Information on EC 1.14.19.38 - acyl-lipid DELTA6-acetylenase

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The expected taxonomic range for this enzyme is: Ceratodon purpureus

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EC NUMBER
COMMENTARY hide
1.14.19.38
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RECOMMENDED NAME
GeneOntology No.
acyl-lipid DELTA6-acetylenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(1)
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a stearidonoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dicranin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
DELTA6 acyl-lipid,ferrocytochrome-b5:oxygen oxidoreductase (6,7-dehydrogenating)
The enzyme, characterized from the moss Ceratodon purpureus, converts the double bond at position 6 of gamma-linolenate and stearidonate into a triple bond. The product of the latter, dicranin, is the main fatty acid found in C. purpureus. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The enzyme also has the activity of EC 1.14.19.47, acyl-lipid (9-3)-desaturase.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
gamma-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
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?
stearidonoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
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?
additional information
?
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the bifunctional enzyme can introduce a DELTA6-cis-double bond into 9,12,(15)-C18-polyenoic acids as well as converting a DELTA6-cis-double bond to a DELTA6-triple bond
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
gamma-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
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?
stearidonoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
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?
additional information
?
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the bifunctional enzyme can introduce a DELTA6-cis-double bond into 9,12,(15)-C18-polyenoic acids as well as converting a DELTA6-cis-double bond to a DELTA6-triple bond
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome b5
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain InvSc1
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.19.38)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)