Information on EC 1.2.3.13 - 4-hydroxyphenylpyruvate oxidase

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The expected taxonomic range for this enzyme is: Arthrobacter globiformis

EC NUMBER
COMMENTARY hide
1.2.3.13
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RECOMMENDED NAME
GeneOntology No.
4-hydroxyphenylpyruvate oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 4-hydroxyphenylpyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2
show the reaction diagram
Involved in tyrosine degradation pathway in Arthrobacter sp.
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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oxidative decarboxylation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
L-tyrosine degradation II
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L-tyrosine degradation IV (to 4-methylphenol)
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tyrosine metabolism
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Tyrosine metabolism
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SYSTEMATIC NAME
IUBMB Comments
4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
Involved in tyrosine degradation pathway in Arthrobacter sp.
CAS REGISTRY NUMBER
COMMENTARY hide
78213-74-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-hydroxyphenylpyruvate + O2
4-hydroxyphenylacetate + CO2
show the reaction diagram
glyoxylate + O2
CO2 + CO2
show the reaction diagram
phenylpyruvate + O2
phenylacetate + CO2
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-hydroxyphenylpyruvate + O2
4-hydroxyphenylacetate + CO2
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
FAD
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optimal activity at 10 nM, can not be replaced by NAD+, NADP+ or FMN
thiamine diphosphate
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optimal activity at 0.004 mM, absolute requirement
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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optimal activity at 0.01 mM
Mn2+
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optimal activity at 0.01 mM
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
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potent inhibitor, other metal chelators ineffective
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
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dithiothreitol
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GSH
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optimal activity at 0.002 mM, can be replaced by 2-mercaptoethanol, cysteine or dithiothreitol
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0
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10% loss of activity per h
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
stabilizing effects of activity with ammonium sulfate, NaCl, Na2SO4 or MgSO4
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, ammonium sulfate precipitation or crude extract, 4 weeks
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