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Disease on EC 1.14.15.16 - vitamin D3 24-hydroxylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Comparable vitamin D3 metabolism in the endometrium of patients with recurrent spontaneous abortion and fertile controls.
Acidosis
Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism.
Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney.
Inhibition of 25-hydroxyvitamin D3-1-hydroxylase by chronic metabolic acidosis.
Acute Kidney Injury
Changes in 25-hydroxyvitamin D3 alpha- and 24-hydroxylase activities of kidney cells isolated from rats with either unilateral kidney damage or acute renal insufficiency.
Adenocarcinoma
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
The vitamin D system is deregulated in pancreatic diseases.
Adenoma
The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.
Alopecia
Analysis of the relation between alopecia and resistance to 1,25-dihydroxyvitamin D.
Alzheimer Disease
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.
Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement.
Ascorbic Acid Deficiency
[Effect of ascorbic acid on 25-hydroxyvitamin D3 metabolism in the kidneys and 1,25-dihydroxyvitamin D3 reception in the small intestine mucosa of guinea pigs]
Bone Resorption
High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease.
The effects of MC903 on 1,25-(OH)2D3 receptor binding, 24-hydroxylase activity and in vitro bone resorption.
Breast Neoplasms
25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and Vitamin D receptor in women with and without breast cancer.
25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue.
A highly sensitive method for large-scale measurements of 1,25-dihydroxyvitamin D.
Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.
Autocrine metabolism of vitamin D in normal and malignant breast tissue.
No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).
Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.
The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.
Using chromatin immunoprecipitation to monitor 1alpha,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter.
Vitamin D-1alpha-hydroxylase and vitamin D-24-hydroxylase in benign and malign breast tissue.
Vitamin D-24-hydroxylase in benign and malignant breast tissue and cell lines.
Carcinoma
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression.
Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.
Analysis of the vitamin D system in cutaneous malignancies.
In vitro biological activities of a series of 2 beta-substituted analogues of 1 alpha,25-dihydroxyvitamin D3.
Responsiveness of human carcinoma cells of gynecologic origin to 1,25-dihydroxycholecalciferol.
Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines.
Carcinoma, Basal Cell
Analysis of the vitamin D system in cutaneous malignancies.
Carcinoma, Squamous Cell
Analysis of the vitamin D system in cutaneous malignancies.
Colonic Neoplasms
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression.
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells.
Expression of 25-hydroxyvitamin D3-24-hydroxylase activity in Caco-2 cells. An in vitro model of intestinal vitamin D catabolism.
Colorectal Neoplasms
Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.
Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis.
Dehydration
Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.
Diabetic Nephropathies
Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure.
Endometrial Neoplasms
Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research.
Endometriosis
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.
Familial Hypophosphatemic Rickets
Abnormal 24-hydroxylation of 25-hydroxyvitamin D in the X-linked hypophosphatemic mouse.
Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets.
Plasma 24,25-dihydroxyvitamin D3 concentrations in X-linked hypophosphatemic mice: studies using mass fragmentographic and radioreceptor assays.
Genetic Diseases, Inborn
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
[Vitamin D supplementation: not too much, not too little!].
Glioma
Expression of 25(OH) vitamin D3 24-hydroxylase gene in glial cells.
Hypercalcemia
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling.
Do the Heterozygous Carriers of a CYP24A1 Mutation Display a Different Biochemical Phenotype Than Wild Types?
Genetic defect in CYP24A1, the vitamin D 24-hydroxylase gene, in a patient with severe infantile hypercalcemia.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report.
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Molecular characterization of a recurrent 10.9?kb CYP24A1 deletion in Idiopathic Infantile Hypercalcemia.
Quantitation of CYP24A1 Enzymatic Activity With a Simple Two-Hybrid System.
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Three Sisters With Heterozygous Gene Variants of CYP24A1: Maternal Hypercalcemia, New-Onset Hypertension, and Neonatal Hypoglycemia.
Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for the Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer.
Vitamin D3 metabolism in dogs.
[Hypercalcemia and inactive mutation of CYP24A1. Case-study and literature review].
[Vitamin D supplementation: not too much, not too little!].
Hyperparathyroidism
Increased 25-hydroxyvitamin D3 1alpha-hydroxylase and reduced 25-hydroxyvitamin D3 24-hydroxylase expression in parathyroid tumors--new prospects for treatment of hyperparathyroidism with vitamin d.
Vitamin D3 metabolism in dogs.
Hyperparathyroidism, Secondary
E-pharmacophore filtering and molecular dynamics simulation studies in the discovery of potent drug-like molecules for chronic kidney disease.
Early lethality in Hyp mice with targeted deletion of Pth gene.
Regulation of messenger ribonucleic acid expression of 1 alpha,25-dihydroxyvitamin D3-24-hydroxylase in rat osteoblasts.
Hypoalbuminemia
Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure.
Hypocalcemia
25-Hydroxyvitamin D 1 alpha- and 24-hydroxylase activities in pig kidney homogenates: effect of vitamin D deficiency.
Regulation of renal vitamin D receptor is an important determinant of 1alpha,25-dihydroxyvitamin D(3) levels in vivo.
Hypoparathyroidism
24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs.
Vitamin D metabolism in hyperthyroidism.
Hypophosphatemia
Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice.
Vitamin D3 metabolism in dogs.
Infections
In vivo activation of the intracrine vitamin d pathway in innate immune cells and mammary tissue during a bacterial infection.
Vitamin D receptor and 1?-hydroxylase are highly expressed in lungs of mice infected with H9N2 avian influenza viruses.
Kidney Calculi
Idiopathic infantile hypercalcemia: case report and review of the literature.
Maternal and infantile hypercalcemia caused by vitamin-D-hydroxylase mutations and vitamin D intake.
Kidney Failure, Chronic
Chronic hypercalcaemia from inactivating mutations of vitamin D 24-hydroxylase (CYP24A1): implications for mineral metabolism changes in chronic renal failure.
Potentiated 1,25(OH)2D3-induced 24-hydroxylase gene expression in uremic rat intestine.
Leiomyoma
Human uterine leiomyoma contains low levels of 1, 25 dihdroxyvitamin D3, and shows dysregulated expression of vitamin D metabolizing enzymes.
Leukemia
Biological activities of 19-nor-1alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring.
Dibutyryl cAMP enhances the effect of 1,25-dihydroxyvitamin D3 on a human promyelocytic leukemia cell, HL-60, at both the receptor and the postreceptor steps.
Effect of uremic serum on 1,25-dihydroxyvitamin D3-induced differentiation of human promyelocytic leukemia cell, HL-60.
Effects of uremic serum on 1,25-dihydroxyvitamin D3-induced differentiation of a human promyelocytic leukemia cell line, HL-60.
Prostaglandin E2 regulates vitamin D receptor expression, vitamin D-24-hydroxylase activity and cell proliferation in an adherent human myeloid leukemia cell line (Ad-HL60).
Leukemia, Myeloid
Prostaglandin E2 regulates vitamin D receptor expression, vitamin D-24-hydroxylase activity and cell proliferation in an adherent human myeloid leukemia cell line (Ad-HL60).
Lung Neoplasms
No Association of Vitamin D Pathway Genetic Variants with Cancer Risks in a Population-Based Cohort of German Older Adults.
Lymphoma
An emerging view of vitamin D.
Melanoma
Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro.
In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells.
Neoplasm Metastasis
No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).
Neoplasms
24-Hydroxylase in cancer: Impact on vitamin D-based anticancer therapeutics.
25(OH)D3 and 1,25(OH)2D3 serum concentration and breast tissue expression of 1alpha-hydroxylase, 24-hydroxylase and Vitamin D receptor in women with and without breast cancer.
25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression.
A 24-phenylsulfone analog of vitamin D inhibits 1alpha,25-dihydroxyvitamin D(3) degradation in vitamin D metabolism-competent cells.
An emerging view of vitamin D.
Autocrine metabolism of vitamin D in normal and malignant breast tissue.
Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide.
CYP24A1 splice variants-Implications for the antitumorigenic actions of 1,25-(OH)(2)D(3) in colorectal cancer.
Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer.
Expression of VDR and CYP24A1 mRNA in human tumors.
Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.
Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells.
MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways.
Modulation of vitamin D synthesis and catabolism in colorectal mucosa: a new target for cancer prevention.
Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients.
No Association of Vitamin D Pathway Genetic Variants with Cancer Risks in a Population-Based Cohort of German Older Adults.
No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM).
Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.
Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.
Responsiveness of human carcinoma cells of gynecologic origin to 1,25-dihydroxycholecalciferol.
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Tumor-Targeted Nanoparticles Deliver a Vitamin D-Based Drug Payload for the Treatment of EGFR Tyrosine Kinase Inhibitor-Resistant Lung Cancer.
[The role of vitamin D in the prevention and the additional therapy of cancers].
Nephrocalcinosis
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Idiopathic infantile hypercalcemia: case report and review of the literature.
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
[Vitamin D supplementation: not too much, not too little!].
Nephrolithiasis
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
High Prevalence of Kidney Cysts in Patients With CYP24A1 Deficiency.
Loss-of-function mutations of CYP24A1, the vitamin D 24- hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis.
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis.
Osteosarcoma
A highly sensitive method for large-scale measurements of 1,25-dihydroxyvitamin D.
Biological activity profiles of 1alpha,25-dihydroxyvitamin D2, D3, D4, D7, and 24-epi-1alpha,25-dihydroxyvitamin D2.
Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement.
Retinoid X receptor isotype identity directs human vitamin D receptor heterodimer transactivation from the 24-hydroxylase vitamin D response elements in yeast.
Ovarian Neoplasms
Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer.
Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells.
Pancreatitis, Chronic
The vitamin D system is deregulated in pancreatic diseases.
Premature Birth
Metabolism of vitamin D3 in the placental tissue of normal and preeclampsia complicated pregnancies and premature births.
Prostatic Neoplasms
Androgen enhances the antiproliferative activity of vitamin D3 by suppressing 24-hydroxylase expression in LNCaP cells.
Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.
Liarozole Acts Synergistically with 1?,25-Dihydroxyvitamin D3 to Inhibit Growth of DU 145 Human Prostate Cancer Cells by Blocking 24-Hydroxylase Activity.
Liarozole acts synergistically with 1alpha,25-dihydroxyvitamin D3 to inhibit growth of DU 145 human prostate cancer cells by blocking 24-hydroxylase activity.
Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines.
Proteinuria
Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats.
Renal Insufficiency
Effect of vitamin D metabolites on calcitriol degradative enzymes in renal failure.
Idiopathic infantile hypercalcemia: case report and review of the literature.
Renal Insufficiency, Chronic
Assessment of 24,25(OH)(2)D levels does not support FGF23-mediated catabolism of vitamin D metabolites.
Rickets
25-Hydroxyvitamin D-24-hydroxylase in phytohemagglutinin-stimulated lymphocytes: intermediate bioresponse to 1,25-dihydroxyvitamin D3 of cells from parents of patients with vitamin D-dependent rickets type II.
Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets.
Impaired stimulation of 25-hydroxyvitamin D-24-hydroxylase in fibroblasts from a patient with vitamin D-dependent rickets, type II. A form of receptor-positive resistance to 1,25-dihydroxyvitamin D3.
Normal 24-hydroxylation of vitamin D metabolites in patients with vitamin D-dependency rickets type I. Structural implications for the vitamin D hydroxylases.
Vitamin D-dependent rickets type II. Defective induction of 25-hydroxyvitamin D3-24-hydroxylase by 1,25-dihydroxyvitamin D3 in cultured skin fibroblasts.
Sarcoidosis
Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis.
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Skin Neoplasms
Vitamin D and skin cancer: a problem in gene regulation.
Thyroid Neoplasms
Thyroid cancer resistance to vitamin D receptor activation is associated with 24-hydroxylase levels but not the ff FokI polymorphism.
Tooth Resorption
Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats.
Tuberculosis
Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription.
Uremia
Potentiated 1,25(OH)2D3-induced 24-hydroxylase gene expression in uremic rat intestine.
Vitamin D Deficiency
25-Hydroxyvitamin D 1 alpha- and 24-hydroxylase activities in pig kidney homogenates: effect of vitamin D deficiency.
Regulation of 25-OH-D3 1 alpha-hydroxylase and 24-hydroxylase activities along the rat nephron and in isolated kidney cells.
Regulation of calf renal 25-hydroxyvitamin D-hydroxylase activities by calcium-regulating hormones.
Vitamin D inquiry in hippocampal neurons: consequences of vitamin D-VDR pathway disruption on calcium channel and the vitamin D requirement.
[Hypercalcemia and inactive mutation of CYP24A1. Case-study and literature review].
vitamin d3 24-hydroxylase deficiency
24-Hydroxylase Deficiency Due to CYP24A1 Sequence Variants: Comparison With Other Vitamin D-mediated Hypercalcemia Disorders.
Simultaneous determination of 24,25- and 25,26-dihydroxyvitamin D3 in serum samples with liquid-chromatography mass spectrometry - A useful tool for the assessment of vitamin D metabolism.
Wilms Tumor
VDR-mediated gene expression patterns in resting human coronary artery smooth muscle cells.