Information on EC 1.14.99.49 - 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase

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The expected taxonomic range for this enzyme is: Streptomyces carzinostaticus

EC NUMBER
COMMENTARY hide
1.14.99.49
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RECOMMENDED NAME
GeneOntology No.
2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2 = 2,7-dihydroxy-5-methyl-1-naphthoate + oxidized acceptor + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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Biosynthesis of enediyne antibiotics
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SYSTEMATIC NAME
IUBMB Comments
2-hydroxy-5-methyl-1-naphthoate,hydrogen-donor:oxygen oxidoreductase (7-hydroxylating)
A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P-450
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a heme-thiolate protein
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
heterologous expression of the gene together with ncsB and ncsB1 in Streptomyces lividans TK24
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