Information on EC 1.14.19.32 - palmitoyl-CoA 14-(E/Z)-desaturase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.19.32
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RECOMMENDED NAME
GeneOntology No.
palmitoyl-CoA 14-(E/Z)-desaturase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14E)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (14Z)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
SYSTEMATIC NAME
IUBMB Comments
palmitoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (14,15 cis/trans-dehydrogenating)
The enzyme, found in the moth Ostrinia furnacalis (Asian corn borer), produces a mixture of (E)- and (Z)- isomers. The products are subsequently truncated by partial beta-oxidation to a blend of 12(E/Z)-tetradec-12-enoyl-CoA, which are converted to the species-specific sex pheromones (E)- and (Z)-tetradec-12-enoyl acetates.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
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origin and evolution of the DELTA14 desaturase, phylogenetic analysis and tree, detailed overview
metabolism
physiological function
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the enzyme is involved in the synthesis of pheromone compound (Z,E)-9,12-tetradecadienyl acetate from pheromone precursor palmitoyl-CoA
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
(14E)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
(14Z)-hexadec-14-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
the enzyme expressed in a baculovirus insect cell system produces a mixture of E and Z isomers
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-
?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in a baculovirus insect cell system
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sequence comparions, phylogenetic analysis
transcriptome analysis, overview
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