Information on EC 1.14.19.14 - linoleoyl-lipid DELTA9 conjugase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.19.14
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RECOMMENDED NAME
GeneOntology No.
linoleoyl-lipid DELTA9 conjugase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a linoleoyl-[glycerolipid] + reduced acceptor + O2 = an (8E,10E,12Z)-octadeca-8,10,12-trienoyl-[glycerolipid] + acceptor + 2 H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
calendate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
linoleoyl-lipid,reduced acceptor:oxygen 8,11-allylic oxidase (8E,10E-forming)
The enzyme, characterized from the plant Calendula officinalis, converts a single cis double bond at position 9 of fatty acids incorporated into glycerolipids into two conjugated trans double bonds at positions 8 and 10.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
enzyme expression is occasionally associated with dramatic changes in morphology of the endoplasmic reticulum
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(6Z,9Z,12Z)-octadec-6,9,12-trienoyl-[glycerolipid] + reduced acceptor + O2
(6Z,9Z,11E,13E)-octadec-6,9,11,13-tetraenoyl -[glycerolipid] + acceptor + H2O
show the reaction diagram
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-
-
?
(9Z)-hexadec-9-enoyl -[glycerolipid] + reduced acceptor + O2
(9Z,12E)-hexadec-9,12-dienoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
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-
-
?
(9Z)-hexadec-9-enoyl-[glycerolipid] + reduced acceptor + O2
(8Z,10Z)-hexadec-8,10-dienoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
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weak activity
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-
?
(9Z)-octadec-9-enoyl-[glycerolipid] + reduced acceptor + O2
(8Z,10Z)-octadec-8,10-dienoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
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weak activity
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-
?
(9Z)-octadec-9-enoyl-[glycerolipid] + reduced acceptor + O2
(9Z,12E)-octadec-9,12-dienoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
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-
-
?
(9Z,12Z)-octadec-9,12-dienoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadec-8,10,12-trienoly-[glycerolipid] + acceptor + H2O
show the reaction diagram
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best substrate
i.e. calendic acid
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?
(9Z,12Z)-octadec-9,12-dienoyl-[glycerolipid] + reduced acceptor + O2
(9Z,11Z,13Z)-octadec-9,12,13-trienoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
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-
?
(9Z,12Z,15Z)-octadec-9,12,15-trienoyl-[glycerolipid] + reduced acceptor + O2
(9Z,11E,13E,15Z)-octadec-9,11,13,15-tetraenoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
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-
-
?
linoleoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadeca-8,10,12-trienoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
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(8E,10E,12Z)-octadeca-8,10,12-trienoate is calendic acid
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?
additional information
?
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FADX is a bifunctional enzyme with robust desaturase/conjugase activity
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(9Z,12Z)-octadec-9,12-dienoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadec-8,10,12-trienoly-[glycerolipid] + acceptor + H2O
show the reaction diagram
-
best substrate
i.e. calendic acid
-
?
linoleoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadeca-8,10,12-trienoyl-[glycerolipid] + acceptor + H2O
show the reaction diagram
Q9FPP7, Q9FPP8
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(8E,10E,12Z)-octadeca-8,10,12-trienoate is calendic acid
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?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
not detected in seed
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43600
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x * 43600, calculated from amino acid sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 43600, calculated from amino acid sequence
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Nicotiana tabacum BY-2 cells and in Saccharomyces cerevisiae
expressed in Saccharomyces cerevisiae strain AMY-2alpha
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expressed in somatic soybean embryos and in Saccharomyces cerevisiae INVSc1 cells; expressed in somatic soybean embryos and in Saccharomyces cerevisiae INVSc1 cells