Information on EC 1.14.19.38 - acyl-lipid DELTA6-acetylenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Ceratodon purpureus

EC NUMBER
COMMENTARY hide
1.14.19.38
-
RECOMMENDED NAME
GeneOntology No.
acyl-lipid DELTA6-acetylenase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(1)
-
-
-
a stearidonoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(2)
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dicranin biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
DELTA6 acyl-lipid,ferrocytochrome-b5:oxygen oxidoreductase (6,7-dehydrogenating)
The enzyme, characterized from the moss Ceratodon purpureus, converts the double bond at position 6 of gamma-linolenate and stearidonate into a triple bond. The product of the latter, dicranin, is the main fatty acid found in C. purpureus. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The enzyme also has the activity of EC 1.14.19.47, acyl-lipid (9-3)-desaturase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
gamma-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
-
-
-
-
?
stearidonoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the bifunctional enzyme can introduce a DELTA6-cis-double bond into 9,12,(15)-C18-polyenoic acids as well as converting a DELTA6-cis-double bond to a DELTA6-triple bond
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
gamma-linolenoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
-
-
-
-
?
stearidonoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+
(9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-[glycerolipid] + ferricytochrome b5 + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the bifunctional enzyme can introduce a DELTA6-cis-double bond into 9,12,(15)-C18-polyenoic acids as well as converting a DELTA6-cis-double bond to a DELTA6-triple bond
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome b5
-
-
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain InvSc1
-