Information on EC 1.14.21.11 - (-)-pluviatolide synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.21.11
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RECOMMENDED NAME
GeneOntology No.
(-)-pluviatolide synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(-)-matairesinol + NADPH + H+ + O2 = (-)-pluviatolide + NADP+ + 2 H2O
show the reaction diagram
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
hinokinin biosynthesis
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yatein biosynthesis I
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SYSTEMATIC NAME
IUBMB Comments
(-)-matairesinol,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)
The enzyme, characterized from the plants Sinopodophyllum hexandrum and Podophyllum peltatum, catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene CYP719A24
UniProt
Manually annotated by BRENDA team
gene CYP719A23
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P450
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NADPH
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene CYP719A23, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis
gene CYP719A24, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis