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Information on EC 1.16.1.8 - [methionine synthase] reductase

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EC Tree
     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.8 [methionine synthase] reductase
IUBMB Comments
In humans, the enzyme is a flavoprotein containing FAD and FMN. The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13, methionine synthase. Electrons are transferred from NADPH to FAD to FMN. Defects in this enzyme lead to hereditary hyperhomocysteinemia.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
methionine synthase reductase, nadph-dependent diflavin oxidoreductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosyl-L-homocysteine + NADP+ = 2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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