Information on EC 1.2.1.94 - farnesal dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.2.1.94
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RECOMMENDED NAME
GeneOntology No.
farnesal dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesal + NAD+ + H2O = (2E,6E)-farnesoate + NADH + 2 H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
juvenile hormone III biosynthesis I
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juvenile hormone III biosynthesis II
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SYSTEMATIC NAME
IUBMB Comments
farnesal:NAD+ oxidoreductase
Invoved in juvenile hormone production in insects. The enzyme was described from the corpora allata of Drosophila melanogaster (fruit fly), Manduca sexta (tobacco hornworm) and Aedes aegypti (dengue mosquito).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Dengue mosquito
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Manually annotated by BRENDA team
Dengue mosquito
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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in the juvenile hormone JH III biosynthesis in insects, the alcohol farnesol, generated by the removal of diphosphate from farnesyl diphosphate, undergoes oxidation to the aldehyde (farnesal) and then to the acid (farnesoic acid). These steps are catalyzed by one or two NAD+-dependent dehydrogenase(s), JH III biosynthesis pathway, overview
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesal + NAD+
(2E,6E)-farnesoate + NADH
show the reaction diagram
(2E,6E)-farnesal + NAD+ + H2O
(2E,6E)-farnesoate + NADH + 2 H+
show the reaction diagram
decanal + NAD+ + H2O
decanoic acid + NADH + H+
show the reaction diagram
octanal + NAD+
octanoic acid + NADH
show the reaction diagram
additional information
?
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no activity with the (2Z,6E)-farnesal
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesal + NAD+
(2E,6E)-farnesoate + NADH
show the reaction diagram
(2E,6E)-farnesal + NAD+ + H2O
(2E,6E)-farnesoate + NADH + 2 H+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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no activity with NADP+
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
farnesal
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massive accumulation of the potentially toxic farnesal can stimulate the activity of a farnesal reductase or another enzyme that could convert farnesal back into farnesol
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.08
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recombinant AaALDH3-1-PB with farnesal and NADP+ as substrate, pH 9.5 and 37°C
7.13
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recombinant AaALDH3-1-PC with farnesal and NADP+ as substrate, pH 9.5 and 37°C
103.7
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recombinant AaALDH3-1-PD with decanal as substrate, pH 9.5 and 37°C
116.8
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recombinant AaALDH3-1-PB with octanal as substrate, pH 9.5 and 37°C
132.5
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recombinant AaALDH3-2 with decanal as substrate, pH 9.5 and 37°C
152.7
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recombinant AaALDH3-1-PA with octanal as substrate, pH 9.5 and 37°C
168.1
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recombinant AaALDH3-1-PD with octanal as substrate, pH 9.5 and 37°C
203.9
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recombinant AaALDH3-2 with octanal as substrate, pH 9.5 and 37°C
209.2
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recombinant AaALDH3-2 with farnesal as substrate, pH 9.5 and 37°C
214.6
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recombinant AaALDH3-1-PC with octanal as substrate, pH 9.5 and 37°C
268
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recombinant AaALDH3-1-PD with farnesal as substrate, pH 9.5 and 37°C
269.1
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recombinant AaALDH3-1-PB with farnesal as substrate, pH 9.5 and 37°C
272.9
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recombinant AaALDH3-1-PA with farnesal as substrate, pH 9.5 and 37°C
287.1
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recombinant AaALDH3-1-PB with decanal as substrate, pH 9.5 and 37°C
362.4
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recombinant AaALDH3-1-PC with decanal as substrate, pH 9.5 and 37°C
468.2
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recombinant AaALDH3-1-PC with farnesal as substrate, pH 9.5 and 37°C
additional information
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no activity of AaALDH3-1-PA with decanal, no activity of AaALDH3-1-PA, AaALDH3-1-PD, and AaALDH3-2 with NADP+
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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AaALDH3-1-RC transcript abundance, quantified by qPCR
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
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the enzyme is found in all fractions of the cell
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Manually annotated by BRENDA team
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
five recombinant His-tagged AaALDH3s, representing AaALDH3-2 and the 4 splice variants of AaALDH3-1, PA, PB, PC, PD, overexpressed in Escherichia coli
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in the presence of an excess of farnesal and NAD+, highly active glands produces 10 times more farnesoic acid than suppressed glands, 24 h after blood feeding
injection of dsRNAs resulted in a approx. 80% significant reduction of AaALDH3-1 and AaALDH3-2 mRNAs, treatment with dsRNA for the AaALDH3-1 gene results in stronger reductions of farnesoic acid and juvenile hormone than treatment with dsRNA for the AaALDH3-2 gene