Information on EC 1.14.19.19 - sphingolipid 10-desaturase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
1.14.19.19
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RECOMMENDED NAME
GeneOntology No.
sphingolipid 10-desaturase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (4E,8E)-sphinga-4,8-dienine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4E,8E,10E)-sphinga-4,8,10-trienine ceramide + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
a (4E,8E)-sphinga-4,8-dienine ceramide,ferrocytochrome b5:oxygen oxidoreductase (10,11 trans-dehydrogenating)
The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product. Similar triunsaturated sphingoid bases are found in some marine invertebrates. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(4E,8E)-sphinga-4,8-dienine ceramide + ferrocytochrome b5 + O2 + H+
(4E,8E,10E)-sphinga-4,8,10-trienine ceramide + ferricytochrome b5 + H2O
show the reaction diagram
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?
(4E,8E)-sphinga-4,8-dienine ceramide + flavoxoxin + O2 + H+
?
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(4E,8E)-sphinga-4,8-dienine ceramide + ferrocytochrome b5 + O2 + H+
(4E,8E,10E)-sphinga-4,8,10-trienine ceramide + ferricytochrome b5 + H2O
show the reaction diagram
Q4G2T3
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-
?
(4E,8E)-sphinga-4,8-dienine ceramide + flavoxoxin + O2 + H+
?
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
flavodoxin YkuN
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flavodoxin YkuP
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Bacillus subtilis strain LSC0400
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expressed in Yarrowia lipolytica strain ATCC 90811 and in Pichia pastoris strain PpDELTAc9m
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the expression or the activities of the enzyme is upregulated by a downshift in growth temperature to 25°C