Disease on EC 1.17.4.1 - ribonucleoside-diphosphate reductase
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Bloom Syndrome
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Breast Neoplasms
Regression of human breast tumor xenografts in response to (E)-2'-deoxy-2'-(fluoromethylene)cytidine, an inhibitor of ribonucleoside diphosphate reductase.
Carcinogenesis
Investigation of Pokemon-regulated proteins in hepatocellular carcinoma using mass spectrometry-based multiplex quantitative proteomics.
Carcinoma
Antitumor and radiosensitizing effects of (E)-2'-deoxy-2'-(fluoromethylene) cytidine, a novel inhibitor of ribonucleoside diphosphate reductase, on human colon carcinoma xenografts in nude mice.
Carcinoma
Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis.
Carcinoma
[Control mechanisms of the ribonucleotide reduction in mammalian tissue (author's transl)]
Carcinoma, Hepatocellular
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Carcinoma, Hepatocellular
Potentiation of antimetabolite action by dibromodulcitol in cell culture.
Carcinoma, Hepatocellular
Some biochemical mechanisms underlying the impairment of T and B cell immunity in C3HA mice during hepatoma growth.
Carcinoma, Hepatocellular
[Changes in the lymphoid cells of DNA and purine nucleotide synthesis and sensitivity to glucocorticoids associated with impairment of differentiation and immune function during tumor growth in mice. Thymocytes]
Carcinosarcoma
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Cytomegalovirus Infections
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Down Syndrome
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Ectodermal Dysplasia
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Endometriosis
An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease.
Esophageal Squamous Cell Carcinoma
Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis.
Glioblastoma
In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor.
Herpes Simplex
2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir.
Herpes Simplex
A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo.
Herpes Simplex
Aanlysis of dCMP deaminase and CDP reductase levels in hamster cells infected by herpes simplex virus.
Herpes Simplex
Herpes simplex virus type 1 ribonucleotide reductase: selective and synergistic inactivation by A1110U and its iron complex.
Herpes Simplex
Ribonucleotide reductase of herpes simplex virus type 2 resembles that of herpes simplex virus type 1.
Herpes Simplex
Selective inhibition of herpes simplex virus ribonucleoside diphosphate reductase by derivatives of 2-acetylpyridine thiosemicarbazone.
Herpes Simplex
Structure-activity relationships among alpha-(N)-heterocyclic acyl thiosemicarbazones and related compounds as inhibitors of herpes simplex virus type 1-specified ribonucleoside diphosphate reductase.
Hypergammaglobulinemia
Cytidine 5'-diphosphate reductase and thymidine kinase activities in phytohemagglutinin-stimulated lymphocytes of normal subjects of various ages and patients with immunodeficiency.
Infections
Aanlysis of dCMP deaminase and CDP reductase levels in hamster cells infected by herpes simplex virus.
Infections
Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase.
Infections
Ribonucleotide reductase of herpes simplex virus type 2 resembles that of herpes simplex virus type 1.
Infections
Tandem cloning of bacteriophage T4 nrdA and nrdB genes and overproduction of ribonucleoside diphosphate reductase (alpha 2 beta 2) and a mutationally altered form (alpha 2 beta 2(93)).
Leukemia
Schedule-dependency assessments of ribonucleoside diphosphate reductase inhibitors when used in combination with platinum compounds plus cyclophosphamide in the treatment of advanced L1210 leukemia.
Leukemia
Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Leukemia, Myeloid
p53-inducible ribonucleotide reductase (p53R2/RRM2B) is a DNA hypomethylation-independent decitabine gene target that correlates with clinical response in myelodysplastic syndrome/acute myelogenous leukemia.
Lymphoma
Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature.
Neoplasms
Computational studies on class I ribonucleotide reductase: understanding the mechanisms of action and inhibition of a cornerstone enzyme for the treatment of cancer.
Neoplasms
Domain-structured N1,N2-derivatized hydrazines as inhibitors of ribonucleoside diphosphate reductase: redox-cycling considerations.
Neoplasms
Metabolism of pyrimidine nucleotides in various tissues and tumor cells from rodents.
Neoplasms
Noncoordinate changes in the components of ribonucleotide reductase in mammalian cells.
Neoplasms
Phase I and pharmacologic study of oral (E)-2'-deoxy-2'-(fluoromethylene) cytidine: on a daily x 5-day schedule.
Neoplasms
Selective cytotoxic activity of a novel ribonucleoside diphosphate reductase inhibitor MDL-101,731 against thyroid cancer in vitro.
Neoplasms
The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo.
Neuroblastoma
In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL101731, a novel ribonucleoside diphosphate reductase inhibitor.
ribonucleoside-diphosphate reductase deficiency
Novel mechanism of resistance to folate analogues: ribonucleoside diphosphate reductase deficiency in bacteriophage T4.
Thyroid Neoplasms
Selective cytotoxic activity of a novel ribonucleoside diphosphate reductase inhibitor MDL-101,731 against thyroid cancer in vitro.
Trypanosomiasis, African
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
Tuberculosis
Characterization of two genes encoding the Mycobacterium tuberculosis ribonucleotide reductase small subunit.
Vaccinia
Amplification of the ribonucleotide reductase small subunit gene: analysis of novel joints and the mechanism of gene duplication in vaccinia virus.
Vaccinia
Vaccinia virus ribonucleotide reductase. Correlation between deoxyribonucleotide supply and demand.
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