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Reference on EC 1.17.1.4 - xanthine dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Battelli, M.G.; Lorenzoni, E.
Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver
Biochem. J.
207
133-138
1982
Rattus sp.
Manually annotated by BRENDA team
Eger, B.T.; Okamoto, K.; Enroth, C.; Sato, M.; Nishino, T.; Pai, E.F.; Nishino, T.
Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk
Acta Crystallogr. Sect. D
56
1656-1658
2000
Bos taurus
-
Manually annotated by BRENDA team
Bruguera, P.; Lopez-Cabrera, A.; Canela, E.I.
Kinetic mechanism of chicken liver xanthine dehydrogenase
Biochem. J.
249
171-178
1988
Gallus gallus
Manually annotated by BRENDA team
Wajner, M.; Harkness, R.A.
Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues
Biochem. Soc. Trans.
16
358-359
1988
Oryctolagus cuniculus, Homo sapiens
-
Manually annotated by BRENDA team
Wajner, M.; Harkness, R.A.
Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues
Biochim. Biophys. Acta
991
79-84
1989
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Stark, K.; Seubert, P.; Lynch, G.; Baudry, M.
Proteolytic conversion of xanthine dehydrogenase to xanthine oxidase: Evidence against a role for calcium-activated protease (calpain)
Biochem. Biophys. Res. Commun.
165
858-864
1989
Rattus sp.
Manually annotated by BRENDA team
Adams, B.; Lowe, D.J.; Smith, A.T.; Scazzocchio, C.; Demais, S.; Bray, R.C.
Expression of Drosophila melanogaster xanthine dehydrogenase in Aspergillus nidulans and some properties of the recombinant enzyme
Biochem. J.
362
223-229
2002
Drosophila melanogaster
Manually annotated by BRENDA team
Kim, J.M.; Schmid, R.D.
Purification and characterization of a microbial xanthine dehydrogenase highly active towards hypoxanthine
GBF Monogr. , Biosens. Appl. Med. , Environ. Prot. Process Control
13
421-424
1989
Pseudomonas putida
-
Manually annotated by BRENDA team
Parschat, K.; Canne, C.; Huttermann, J.; Kappl, R.; Fetzner, S.
Xanthine dehydrogenase from Pseudomonas putida 86: Specificity, oxidation-reduction potentials of its redox-active centers, and first EPR characterization
Biochim. Biophys. Acta
1544
151-165
2001
Pseudomonas putida, Pseudomonas putida 86
Manually annotated by BRENDA team
Morita, Y.; Sawada, M.; Seno, H.; Takaishi, S.; Fukutawa, H.; Miyake, N.; Hiai, H.; Chiba, T.
Identification of xanthine dehydrogenase/xanthine oxidase as a rat paneth cell zinc-binding protein
Biochim. Biophys. Acta
1540
43-49
2001
Rattus sp.
Manually annotated by BRENDA team
Enroth, C.; Eger, B.T.; Okamoto, K.; Nishino, T.; Nishino, T.; Pai, E.F.
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
Proc. Natl. Acad. Sci. USA
97
10723-10728
2000
Bos taurus
Manually annotated by BRENDA team
McManaman, J.L.; Neville, M.C.; Wright, R.M.
Mouse mammary gland xanthine oxidoreductase: Purification, characterization, and regulation
Arch. Biochem. Biophys.
371
308-316
1999
Mus musculus
Manually annotated by BRENDA team
Schrder, T.; Rienhfer, A.; Andreesen, J.R.
Selenium-containing xanthine dehydrogenase from Eubacterium barkeri
Eur. J. Biochem.
264
862-871
1999
Eubacterium barkeri
Manually annotated by BRENDA team
Ichimori, K.; Fukahori, M.; Nakazawa, H.; Okamoto, K.; Nishino, T.
Inhibition of xanthine oxidase and xanthine dehydrogenase by nitric oxid
J. Biol. Chem.
274
7763-7768
1999
Bos taurus
Manually annotated by BRENDA team
Montalbini, P.
Purification and some properties of xanthine dehydrogenase from wheat leaves
Plant Sci.
134
89-102
1998
Triticum aestivum
-
Manually annotated by BRENDA team
Christiansen, L.C.; Schou, S.; Nygaard, P.; Saxild, H.H.
Xanthine metabolism in Bacillus subtilis: Characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in the xanthine salvage and catabolism
J. Bacteriol.
179
2540-2550
1997
Bacillus subtilis
Manually annotated by BRENDA team
Gremer, L.; Meyer, O.
Characterization of xanthine dehydrogenase from the anaerobic bacterium Veillonella atypica and identification of molybdopterin-cytosine-dinucleotide-containing molybdenum cofactor
Eur. J. Biochem.
238
862-866
1996
Veillonella atypica
Manually annotated by BRENDA team
Suleiman, S.A.; Stevens, J.B.
Purification of xanthine dehydrogenase from rat liver: A rapid procedure with high enzyme yields
Arch. Biochem. Biophys.
258
219-225
1987
Rattus sp.
Manually annotated by BRENDA team
Irie, S.
Subunit constitution of electrophoretically purified xanthine dehydrogenase of avian liver
J. Biochem.
95
405-412
1984
Gallus gallus
Manually annotated by BRENDA team
Prez-Vicente, R.; Pineda, M.; Cardenas, J.
Occurrence of an NADH diaphorase activity associated with xanthine dehydrogenase in Chlamydomonas reinhardtii
FEMS Microbiol. Lett.
43
321-325
1987
Chlamydomonas reinhardtii
-
Manually annotated by BRENDA team
Fhaolain, I.N.; Coughlan, M.P.
Effects of limited proteolysis on the structure and activity of turkey liver xanthine dehydrogenase
Biochem. Soc. Trans.
5
1705-1707
1977
Meleagris gallopavo
Manually annotated by BRENDA team
Rocher-Chambonnet, C.; Berreur, P.; Houde, M.; Tiveron, M.C.; Lepesant, J.A.; Bregegere, F.
Cloning and partial characterization of the xanthine dehydrogenase gene of Calliphora vicina, a distant relative of Drosophila melanogaster
Gene
59
201-212
1987
Calliphora vicina
Manually annotated by BRENDA team
Schopfer, L.M.; Massey, V.; Nishino, T.
Rapid reaction studies on the reduction and oxidation of chicken liver xanthine dehydrogenase by the xanthine/urate and NAD/NADH couples
J. Biol. Chem.
263
13528-13538
1988
Gallus gallus
Manually annotated by BRENDA team
Self, W.T.; Stadtman, T.C.
Selenium-dependent metabolism of purines: A selenium-dependent purine hydroxylase and xanthine dehydrogenase were purified from Clostridium purinolyticum and characterized
Proc. Natl. Acad. Sci. USA
97
7208-7213
2000
Gottschalkia purinilytica
Manually annotated by BRENDA team
Hughes, R.K.; Doyle, W.A.; Chovnick, A.; Whittle, J.R.S.; Burke, J.F.; Bray, R.C.
Use of rosy mutant strains of Drosophila melanogaster to probe the structure and function of xanthine dehydrogenase
Biochem. J.
285
507-513
1992
Drosophila melanogaster
-
Manually annotated by BRENDA team
Rajagopalan, K.V.; Handler, P.
Purification and properties of chicken liver xanthine dehydrogenase
J. Biol. Chem.
242
4097-4107
1967
Gallus gallus
Manually annotated by BRENDA team
Waud, W.R.; Rajagopalan, K.V.
Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase
Arch. Biochem. Biophys.
172
354-364
1976
Rattus sp.
Manually annotated by BRENDA team
Sin, I.L.
Purification and properties of xanthine dehydrogenase from Pseudomonas acidovorans
Biochim. Biophys. Acta
410
12-20
1975
Delftia acidovorans
Manually annotated by BRENDA team
Della Corte, E.; Stirpe, F.
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme
Biochem. J.
126
739-745
1972
Gallus gallus, no activity in Columba livia, Rattus sp.
Manually annotated by BRENDA team
Xiang, Q.; Edmondson, D.E.
Purification and characterization of a prokaryotic xanthine dehydrogenase from Comamonas acidovorans
Biochemistry
35
5441-5450
1996
Delftia acidovorans
Manually annotated by BRENDA team
Doyle, W.A.; Burke, J.F.; Chovnick, A.; Dutton, F.L.; Whittle, J.R.S.; Bray, R.C.
Properties of xanthine dehydrogenase variants from rosy mutant strains of Drosophila melanogaster and their relevance to the enzyme's structure and mechanism
Eur. J. Biochem.
239
782-795
1996
Drosophila melanogaster
Manually annotated by BRENDA team
Wright, R.M.; Vaitaitis, G.M.; Wilson, C.M.; Repine, T.B.; Terada, L.S.; Repine, J.E.
cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase
Proc. Natl. Acad. Sci. USA
90
10690-10694
1993
Homo sapiens
Manually annotated by BRENDA team
Leydecker, M.T.; Moureaux, T.; Kraepiel, Y.; Schnorr, K.; Caboche, M.
Molybdenum cofactor mutants, specifically impaired in xanthine dehydrogenase activity and abscisic acid biosynthesis, simultaneously overexpress nitrate reductase
Plant Physiol.
107
1427-1431
1995
Nicotiana plumbaginifolia
Manually annotated by BRENDA team
Waud, W.R.; Rajagopalan, K.V.
The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O)
Arch. Biochem. Biophys.
172
365-379
1976
Bos taurus, Rattus sp.
Manually annotated by BRENDA team
Hunt, J.; Massey, V.
Purification and properties of milk xanthine dehydrogenase
J. Biol. Chem.
267
21479-21485
1992
Bos taurus
Manually annotated by BRENDA team
Nguyen, J.; Feierabend, J.
Some properties and subcellular localization of xanthine dehydrogenase in pea leaves
Plant Sci. Lett.
13
125-132
1978
Pisum sativum
-
Manually annotated by BRENDA team
Perez-Vicente, R.; Alamillo, J.M.; Cardenas, J.; Pineda, M.
Purification and substrate inactivation of xanthine dehydrogenase from Chlamydomonas reinhardtii
Biochim. Biophys. Acta
1117
159-166
1992
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Panus, P.C.; Burgess, B.; Freeman, B.A.
Characterization of cultured alveolar epithelial cell xanthine dehydrogenase/oxidase
Biochim. Biophys. Acta
1091
303-309
1991
Rattus sp.
Manually annotated by BRENDA team
Wagner, R.; Cammack, R.; Andreesen, J.R.
Purification and characterization of xanthine dehydrogenase from Clostridium acidiurici grown in the presence of selenium
Biochim. Biophys. Acta
791
63-74
1984
Gottschalkia acidurici
-
Manually annotated by BRENDA team
Woolfolk, C.A.
Purification and properties of a novel ferricyanide-linked xanthine dehydrogenase from Pseudomonas putida 40
J. Bacteriol.
163
600-609
1985
Pseudomonas putida
Manually annotated by BRENDA team
Woolfolk, C.A.; Downard, J.S.
Distribution of xanthine oxidase and xanthine dehydrogenase specificity types among bacteria
J. Bacteriol.
130
1175-1191
1977
Alcaligenes sp., Arthrobacter sp., Bacillus sp. (in: Bacteria), Streptomyces sp., Clostridium sp., Escherichia sp., Penicillium sp., Lactobacillus sp., no activity in Klebsiella sp., Nocardia sp., Peptococcus sp., Pseudomonas sp., Pseudomonas putida, Serratia sp., Veillonella sp., Pseudomonas putida 40
Manually annotated by BRENDA team
Yen, T.T.T.; Glassman, E.
Electrophoretic variants of xanthine dehydrogenase in Drosophila melanogaster: II. Enzyme kinetics
Biochim. Biophys. Acta
146
35-44
1967
Bos taurus, Drosophila melanogaster
Manually annotated by BRENDA team
Seybold, W.D.
Purification and partial characterization of xanthine dehydrogenase from Drosophila melanogaster
Biochim. Biophys. Acta
334
266-271
1974
Drosophila melanogaster
-
Manually annotated by BRENDA team
Smith, S.T.; Rajagopalan, K.V.; Handler, P.
Purification and properties of xanthine dehydrogenase from Micrococcus lactilyticus
J. Biol. Chem.
242
4108-4117
1967
Veillonella atypica
Manually annotated by BRENDA team
Hughes, R.K.; Bennett, B.; Bray, R.C.
Xanthine dehydrogenase from Drosophila melanogaster: Purification and properties of the wild-type enzyme and of a variant lacking iron-sulfur centers
Biochemistry
31
3073-3083
1992
Drosophila melanogaster
Manually annotated by BRENDA team
Kaminski, Z.W.; Jezewska, M.M.
Effect of NADH on hypoxanthine hydroxylation by native NAD+-dependent xanthine oxidoreductase of rat liver, and the possible biological role of this effect
Biochem. J.
200
597-603
1981
Rattus sp.
Manually annotated by BRENDA team
Kaminsky, Z.W.; Jezewska, M.M.
Involvement of a single thiol group in the conversion of the NAD+-dependent activity of rat liver xanthine oxidoreductase to the O2-dependent activity
Biochem. J.
207
341-346
1982
Rattus sp.
Manually annotated by BRENDA team
Topham, R.W.; Walker, M.C.; Calisch, M.
Liver xanthine dehydrogenase and iron mobilization
Biochem. Biophys. Res. Commun.
109
1240-1246
1982
Rattus sp.
Manually annotated by BRENDA team
Triplett, E.W.; Blevins, D.G.; Randall, D.D.
Purification and properties of soybean nodule xanthine dehydrogenase
Arch. Biochem. Biophys.
219
39-46
1982
Glycine max
Manually annotated by BRENDA team
Truglio, J.J.; Theis, K.; Leimkuhler, S.; Rappa, R.; Rajagopalan, K.V.; Kisker, C.
Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus
Structure
10
115-125
2002
Rhodobacter capsulatus
Manually annotated by BRENDA team
Lyon, E.S.; Garrett, R.H.
Regulation, purification, and properties of xanthine dehydrogenase in Neurospora crassa
J. Biol. Chem.
253
2604-2614
1978
Neurospora crassa
Manually annotated by BRENDA team
Parzen, S.D.; Fox, A.S.
Purification of xanthine dehydrogenase from Drosophila melanogaster
Biochim. Biophys. Acta
92
465-471
1964
Drosophila melanogaster
Manually annotated by BRENDA team
Coolbear, K.P.; Herzberg, G.R.; Brosnan, J.T.
Xanthine dehydrogenase in chicken liver: Its subcelluar localization ant its possible role on gluconeogenesis from amino acids
Biochem. Soc. Trans.
9
394-395
1981
Gallus gallus
-
Manually annotated by BRENDA team
Watt, W.B.
Xanthine dehydrogenase and pteridine metabolism in Colias butterflies
J. Biol. Chem.
247
1445-1451
1972
Colias eurytheme
Manually annotated by BRENDA team
Aretz, W.; Kaspari, H.; Klemme, J.H.
Molecular and kinetic characterization of xanthine dehydrogenase from the phototrophic bacterium Rodopseudomonas capsulata
Z. Naturforsch. C
36
933-941
1981
Rhodobacter capsulatus
-
Manually annotated by BRENDA team
Boland, M.J.; Blevins, D.G.; Randall, D.D.
Soybean nodule xanthine dehydrogenase: A kinetic study
Arch. Biochem. Biophys.
222
435-441
1983
Glycine max
Manually annotated by BRENDA team
Edwards, T.C.R.; Candido, E.P.M.
Xanthine dehydrogenase from Drosophila melanogaster. A comparison of the kinetic parameters of the pure enzyme from two wild-type isoalleles differing at a putative regulatory site
Mol. Gen. Genet.
154
1-6
1977
Drosophila melanogaster
Manually annotated by BRENDA team
Fernandez, E.; Cardenas, J.
Occurrence of xanthine dehydrogenase in Chlamydomonas reinhardii: A common cofactor shared by xanthine dehydrogenase and nitrate reductase
Planta
153
254-257
1981
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
Tramper, J.; Angelino, S.A.G.F.; Muller, F.; van der Plas, H.C.
Kinetics and stability of immobilized chicken liver xanthine dehydrogenase
Biotechnol. Bioeng.
21
1767-1786
1979
Gallus gallus
Manually annotated by BRENDA team
Wagner, R.; Andreesen, J.R.
Selenium requirement for active xanthine dehydrogenase from Clostridium acidiurici and Clostridium cylindrosporum
Arch. Microbiol.
121
255-260
1979
Clostridium cylindrosporum, Gottschalkia acidurici
Manually annotated by BRENDA team
Coughlan, M.P.; Johnson, D.B.
The inactivation of xanthine-oxidizing enzymes, native and deflavo forms, in the presence of oxygen
Biochem. Soc. Trans.
7
18-21
1979
Meleagris gallopavo
Manually annotated by BRENDA team
Ohe, T.; Watanabe, Y.
Purification and properties of xanthine dehydrogenase from Streptomyces cyanogenus
J. Biochem.
86
45-53
1979
Streptomyces cyanogenus
Manually annotated by BRENDA team
Sakai, T.; Jun, H.K.
Purification, crystallization, and some properties of xanthine dehydrogenase from Pseudomonas synxantha A 3
Agric. Biol. Chem.
43
753-760
1979
Pseudomonas synxantha
-
Manually annotated by BRENDA team
Nakamura, M.; Yamazaki, I.
Preparation of bovine milk xanthine oxidase as a dehydrogenase form
J. Biochem.
92
1279-1286
1982
Bos taurus
Manually annotated by BRENDA team
Taylor, N.J.; Cowan, A.K.
Xanthine dehydrogenase and aldehyde oxidase impact plant hormone homeostasis and affect fruit size in 'Hass' avocado
J. Plant Res.
117
121-130
2004
Persea americana
Manually annotated by BRENDA team
Frederiks, W.M.; Vreeling-Sindelarova, H.
Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells
Acta Histochem.
104
29-37
2002
Rattus norvegicus
Manually annotated by BRENDA team
Baghiani, A.; Harrison, R.; Benboubetra, M.
Purification and partial characterisation of camel milk xanthine oxidoreductase
Arch. Physiol. Biochem.
111
407-414
2003
Camelus dromedarius
Manually annotated by BRENDA team
Ivanov, N.V.; Hubalek, F.; Trani, M.; Edmondson, D.E.
Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase
Eur. J. Biochem.
270
4744-4754
2003
Delftia acidovorans (Q8RLC0), Delftia acidovorans (Q8RLC1)
Manually annotated by BRENDA team
Self, W.T.
Regulation of purine hydroxylase and xanthine dehydrogenase from Clostridium purinolyticum in response to purines, selenium, and molybdenum
J. Bacteriol.
184
2039-2044
2002
Gottschalkia purinilytica
Manually annotated by BRENDA team
Nishino, T.; Amaya, Y.; Kawamoto, S.; Kashima, Y.; Okamoto, K.
Purification and characterization of multiple forms of rat liver xanthine oxidoreductase expressed in baculovirus-insect cell system
J. Biochem.
132
597-606
2002
Rattus norvegicus
Manually annotated by BRENDA team
Okamoto, K.; Eger, B.T.; Nishino, T.; Kondo, S.; Pai, E.F.
An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
J. Biol. Chem.
278
1848-1855
2003
Bos taurus (P80457)
Manually annotated by BRENDA team
Leimkuhler, S.; Hodson, R.; George, G.N.; Rajagopalan, K.V.
Recombinant Rhodobacter capsulatus xanthine dehydrogenase, a useful model system for the characterization of protein variants leading to xanthinuria I in humans
J. Biol. Chem.
278
20802-20811
2003
Bos taurus, Rhodobacter capsulatus
Manually annotated by BRENDA team
Hesberg, C.; Hansch, R.; Mendel, R.R.; Bittner, F.
Tandem orientation of duplicated xanthine dehydrogenase genes from Arabidopsis thaliana: differential gene expression and enzyme activities
J. Biol. Chem.
279
13547-13554
2004
Arabidopsis thaliana (Q8GUQ8), Arabidopsis thaliana
Manually annotated by BRENDA team
Leimkuhler, S.; Stockert, A.L.; Igarashi, K.; Nishino, T.; Hille, R.
The role of active site glutamate residues in catalysis of Rhodobacter capsulatus xanthine dehydrogenase
J. Biol. Chem.
279
40437-40444
2004
Rhodobacter capsulatus
Manually annotated by BRENDA team
Nishino, T.; Okamoto, K.; Kawaguchi, Y.; Hori, H.; Matsumura, T.; Eger, B.T.; Pai, E.F.
Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant
J. Biol. Chem.
280
24888-24894
2005
Rattus norvegicus
Manually annotated by BRENDA team
Benboubetra, M.; Baghiani, A.; Atmani, D.; Harrison, R.
Physicochemical and kinetic properties of purified sheep's milk xanthine oxidoreductase
J. Dairy Sci.
87
1580-1584
2004
Bos taurus, Capra hircus, Homo sapiens, Ovis aries
Manually annotated by BRENDA team
Yesbergenova, Z.; Yang, G.; Oron, E.; Soffer, D.; Fluhr, R.; Sagi, M.
The plant Mo-hydroxylases aldehyde oxidase and xanthine dehydrogenase have distinct reactive oxygen species signatures and are induced by drought and abscisic acid
Plant J.
42
862-876
2005
Arabidopsis thaliana, Solanum lycopersicum
Manually annotated by BRENDA team
Sauer, P.; Frebortova, J.; Sebela, M.; Galuszka, P.; Jacobsen, S.; Pec, P.; Frebort, I.
Xanthine dehydrogenase of pea seedlings: a member of the plant molybdenum oxidoreductase family
Plant Physiol. Biochem.
40
393-400
2002
Pisum sativum
-
Manually annotated by BRENDA team
Okamoto, K.; Matsumoto, K.; Hille, R.; Eger, B.T.; Pai, E.F.; Nishino, T.
The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition
Proc. Natl. Acad. Sci. USA
101
7931-7936
2004
Bos taurus (P80457)
Manually annotated by BRENDA team
Ivanov, N.V.; Trani, M.; Edmondson, D.E.
High-level expression and characterization of a highly functional Comamonas acidovorans xanthine dehydrogenase in Pseudomonas aeruginosa
Protein Expr. Purif.
37
72-82
2004
Delftia acidovorans
Manually annotated by BRENDA team
Joshi, M.S.; Rajagopalan, K.V.
Specific incorporation of molybdopterin in xanthine dehydrogenase of Pseudomonas aeruginosa
Arch. Biochem. Biophys.
308
331-334
1994
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Johnson, J.L.; Chaudhury, M.; Rajagopalan, K.V.
Identification of a molybdopterin-containing molybdenum cofactor in xanthine dehydrogenase from Pseudomonas aeruginosa
BioFactors
3
103-107
1991
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Abdulnour, R.E.; Peng, X.; Finigan, J.H.; Han, E.J.; Hasan, E.J.; Birukov, K.G.; Reddy, S.P.; Watkins, J.E.; Kayyali, U.S.; Garcia, J.G.; Tuder, R.M.; Hassoun, P.M.
Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
Am. J. Physiol. Lung Cell Mol. Physiol.
291
L345-L353
2006
Mus musculus
Manually annotated by BRENDA team
Godber, B.L.; Schwarz, G.; Mendel, R.R.; Lowe, D.J.; Bray, R.C.; Eisenthal, R.; Harrison, R.
Molecular characterization of human xanthine oxidoreductase: the enzyme is grossly deficient in molybdenum and substantially deficient in iron-sulphur centres
Biochem. J.
388
501-508
2005
Bos taurus, Homo sapiens (P47989)
Manually annotated by BRENDA team
Cheung, K.J.; Tzameli, I.; Pissios, P.; Rovira, I.; Gavrilova, O.; Ohtsubo, T.; Chen, Z.; Finkel, T.; Flier, J.S.; Friedman, J.M.
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity
Cell Metab.
5
115-128
2007
Mus musculus
Manually annotated by BRENDA team
Maia, L.; Vala, A.; Mira, L.
NADH oxidase activity of rat liver xanthine dehydrogenase and xanthine oxidase-contribution for damage mechanisms
Free Radic. Res.
39
979-986
2005
Rattus norvegicus
Manually annotated by BRENDA team
Atmani, D.; Baghiani, A.; Harrison, R.; Benboubetra, M.
NADH oxidation and superoxide production by caprine milk xanthine oxidoreductase
Int. Dairy J.
15
1113-1121
2005
Capra hircus
Manually annotated by BRENDA team
Yamaguchi, Y.; Matsumura, T.; Ichida, K.; Okamoto, K.; Nishino, T.
Human Xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
J. Biochem.
141
513-524
2007
Homo sapiens
Manually annotated by BRENDA team
Asai, R.; Nishino, T.; Matsumura, T.; Okamoto, K.; Igarashi, K.; Pai, E.F.; Nishino, T.
Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase
J. Biochem.
141
525-534
2007
Rattus norvegicus (P22985)
Manually annotated by BRENDA team
Neumann, M.; Schulte, M.; Juenemann, N.; Stoecklein, W.; Leimkuehler, S.
Rhodobacter capsulatus XdhC is involved in molybdenum cofactor binding and insertion into xanthine dehydrogenase
J. Biol. Chem.
281
15701-15708
2006
Rhodobacter capsulatus
Manually annotated by BRENDA team
Pauff, J.M.; Hemann, C.F.; Juenemann, N.; Leimkuehler, S.; Hille, R.
The role of arginine 310 in catalysis and substrate specificity in xanthine dehydrogenase from Rhodobacter capsulatus
J. Biol. Chem.
282
12785-12790
2007
Rhodobacter capsulatus
Manually annotated by BRENDA team
Roberts, L.E.; Fini, M.A.; Derkash, N.; Wright, R.M.
PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor
J. Cell. Biochem.
101
1567-1587
2007
Rattus norvegicus
Manually annotated by BRENDA team
Zhao, X.; Zhu, J.X.; Mo, S.F.; Pan, Y.; Kong, L.D.
Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver
J. Ethnopharmacol.
103
357-365
2006
Mus musculus
Manually annotated by BRENDA team
Omura, K.; Nakazawa, T.; Sato, T.; Iwanaga, T.; Nagata, O.
Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor
Drug Metab. Dispos.
35
2143-2148
2007
Homo sapiens
Manually annotated by BRENDA team
Silanikove, N.; Shapiro, F.
Distribution of xanthine oxidase and xanthine dehydrogenase activity in bovine milk: Physiological and technological implications
Int. Dairy J.
17
1188-1194
2007
Bos taurus
Manually annotated by BRENDA team
Hagopian, K.
Rat liver xanthine oxidoreductase: effect of adenine on the oxidase and dehydrogenase activities
Ital. J. Biochem.
56
6-17
2007
Rattus norvegicus
Manually annotated by BRENDA team
Le, A.; Damico, R.; Damarla, M.; Boueiz, A.; Pae, H.H.; Skirball, J.; Hasan, E.; Peng, X.; Chesley, A.; Crow, M.T.; Reddy, S.P.; Tuder, R.M.; Hassoun, P.M.
Alveolar cell apoptosis is dependent on p38-MAPK-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury
J. Appl. Physiol.
105
1282-1290
2008
Homo sapiens
Manually annotated by BRENDA team
Maia, L.; Duarte, R.O.; Ponces-Freire, A.; Moura, J.J.; Mira, L.
NADH oxidase activity of rat and human liver xanthine oxidoreductase: potential role in superoxide production
J. Biol. Inorg. Chem.
12
777-787
2007
Rattus norvegicus
Manually annotated by BRENDA team
Fini, M.A.; Orchard-Webb, D.; Kosmider, B.; Amon, J.D.; Kelland, R.; Shibao, G.; Wright, R.M.
Migratory activity of human breast cancer cells is modulated by differential expression of xanthine oxidoreductase
J. Cell. Biochem.
1005
1008-1026
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Khobragade, C.N.; Bodade, R.G.; Shinde, M.S.; Jaju, D.R.; Bhosle, R.B.; Dawane, B.S.
Microbial and xanthine dehydrogenase inhibitory activity of some flavones
J. Enzyme Inhib. Med. Chem.
23
341-346
2008
Fusarium verticillioides, Gallus gallus, Microsporum canis, Penicillium chrysogenum, Serratia marcescens, Staphylococcus aureus, Trichoderma viride
Manually annotated by BRENDA team
Isabelle, M.; Vergeade, A.; Moritz, F.; Dautreaux, B.; Henry, J.P.; Lallemand, F.; Richard, V.; Mulder, P.; Thuillez, C.; Monteil, C.
NADPH oxidase inhibition prevents cocaine-induced up-regulation of xanthine oxidoreductase and cardiac dysfunction
J. Mol. Cell. Cardiol.
42
326-332
2007
Rattus norvegicus
Manually annotated by BRENDA team
Okamoto, K.; Nishino, T.
Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors: allopurinol, febuxostat, and FYX-051
J. Nippon Med. Sch.
75
2-3
2008
Bos taurus
Manually annotated by BRENDA team
Corpas, F.J.; Palma, J.M.; Sandalio, L.M.; Valderrama, R.; Barroso, J.B.; Del Rio, L.A.
Peroxisomal xanthine oxidoreductase: Characterization of the enzyme from pea (Pisum sativum L.) leaves
J. Plant Physiol.
165
1319-1330
2008
Pisum sativum (B3FYT9)
Manually annotated by BRENDA team
Tsujii, A.; Nishino, T.
Mechanism of transition from xanthine dehydrogenase to xanthine oxidase: Effect of guanidine-HCl or urea on the activity
Nucleosides Nucleotides Nucleic Acids
27
881-887
2008
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Okamoto, K.; Eger, B.T.; Nishino, T.; Pai, E.F.; Nishino, T.
Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol
Nucleosides Nucleotides Nucleic Acids
27
888-893
2008
Bos taurus
Manually annotated by BRENDA team
Sulikowski, T.; Domanski, L.; Ciechanowski, K.; Adler, G.; Pawlik, A.; Safranow, K.; Dziedziejko, V.; Chlubek, D.; Ciechanowicz, A.
Effect of trimetazidine on xanthine oxidoreductase expression in rat kidney with ischemia-reperfusion injury
Arch. Med. Res.
39
459-462
2008
Rattus norvegicus
Manually annotated by BRENDA team
Kaminsky, Y.; Kosenko, C.I.e.
Brain purine metabolism and xanthine dehydrogenase/oxidase conversion in hyperammonemia are under control of NMDA receptors and nitric oxide
Brain Res.
1294
193-201
2009
Rattus norvegicus
Manually annotated by BRENDA team
Carro, M.D.; Falkenstein, E.; Radke, W.J.; Klandorf, H.
Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens
Comp. Biochem. Physiol. C
151
12-17
2009
Gallus gallus
Manually annotated by BRENDA team
Nishino, T.; Okamoto, K.; Eger, B.T.; Pai, E.F.; Nishino, T.
Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase
FEBS J.
275
3278-3289
2008
Bos taurus, Gallus gallus, Homo sapiens, Rattus norvegicus, Rhodobacter capsulatus
Manually annotated by BRENDA team
Schumann, S.; Saggu, M.; Moeller, N.; Anker, S.D.; Lendzian, F.; Hildebrandt, P.; Leimkuehler, S.
The mechanism of assembly and cofactor insertion into Rhodobacter capsulatus xanthine dehydrogenase
J. Biol. Chem.
283
16602-16611
2008
Rhodobacter capsulatus
Manually annotated by BRENDA team
Dietzel, U.; Kuper, J.; Doebbler, J.A.; Schulte, A.; Truglio, J.J.; Leimkuehler, S.; Kisker, C.
Mechanism of substrate and inhibitor binding of Rhodobacter capsulatus xanthine dehydrogenase
J. Biol. Chem.
284
8768-8776
2009
Rhodobacter capsulatus (O54050)
Manually annotated by BRENDA team
Taibi, G.; Carruba, G.; Miceli, V.; Cocciadiferro, L.; Nicotra, C.M.
Estradiol decreases xanthine dehydrogenase enzyme activity and protein expression in non-tumorigenic and malignant human mammary epithelial cells
J. Cell. Biochem.
108
688-692
2009
Homo sapiens
Manually annotated by BRENDA team
Haidari, F.; Ali Keshavarz, S.; Reza Rashidi, M.; Mohammad Shahi, M.
Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity
J. Clin. Biochem. Nutr.
45
285-291
2009
Rattus norvegicus
Manually annotated by BRENDA team
Taibi, G.; Di Gaudio, F.; Nicotra, C.M.
Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells
J. Enzyme Inhib. Med. Chem.
23
317-327
2008
Homo sapiens
Manually annotated by BRENDA team
Haidari, F.; Rashidi, M.R.; Keshavarz, S.A.; Mahboob, S.A.; Eshraghian, M.R.; Shahi, M.M.
Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats
Pak. J. Biol. Sci.
11
1779-1784
2008
Rattus norvegicus
Manually annotated by BRENDA team
Zarepour, M.; Kaspari, K.; Stagge, S.; Rethmeier, R.; Mendel, R.R.; Bittner, F.
Xanthine dehydrogenase AtXDH1 from Arabidopsis thaliana is a potent producer of superoxide anions via its NADH oxidase activity
Plant Mol. Biol.
72
301-310
2009
Arabidopsis thaliana, Arabidopsis thaliana (Q8GUQ8)
Manually annotated by BRENDA team
Carro, M.D.; Falkenstein, E.; Blemings, K.P.; Klandorf, H.
Determination of xanthine oxidoreductase activity in broilers: effect of pH and temperature of the assay and distribution in tissues
Poult. Sci.
88
2406-2414
2009
Gallus gallus
Manually annotated by BRENDA team
Shimo, T.; Ashizawa, N.; Moto, M.; Matsumoto, K.; Iwanaga, T.; Nagata, O.
FYX-051, a xanthine oxidoreductase inhibitor, induces nephropathy in rats, but not in monkeys
Toxicol. Pathol.
37
438-445
2009
Rattus norvegicus
Manually annotated by BRENDA team
Cao, H.; Pauff, J.; Hille, R.
Substrate orientation and the origin of catalytic power in xanthine oxidoreductase
Indian J. Chem.
50
355-362
2011
Rhodobacter capsulatus
-
Manually annotated by BRENDA team
Okamoto, K.; Kawaguchi, Y.; Eger, B.; Pai, E.; Nishino, T.
Crystal structures of urate bound form of xanthine oxidoreductase: Substrate orientation and structure of the key reaction intermediate
J. Am. Chem. Soc.
132
17080-17083
2010
Bos taurus, Rattus norvegicus (P22985)
Manually annotated by BRENDA team
Srivastava, M.; Mallard, C.; Barke, T.; Hancock, L.E.; Self, W.T.
A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production
J. Bacteriol.
193
1643-1652
2011
Enterococcus faecalis
Manually annotated by BRENDA team
Ishikita, H.; Eger, B.T.; Okamoto, K.; Nishino, T.; Pai, E.F.
Protein conformational gating of enzymatic activity in xanthine oxidoreductase
J. Am. Chem. Soc.
134
999-1009
2012
Bos taurus (P80457)
Manually annotated by BRENDA team
Kalimuthu, P.; Leimkuehler, S.; Bernhardt, P.V.
Catalytic electrochemistry of xanthine dehydrogenase
J. Phys. Chem. B
116
11600-11607
2012
Rhodobacter capsulatus
Manually annotated by BRENDA team
Chen, C.; Cheng, G.; Hao, H.; Dai, M.; Wang, X.; Huang, L.; Liu, Z.; Yuan, Z.
Mechanism of porcine liver xanthine oxidoreductase mediated N-oxide reduction of cyanoacetylhydrazone 2-formylquinoxaline-1,4-dioxide as revealed by docking and mutagenesis studies
PLoS ONE
8
e73912
2013
Sus scrofa
Manually annotated by BRENDA team
Settle, T.; Carro, M.D.; Falkenstein, E.; Radke, W.; Klandorf, H.
The effects of allopurinol, uric acid, and inosine administration on xanthine oxidoreductase activity and uric acid concentrations in broilers
Poult. Sci.
91
2895-2903
2012
Gallus gallus
Manually annotated by BRENDA team
Correia, M.A.; Otrelo-Cardoso, A.R.; Schwuchow, V.; Sigfridsson Clauss, K.G.; Haumann, M.; Romao, M.J.; Leimkuehler, S.; Santos-Silva, T.
The Escherichia coli periplasmic aldehyde oxidoreductase is an exceptional member of the xanthine oxidase family of molybdoenzymes
ACS Chem. Biol.
11
2923-2935
2016
Escherichia coli (P77165 and P77324 and P77489), Escherichia coli
Manually annotated by BRENDA team
Sarauli, D.; Borowski, A.; Peters, K.; Schulz, B.; Fattakhova-Rohlfing, D.; Leimkuehler, S.; Lisdat, F.
Investigation of the pH-dependent impact of sulfonated polyaniline on bioelectrocatalytic activity of xanthine dehydrogenase
ACS Catal.
6
7152-7159
2016
Rhodobacter capsulatus (O54050 AND O54051)
-
Manually annotated by BRENDA team
Wang, C.; Li, G.; Zhang, C.; Xing, X.
Enhanced catalytic properties of novel (alphabetagamma)2 heterohexameric Rhodobacter capsulatus xanthine dehydrogenase by separate expression of the redox domains in Escherichia coli
Biochem. Eng. J.
119
1-8
2017
Rhodobacter capsulatus (O54050 AND O54051 AND Q9X7K2), Rhodobacter capsulatus CGMCC 1.3366 (O54050 AND O54051 AND Q9X7K2)
-
Manually annotated by BRENDA team
Wang, C.H.; Zhang, C.; Xing, X.H.
Xanthine dehydrogenase an old enzyme with new knowledge and prospects
Bioengineered
7
395-405
2016
Acinetobacter baumannii, Enterobacter cloacae, Bos taurus, Gallus gallus, Clostridium cylindrosporum, Drosophila melanogaster, Ovis aries, Homo sapiens, Micrococcus sp., Pseudomonas putida, Rattus norvegicus, Rhodobacter capsulatus, Streptomyces cyanogenus, Acinetobacter phage Ab105-3phi, Arthrobacter luteolus, Escherichia coli (Q46799 AND Q46800), Arabidopsis thaliana (Q8GUQ8), Rhodobacter capsulatus B10XDHB
Manually annotated by BRENDA team
Wang, C.H.; Zhang, C.; Xing, X.H.
Metabolic engineering of Escherichia coli cell factory for highly active xanthine dehydrogenase production
Biores. Technol.
245
1782-1789
2017
Rhodobacter capsulatus (O54050 AND O54051), Rhodobacter capsulatus CGMCC 1.3366 (O54050 AND O54051)
Manually annotated by BRENDA team
Isoe, J.; Petchampai, N.; Isoe, Y.E.; Co, K.; Mazzalupo, S.; Scaraffia, P.Y.
Xanthine dehydrogenase-1 silencing in Aedes aegypti mosquitoes promotes a blood feeding-induced adulticidal activity
FASEB J.
31
2276-2286
2017
Aedes aegypti (A0A1S4F2J6), Aedes aegypti (A0A1S4G2F8), Aedes aegypti
Manually annotated by BRENDA team
Nishino, T.; Okamoto, K.; Kawaguchi, Y.; Matsumura, T.; Eger, B.T.; Pai, E.F.; Nishino, T.
The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
FEBS J.
282
3075-3090
2015
Rattus norvegicus (P22985)
Manually annotated by BRENDA team
Reschke, S.; Mebs, S.; Sigfridsson-Clauss, K.G.; Kositzki, R.; Leimkuehler, S.; Haumann, M.
Protonation and sulfido versus oxo ligation changes at the molybdenum cofactor in xanthine dehydrogenase (XDH) variants studied by X-ray absorption spectroscopy
Inorg. Chem.
56
2165-2176
2017
Rhodobacter capsulatus
Manually annotated by BRENDA team
Hall, J.; Reschke, S.; Cao, H.; Leimkuehler, S.; Hille, R.
The reductive half-reaction of xanthine dehydrogenase from Rhodobacter capsulatus the role of Glu232 in catalysis
J. Biol. Chem.
289
32121-32130
2014
Rhodobacter capsulatus (O54050 AND O54051)
Manually annotated by BRENDA team
Watanabe, S.; Kounosu, Y.; Shimada, H.; Sakamoto, A.
Arabidopsis xanthine dehydrogenase mutants defective in purine degradation show a compromised protective response to drought and oxidative stress
Plant Biotechnol.
31
173-178
2014
Arabidopsis thaliana (Q8GUQ8), Arabidopsis thaliana Col-0 (Q8GUQ8)
-
Manually annotated by BRENDA team
You, S.; Zhu, B.; Wang, F.; Han, H.; Sun, M.; Zhu, H.; Peng, R.; Yao, Q.
A Vitis vinifera xanthine dehydrogenase gene, VvXDH, enhances salinity tolerance in transgenic Arabidopsis
Plant Biotechnol. Rep.
11
147-160
2017
Vitis vinifera (F6GU50)
-
Manually annotated by BRENDA team
Hofmann, N.
Opposing functions for plant xanthine dehydrogenase in response to powdery mildew infection production and scavenging of reactive oxygen species
Plant Cell
28
1001
2016
Mammalia, Arabidopsis thaliana (Q8GUQ8), Arabidopsis thaliana Col-0 (Q8GUQ8)
Manually annotated by BRENDA team
Ma, X.; Wang, W.; Bittner, F.; Schmidt, N.; Berkey, R.; Zhang, L.; King, H.; Zhang, Y.; Feng, J.; Wen, Y.; Tan, L.; Li, Y.; Zhang, Q.; Deng, Z.; Xiong, X.; Xiao, S.
Dual and opposing roles of xanthine dehydrogenase in defense-associated reactive oxygen species metabolism in Arabidopsis
Plant Cell
28
1108-1126
2016
Arabidopsis thaliana (Q8GUQ8), Arabidopsis thaliana Col-0 (Q8GUQ8)
Manually annotated by BRENDA team
Takei, M.; Kogure, S.; Yokoyama, C.; Kouzuma, Y.; Suzuki, Y.
Identification of an aldehyde oxidase involved in indole-3-acetic acid synthesis in Bombyx mori silk gland
Biosci. Biotechnol. Biochem.
83
129-136
2019
Bombyx mori (Q17209)
Manually annotated by BRENDA team