Information on EC 1.17.5.B2 - carotenoid ketolase (quinone)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.17.5.B2
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
carotenoid ketolase (quinone)
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-carotene + benzoquinone + H2O = echinenone + benzoquinol + 2 H+
show the reaction diagram
SYSTEMATIC NAME
IUBMB Comments
carotene:quinone oxidoreductase
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene crtO
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
CrtO belongs to the CrtI family which comprises carotene desaturases and carotenoid oxidases. Phylogenetic tree of beta-carotene 4-ketolase CrtO and other enzymes related to bacterial phytoene desaturases CrtI including CrtN (4,4'-diapophytoene desaturase), CrtNb (4,4'-diapolycopene oxidase) and CrtNc (4,4'-diapolycopene-4,40-dial oxidase), overview
metabolism
CrtW and CrtO are two distinct non-homologous beta-carotene ketolases catalyzing the formation of echinenone and canthaxanthin
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4,4'-dihydroxy-beta-carotene + benzoquinone
canthaxanthin + benzoquinol
show the reaction diagram
via 4-hydroxy-4'-oxo-beta-carotene
-
-
?
beta-carotene + benzoquinone + H2O
echinenone + benzoquinol + 2 H+
show the reaction diagram
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme from Escherichia coli
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene crtO, phylogenetic tree, recombinant expression in Escherichia coli