Reference on EC 1.17.7.4 - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rohdich, F.; Hecht, S.; Grtner, K.; Adam, P.; Krieger, C.; Amslinger, S.; Arigoni, D.; Bacher, A.; Eisenreich, W.
Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein
Proc. Natl. Acad. Sci. USA
99
1158-1163
2002
Escherichia coli (P62623)
Hintz, M.; Reichenberg, A.; Altincicek, B.; Bahr, U.; Gschwind, R.M.; Kollas, A.K.; Beck, E.; Wiesner, J.; Eberl, M.; Jomaa, H.
Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gd T cells in Escherichia coli
FEBS Lett.
509
317-322
2001
Escherichia coli
Charon, L.; Pale-Grosdemange, C.; Rohmer, M.
On the reduction steps in the mevalonate independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in the bacterium Zymomonas mobilis
Tetrahedron Lett.
40
7231-7234
1999
Zymomonas mobilis
-
Altincicek, B.; Duin, E.C.; Reichenberg, A.; Hedderich, R.; Kollas, A.K.; Hintz, M.; Wagner, S.; Wiesner, J.; Beck, E.; Jomaa, H.
LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis
FEBS Lett.
532
437-440
2002
Aquifex aeolicus (O67625)
Wolff, M.; Seemann, M.; Tse Sum Bui, B.; Frapart, Y.; Tritsch, D.; Estrabot, A.G.; Rodriguez-Concepcion, M.; Boronat, A.; Marquet, A.; Rohmer, M.
Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein
FEBS Lett.
541
115-120
2003
Escherichia coli
Graewert, T.; Kaiser, J.; Zepeck, F.; Laupitz, R.; Hecht, S.; Amslinger, S.; Schramek, N.; Schleicher, E.; Weber, S.; Haslbeck, M.; Buchner, J.; Rieder, C.; Arigoni, D.; Bacher, A.; Eisenreich, W.; Rohdich, F.
IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis
J. Am. Chem. Soc.
126
12847-12855
2004
Escherichia coli
Botella-Pavia, P.; Besumbes, O.; Phillips, M.A.; Carretero-Paulet, L.; Boronat, A.; Rodriguez-Concepcion, M.
Regulation of carotenoid biosynthesis in plants: Evidence for a key role of hydroxymethylbutenyl diphosphate reductase in controlling the supply of plastidial isoprenoid precursors
Plant J.
40
188-199
2004
Solanum lycopersicum
Guevara-Garcia, A.; San Roman, C.; Arroyo, A.; Cortes, M.E.; De la Luz Gutierrez-Nava, M.; Leon, P.
Characterization of the Arabidopsis clb6 mutant illustrates the importance of posttranscriptional regulation of the methyl-D-erythritol 4-phosphate pathway
Plant Cell
17
628-643
2005
Arabidopsis thaliana
Tritsch, D.; Hemmerlin, A.; Bach, T.J.; Rohmer, M.
Plant isoprenoid biosynthesis via the MEP pathway: In vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures
FEBS Lett.
584
129-134
2010
Nicotiana tabacum
Ramos, A.A.; Marques, A.R.; Rodrigues, M.; Henriques, N.; Baumgartner, A.; Castilho, R.; Brenig, B.; Varela, J.C.
Molecular and functional characterization of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Dunaliella salina
J. Plant Physiol.
166
968-977
2009
Dunaliella salina (C5H8E3), Dunaliella salina, Dunaliella salina CCAP 19/30 (C5H8E3)
Wang, K.; Wang, W.; No, J.H.; Zhang, Y.; Zhang, Y.; Oldfield, E.
Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms
J. Am. Chem. Soc.
132
6719-6727
2010
Aquifex aeolicus
Wang, W.; Li, J.; Wang, K.; Smirnova, T.I.; Oldfield, E.
Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation
J. Am. Chem. Soc.
133
6525-6528
2011
Aquifex aeolicus
Graewert, T.; Span, I.; Eisenreich, W.; Rohdich, F.; Eppinger, J.; Bacher, A.; Groll, M.
Probing the reaction mechanism of IspH protein by x-ray structure analysis
Proc. Natl. Acad. Sci. USA
107
1077-1081
2010
Escherichia coli
Wang, W.; Wang, K.; Liu, Y.; No, J.; Li, J.; Nilges, M.; Oldfield, E.
Bioorganometallic mechanism of action, and inhibition, of IspH
Proc. Natl. Acad. Sci. USA
107
4522-4527
2010
Aquifex aeolicus, no activity in Homo sapiens
Rekittke, I.; Olkhova, E.; Wiesner, J.; Demmer, U.; Warkentin, E.; Jomaa, H.; Ermler, U.
Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum
FEBS Lett.
587
3968-3972
2013
Plasmodium falciparum (Q9BJX6)
Kumar, H.; Kumar, S.
A functional (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase exhibits diurnal regulation of expression in Stevia rebaudiana (Bertoni)
Gene
527
332-338
2013
Stevia rebaudiana
Wang, W.; Wang, K.; Span, I.; Jauch, J.; Bacher, A.; Groll, M.; Oldfield, E.
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation
J. Am. Chem. Soc.
134
11225-11234
2012
Escherichia coli
Janthawornpong, K.; Krasutsky, S.; Chaignon, P.; Rohmer, M.; Poulter, C.D.; Seemann, M.
Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway
J. Am. Chem. Soc.
135
1816-1822
2013
Escherichia coli
Kwon, M.; Shin, B.; Lee, J.; Han, J.; Kim, S.
Characterization of Burkholderia glumae BGR1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR), the terminal enzyme in 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway
J. Korean Soc. Appl. Biol. Chem.
56
35-40
2013
Burkholderia glumae
-
Caballero, M.C.; Pedroni, M.J.; Palmer, G.H.; Suarez, C.E.; Davitt, C.; Lau, A.O.
Characterization of acyl carrier protein and LytB in Babesia bovis apicoplast
Mol. Biochem. Parasitol.
181
125-133
2012
Babesia bovis
Martin, D.M.; Chiang, A.; Lund, S.T.; Bohlmann, J.
Biosynthesis of wine aroma: transcript profiles of hydroxymethylbutenyl diphosphate reductase, geranyl diphosphate synthase, and linalool/nerolidol synthase parallel monoterpenol glycoside accumulation in Gewuerztraminer grapes
Planta
236
919-929
2012
Vitis vinifera
Lv, H.; Zhang, X.; Liao, B.; Liu, W.; He, L.; Song, J.; Sun, C.; Luo, H.; Chen, S.
Cloning and analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase genes HsHDR1 and HsHDR2 in Huperzia serrate
Acta Pharm. Sin. B
5
583-589
2015
Huperzia serrata (A0A0G3EHB0), Huperzia serrata (A0A0G3EJZ3), Huperzia serrata
Hao, G.; Shi, R.; Tao, R.; Fang, Q.; Jiang, X.; Ji, H.; Feng, L.; Huang, L.
Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba
Plant Physiol. Biochem.
70
21-32
2013
Salvia miltiorrhiza f. alba (T1RJ09)
Hsieh, W.Y.; Sung, T.Y.; Wang, H.T.; Hsieh, M.H.
Functional evidence for the critical amino-terminal conserved domain and key amino acids of Arabidopsis 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Plant Physiol.
166
57-69
2014
Arabidopsis thaliana (Q94B35)
Hsieh, W.Y.; Hsieh, M.H.
The amino-terminal conserved domain of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase is critical for its function in oxygen-evolving photosynthetic organisms
Plant Signal. Behav.
10
e988072
2015
Arabidopsis thaliana (Q94B35)
Cheng, Q.; Tong, Y.; Wang, Z.; Su, P.; Gao, W.; Huang, L.
Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii
Acta Pharm. Sin. B
7
208-214
2017
Tripterygium wilfordii (A0A088GJ08), Tripterygium wilfordii
Ma, D.; Li, G.; Zhu, Y.; Xie, D.
Overexpression and suppression of Artemisia annua 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 gene (AaHDR1) differentially regulate artemisinin and terpenoid biosynthesis
Front. Plant Sci.
8
doi: 10.3389/fpls.2017.00077
2017
Artemisia annua (A0A1V0C086), Artemisia annua
Shin, B.; Jung, Y.; Kim, S.; Pan, C.
Transformation of the diatom Phaeodactylum tricornutum with its endogenous (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene
J. Appl. Biol. Chem.
58
273-279
2015
Phaeodactylum tricornutum
-
Hsieh, W.; Hsieh, M.
The amino-terminal conserved domain of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase is critical for its function in oxygen-evolving photosynthetic organisms
Plant Signal. Behav.
10
e988072
2015
Arabidopsis thaliana (Q94B35)
Zhang, Z.; Lv, H.; Guo, X.; He, L.; Song, J.; Sun, C.; Luo, H.
Cloning and bioinformatics analysis of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (PcHDR1) gene in Phlegmarirus carinatus
Zhongguo Zhong Yao Za Zhi
41
4169-4174
2016
Phlegmariurus carinatus (I6TT54), Phlegmariurus carinatus
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