse environments
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-
Vitamin B6 metabolism
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-
SYSTEMATIC NAME
IUBMB Comments
pyridoxal:oxygen 4-oxidoreductase
A molybdenum protein.
CAS REGISTRY NUMBER
COMMENTARY hide
76415-81-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4,5-trimethoxybenzaldehyde + H2O + O2
2,4,5-trimethoxybenzoate + ?
show the reaction diagram
-
-
-
-
?
3,4,5-trimethoxybenzaldehyde + H2O + O2
3,4,5-trimethoxybenzoate + ?
show the reaction diagram
-
-
-
-
?
3,7-dimethyl-2,6-octadienal + H2O + O2
3,7-dimethyl-2,6-octadienoate + ?
show the reaction diagram
-
-
-
-
?
3,7-dimethyl-6-octenal + H2O + O2
3,7-dimethyl-6-octenoate + ?
show the reaction diagram
-
-
-
-
?
3-hydroxybenzaldehyde + H2O + O2
3-hydroxybenzoate + ?
show the reaction diagram
-
-
-
-
?
3-methoxy-4-hydroxybenzaldehyde + H2O + O2
3-methoxy-4-hydroxybenzoate + ?
show the reaction diagram
-
-
-
-
?
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + ?
show the reaction diagram
-
-
-
-
?
pyridoxal + H2O + O2
4-pyridoxate + ?
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
molybdopterin
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Molybdenum
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.57 - 0.85
2,4,5-trimethoxybenzaldehyde
0.028
pyridoxal
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5 - 8
-
immediately after extraction the optimum is pH 8.0, after 5 h it is pH 7.5
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
distribution pattern in imaginal wing dics for a series of strains of Drosophila melanogaster heterozygous for different Minute mutations. The amount of enzyme activity is roughly correlated with the expressivity in the Minute mutation. M(3)w124Sb63bmwh/TM2, which is a strong Minute, has a high level of activity in ist imaginal discs
Manually annotated by BRENDA team
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
-
unstable above
390445
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
-
activity in crude extract is increased after 1 min to 130-140% of the initial unheated activity. 110% after 5 min, 25% of the original activity after 30 min
60
-
considerable denaturation
additional information
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activity is increased during the first 4-8 h following extraction when the extract is held at 4°C