Reference on EC 1.17.3.2 - xanthine oxidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Maia, L.; Mira, L.
Xanthine oxidase and aldehyde oxidase: A simple procedure for the simultaneous purification from rat liver
Arch. Biochem. Biophys.
400
48-53
2002
Rattus norvegicus
Kramer, S.P.; Johnson, J.L.; Ribeiro, A.A.; Millington, D.S.; Rajagopalan, K.V.
The structure of the molybdenum cofactor. Characterization of di-(carboxamidomethyl)molybdopterin from sulfite oxidase and xanthine oxidase
J. Biol. Chem.
262
16357-16363
1987
Bos taurus
Johnson, J.L.; Hainline, B.E.; Rajagopalan, K.V.
Characterization of the molybdenum cofactor of sulfite oxidase, xanthine, oxidase, and nitrate reductase. Identification of a pteridine as a structural component
J. Biol. Chem.
255
1783-1786
1980
Bos taurus
Bray, R.C.
Molybdenum iron-sulfur flavin hydroxylases and related enzymes
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
12
299-419
1975
Bos taurus, Drosophila melanogaster, Gallus gallus
-
Eger, B.T.; Okamoto, K.; Enroth, C.; Sato, M.; Nishino, T.; Pai, E.F.; Nishino, T.
Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk
Acta Crystallogr. Sect. D
56
1656-1658
2000
Bos taurus
-
Enroth, C.; Eger, B.T.; Okamoto, K.; Nishino, T.; Nishino, T.; Pai, E.F.
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
Proc. Natl. Acad. Sci. USA
97
10723-10728
2000
Bos taurus
McManaman, J.L.; Neville, M.C.; Wright, R.M.
Mouse mammary gland xanthine oxidoreductase: Purification, characterization, and regulation
Arch. Biochem. Biophys.
371
308-316
1999
Mus musculus
Waud, W.R.; Rajagopalan, K.V.
Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase
Arch. Biochem. Biophys.
172
354-364
1976
Rattus norvegicus
Della Corte, E.; Stirpe, F.
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme
Biochem. J.
126
739-745
1972
Rattus norvegicus
Romao, M.J.; Archer, M.; Moura, I.; Moura, J.J.G.; Legall, J.; Engh, R.; Schneider, M.; Hof, P.; Huber, R.
Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas
Science
270
1170-1176
1995
Megalodesulfovibrio gigas
Taneja, R.; Taneja, V.
Xanthine oxidase in lentil (Lens esculenta) seedlings
Biochim. Biophys. Acta
485
489-491
1977
Lens culinaris
Woolfolk, C.A.; Downard, J.S.
Bacterial xanthine oxidase from Arthrobacter S-2
J. Bacteriol.
135
422-428
1978
Arthrobacter sp., Arthrobacter sp. S-2
Nathans, G.R.; Hade, E.P.K.
Bovine milk xanthine oxidase: purification by ultrafiltration and conventional methods which omit addition of proteases: some criteria for homogeneity of native xanthine oxidase
Biochim. Biophys. Acta
526
328-344
1978
Bos taurus
Machida, Y.; Nakanishi, T.
Purification and properties of xanthine oxidase from Enterobacter cloacae
Agric. Biol. Chem.
45
425-432
1981
Enterobacter cloacae, Enterobacter cloacae KY 3074
-
Bruder, G.; Heid, H.; Jarasch, E.D.; Keenan, T.W.; Mather, I.H.
Characteristics of membrane-bound and soluble forms of xanthine oxidase from milk and endothelial cells of capillaries
Biochim. Biophys. Acta
701
357-369
1982
Bos taurus
Krenitsky, T.A.; Spector, T.; Hall, W.W.
Xanthine oxidase from human liver: purification and characterization
Arch. Biochem. Biophys.
247
108-119
1986
Homo sapiens
Berglund, L.; Rasmussen, J.T.; Andersen, M.D.; Rasmussen, M.S.; Petersen, T.E.
Purification of the bovine xanthine oxidoreductase from milk fat globule membranes and cloning of complementary deoxyribonucleic acid
J. Dairy Sci.
79
198-204
1996
Bos taurus
Radi, R.; Rubbo, H.; Bush, K.; Freeman, B.A.
Xanthine oxidase binding to glycosaminoglycans: kinetics and superoxide dismutase interactions of immobilized xanthine oxidase-heparin complexes
Arch. Biochem. Biophys.
339
125-135
1997
Homo sapiens
zer, N.; Muftuoglu, M.; Ataman, D.; Ercan, A.; gus, I.H.
Simple, high-yield purification of xanthine oxidase from bovine milk
J. Biochem. Biophys. Methods
39
153-159
1999
Bos taurus
Houston, M.; Esteveze, A.; Chumley, P.; Aslan, M.; Marklund, S.; Parks, D.A.; Freeman, B.A.
Binding of xanthine oxidase to vascular endothelium
J. Biol. Chem.
274
4985-4994
1999
Bos taurus
Moini, H.; Guo, Q.; Packer, L.
Enzyme inhibiton and protein-binding action of the procyanidin-rich french maritime pine bark extract, pycnogenol: effect on xanthine oxidase
J. Agric. Food Chem.
48
5630-5639
2000
Rattus norvegicus
Pritsos, C.A.
Cellular distribution, metabolism and regulation of the xanthine oxidoreductase enzyme system
Chem. Biol. Interact.
129
195-208
2000
Bos taurus, Homo sapiens
Clynes, M.M.; Hurley, M.P.; Shannon, M.F.
Xanthine oxidase activity in mammalian cell cultures
Biochem. Soc. Trans.
7
72-74
1979
Mus musculus
Catigani, G.L.; Chytil, F.; Darby, W.J.
Purification and characterization of xanthine oxidase from livers of vitamin E deficient rabbits
Biochim. Biophys. Acta
377
34-41
1975
Oryctolagus cuniculus
Zikakis, J.P.; Dressel, M.A.; Silver, M.R.
Bovine, caprine, and human milk xanthine oxidases: isolation, purification, and characterization
Instrum. Anal. Foods, Recent Prog. (Proc. Symp. Int. Flavor Conf. , 3rd Ed. , Charalambous, G. , Inglett, G. , eds. )
2
243-303
1983
Bos taurus, Canis lupus familiaris, Capra hircus, Cavia porcellus, Oryctolagus cuniculus, Equus asinus, Equus caballus, Erythrocebus patas, Felis catus, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Erythrocebus patas Patas monkey
-
Avis, P.G.; Bergel, F.; Bray, R.C.
Cellular constituents. The chemistry of xanthine oxidase. Part I. The preparation of a crystalline xanthine oxidase from cow's milk
J. Chem. Soc.
2
1100-1105
1955
Bos taurus
-
Coughlan, M.P.; Rajagopalan, K.V.; Handler, P.
The role of molybdenum in xanthine oxidase and related enzymes. Reactivity with cyanide, arsenite, and methanol
J. Biol. Chem.
244
2658-2663
1969
Bos taurus
Stirpe, F.; Della Corte, E.
The regulation of rat liver xanthine oxidase: conversion of type D (dehydrogenase) into type O (oxidase) by a thermolabile factor, and reversibility by dithioerythritol
Biochim. Biophys. Acta
212
195-197
1970
Bos taurus, Rattus norvegicus
Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction
J. Biol. Chem.
276
24482-24489
2001
Bos taurus
Bray, R.C.
Xanthine oxidase
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
7
533-556
1963
Bos taurus
-
Batelli, M.G.; Lorenzoni, E.; Stirpe, F.
Milk xanthine oxidase type D (dehydrogenase) and type O (oxidase). Purification, interconversion and some properties
Biochem. J.
131
191-198
1973
Bos taurus
Hayden, T.J.; Ryan, J.P.; Duke, E.J.
Comparative aspects of xanthine-oxygen oxidoreductase systems
Biochem. Soc. Trans.
1
247-250
1973
Gallus gallus, Drosophila melanogaster, Locusta sp., Mus musculus
-
De Renzo, E.C.
Chemistry and biochemistry of xanthine oxidase
Adv. Enzymol. Relat. Subj. Biochem.
17
293-328
1956
Bos taurus, Gallus gallus, Rattus norvegicus
Tramper, J.
Preparation of immobilized milk xanthine oxidase and application in organic synthesis
Methods Enzymol.
136
254-262
1987
Bos taurus
-
Waud, W.R.; Brady, F.O.; Wiley, R.D.; Rajagopalan, K.V.
A new purification procedure for bovine milk xanthine oxidase: effect of proteolysis on the subunit structure
Arch. Biochem. Biophys.
169
695-701
1975
Bos taurus
Van Spanning, R.J.M.; Wansell-Bettenhaussen, C.W.; Oltmann, L.F.; Stouthamer, A.H.
Extraction and purification of molybdenum cofactor from milk xanthine oxidase
Eur. J. Biochem.
169
349-352
1987
Bos taurus
Cabre, F.; Canela, E.I.
Purification properties and functional groups of bovine liver xanthine oxidase
Biochem. Soc. Trans.
15
511-512
1987
Bos taurus
-
Morpeth, F.F.; Bray, R.C.
Mechanism-based inactivation of mitochondrial monoamine oxidase by N-(1-methylcyclopropyl)benzylamine
Biochemistry
23
1322-1338
1984
Bos taurus
Morpeth, F.F.
Studies on the specificity toward aldehyde substrates and steady-state kinetics of xanthine oxidase
Biochim. Biophys. Acta
744
328-334
1983
Bos taurus
Briley, M.S.; Eisenthal, R.
Association of xanthine oxidase with the bovine milk-fat-globule membrane. Nature of the enzyme-membrane association
Biochem. J.
147
417-423
1975
Bos taurus
Carpani, G.; Racchi, M.; Ghezzi, P.; Terao, M.; Garattini, E.
Purification and characterization of mouse liver xanthine oxidase
Arch. Biochem. Biophys.
279
237-241
1990
Mus musculus
Panoutsopoulos, G.I.; Beedham, C.
Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes
Acta Biochim. Pol.
51
649-663
2004
Bos taurus
Frederiks, W.M.; Vreeling-Sindelarova, H.
Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells
Acta Histochem.
104
29-37
2002
Rattus norvegicus
Mohamadin, A.M.; Abdel-Naim, A.B.
In vitro activation of dibromoacetonitrile to cyanide: role of xanthine oxidase
Arch. Toxicol.
77
86-93
2003
Bos taurus
Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues
Biochemistry
42
1150-1159
2003
Bos taurus
Tai, L.A.; Hwang, K.C.
Cooperative catalysis in the homodimer subunits of xanthine oxidase
Biochemistry
43
4869-4876
2004
Bos taurus
Masuoka, N.; Kubo, I.
Characterization of xanthine oxidase inhibition by anacardic acids
Biochim. Biophys. Acta
1688
245-249
2004
Bos taurus
Lovstad, R.A.
A kinetic study on iron stimulation of the xanthine oxidase dependent oxidation of ascorbate
BioMetals
16
435-439
2003
Bos taurus
Millar, T.M.
Peroxynitrite formation from the simultaneous reduction of nitrite and oxygen by xanthine oxidase
FEBS Lett.
562
129-133
2004
Bos taurus
Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation
J. Biol. Chem.
279
16939-16946
2004
Bos taurus
Li, H.; Cui, H.; Liu, X.; Zweier, J.L.
Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation
J. Biol. Chem.
280
16594-16600
2005
Bos taurus
Choi, E.Y.; Stockert, A.L.; Leimkuhler, S.; Hille, R.
Studies on the mechanism of action of xanthine oxidase
J. Inorg. Biochem.
98
841-848
2004
Bos taurus
Deng, T.S.; Roenneberg, T.
The flavo-enzyme xanthine oxidase is under circadian control in the marine alga Gonyaulax
Naturwissenschaften
89
171-175
2002
Lingulodinium polyedra
Gongora, L.; Manez, S.; Giner, R.M.; Recio, M.d.C.; Schinella, G.; Rios, J.L.
Inhibition of xanthine oxidase by phenolic conjugates of methylated quinic acid
Planta Med.
69
396-401
2003
Bos taurus
Takahashi, M.; Ushijima, T.; Ozaki, Y.
Changes in hepatic superoxide dismutase and xanthine oxidase activity in mice infected with Salmonella typhimurium and Pseudomonas aeruginosa
J. Med. Microbiol.
26
281-284
1988
Mus musculus
Casero, E.; de Quesada, A.M.; Jin, J.; Quintana, M.C.; Pariente, F.; Abruna, H.D.; Vazquez, L.; Lorenzo, E.
Comprehensive study of bioanalytical platforms: xanthine oxidase
Anal. Chem.
78
530-537
2006
Bos taurus
Galbusera, C.; Orth, P.; Fedida, D.; Spector, T.
Superoxide radical production by allopurinol and xanthine oxidase
Biochem. Pharmacol.
71
1747-1752
2006
Bos taurus
Griguer, C.E.; Oliva, C.R.; Kelley, E.E.; Giles, G.I.; Lancaster, J.R.; Gillespie, G.Y.
Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells
Cancer Res.
66
2257-2263
2006
Homo sapiens
Noro, T.; Oda, Y.; Miyase, T.; Ueno, A.; Fukushima, S.
Inhibitors of xanthine oxidase from the flowers and buds of Daphne genkwa
Chem. Pharm. Bull.
31
3984-3987
1983
Bos taurus
Veskoukis, A.S.; Kouretas, D.; Panoutsopoulos, G.I.
Substrate specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase for methyl- and nitrobenzaldehydes
Eur. J. Drug Metab. Pharmacokinet.
31
11-16
2005
Bos taurus
Rus, D.A.; Sastre, J.; Vina, J.; Pallardo, F.V.
Induction of mitochondrial xanthine oxidase activity during apoptosis in the rat mammary gland
Front. Biosci.
12
1184-1189
2007
Rattus norvegicus
Dew, T.P.; Day, A.J.; Morgan, M.R.
Xanthine oxidase activity in vitro: effects of food extracts and components
J. Agric. Food Chem.
53
6510-6515
2005
Bos taurus
Yamaguchi, Y.; Matsumura, T.; Ichida, K.; Okamoto, K.; Nishino, T.
Human Xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
J. Biochem.
141
513-524
2007
Homo sapiens
Asai, R.; Nishino, T.; Matsumura, T.; Okamoto, K.; Igarashi, K.; Pai, E.F.; Nishino, T.
Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase
J. Biochem.
141
525-534
2007
Rattus norvegicus (P22985)
Kalra, S.; Paul, M.K.; Balaram, H.; Mukhopadhyay, A.K.
Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase - an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine
J. Chromatogr. B
850
7-14
2007
Bos taurus, Homo sapiens
Tamta, H.; Thilagavathi, R.; Chakraborti, A.K.; Mukhopadhyay, A.K.
6-(N-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studies
J. Enzyme Inhib. Med. Chem.
20
317-324
2005
Bos taurus
Zhao, X.; Zhu, J.X.; Mo, S.F.; Pan, Y.; Kong, L.D.
Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver
J. Ethnopharmacol.
103
357-365
2006
Mus musculus
Takano, Y.; Hase-Aoki, K.; Horiuchi, H.; Zhao, L.; Kasahara, Y.; Kondo, S.; Becker, M.A.
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
Life Sci.
76
1835-1847
2005
Bos taurus
Akcam, M.; Elmas, O.; Yilmaz, A.; Caglar, S.; Artan, R.; Gelen, T.; Aliciguezel, Y.
Myeloperoxidase, xanthine oxidase and superoxide dismutase in the gastric mucosa of Helicobacter pylori positive and negative pediatric patients
Mol. Cell. Biochem.
290
125-130
2006
Homo sapiens
Masuoka, N.; Nihei, K.; Kubo, I.
Xanthine oxidase inhibitory activity of alkyl gallates
Mol. Nutr. Food Res.
50
725-731
2006
Bos taurus (P80457)
Banach, K.; Bojarska, E.; Kazimierczuk, Z.; Magnowska, L.; Bzowska, A.
Kinetic model of oxidation catalyzed by xanthine oxidase-the final enzyme in degradation of purine nucleosides and nucleotides
Nucleosides Nucleotides Nucleic Acids
24
465-469
2005
Bos taurus
Nguyen, M.T.; Awale, S.; Tezuka, Y.; Ueda, J.Y.; Tran, Q.; Kadota, S.
Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense
Planta Med.
72
46-51
2006
Bos taurus
Lorne, E.; Zmijewski, J.W.; Zhao, X.; Liu, G.; Tsuruta, Y.; Park, Y.J.; Dupont, H.; Abraham, E.
Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production
Am. J. Physiol.
294
C985-C993
2008
Mus musculus
Baudry, N.; Laemmel, E.; Vicaut, E.
In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice: involvement of xanthine oxidase and mitochondria
Am. J. Physiol. Heart Circ. Physiol.
294
H821-H828
2008
Mus musculus
Szasz, T.; Thompson, J.M.; Watts, S.W.
A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase
Am. J. Physiol. Heart Circ. Physiol.
295
H1341-H1350
2008
Rattus norvegicus (P22985)
Landmesser, U.; Spiekermann, S.; Preuss, C.; Sorrentino, S.; Fischer, D.; Manes, C.; Mueller, M.; Drexler, H.
Angiotensin II induces endothelial xanthine oxidase activation: role for endothelial dysfunction in patients with coronary disease
Arterioscler. Thromb. Vasc. Biol.
27
943-948
2007
Homo sapiens
Silanikove, N.; Shapiro, F.; Leitner, G.
Posttranslational ruling of xanthine oxidase activity in bovine milk by its substrates
Biochem. Biophys. Res. Commun.
363
561-565
2007
Bos taurus
Lin, H.C.; Tsai, S.H.; Chen, C.S.; Chang, Y.C.; Lee, C.M.; Lai, Z.Y.; Lin, C.M.
Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities
Biochem. Pharmacol.
75
1416-1425
2008
Mus musculus
Tamta, H.; Kalra, S.; Thilagavathi, R.; Chakraborti, A.K.; Mukhopadhyay, A.K.
Nature and position of functional group on thiopurine substrates influence activity of xanthine oxidase - enzymatic reaction pathways of 6-mercaptopurine and 2-mercaptopurine are different
Biochemistry (Moscow)
72
170-177
2007
Bos taurus
Begas, E.; Kouvaras, E.; Tsakalof, A.; Papakosta, S.; Asprodini, E.K.
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios
Biomed. Chromatogr.
21
190-200
2007
Homo sapiens
Hsieh, J.F.; Wu, S.H.; Yang, Y.L.; Choong, K.F.; Chen, S.T.
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors
Bioorg. Med. Chem.
15
3450-3456
2007
Homo sapiens
Ly, M.H.; Hoang, L.C.; Belin, J.M.; Wache, Y.
Improved co-oxidation of beta-carotene to beta-ionone using xanthine oxidase-generated reactive oxygen species in a multiphasic system
Biotechnol. J.
3
220-225
2008
Bos taurus
Kalra, S.; Jena, G.; Tikoo, K.; Mukhopadhyay, A.K.
Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol
BMC Biochem.
8
8
2007
Bos taurus
George, J.; Struthers, A.D.
The role of urate and xanthine oxidase inhibitors in cardiovascular disease
Cardiovasc. Ther.
26
59-64
2008
Homo sapiens, Rattus norvegicus
Huang, X.F.; Li, H.Q.; Shi, L.; Xue, J.Y.; Ruan, B.F.; Zhu, H.L.
Synthesis of resveratrol analogues, and evaluation of their cytotoxic and xanthine oxidase inhibitory activities
Chem. Biodivers.
5
636-642
2008
Homo sapiens
Liu, X.; Chen, R.; Shang, Y.; Jiao, B.; Huang, C.
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats
Chem. Biol. Interact.
176
137-142
2008
Rattus norvegicus
Sato, E.; Mokudai, T.; Niwano, Y.; Kamibayashi, M.; Kohno, M.
Existence of a new reactive intermediate oxygen species in hypoxanthine and xanthine oxidase reaction
Chem. Pharm. Bull.
56
1194-1197
2008
Bos taurus
Luchtemberg, M.N.; Petronilho, F.; Constantino, L.; Gelain, D.P.; Andrades, M.; Ritter, C.; Moreira, J.C.; Streck, E.L.; Dal-Pizzol, F.
Xanthine oxidase activity in patients with sepsis
Clin. Biochem.
41
1186-1190
2008
Homo sapiens
Loftus, J.P.; Belknap, J.K.; Stankiewicz, K.M.; Black, S.J.
Laminar xanthine oxidase, superoxide dismutase and catalase activities in the prodromal stage of black-walnut induced equine laminitis
Equine Vet. J.
39
48-53
2007
Equus caballus
Reigan, P.; Gbaj, A.; Stratford, I.J.; Bryce, R.A.; Freeman, S.
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors
Eur. J. Med. Chem.
43
1248-1260
2008
Bos taurus
Gupta, S.; Rodrigues, L.M.; Esteves, A.P.; Oliveira-Campos, A.M.; Nascimento, M.S.; Nazareth, N.; Cidade, H.; Neves, M.P.; Fernandes, E.; Pinto, M.; Cerqueira, N.M.; Bras, N.
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors
Eur. J. Med. Chem.
43
771-780
2008
Homo sapiens
You, Z.L.; Shi, D.H.; Xu, C.; Zhang, Q.; Zhu, H.L.
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase
Eur. J. Med. Chem.
43
862-871
2008
Mus musculus
Inkster, M.E.; Cotter, M.A.; Cameron, N.E.
Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats
Eur. J. Pharmacol.
561
63-71
2007
Rattus norvegicus
Chang, Y.C.; Lee, F.W.; Chen, C.S.; Huang, S.T.; Tsai, S.H.; Huang, S.H.; Lin, C.M.
Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities
Free Radic. Biol. Med.
43
1541-1551
2007
Mus musculus
Shin, M.H.; Moon, Y.J.; Seo, J.E.; Lee, Y.; Kim, K.H.; Chung, J.H.
Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression
Free Radic. Biol. Med.
44
635-645
2008
Homo sapiens
Aranda, R.; Domenech, E.; Rus, A.D.; Real, J.T.; Sastre, J.; Vina, J.; Pallardo, F.V.
Age-related increase in xanthine oxidase activity in human plasma and rat tissues
Free Radic. Res.
41
1195-1200
2007
Homo sapiens, Rattus norvegicus
Ohta, Y.; Matsura, T.; Kitagawa, A.; Tokunaga, K.; Yamada, K.
Xanthine oxidase-derived reactive oxygen species contribute to the development of D-galactosamine-induced liver injury in rats
Free Radic. Res.
41
135-144
2007
Rattus norvegicus
Lavelli, V.
Antioxidant activity of minimally processed red chicory (Cichorium intybus L.) evaluated in xanthine oxidase-, myeloperoxidase-, and diaphorase-catalyzed reactions
J. Agric. Food Chem.
56
7194-7200
2008
Bos taurus
Pauff, J.M.; Zhang, J.; Bell, C.E.; Hille, R.
Substrate orientation in xanthine oxidase: crystal structure of enzyme in reaction with 2-hydroxy-6-methylpurine
J. Biol. Chem.
283
4818-4824
2008
Bos taurus (P80457)
Hayashi, K.; Kimata, H.; Obata, K.; Matsushita, A.; Fukata, A.; Hashimoto, K.; Noda, A.; Iwase, M.; Koike, Y.; Yokota, M.; Nagata, K.
Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters
J. Card. Fail.
14
238-244
2008
Mesocricetus auratus
Khosravan, R.; Kukulka, M.J.; Wu, J.T.; Joseph-Ridge, N.; Vernillet, L.
The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
J. Clin. Pharmacol.
48
1014-1024
2008
Homo sapiens
Wang, G.F.; Shang, Y.J.; Jiao, B.H.; Huang, C.G.
Renierol from marine sponge Haliclona sp.: a natural inhibitor of xanthine oxidase with hypouricemic effects
J. Enzyme Inhib. Med. Chem.
23
406-410
2008
Mus musculus
Liu, X.; Chen, R.; Shang, Y.; Jiao, B.; Huang, C.
Superoxide radicals scavenging and xanthine oxidase inhibitory activity of magnesium lithospermate B from Salvia miltiorrhiza
J. Enzyme Inhib. Med. Chem.
24
663-668
2008
Mus musculus
Matesanz, N.; Lafuente, N.; Azcutia, V.; Martin, D.; Cuadrado, A.; Nevado, J.; Rodriguez-Manas, L.; Sanchez-Ferrer, C.F.; Peiro, C.
Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases
J. Hypertens.
25
609-618
2007
Homo sapiens
Mostefai, H.A.; Agouni, A.; Carusio, N.; Mastronardi, M.L.; Heymes, C.; Henrion, D.; Andriantsitohaina, R.; Martinez, M.C.
Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells
J. Immunol.
180
5028-5035
2008
Homo sapiens
Devrim, E.; Avci, A.; Ergueder, I.B.; Karagenc, N.; Kuelah, B.; Durak, I.
Activities of xanthine oxidase and superoxide dismutase enzymes in rat intestinal tissues in sepsis
J. Trauma
64
733-735
2008
Rattus norvegicus
Zhao, L.; Roche, B.M.; Wessale, J.L.; Kijtawornrat, A.; Lolly, J.L.; Shemanski, D.; Hamlin, R.L.
Chronic xanthine oxidase inhibition following myocardial infarction in rabbits: effects of early versus delayed treatment
Life Sci.
82
495-502
2008
Oryctolagus cuniculus
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V.; Oginskaya, E.
Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivative
Neoplasma
54
229-234
2007
Mus musculus
Sanchez-Lozada, L.G.; Tapia, E.; Soto, V.; Avila-Casado, C.; Franco, M.; Zhao, L.; Johnson, R.J.
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia
Nephrol. Dial. Transplant.
23
1179-1185
2008
Rattus norvegicus
Kaszaki, J.; Palasthy, Z.; Erczes, D.; Racz, A.; Torday, C.; Varga, G.; Vecsei, L.; Boros, M.
Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs
Neurogastroenterol. Motil.
20
53-62
2008
Canis lupus familiaris
Tsujii, A.; Nishino, T.
Mechanism of transition from xanthine dehydrogenase to xanthine oxidase: Effect of guanidine-HCl or urea on the activity
Nucleosides Nucleotides Nucleic Acids
27
881-887
2008
Bos taurus
Kudo, M.; Moteki, T.; Sasaki, T.; Konno, Y.; Ujiie, S.; Onose, A.; Mizugaki, M.; Ishikawa, M.; Hiratsuka, M.
Functional characterization of human xanthine oxidase allelic variants
Pharmacogenet. Genomics
18
243-251
2008
Homo sapiens
Yan, H.; Ma, Y.; Liu, M.; Zhou, L.
The dual actions of Paederia scandens extract as a hypouricemic agent: xanthine oxidase inhibitory activity and uricosuric effect
Planta Med.
74
1345-1350
2008
Rattus norvegicus
Soucy, K.G.; Lim, H.K.; Benjo, A.; Santhanam, L.; Ryoo, S.; Shoukas, A.A.; Vazquez, M.E.; Berkowitz, D.E.
Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta
Radiat. Environ. Biophys.
46
179-186
2007
Rattus norvegicus
Mittal, A.; Phillips, A.R.; Loveday, B.; Windsor, J.A.
The potential role for xanthine oxidase inhibition in major intra-abdominal surgery
World J. Surg.
32
288-295
2008
Felis silvestris, Homo sapiens, Mus musculus, Rattus norvegicus
Mukoyoshi, M.; Nishimura, S.; Hoshide, S.; Umeda, S.; Kanou, M.; Taniguchi, K.; Muroga, H.
In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition
Xenobiotica
38
496-510
2008
Homo sapiens
Hadizadeh, M.; Keyhani, E.; Keyhani, J.; Khodadadi, C.
Functional and structural alterations induced by copper in xanthine oxidase
Acta Biochim. Biophys. Sin.
41
603-617
2009
Bos taurus
Rashidi, M.R.; Soruraddin, M.H.; Taherzadeh, F.; Jouyban, A.
Catalytic activity and stability of xanthine oxidase in aqueous-organic mixtures
Biochemistry (Moscow)
74
97-101
2009
Bos taurus
Carro, M.D.; Falkenstein, E.; Radke, W.J.; Klandorf, H.
Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens
Comp. Biochem. Physiol. C
151
12-17
2009
Gallus gallus
Nishino, T.; Okamoto, K.; Eger, B.T.; Pai, E.F.; Nishino, T.
Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase
FEBS J.
275
3278-3289
2008
Bos taurus, Rattus norvegicus
Sousa, C.; Pereira, D.M.; Valentao, P.; Ferreres, F.; Pereira, J.A.; Seabra, R.M.; Andrade, P.B.
Pieris brassicae inhibits xanthine oxidase
J. Agric. Food Chem.
57
2288-2294
2009
Bos taurus
Kelley, E.E.; Batthyany, C.I.; Hundley, N.J.; Woodcock, S.R.; Bonacci, G.; Del Rio, J.M.; Schopfer, F.J.; Lancaster, J.R.; Freeman, B.A.; Tarpey, M.M.
Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase
J. Biol. Chem.
283
36176-36184
2008
Bos taurus
Iswantini, D.; Darusman, L.; Hidayat, R.
Indonesian Sidaguri (Sida rhombifolia L.) as antigout and inhibition kinetics of flavonoids crude extract on the activity of xanthine oxidase
J. Biol. Sci.
9
504-508
2009
Homo sapiens
-
Haidari, F.; Ali Keshavarz, S.; Reza Rashidi, M.; Mohammad Shahi, M.
Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity
J. Clin. Biochem. Nutr.
45
285-291
2009
Rattus norvegicus
Murata, K.; Nakao, K.; Hirata, N.; Namba, K.; Nomi, T.; Kitamura, Y.; Moriyama, K.; Shintani, T.; Iinuma, M.; Matsuda, H.
Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
J. Nat. Med.
63
355-359
2009
Bos taurus
Pauff, J.M.; Hille, R.
Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin
J. Nat. Prod.
72
725-731
2009
Bos taurus
Naoghare, P.K.; Kwon, H.T.; Song, J.M.
On-chip assay for determining the inhibitory effects and modes of action of drugs against xanthine oxidase
J. Pharm. Biomed. Anal.
51
1-6
2010
Homo sapiens
Tan, W.J.; Xu, J.C.; Li, L.; Chen, K.L.
Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei
Nat. Prod. Res.
23
393-398
2009
Selaginella labordei
Boumerfeg, S.; Baghiani, A.; Messaoudi, D.; Khennouf, S.; Arrar, L.
Antioxidant properties and xanthine oxidase inhibitory effects of Tamus communis L. root extracts
Phytother. Res.
23
283-288
2009
Bos taurus, Ovis aries, Homo sapiens
Zarepour, M.; Kaspari, K.; Stagge, S.; Rethmeier, R.; Mendel, R.R.; Bittner, F.
Xanthine dehydrogenase AtXDH1 from Arabidopsis thaliana is a potent producer of superoxide anions via its NADH oxidase activity
Plant Mol. Biol.
72
301-310
2009
Arabidopsis thaliana
Chien, S.C.; Yang, C.W.; Tseng, Y.H.; Tsay, H.S.; Kuo, Y.H.; Wang, S.Y.
Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice
Planta Med.
75
302-306
2009
Mus musculus
Hu, L.; Hu, H.; Wu, W.; Chai, X.; Luo, J.; Wu, Q.
Discovery of novel xanthone derivatives as xanthine oxidase inhibitors
Bioorg. Med. Chem. Lett.
21
4013-4015
2011
Bos taurus
Sathisha, K.R.; Khanum, S.A.; Chandra, J.N.; Ayisha, F.; Balaji, S.; Marathe, G.K.; Gopal, S.; Rangappa, K.S.
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives
Bioorg. Med. Chem.
19
211-220
2011
Bos taurus, Rattus norvegicus
Amini, K.; Sorouraddin, M.; Rashidi, M.
Activity and stability of rat liver xanthine oxidase in the presence of pyridine
Can. J. Chem.
89
1-7
2011
Rattus norvegicus
-
Tai, L.A.; Hwang, K.C.
Regulation of xanthine oxidase activity by substrates at active sites via cooperative interactions between catalytic subunits: implication to drug pharmacokinetics
Curr. Med. Chem.
18
69-78
2011
Bos taurus
Wang, S.; Yan, J.; Wang, J.; Chen, J.; Zhang, T.; Zhao, Y.; Xue, M.
Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors
Eur. J. Med. Chem.
45
2663-2670
2010
Bos taurus
Huang, J.; Wang, S.; Zhu, M.; Chen, J.; Zhu, X.
Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice
Food Chem. Toxicol.
49
1943-1947
2011
Mus musculus, Mus musculus BALB/c
Cao, H.; Pauff, J.; Hille, R.
Substrate orientation and the origin of catalytic power in xanthine oxidoreductase
Indian J. Chem.
50A
355-362
2011
Bos taurus
-
Shanmugam, M.; Zhang, B.; McNaughton, R.L.; Kinney, R.A.; Hille, R.; Hoffman, B.M.
The structure of formaldehyde-inhibited xanthine oxidase determined by 35 GHz 2H ENDOR spectroscopy
J. Am. Chem. Soc.
132
14015-14017
2010
Bos taurus
Okamoto, K.; Kawaguchi, Y.; Eger, B.; Pai, E.; Nishino, T.
Crystal structures of urate bound form of xanthine oxidoreductase: Substrate orientation and structure of the key reaction intermediate
J. Am. Chem. Soc.
132
17080-17083
2010
Bos taurus, Rattus norvegicus (P22985)
Cao, H.; Pauff, J.M.; Hille, R.
Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid
J. Biol. Chem.
285
28044-28053
2010
Bos taurus (P80457)
Gibbings, S.; Elkins, N.D.; Fitzgerald, H.; Tiao, J.; Weyman, M.E.; Shibao, G.; Fini, M.A.; Wright, R.M.
Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha
J. Biol. Chem.
286
961-975
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Berner, J.M.; Van der Westhuizen, A.J.
Inhibition of xanthine oxidase activity results in the inhibition of Russian wheat aphid-induced defense enzymes
J. Chem. Ecol.
36
1375-1380
2010
Triticum aestivum, Triticum aestivum Tugela DN
Metz, S.; Thiel, W.
QM/MM studies of xanthine oxidase: variations of cofactor, substrate, and active-site Glu802
J. Phys. Chem. B
114
1506-1517
2010
Bos taurus
Bytyqi-Damoni, A.; Genc, H.; Zengin, M.; Beyaztas, S.; Gencer, N.; Arslan, O.
In vitro effect of novel beta-lactam compounds on xanthine oxidase enzyme activity
Artif. Cells Blood Substit. Immobil. Biotechnol.
40
369-377
2012
Bos taurus
Cao, H.; Hall, J.; Hille, R.
Substrate Orientation and Specificity in Xanthine Oxidase: Crystal structures of the enzyme in complex with indole-3-acetaldehyde and guanine
Biochemistry
53
533-541
2014
Bos taurus
Zhang, Y.; Xin, Y.; Yang, H.; Zhang, L.; Xia, X.; Tong, Y.; Chen, Y.; Wang, W.
Thermal inactivation of xanthine oxidase from Arthrobacter M3: mechanism and the corresponding thermostabilization strategy
Bioprocess Biosyst. Eng.
37
719-725
2014
Arthrobacter
Jankowska, D.A.; Trautwein-Schult, A.; Cordes, A.; Hoferichter, P.; Klein, C.; Bode, R.; Baronian, K.; Kunze, G.
Arxula adeninivorans xanthine oxidoreductase and its application in the production of food with low purine content
J. Appl. Microbiol.
115
796-807
2013
Blastobotrys adeninivorans (R4ZGN4)
Zhang, Y.; Xin, Y.; Yang, H.; Zhang, L.; Xia, X.; Tong, Y.; Chen, Y.; Ma, L.; Wang, W.
Novel affinity purification of xanthine oxidase from Arthrobacter M3
J. Chromatogr. B
906
19-24
2012
Arthrobacter sp.
Xin, Y.; Yang, H.; Xia, X.; Zhang, L.; Zhang, Y.; Cheng, C.; Wang, W.
Expression, purification and partial characterization of a xanthine oxidase (XOD) in Arthrobacter sp
Process Biochem.
47
1539-1544
2012
Arthrobacter sp.
-
Kumar, D.; Kaur, G.; Negi, A.; Kumar, S.; Singh, S.; Kumar, R.
Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives
Bioorg. Chem.
57
57-64
2014
Bos taurus (P80457)
Zafar, H.; Hayat, M.; Saied, S.; Khan, M.; Salar, U.; Malik, R.; Choudhary, M.I.; Khan, K.M.
Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides a systematic approach from in vitro, in silico to in vivo studies
Bioorg. Med. Chem.
25
2351-2371
2017
Bos taurus (P80457)
Zhang, Y.; Yang, H.; Xin, Y.; Zhang, L.; Wang, W.
Enhancing xanthine oxidase fermentation with pH-shift strategy based on kinetic analysis by Arthrobacter M3
Bioprocess Biosyst. Eng.
37
1899-1905
2014
Arthrobacter sp., Arthrobacter sp. M3
Dai, Y.; Cao, Y.; Zhang, Z.; Vallurupalli, S.; Mehta, J.L.
Xanthine oxidase induces foam cell formation through LOX-1 and NLRP3 activation
Cardiovasc. Drugs Ther.
31
19-27
2017
Homo sapiens
Lopez-Cruz, R.I.; Perez-Milicua, M.B.; Crocker, D.E.; Gaxiola-Robles, R.; Bernal-Vertiz, J.A.; de la Rosa, A.; Vazquez-Medina, J.P.; Zenteno-Savin, T.
Purine nucleoside phosphorylase and xanthine oxidase activities in erythrocytes and plasma from marine, semiaquatic and terrestrial mammals
Comp. Biochem. Physiol. A
171
31-35
2014
Tursiops truncatus, Lontra longicaudis annectens, Sus scrofa (F1S3Y7), Mirounga angustirostris (H9A5F8), Mirounga angustirostris, Homo sapiens (P47989), Homo sapiens
Tang, H.J.; Zhang, X.W.; Yang, L.; Li, W.; Li, J.H.; Wang, J.X.; Chen, J.
Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzo[b]furan derivatives based on salvianolic acid C
Eur. J. Med. Chem.
124
637-648
2016
Bos taurus (P80457)
Nishino, T.; Okamoto, K.; Kawaguchi, Y.; Matsumura, T.; Eger, B.T.; Pai, E.F.; Nishino, T.
The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
FEBS J.
282
3075-3090
2015
Rattus norvegicus (P22985)
Sharma, N.K.; Thakur, S.; Thakur, N.; Savitri, N.; Bhalla, T.C.
Thermostable xanthine oxidase activity from Bacillus pumilus RL-2d isolated from Manikaran thermal spring production and characterization
Indian J. Microbiol.
56
88-98
2016
Bacillus pumilus, Bacillus pumilus RL-2d
Lin, S.; Zhang, G.; Liao, Y.; Pan, J.
Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism
Int. J. Biol. Macromol.
81
274-282
2015
Bos taurus (P80457)
Di Majo, D.; La Guardia, M.; Leto, G.; Crescimanno, M.; Flandina, C.; Giammanco, M.
Flavonols and flavan-3-ols as modulators of xanthine oxidase and manganese superoxide dismutase activity
Int. J. Food Sci. Nutr.
65
886-892
2014
Bos taurus (P80457)
Masuoka, N.; Kubo, I.
Suppression of superoxide anion generation catalyzed by xanthine oxidase with alkyl caffeates and the scavenging activity
Int. J. Food Sci. Nutr.
67
283-287
2016
Bos taurus (P80457)
Hall, J.; Reschke, S.; Cao, H.; Leimkuehler, S.; Hille, R.
The reductive half-reaction of xanthine dehydrogenase from Rhodobacter capsulatus the role of Glu232 in catalysis
J. Biol. Chem.
289
32121-32130
2014
Rhodobacter capsulatus (O54050)
Beyaztas, S.; Arslan, O.
Purification of xanthine oxidase from bovine milk by affinity chromatography with a novel gel
J. Enzyme Inhib. Med. Chem.
30
442-447
2015
Bos taurus (P80457), Bos taurus
de Araujo, M.E.M.B.; Franco, Y.E.M.; Alberto, T.G.; Messias, M.C.F.; Leme, C.W.; Sawaya, A.C.H.F.; Carvalho, P.O.
Kinetic study on the inhibition of xanthine oxidase by acylated derivatives of flavonoids synthesised enzymatically
J. Enzyme Inhib. Med. Chem.
32
978-985
2017
Bos taurus (P80457)
Baldissera, M.D.; Souza, C.F.; Doleski, P.H.; Monteiro, S.G.; da Silva, A.S.; Baldisserotto, B.
Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis The influence of these enzymes on inflammatory and oxidative status
J. Fish Dis.
41
263-268
2018
Bagrus bajad
Cao, H.; Pauff, J.M.; Hille, R.
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin
J. Nat. Prod.
77
1693-1699
2014
Bos taurus (P80457)
Souza, C.F.; Verdi, C.M.; Baldissera, M.D.; Doleski, P.H.; Vizzotto, B.S.; Santos, R.C.V.; Baldisserotto, B.
Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae
Microb. Pathog.
113
25-28
2017
Bagrus bajad
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