Information on EC 1.17.3.1 - pteridine oxidase

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The expected taxonomic range for this enzyme is: Ricinus communis

EC NUMBER
COMMENTARY hide
1.17.3.1
-
RECOMMENDED NAME
GeneOntology No.
pteridine oxidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + (?)
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)
Different from EC 1.17.3.2 xanthine oxidase; does not act on hypoxanthine.
CAS REGISTRY NUMBER
COMMENTARY hide
74082-65-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
castor bean
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-amino-4-hydroxypteridine + O2
2-amino-4,7-dihydroxypteridine + ?
show the reaction diagram
additional information
?
-
-
other electron acceptors such as ferricyanide, cytochrome c, 2,6-dichlorophenol indophenol and methylene blue are ineffective, enzyme does not act on hypoxanthine
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-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-amino-4-hydroxypteridine + O2
2-amino-4,7-dihydroxypteridine + ?
show the reaction diagram
-
catabolism of purines via pteridines in plants
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hypoxanthine
-
-
xanthine
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-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.016
hypoxanthine
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.2 - 8.1
-
half-maximal activity at pH 5.2 and 8.1
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
germinating, endosperm tissue
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
310000
-
gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial, using ammonium sulfate precipitation followed by gradient elution from a Celite column
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