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Reference on EC 1.14.19.1 - stearoyl-CoA 9-desaturase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fulco, A.J.; Bloch, K.
Cofactor requirements for the formation of DELTA9-unsaturated fatty acids in Mycobacterium phlei
J. Biol. Chem.
239
993-997
1964
Mycolicibacterium phlei
Manually annotated by BRENDA team
Oshino, N.; Imai, Y.; Sato, R.
A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes
J. Biochem.
69
155-167
1971
Rattus norvegicus
Manually annotated by BRENDA team
Strittmatter, P.; Spatz, L.; Corcoran, D.; Rogers, M.J.; Setlow, B.; Redline, R.
Purification and properties of rat liver microsomal stearyl coenzyme A desaturase
Proc. Natl. Acad. Sci. USA
71
4565-4569
1974
Rattus norvegicus, Rattus norvegicus Long-Evans
Manually annotated by BRENDA team
Joshi, V.C.; Prasad, M.R.; Sreekrishna, K.
Terminal enzyme of stearoyl-CoA desaturation from chicken liver
Methods Enzymol.
71
252-258
1981
Gallus gallus
Manually annotated by BRENDA team
Jones, D.P.; Gaylor, J.L.
A non-substrate-binding protein that stimulates microsomal stearyl-CoA desaturase
Methods Enzymol.
71
258-263
1981
Rattus norvegicus
Manually annotated by BRENDA team
Strittmatter, P.; Enoch, H.G.
Purification of stearyl-CoA desaturase from liver
Methods Enzymol.
52
188-193
1978
Rattus norvegicus, Rattus norvegicus Long-Evans
Manually annotated by BRENDA team
Fujiwara, Y.; Okayasu, T.; Ishibashi, T.; Imai, Y.
Immunochemical evidence for the enzymatic difference of DELTA6-desaturase from DELTA9- and DELTA5-desaturase in rat liver microsomes
Biochem. Biophys. Res. Commun.
110
36-41
1983
Rattus norvegicus
Manually annotated by BRENDA team
Foot, M.; Jeffcoat, R.; Russell, N.
Some properties, including the substrate in vivo, of the DELTA9-desaturase in Micrococcus cryophilus
Biochem. J.
209
345-353
1983
Psychrobacter urativorans
Manually annotated by BRENDA team
Wilson, A.C.; Miller, R.W.
Growth temperature-dependent stearoyl coenzyme A desaturase activity of Fusarium oxysporum microsomes
Can. J. Biochem.
56
1109-1114
1978
Fusarium oxysporum
Manually annotated by BRENDA team
Baker, N.; Lynen, F.
Factors involved in fatty acyl CoA desaturation by fungal microsomes. The relative roles of acyl CoA and phospholipids as substrates
Eur. J. Biochem.
19
200-210
1971
Neurospora crassa
Manually annotated by BRENDA team
Sreekrishna, K.; Joshi, V.C.
Inhibition of the microsomal stearoyl coenyme A desaturation by divalent copper and its chelates
Biochim. Biophys. Acta
619
267-273
1980
Gallus gallus
Manually annotated by BRENDA team
Scott, W.; Foote, J.L.
The inhibition of stearoyl-coenzyme A desaturase by phenyllactate and phenylpyruvate
Biochim. Biophys. Acta
573
197-200
1979
Rattus norvegicus
Manually annotated by BRENDA team
Jeffcoat, R.; Brawn, P.R.; Safford, R.; James, A.T.
Properties of rat liver microsomal stearoyl-coenzyme A desaturase
Biochem. J.
161
431-437
1977
Rattus norvegicus
Manually annotated by BRENDA team
Russell, N.J.
The positional specificity of a desaturase in the psychrophilic bacterium Micrococcus cryophilus (ATCC 15174)
Biochim. Biophys. Acta
531
179-186
1978
Psychrobacter urativorans
Manually annotated by BRENDA team
Jeffcoat, R.
The physiological role and control of mammalian fatty acyl-coenzyme A desaturases
Biochem. Soc. Trans.
5
811-818
1977
Gallus gallus, Rattus norvegicus
Manually annotated by BRENDA team
Prasad, M.R.; Joshi, V.C.
Purification and properties of hen liver microsomal terminal enzyme involved in stearoyl coenzyme A desaturation and its quantitation in neonatal chicks
J. Biol. Chem.
254
6362-6369
1979
Gallus gallus, Rattus norvegicus
Manually annotated by BRENDA team
Ghesquier, D.; Carreau, J.P.; Robert, J.C.; Abastado, M.; Cheret, A.M.; Lewin, M.J.M.
Cytochrome b5-dependent DELTA9 desaturation of fatty acids in gastric microsomes
Biochim. Biophys. Acta
751
349-354
1983
Sus scrofa
Manually annotated by BRENDA team
McDonald, T.M.; Kinsella, J.E.
Stearyl-CoA desaturase of bovine mammary microsomes
Arch. Biochem. Biophys.
156
223-231
1973
Bos taurus
Manually annotated by BRENDA team
Oshino, N.; Imai, Y.; Sato, R.
Electron-transfer mechanism associated with fatty acid desaturation catalyzed by liver microsomes
Biochim. Biophys. Acta
128
13-27
1966
Rattus norvegicus
Manually annotated by BRENDA team
Trueman, R.J.; Tiku, P.E.; Caddick, M.X.; Cossins, A.R.
Thermal thresholds of lipid restructuring and DELTA9-desaturase expression in the liver of carp (Cyprinus carpio L.)
J. Exp. Biol.
203
641-650
2000
Cyprinus carpio, Rattus norvegicus, Cyprinus carpio L.
Manually annotated by BRENDA team
Griffiths, G.; Griffiths, W.T.; Stobart, A.K.
DELTA-9 desaturase activity in developing cotyledons of sunflower (Helianthus annuus. L)
Phytochemistry
48
261-267
1998
Helianthus annuus
-
Manually annotated by BRENDA team
Mziaut, H.; Korza, G.; Elkahloun, A.G.; Ozols, J.
Induction of stearoyl CoA desaturase is associated with high-level induction of emerin RNA
Biochem. Biophys. Res. Commun.
282
910-915
2001
Cricetinae, Rattus norvegicus
Manually annotated by BRENDA team
Choi, Y.; Park, Y.; Pariza, M.W.; Ntambi, J.M.
Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid in HepG2 cells
Biochem. Biophys. Res. Commun.
284
689-693
2001
Homo sapiens
Manually annotated by BRENDA team
MacKenzie, D.A.; Carter, A.T.; Wongwathanarat, P.; Eagles, J.; Salt, J.; Archer, D.B.
A third fatty acid DELTA9-desaturase from Mortierella alpina with a different substrate specificity to ole1p and ole2p
Microbiology
148
1725-1735
2002
Mortierella alpina, Mortierella alpina CBS 528.72 / ATCC 32222
Manually annotated by BRENDA team
Marillia, E.F.; Giblin, E.M.; Covello, P.S.; Taylor, D.C.
A desaturase-like protein from white spruce is a DELTA9 desaturase
FEBS Lett.
526
49-52
2002
Picea glauca
Manually annotated by BRENDA team
Tiku, P.E.; Gracey, A.Y.; Macartney, A.I.; Beynon, R.J.; Cossins, A.R.
Cold-induced expression of DELTA9-desaturase in carp by transcriptional and posttranslational mechanisms
Science
271
815-818
1996
Cyprinus carpio
Manually annotated by BRENDA team
Macartney, A.I.; Tiku, P.E.; Cossins, A.R.
An isothermal induction of DELTA9-desaturase in cultured carp hepatocytes
Biochim. Biophys. Acta
1302
207-216
1996
Cyprinus carpio, Cyprinus carpio L.
Manually annotated by BRENDA team
Yang, Y.S.; Broadwater, J.A.; Pulver, S.C.; Fox, B.G.; Solomon, E.I.
Circular dichroism and magnetic circular dichroism studies of the reduced binuclear non-heme iron site of stearoyl-ACP DELTA9-desaturase: substrate binding and comparison to ribonucleotide reductase
J. Am. Chem. Soc.
121
2770-2783
1999
Spinacia oleracea
-
Manually annotated by BRENDA team
Miyazaki, M.; Kim, H.J.; Man, W.C.; Ntambi, J.M.
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol
J. Biol. Chem.
276
39455-39461
2001
Mus musculus
Manually annotated by BRENDA team
Kachroo, P.; Shanklin, J.; Shah, J.; Whittle, E.J.; Klessig, D.F.
A fatty acid desaturase modulates the activation of defense signaling pathways in plants
Proc. Natl. Acad. Sci. USA
98
9448-9453
2001
Arabidopsis sp.
Manually annotated by BRENDA team
Polley, S.D.; Tiku, P.E.; Trueman, R.T.; Caddick, M.X.; Morozov, I.Y.; Cossins, A.R.
Differential expression of cold- and diet-specific genes encoding two carp liver DELTA9-acyl-CoA desaturase isoforms
Am. J. Physiol.
284
R41-R50
2003
Cyprinus carpio (Q9PU86), Cyprinus carpio
Manually annotated by BRENDA team
Sakai, H.; Kajiwara, S.
A stearoyl-CoA-specific Delta 9 fatty acid desaturase from the basidiomycete Lentinula edodes
Biosci. Biotechnol. Biochem.
67
2431-2437
2003
Lentinula edodes (Q76C19), Lentinula edodes
Manually annotated by BRENDA team
Hsieh, S.L.; Kuo, C.M.
Stearoyl-CoA desaturase expression and fatty acid composition in milkfish (Chanos chanos) and grass carp (Ctenopharyngodon idella) during cold acclimation
Comp. Biochem. Physiol. B
141
95-101
2005
Ctenopharyngodon idella, Chanos chanos
Manually annotated by BRENDA team
Rodriguez, S.; Hao, G.; Liu, W.; Pina, B.; Rooney, A.P.; Camps, F.; Roelofs, W.L.; Fabrias, G.
Expression and evolution of DELTA9 and DELTA11 desaturase genes in the moth Spodoptera littoralis
Insect Biochem. Mol. Biol.
34
1315-1328
2004
Spodoptera littoralis
Manually annotated by BRENDA team
Awad, A.C.; Shin, H.S.; Romsos, D.R.; Gray, J.I.
Direct desaturation of free myristic acid by hen liver microsomal DELTA9-desaturase without prior activation to myristoyl-CoA derivative
J. Agric. Food Chem.
52
3194-3201
2004
Gallus gallus
Manually annotated by BRENDA team
Awad, A.C.; Shin, H.S.; Romsos, D.R.; Gray, J.I.
Desaturation of myristoyl-CoA to myristoleoyl-CoA by hen liver microsomal DELTA9-desaturase
J. Agric. Food Chem.
52
4234-4239
2004
Gallus gallus
Manually annotated by BRENDA team
Miyazaki, M.; Jacobson, M.J.; Man, W.C.; Cohen, P.; Asilmaz, E.; Friedman, J.M.; Ntambi, J.M.
Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
J. Biol. Chem.
278
33904-33911
2003
Mus musculus (P13011), Mus musculus
Manually annotated by BRENDA team
Jiang, G.; Li, Z.; Liu, F.; Ellsworth, K.; Dallas-Yang, Q.; Wu, M.; Ronan, J.; Esau, C.; Murphy, C.; Szalkowski, D.; Bergeron, R.; Doebber, T.; Zhang, B.B.
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1
J. Clin. Invest.
115
1030-1038
2005
Mus musculus
Manually annotated by BRENDA team
Siebert, B.D.; Pitchford, W.S.; Kruk, Z.A.; Kuchel, H.; Deland, M.P.; Bottema, C.D.
Differences in DELTA9 desaturase activity between Jersey- and Limousin-sired cattle
Lipids
38
539-543
2003
Bos taurus
Manually annotated by BRENDA team
Heilmann, I.; Pidkowich, M.S.; Girke, T.; Shanklin, J.
Switching desaturase enzyme specificity by alternate subcellular targeting
Proc. Natl. Acad. Sci. USA
101
10266-10271
2004
Arabidopsis thaliana
Manually annotated by BRENDA team
Wang, J.; Yu, L.; Schmidt, R.E.; Su, C.; Huang, X.; Gould, K.; Cao, G.
Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates
Biochem. Biophys. Res. Commun.
332
735-742
2005
Homo sapiens, Homo sapiens (Q86SK9)
Manually annotated by BRENDA team
Scaglia, N.; Caviglia, J.M.; Igal, R.A.
High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts
Biochim. Biophys. Acta
1687
141-151
2005
Homo sapiens
Manually annotated by BRENDA team
Doran, O.; Moule, S.K.; Teye, G.A.; Whittington, F.M.; Hallett, K.G.; Wood, J.D.
A reduced protein diet induces stearoyl-CoA desaturase protein expression in pig muscle but not in subcutaneous adipose tissue: relationship with intramuscular lipid formation
Br. J. Nutr.
95
609-617
2006
Sus scrofa
Manually annotated by BRENDA team
Hulver, M.W.; Berggren, J.R.; Carper, M.J.; Miyazaki, M.; Ntambi, J.M.; Hoffman, E.P.; Thyfault, J.P.; Stevens, R.; Dohm, G.L.; Houmard, J.A.; Muoio, D.M.
Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
Cell Metab.
2
251-261
2005
Homo sapiens
Manually annotated by BRENDA team
Biddinger, S.B.; Almind, K.; Miyazaki, M.; Kokkotou, E.; Ntambi, J.M.; Kahn, C.R.
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
Diabetes
54
1314-1323
2005
Mus musculus
Manually annotated by BRENDA team
Riserus, U.; Tan, G.D.; Fielding, B.A.; Neville, M.J.; Currie, J.; Savage, D.B.; Chatterjee, V.K.; Frayn, K.N.; ORahilly, S.; Karpe, F.
Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma
Diabetes
54
1379-1384
2005
Homo sapiens
Manually annotated by BRENDA team
Biddinger, S.B.; Miyazaki, M.; Boucher, J.; Ntambi, J.M.; Kahn, C.R.
Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
Diabetes
55
2032-2041
2006
Mus musculus
Manually annotated by BRENDA team
Voss, M.D.; Beha, A.; Tennagels, N.; Tschank, G.; Herling, A.W.; Quint, M.; Gerl, M.; Metz-Weidmann, C.; Haun, G.; Korn, M.
Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance
Diabetologia
48
2622-2630
2005
Rattus norvegicus
Manually annotated by BRENDA team
Dobrzyn, P.; Dobrzyn, A.
Stearoyl-CoA desaturase: a new therapeutic target of liver steatosis
Drug Develop. Res.
67
643-650
2006
Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q6T707), Mus musculus (Q99PL7)
-
Manually annotated by BRENDA team
Mutch, D.M.; Grigorov, M.; Berger, A.; Fay, L.B.; Roberts, M.A.; Watkins, S.M.; Williamson, G.; German, J.B.
An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
FASEB J.
19
599-601
2005
Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q99PL7), Mus musculus, Mus musculus Rj:NMRI (P13011), Mus musculus Rj:NMRI (P13516), Mus musculus Rj:NMRI (Q99PL7)
Manually annotated by BRENDA team
Mainieri, D.; Summermatter, S.; Seydoux, J.; Montani, J.P.; Rusconi, S.; Russell, A.P.; Boss, O.; Buchala, A.J.; Dulloo, A.G.
A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis
FASEB J.
20
1751-1753
2006
Rattus norvegicus (P07308)
Manually annotated by BRENDA team
Archibeque, S.L.; Lunt, D.K.; Gilbert, C.D.; Tume, R.K.; Smith, S.B.
Fatty acid indices of stearoyl-CoA desaturase do not reflect actual stearoyl-CoA desaturase enzyme activities in adipose tissues of beef steers finished with corn-, flaxseed-, or sorghum-based diets
J. Anim. Sci.
83
1153-1166
2005
Bos taurus
Manually annotated by BRENDA team
Chung, K.Y.; Lunt, D.K.; Kawachi, H.; Yano, H.; Smith, S.B.
Lipogenesis and stearoyl-CoA desaturase gene expression and enzyme activity in adipose tissue of short- and long-fed Angus and Wagyu steers fed corn- or hay-based diets
J. Anim. Sci.
85
380-387
2007
Bos taurus
Manually annotated by BRENDA team
Scaglia, N.; Igal, R.A.
Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells
J. Biol. Chem.
280
25339-25349
2005
Homo sapiens (O00767), Homo sapiens
Manually annotated by BRENDA team
Man, W.C.; Miyazaki, M.; Chu, K.; Ntambi, J.M.
Membrane topology of mouse stearoyl-CoA desaturase 1
J. Biol. Chem.
281
1251-1260
2006
Mus musculus
Manually annotated by BRENDA team
Sampath, H.; Miyazaki, M.; Dobrzyn, A.; Ntambi, J.M.
Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
J. Biol. Chem.
282
2483-2493
2007
Mus musculus
Manually annotated by BRENDA team
Flowers, M.T.; Miyazaki, M.; Liu, X.; Ntambi, J.M.
Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance
J. Clin. Invest.
116
1478-1481
2006
Mus musculus
Manually annotated by BRENDA team
Gutierrez-Juarez, R.; Pocai, A.; Mulas, C.; Ono, H.; Bhanot, S.; Monia, B.P.; Rossetti, L.
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
J. Clin. Invest.
116
1686-1695
2006
Mus musculus, Rattus norvegicus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Shingfield, K.J.; Toivonen, V.; Vanhatalo, A.; Huhtanen, P.; Griinari, J.M.
Short communication: indigestible markers reduce the mammary DELTA9-desaturase index and alter the milk fatty acid composition in cows
J. Dairy Sci.
89
3006-3010
2006
Bos taurus
Manually annotated by BRENDA team
Dobrzyn, A.; Dobrzyn, P.
Stearoyl-CoA desaturase - a new player in skeletal muscle metabolism regulation
J. Physiol. Pharmacol.
57 Suppl 10
31-42
2006
Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Dobrzyn, A.; Ntambi, J.M.
Stearoyl-CoA desaturase as a new drug target for obesity treatment
Obes. Rev.
6
169-174
2005
Mus musculus
Manually annotated by BRENDA team
Shang, X.G.; Wang, F.L.; Li, D.F.; Yin, J.D.; Li, X.J.; Yi, G.F.
Effect of dietary conjugated linoleic acid on the fatty acid composition of egg yolk, plasma and liver as well as hepatic stearoyl-coenzyme A desaturase activity and gene expression in laying hens
Poult. Sci.
84
1886-1892
2005
Gallus gallus
Manually annotated by BRENDA team
Chong, M.F.; Hodson, L.; Bickerton, A.S.; Roberts, R.; Neville, M.; Karpe, F.; Frayn, K.N.; Fielding, B.A.
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding
Am. J. Clin. Nutr.
87
817-823
2008
Homo sapiens
Manually annotated by BRENDA team
Dobrzyn, P.; Sampath, H.; Dobrzyn, A.; Miyazaki, M.; Ntambi, J.M.
Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
Am. J. Physiol. Endocrinol. Metab.
294
E357-E364
2008
Mus musculus
Manually annotated by BRENDA team
Mar-Heyming, R.; Miyazaki, M.; Weissglas-Volkov, D.; Kolaitis, N.A.; Sadaat, N.; Plaisier, C.; Pajukanta, P.; Cantor, R.M.; de Bruin, T.W.; Ntambi, J.M.; Lusis, A.J.
Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia
Arterioscler. Thromb. Vasc. Biol.
28
1193-1199
2008
Homo sapiens
Manually annotated by BRENDA team
Zhao, H.; Serby, M.D.; Smith, H.T.; Cao, N.; Suhar, T.S.; Surowy, T.K.; Camp, H.S.; Collins, C.A.; Sham, H.L.; Liu, G.
Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors
Bioorg. Med. Chem. Lett.
17
3388-3391
2007
Homo sapiens
Manually annotated by BRENDA team
Xin, Z.; Zhao, H.; Serby, M.D.; Liu, B.; Liu, M.; Szczepankiewicz, B.G.; Nelson, L.T.; Smith, H.T.; Suhar, T.S.; Janis, R.S.; Cao, N.; Camp, H.S.; Collins, C.A.; Sham, H.L.; Surowy, T.K.; Liu, G.
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
Bioorg. Med. Chem. Lett.
18
4298-4302
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Stefan, N.; Peter, A.; Cegan, A.; Staiger, H.; Machann, J.; Schick, F.; Claussen, C.D.; Fritsche, A.; Haering, H.U.; Schleicher, E.
Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans
Diabetologia
51
648-656
2008
Homo sapiens
Manually annotated by BRENDA team
Pavan, E.; Duckett, S.K.
Corn oil supplementation to steers grazing endophyte-free tall fescue. II. Effects on longissimus muscle and subcutaneous adipose fatty acid composition and stearoyl-CoA desaturase activity and expression
J. Anim. Sci.
85
1731-1740
2007
Bos taurus (Q9TT94)
Manually annotated by BRENDA team
Chang, Y.; Wesenberg, G.; Bingman, C.A.; Fox, B.G.
In vivo inactivation of mycobacterial integral membrane stearoyl-CoA desaturase DesA3 by a C-terminal specific degradation process
J. Bacteriol.
190
6686-6696
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Christianson, J.L.; Nicoloro, S.; Straubhaar, J.; Czech, M.P.
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells
J. Biol. Chem.
283
2906-2916
2008
Mus musculus
Manually annotated by BRENDA team
Major, C.A.; Ryan, K.; Bennett, A.J.; Lock, A.L.; Bauman, D.E.; Salter, A.M.
Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster
J. Lipid Res.
49
1456-1465
2008
Mesocricetus auratus
Manually annotated by BRENDA team
Yee, J.K.; Mao, C.S.; Hummel, H.S.; Lim, S.; Sugano, S.; Rehan, V.K.; Xiao, G.; Lee, W.N.
Compartmentalization of stearoyl-CoA desaturase enzyme-1 activity in HepG2 cells
J. Lipid Res.
49
2124-2134
2008
Homo sapiens
Manually annotated by BRENDA team
Liu, G.; Lynch, J.K.; Freeman, J.; Liu, B.; Xin, Z.; Zhao, H.; Serby, M.D.; Kym, P.R.; Suhar, T.S.; Smith, H.T.; Cao, N.; Yang, R.; Janis, R.S.; Krauser, J.A.; Cepa, S.P.; Beno, D.W.; Sham, H.L.; Collins, C.A.; Surowy, T.K.; Camp, H.S.
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors
J. Med. Chem.
50
3086-3100
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Toyama, T.; Kudo, N.; Mitsumoto, A.; Hibino, Y.; Tsuda, T.; Kawashima, Y.
Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats
J. Pharmacol. Sci.
103
383-390
2007
Rattus norvegicus (P07308), Rattus norvegicus (Q6P7B9)
Manually annotated by BRENDA team
Lengi, A.J.; Corl, B.A.
Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5
Lipids
42
499-508
2007
Bos taurus (Q2KIA4), Bos taurus (Q9TT94), Bos taurus
Manually annotated by BRENDA team
Wang, J.; Yu, L.; Wang, H.; Gao, Y.; Schrementi, J.P.; Porter, R.K.; Yurek, D.A.; Kuo, M.; Suen, C.S.; Cao, G.; Bean, J.S.; Kauffman, R.F.; Qian, Y.
Identification and characterization of hamster stearoyl-CoA desaturase isoforms
Lipids
43
197-205
2008
Mesocricetus auratus (A7LCI9), Mesocricetus auratus (A7LCJ0), Mesocricetus auratus (Q64420), Mesocricetus auratus
Manually annotated by BRENDA team
Paillard, F.; Catheline, D.; Duff, F.L.; Bouriel, M.; Deugnier, Y.; Pouchard, M.; Daubert, J.C.; Legrand, P.
Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity
Nutr. Metab. Cardiovasc. Dis.
18
436-440
2008
Homo sapiens
Manually annotated by BRENDA team
Melhus, H.; Riserus, U.; Warensjoe, E.; Wernroth, L.; Jensevik, K.; Berglund, L.; Vessby, B.; Michaelsson, K.
A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men
Osteoporos. Int.
19
929-934
2008
Homo sapiens
Manually annotated by BRENDA team
McNamara, R.K.; Liu, Y.; Jandacek, R.; Rider, T.; Tso, P.
The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity
Prostaglandins Leukot. Essent. Fatty Acids
78
293-304
2008
Homo sapiens
Manually annotated by BRENDA team
Goren, M.A.; Fox, B.G.
Wheat germ cell-free translation, purification, and assembly of a functional human stearoyl-CoA desaturase complex
Protein Expr. Purif.
62
171-178
2008
Homo sapiens (O00767), Homo sapiens
Manually annotated by BRENDA team
Peter, A.; Weigert, C.; Staiger, H.; Rittig, K.; Cegan, A.; Lutz, P.; Machicao, F.; Haering, H.U.; Schleicher, E.
Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity
Am. J. Physiol. Endocrinol. Metab.
295
E339-E349
2008
Homo sapiens
Manually annotated by BRENDA team
Paton, C.M.; Ntambi, J.M.
Biochemical and physiological function of stearoyl-CoA desaturase
Am. J. Physiol. Endocrinol. Metab.
297
E28-E37
2009
Mus musculus
Manually annotated by BRENDA team
Soulard, P.; McLaughlin, M.; Stevens, J.; Connolly, B.; Coli, R.; Wang, L.; Moore, J.; Kuo, M.S.; LaMarr, W.A.; Ozbal, C.C.; Bhat, B.G.
Development of a high-throughput screening assay for stearoyl-CoA desaturase using rat liver microsomes, deuterium labeled stearoyl-CoA and mass spectrometry
Anal. Chim. Acta
627
105-111
2008
Rattus norvegicus
Manually annotated by BRENDA team
Dillon, R.; Greig, M.J.; Bhat, B.G.
Development of a novel LC/MS method to quantitate cellular stearoyl-CoA desaturase activity
Anal. Chim. Acta
627
99-104
2008
Homo sapiens
Manually annotated by BRENDA team
Macdonald, M.L.; Bissada, N.; Vallance, B.A.; Hayden, M.R.
Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
Biochim. Biophys. Acta
1791
1166-1172
2009
Mus musculus
Manually annotated by BRENDA team
Flowers, M.T.; Ntambi, J.M.
Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
Biochim. Biophys. Acta
1791
85-91
2009
Mus musculus
Manually annotated by BRENDA team
Koltun, D.O.; Parkhill, E.Q.; Vasilevich, N.I.; Glushkov, A.I.; Zilbershtein, T.M.; Ivanov, A.V.; Cole, A.G.; Henderson, I.; Zautke, N.A.; Brunn, S.A.; Mollova, N.; Leung, K.; Chisholm, J.W.; Zablocki, J.
Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors
Bioorg. Med. Chem. Lett.
19
2048-2052
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Koltun, D.O.; Vasilevich, N.I.; Parkhill, E.Q.; Glushkov, A.I.; Zilbershtein, T.M.; Mayboroda, E.I.; Boze, M.A.; Cole, A.G.; Henderson, I.; Zautke, N.A.; Brunn, S.A.; Chu, N.; Hao, J.; Mollova, N.; Leung, K.; Chisholm, J.W.; Zablocki, J.
Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors
Bioorg. Med. Chem. Lett.
19
3050-3053
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Koltun, D.O.; Zilbershtein, T.M.; Migulin, V.A.; Vasilevich, N.I.; Parkhill, E.Q.; Glushkov, A.I.; McGregor, M.J.; Brunn, S.A.; Chu, N.; Hao, J.; Mollova, N.; Leung, K.; Chisholm, J.W.; Zablocki, J.
Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors
Bioorg. Med. Chem. Lett.
19
4070-4074
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Uto, Y.; Ogata, T.; Harada, J.; Kiyotsuka, Y.; Ueno, Y.; Miyazawa, Y.; Kurata, H.; Deguchi, T.; Watanabe, N.; Takagi, T.; Wakimoto, S.; Okuyama, R.; Abe, M.; Kurikawa, N.; Kawamura, S.; Yamato, M.; Osumi, J.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
Bioorg. Med. Chem. Lett.
19
4151-4158
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Uto, Y.; Ogata, T.; Kiyotsuka, Y.; Miyazawa, Y.; Ueno, Y.; Kurata, H.; Deguchi, T.; Yamada, M.; Watanabe, N.; Takagi, T.; Wakimoto, S.; Okuyama, R.; Konishi, M.; Kurikawa, N.; Kono, K.; Osumi, J.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation
Bioorg. Med. Chem. Lett.
19
4159-4166
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Li, C.S.; Belair, L.; Guay, J.; Murgasva, R.; Sturkenboom, W.; Ramtohul, Y.K.; Zhang, L.; Huang, Z.
Thiazole analog as stearoyl-CoA desaturase 1 inhibitor
Bioorg. Med. Chem. Lett.
19
5214-5217
2009
Rattus norvegicus
Manually annotated by BRENDA team
Uto, Y.; Ogata, T.; Kiyotsuka, Y.; Ueno, Y.; Miyazawa, Y.; Kurata, H.; Deguchi, T.; Watanabe, N.; Konishi, M.; Okuyama, R.; Kurikawa, N.; Takagi, T.; Wakimoto, S.; Ohsumi, J.
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats
Bioorg. Med. Chem. Lett.
20
341-345
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Petersson, H.; Basu, S.; Cederholm, T.; Riserus, U.
Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: Longitudinal analyses in middle-aged men
Br. J. Nutr.
99
1186-1189
2008
Homo sapiens
Manually annotated by BRENDA team
Chen, C.; Shah, Y.M.; Morimura, K.; Krausz, K.W.; Miyazaki, M.; Richardson, T.A.; Morgan, E.T.; Ntambi, J.M.; Idle, J.R.; Gonzalez, F.J.
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
Cell Metab.
7
135-147
2008
Mus musculus
Manually annotated by BRENDA team
Matouskova, P.; Luxova, A.; Matouskova, J.; Jiros, P.; Svatos, A.; Valterova, I.; Pichova, I.
A DELTA9 desaturase from Bombus lucorum males: investigation of the biosynthetic pathway of marking pheromones
ChemBioChem
9
2534-2541
2008
Bombus lucorum (A5CKE1), Bombus lucorum
Manually annotated by BRENDA team
Peter, A.; Weigert, C.; Staiger, H.; Machicao, F.; Schick, F.; Machann, J.; Stefan, N.; Thamer, C.; Haering, H.U.; Schleicher, E.
Individual stearoyl-CoA desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo
Diabetes
58
1757-1765
2009
Homo sapiens
Manually annotated by BRENDA team
Kotronen, A.; Seppaenen-Laakso, T.; Westerbacka, J.; Kiviluoto, T.; Arola, J.; Ruskeepaeae, A.L.; Oresic, M.; Yki-Jaervinen, H.
Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
Diabetes
58
203-208
2009
Homo sapiens
Manually annotated by BRENDA team
Issandou, M.; Bouillot, A.; Brusq, J.M.; Forest, M.C.; Grillot, D.; Guillard, R.; Martin, S.; Michiels, C.; Sulpice, T.; Daugan, A.
Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models
Eur. J. Pharmacol.
618
28-36
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Dobrzyn, A.; Dobrzyn, P.
Inhibition of stearoyI-CoA desaturase by cyclic amine derivatives
Expert Opin. Ther. Pat.
18
457-460
2008
Homo sapiens, Rattus norvegicus
-
Manually annotated by BRENDA team
Liu, G.
Stearoyl-CoA desaturase inhibitors: update on patented compounds
Expert Opin. Ther. Pat.
19
1169-1191
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Taugbol, O.; Karlengen, I.J.; Bolstad, T.; Aastveit, A.H.; Harstad, O.M.
Cobalt supplied per os reduces the mammary DELTA9-desaturase index of bovine milk
J. Anim. Sci.
86
3062-3068
2008
Bos taurus
Manually annotated by BRENDA team
Sampath, H.; Flowers, M.T.; Liu, X.; Paton, C.M.; Sullivan, R.; Chu, K.; Zhao, M.; Ntambi, J.M.
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
J. Biol. Chem.
284
19961-19973
2009
Mus musculus
Manually annotated by BRENDA team
Li, Z.Z.; Berk, M.; McIntyre, T.M.; Feldstein, A.E.
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase
J. Biol. Chem.
284
5637-5644
2009
Mus musculus
Manually annotated by BRENDA team
Velliquette, R.; Gillies, P.; Kris-Etherton, P.; Green, J.; Zhao, G.; Vanden Heuvel, J.
Regulation of human stearoyl-CoA desaturase by omega-3 and omega-6 fatty acids: Implications for the dietary management of elevated serum triglycerides
J. Clin. Lipidol.
3
281-288
2009
Homo sapiens
Manually annotated by BRENDA team
Soyeurt, H.; Dehareng, F.; Mayeres, P.; Bertozzi, C.; Gengler, N.
Variation of DELTA9-desaturase activity in dairy cattle
J. Dairy Sci.
91
3211-3224
2008
Bos taurus
Manually annotated by BRENDA team
Li, Y.; Xu, X.; Dietrich, M.; Urlacher, V.; Schmid, R.; Ouyang, P.; He, B.
Identification and functional expression of a DELTA9 fatty acid desaturase from the marine bacterium Pseudoalteromonas sp. MLY15
J. Mol. Catal. B
56
96-101
2009
Pseudoalteromonas sp., Pseudoalteromonas sp. MLY15
-
Manually annotated by BRENDA team
Zhou, Y.E.; Egeland, G.M.; Meltzer, S.J.; Kubow, S.
The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents
Metab. Clin. Exp.
58
158-166
2009
Homo sapiens
Manually annotated by BRENDA team
Gratraud, P.; Huws, E.; Falkard, B.; Adjalley, S.; Fidock, D.A.; Berry, L.; Jacobs, W.R.; Baird, M.S.; Vial, H.; Kremer, L.
Oleic acid biosynthesis in Plasmodium falciparum: Characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target
PLoS ONE
4
e6889
2009
Plasmodium falciparum (Q8I0W9), Plasmodium falciparum
Manually annotated by BRENDA team
Lausada, N.; de Gomez Dumm, I.N.; Raimondi, J.C.; de Alaniz, M.J.
Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells
Transplant. Proc.
41
1865-1870
2009
Homo sapiens
Manually annotated by BRENDA team
Reh, R.; Ozols, J.; Clement, B.
Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs
Xenobiotica
38
1177-1190
2008
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Lienard, M.A.; Lassance, J.M.; Wang, H.L.; Zhao, C.H.; Piskur, J.; Johansson, T.; Loefstedt, C.
Elucidation of the sex-pheromone biosynthesis producing 5,7-dodecadienes in Dendrolimus punctatus (Lepidoptera: Lasiocampidae) reveals DELTA 11- and DELTA 9-desaturases with unusual catalytic properties
Insect Biochem. Mol. Biol.
40
440-452
2010
Dendrolimus punctatus (B7SB75), Dendrolimus punctatus (B7SB76), Dendrolimus punctatus (B7SB77), Dendrolimus punctatus (B7SB78), Dendrolimus punctatus (B7SB79), Dendrolimus punctatus
Manually annotated by BRENDA team
Green, C.; Olson, L.
Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic beta-cells by stearoyl-CoA desaturase and Elovl6
Am. J. Physiol. Endocrinol. Metab.
300
640-649
2011
Rattus norvegicus
Manually annotated by BRENDA team
Wu, Z.; Li, D.; Gou, K.
Overexpression of stearoyl-CoA desaturase-1 results in an increase of conjugated linoleic acid (CLA) and n-7 fatty acids in 293 cells
Biochem. Biophys. Res. Commun.
398
473-476
2010
Homo sapiens (O00767), Homo sapiens
Manually annotated by BRENDA team
Ramtohul, Y.K.; Black, C.; Chan, C.C.; Crane, S.; Guay, J.; Guiral, S.; Huang, Z.; Oballa, R.; Xu, L.J.; Zhang, L.; Li, C.S.
SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors
Bioorg. Med. Chem. Lett.
20
1593-1597
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Powell, D.A.; Ramtohul, Y.; Lebrun, M.E.; Oballa, R.; Bhat, S.; Falgueyret, J.P.; Guiral, S.; Huang, Z.; Skorey, K.; Tawa, P.; Zhang, L.
2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors
Bioorg. Med. Chem. Lett.
20
6366-6369
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Isabel, E.; Powell, D.A.; Black, W.C.; Chan, C.C.; Crane, S.; Gordon, R.; Guay, J.; Guiral, S.; Huang, Z.; Robichaud, J.; Skorey, K.; Tawa, P.; Xu, L.; Zhang, L.; Oballa, R.
Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors
Bioorg. Med. Chem. Lett.
21
479-483
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Igal, R.A.
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer
Carcinogenesis
31
1509-1515
2010
Homo sapiens
Manually annotated by BRENDA team
Su, C.; Gullberg, H.; Simko, H.; Luthman, M.; Edlund, P.O.; Lundbaeck, T.
A novel assay of cellular stearoyl-CoA desaturase activity of primary rat hepatocytes by HPLC
J. Chromatogr. B
878
2427-2432
2010
Rattus norvegicus
Manually annotated by BRENDA team
Turyn, J.; Stojek, M.; Swierczynski, J.
Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding
Mol. Cell. Biochem.
345
181-188
2010
Rattus norvegicus
Manually annotated by BRENDA team
Tremblay, A.E.; Tan, N.; Whittle, E.; Hodgson, D.J.; Dawson, B.; Buist, P.H.; Shanklin, J.
Stereochemistry of 10-sulfoxidation catalyzed by a soluble Delta9 desaturase
Org. Biomol. Chem.
8
1322-1328
2010
Ricinus communis
Manually annotated by BRENDA team
Stamatikos, A.D.; Paton, C.M.
Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism
Am. J. Physiol. Endocrinol. Metab.
305
E767-E775
2013
Mus musculus
Manually annotated by BRENDA team
Alloatti, A.; Gupta, S.; Gualdron-Lopez, M.; Nguewa, P.A.; Altabe, S.G.; Deumer, G.; Wallemacq, P.; Michels, P.A.; Uttaro, A.D.
Stearoyl-CoA desaturase is an essential enzyme for the parasitic protist Trypanosoma brucei
Biochem. Biophys. Res. Commun.
412
286-290
2011
Trypanosoma brucei, Trypanosoma brucei Lister 427
Manually annotated by BRENDA team
Ramtohul, Y.K.; Powell, D.; Leclerc, J.P.; Leger, S.; Oballa, R.; Black, C.; Isabel, E.; Li, C.S.; Crane, S.; Robichaud, J.; Guay, J.; Guiral, S.; Zhang, L.; Huang, Z.
Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors
Bioorg. Med. Chem. Lett.
21
5692-5696
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Matter, H.; Zoller, G.; Herling, A.W.; Sanchez-Arias, J.A.; Philippo, C.; Namane, C.; Kohlmann, M.; Pfenninger, A.; Voss, M.D.
Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization
Bioorg. Med. Chem. Lett.
23
1817-1822
2013
Rattus norvegicus
Manually annotated by BRENDA team
Yang, S.M.; Tang, Y.; Zhang, R.; Lu, H.; Kuo, G.H.; Gaul, M.D.; Li, Y.; Ho, G.; Conway, J.G.; Liang, Y.; Lenhard, J.M.; Demarest, K.T.; Murray, W.V.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs
Bioorg. Med. Chem. Lett.
23
6773-6776
2013
Rattus norvegicus
Manually annotated by BRENDA team
Yang, S.M.; Tang, Y.; Rano, T.; Lu, H.; Kuo, G.H.; Gaul, M.D.; Li, Y.; Ho, G.; Lang, W.; Conway, J.G.; Liang, Y.; Lenhard, J.M.; Demarest, K.T.; Murray, W.V.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs
Bioorg. Med. Chem. Lett.
24
1437-1441
2014
Rattus norvegicus
Manually annotated by BRENDA team
Nashed, M.; Chisholm, J.W.; Igal, R.A.
Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells
Exp. Biol. Med. (Maywood)
237
1007-1017
2012
Homo sapiens
Manually annotated by BRENDA team
Yokoyama, S.; Hosoi, T.; Ozawa, K.
Stearoyl-CoA desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice
Gene
497
340-343
2012
Mus musculus
Manually annotated by BRENDA team
Sampath, H.; Ntambi, J.M.
The role of Stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
J. Biol. Chem.
289
2482-2488
2014
Mus musculus
Manually annotated by BRENDA team
Takahashi, H.; Nakayama, R.; Hayashi, S.; Nemoto, T.; Murase, Y.; Nomura, K.; Takahashi, T.; Kubo, K.; Marui, S.; Yasuhara, K.; Nakamura, T.; Sueo, T.; Takahashi, A.; Tsutsumiuchi, K.; Ohta, T.; Kawai, A.; Sugita, S.; Yamamoto, S.; Kobayashi, T.; Honda, H.; Yoshida, T.; Hasegawa, T.
Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses
PLoS ONE
8
e78250
2013
Homo sapiens (O00767), Homo sapiens
Manually annotated by BRENDA team
Nagi, M.; Cook, L.; Prasad, M.R.; Cinti, D.L.
Site of participation of cytochrome b5 in hepatic microsomal fatty acid chain elongation. Electron input in the first reduction step
J. Biol. Chem.
258
14823-14828
1983
Rattus norvegicus
Manually annotated by BRENDA team
Koeberle, A.; Loeser, K.; Thuermer, M.
Stearoyl-CoA desaturase-1 and adaptive stress signaling
Biochim. Biophys. Acta
1861
1719-1726
2016
Homo sapiens (O00767), Mus musculus (P13516)
Manually annotated by BRENDA team
Aardema, H.; van Tol, H.T.A.; Wubbolts, R.W.; Brouwers, J.F.H.M.; Gadella, B.M.; Roelen, B.A.J.
Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress
Biol. Reprod.
96
982-992
2017
Bos taurus (Q9TT94), Bos taurus
Manually annotated by BRENDA team
Sun, S.; Zhang, Z.; Pokrovskaia, N.; Chowdhury, S.; Jia, Q.; Chang, E.; Khakh, K.; Kwan, R.; McLaren, D.G.; Radomski, C.C.; Ratkay, L.G.; Fu, J.; Dales, N.A.; Winther, M.D.
Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors
Bioorg. Med. Chem.
23
455-465
2015
Homo sapiens (O00767), Mus musculus (P13516)
Manually annotated by BRENDA team
Iwai, T.; Kume, S.; Chin-Kanasaki, M.; Kuwagata, S.; Araki, H.; Takeda, N.; Sugaya, T.; Uzu, T.; Maegawa, H.; Araki, S.I.
Stearoyl-CoA desaturase-1 protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells
Int. J. Mol. Sci.
17
E1868
2016
Mus musculus (P13516)
Manually annotated by BRENDA team
Ma, M.K.F.; Lau, E.Y.T.; Leung, D.H.W.; Lo, J.; Ho, N.P.Y.; Cheng, L.K.W.; Ma, S.; Lin, C.H.; Copland, J.A.; Ding, J.; Lo, R.C.L.; Ng, I.O.L.; Lee, T.K.W.
Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation
J. Hepatol.
67
979-990
2017
Homo sapiens (O00767), Homo sapiens
Manually annotated by BRENDA team
Jung, W.; Kim, E.J.; Han, S.J.; Choi, H.G.; Kim, S.
Characterization of stearoyl-CoA desaturases from a psychrophilic antarctic copepod, Tigriopus kingsejongensis
Mar. Biotechnol.
18
564-574
2016
Tigriopus kingsejongensis
Manually annotated by BRENDA team
Yang, C.; Lim, W.; Bazer, F.W.; Song, G.
Oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity
Mol. Hum. Reprod.
23
755-770
2017
Homo sapiens (O00767), Homo sapiens
Manually annotated by BRENDA team
Bai, Y.; McCoy, J.G.; Levin, E.J.; Sobrado, P.; Rajashankar, K.R.; Fox, B.G.; Zhou, M.
X-ray structure of a mammalian stearoyl-CoA desaturase
Nature
524
252-256
2015
Mus musculus (P13516), Mus musculus (Q99PL7), Mus musculus
Manually annotated by BRENDA team
Rodriguez-Cuenca, S.; Whyte, L.; Hagen, R.; Vidal-Puig, A.; Fuller, M.
Stearoyl-CoA desaturase 1 Is a key determinant of membrane lipid composition in 3T3-L1 adipocytes
PLoS ONE
11
e0162047
2016
Mus musculus (P13516)
Manually annotated by BRENDA team
Poliakov, E.; Samuel, W.; Duncan, T.; Gutierrez, D.B.; Mata, N.L.; Redmond, T.M.
Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets beta-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide DELTA4-desaturase 1
PLoS ONE
12
e0176487
2017
Homo sapiens (O00767)
Manually annotated by BRENDA team
Lyn, R.K.; Singaravelu, R.; Kargman, S.; OHara, S.; Chan, H.; Oballa, R.; Huang, Z.; Jones, D.M.; Ridsdale, A.; Russell, R.S.; Partridge, A.W.; Pezacki, J.P.
Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes
Sci. Rep.
4
4549
2014
Homo sapiens (O00767)
Manually annotated by BRENDA team
Chen, L.; Ren, J.; Yang, L.; Li, Y.; Fu, J.; Li, Y.; Tian, Y.; Qiu, F.; Liu, Z.; Qiu, Y.
Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis
Sci. Rep.
6
19665
2016
Homo sapiens (O00767)
Manually annotated by BRENDA team
ALJohani, A.M.; Syed, D.N.; Ntambi, J.M.
Insights into stearoyl-CoA desaturase-1 regulation of systemic metabolism
Trends Endocrinol. Metab.
28
831-842
2017
Homo sapiens (O00767), Homo sapiens (Q86SK9), Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q8BNZ5), Mus musculus (Q8CFY4)
Manually annotated by BRENDA team