Information on EC 1.2.1.57 - butanal dehydrogenase

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The expected taxonomic range for this enzyme is: Clostridium acetobutylicum

EC NUMBER
COMMENTARY hide
1.2.1.57
-
RECOMMENDED NAME
GeneOntology No.
butanal dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Butanoate metabolism
-
-
pyruvate fermentation to butanol I
-
-
pyruvate fermentation to butanol II (engineered)
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-
SYSTEMATIC NAME
IUBMB Comments
butanal:NAD(P)+ oxidoreductase (CoA-acylating)
Also acts on acetaldehyde, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
116412-25-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetaldehyde + CoA + NAD+
acetyl-CoA + NADH
show the reaction diagram
-
-
-
-
r
butanal + CoA + NAD+
butanoyl-CoA + NADH
show the reaction diagram
butanal + CoA + NADP+
butanoyl-CoA + NADPH
show the reaction diagram
hexanal + CoA + NAD+
hexanoyl-CoA + NADH
show the reaction diagram
-
-
-
-
r
propionaldehyde + NAD+
propanoyl-CoA + NADH
show the reaction diagram
-
-
-
-
r
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CoASH
-
at 0.3 mM
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7.2
acetaldehyde
-
-
0.055
acetyl-CoA
-
-
0.045
Butanoyl-CoA
-
CoA
6.7
propionaldehyde
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
formation of butyraldehyde
9
-
formation of butyryl-CoA
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
56000
-
2 * 56000, SDS-PAGE
115000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 56000, SDS-PAGE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
2-mercaptoethanol or dithiothreitol helps to maintain enzyme activity
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C, half-life: 3 days, enzyme in crude extract
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE