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Reference on EC 1.14.14.17 - squalene monooxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tai, H.H.; Bloch, K.
Squalene epoxidase of rat liver
J. Biol. Chem.
247
3767-3773
1972
Rattus norvegicus
Manually annotated by BRENDA team
Van Tamelen, E.E.; Heys, J.R.
Enzymic epoxidation of squalene variants
J. Am. Chem. Soc.
97
1252-1253
1975
Rattus norvegicus
Manually annotated by BRENDA team
Ferguson, J.B.; Bloch, K.
Purification and properties of a soluble protein activator of rat liver squalene epoxidase
J. Biol. Chem.
252
5381-5385
1977
Rattus norvegicus
Manually annotated by BRENDA team
Ono, T.; Bloch, K.
Solubilization and partial characterization of rat liver squalene epoxidase
J. Biol. Chem.
250
1571-1579
1975
Rattus norvegicus
Manually annotated by BRENDA team
Ono, T.; Takahashi, K.; Odani, S.; Konno, H.; Imai, Y.
Purification of squalene epoxidase from rat liver microsomes
Biochem. Biophys. Res. Commun.
96
522-528
1980
Rattus norvegicus
Manually annotated by BRENDA team
Astruc, M.; Tabacik, C.; Descomps, B.; Crastes de Paulet, A.
Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues
Biochim. Biophys. Acta
487
204-211
1977
Rattus norvegicus
Manually annotated by BRENDA team
Jordan, D.B.
Squalene oxidase: the elusive flavoenzyme of sterol biosynthesis
Flavins and Flavoproteins (Proc. Int. Symp. , 10th, Meeting Date 1990, Curti, B. , Ronchi S. , Zanetti, G. , eds. ) de Gruyter, Berlin, New York
865-868
1991
Rattus norvegicus
-
Manually annotated by BRENDA team
Ono, T.; Nakazono, K.; Kosaka, H.
Purification and partial characterization of squalene epoxidase from rat liver microsomes
Biochim. Biophys. Acta
709
84-90
1982
Rattus norvegicus
Manually annotated by BRENDA team
Ono, T.; Imai, Y.
Squalene epoxidase from rat liver microsomes
Methods Enzymol.
110
375-380
1985
Rattus norvegicus
Manually annotated by BRENDA team
M'Baya, B.; Karst, F.
In vitro assay of squalene epoxidase of Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
147
556-564
1987
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ryder, N.S.; Dupont, M.C.
Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes
Biochem. J.
230
765-770
1985
Candida albicans, Candida parapsilosis, Rattus norvegicus
Manually annotated by BRENDA team
Ryder, N.S.; Dupont, M.C.
Properties of a particulate squalene epoxidase from Candida albicans
Biochim. Biophys. Acta
794
466-471
1984
Candida albicans
Manually annotated by BRENDA team
Lin, L.F.H.
Roles of phospholipid and detergent in soluble protein activation of squalene epoxidase
Biochemistry
19
5135-5140
1980
Rattus norvegicus
Manually annotated by BRENDA team
Satoh, T.; Horie, M.; Watanabe, H.; Tsuchiya, Y.; Kamei, T.
Enzymic properties of squalene epoxidase from Saccharomyces cerevisiae
Biol. Pharm. Bull.
16
349-352
1993
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Nagumo, A.; Kamei, T.; Sakakibara, J.; Ono, T.
Purification and characterization of recombinant squalene epoxidase
J. Lipid Res.
36
1489-1497
1995
Rattus norvegicus
Manually annotated by BRENDA team
Favre, B.; Ryder, N.S.
Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents
Antimicrob. Agents Chemother.
40
443-447
1996
Trichophyton rubrum
Manually annotated by BRENDA team
Laden, B.P.; Tang, Y.; Porter, T.D.
Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase
Arch. Biochem. Biophys.
374
381-388
2000
Homo sapiens
Manually annotated by BRENDA team
Abe, I.; Kashiwagi, Y.; Noguchi, H.
Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates
Bioorg. Med. Chem. Lett.
10
2525-2528
2000
Rattus norvegicus
Manually annotated by BRENDA team
Abe, I.; Seki, T.; Umehara, K.; Miyase, T.; Noguchi, H.; Sakakibara, J.; Ono, T.
Green tea polyphenols: novel and potent inhibitors of squalene epoxidase
Biochem. Biophys. Res. Commun.
268
767-771
2000
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Abe, I.; Seki, T.; Noguchi, H.; Kashiwada, Y.
Galloyl esters from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis
Planta Med.
66
753-756
2000
Rattus norvegicus
Manually annotated by BRENDA team
Sawada, M.; Matsuo, M.; Hagihara, H.; Tenda, N.; Nagayoshi, A.; Okumura, H.; Washizuka, K.; Seki, J.; Goto, T.
Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells
Eur. J. Pharmacol.
431
11-16
2001
Homo sapiens
Manually annotated by BRENDA team
Laden, B.P.; Porter, T.D.
Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls
J. Lipid Res.
42
235-240
2001
Homo sapiens
Manually annotated by BRENDA team
Gupta, N.; Porter, T.D.
Inhibition of human squalene monooxygenase by selenium compounds
J. Biochem. Mol. Toxicol.
16
18-23
2002
Homo sapiens
Manually annotated by BRENDA team
Wentzinger, L.F.; Bach, T.J.; Hartmann, M.A.
Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase
Plant Physiol.
130
334-346
2002
Nicotiana tabacum
Manually annotated by BRENDA team
Osborne, C.S.; Leitner, I.; Favre, B.; Ryder, N.S.
Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine
Antimicrob. Agents Chemother.
49
2840-2844
2005
Candida albicans, Trichophyton rubrum
Manually annotated by BRENDA team
Lee, H.K.; Zheng, Y.F.; Xiao, X.Y.; Bai, M.; Sakakibara, J.; Ono, T.; Prestwich, G.D.
Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase
Biochem. Biophys. Res. Commun.
315
1-9
2004
Rattus norvegicus
Manually annotated by BRENDA team
Pasrija, R.; Krishnamurthy, S.; Prasad, T.; Ernst, J.F.; Prasad, R.
Squalene epoxidase encoded by ERG1 affects morphogenesis and drug susceptibilities of Candida albicans
J. Antimicrob. Chemother.
55
905-913
2005
Candida albicans
Manually annotated by BRENDA team
Liu, Y.; Yao, Z.X.; Papadopoulos, V.
Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
Mol. Endocrinol.
19
1918-1931
2005
Mus musculus
Manually annotated by BRENDA team
Musso, D.L.; Clarke, M.J.; Kelley, J.L.; Boswell, G.E.; Chen, G.
Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene epoxidase
Org. Biomol. Chem.
1
498-506
2003
Rattus norvegicus
Manually annotated by BRENDA team
Ruckenstuhl, C.; Lang, S.; Poschenel, A.; Eidenberger, A.; Baral, P.K.; Kohut, P.; Hapala, I.; Gruber, K.; Turnowsky, F.
Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants
Antimicrob. Agents Chemother.
51
275-284
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Nakano, C.; Motegi, A.; Sato, T.; Onodera, M.; Hoshino, T.
Sterol biosynthesis by a prokaryote: first in vitro identification of the genes encoding squalene epoxidase and lanosterol synthase from Methylococcus capsulatus
Biosci. Biotechnol. Biochem.
71
2543-2550
2007
Methylococcus capsulatus (Q603D5), Methylococcus capsulatus
Manually annotated by BRENDA team
Ruckenstuhl, C.; Poschenel, A.; Possert, R.; Baral, P.K.; Gruber, K.; Turnowsky, F.
Structure-function correlations of two highly conserved motifs in Saccharomyces cerevisiae squalene epoxidase
Antimicrob. Agents Chemother.
52
1496-1499
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Li, L.; Porter, T.D.
Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase
Arch. Biochem. Biophys.
461
76-84
2007
Mus musculus
Manually annotated by BRENDA team
Abe, I.; Abe, T.; Lou, W.; Masuoka, T.; Noguchi, H.
Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase
Biochem. Biophys. Res. Commun.
352
259-263
2007
Rattus norvegicus
Manually annotated by BRENDA team
Godio, R.P.; Fouces, R.; Martin, J.F.
A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium
Chem. Biol.
14
1334-1346
2007
Hypholoma sublateritium
Manually annotated by BRENDA team
He, F.; Zhu, Y.; He, M.; Zhang, Y.
Molecular cloning and characterization of the gene encoding squalene epoxidase in Panax notoginseng
DNA Seq.
19
270-273
2008
Panax notoginseng (Q1PID4), Panax notoginseng
Manually annotated by BRENDA team
Motavaze, K.; Namvar, Z.; Emami, M.; Noorbakhsh, F.; Rezaie, S.
Molecular characterization of a Squalene epoxidase gene in dermatophyte pathogen Trichophyton tonsurans
Iran. Biomed. J.
12
55-58
2008
Trichophyton tonsurans
Manually annotated by BRENDA team
Rasbery, J.M.; Shan, H.; LeClair, R.J.; Norman, M.; Matsuda, S.P.; Bartel, B.
Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development
J. Biol. Chem.
282
17002-17013
2007
Arabidopsis thaliana (O65403), Arabidopsis thaliana (O81000), Arabidopsis thaliana (Q8VYH2), Arabidopsis thaliana (Q9SM02), Arabidopsis thaliana
Manually annotated by BRENDA team
Uchida, H.; Sugiyama, R.; Nakayachi, O.; Takemura, M.; Ohyama, K.
Expression of the gene for sterol-biosynthesis enzyme squalene epoxidase in parenchyma cells of the oil plant, Euphorbia tirucalli
Planta
226
1109-1115
2007
Euphorbia tirucalli (A7VJN1), Euphorbia tirucalli
Manually annotated by BRENDA team
Hu, F.; Zhong, J.
Jasmonic acid mediates gene transcription of ginsenoside biosynthesis in cell cultures of Panax notoginseng treated with chemically synthesized 2-hydroxyethyl jasmonate
Process Biochem.
43
113-118
2008
Panax notoginseng
-
Manually annotated by BRENDA team
Gerpe, A.; Alvarez, G.; Benitez, D.; Boiani, L.; Quiroga, M.; Hernandez, P.; Sortino, M.; Zacchino, S.; Gonzalez, M.; Cerecetto, H.
5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene
Bioorg. Med. Chem.
17
7500-7509
2009
Trypanosoma cruzi
Manually annotated by BRENDA team
Helms, M.W.; Kemming, D.; Pospisil, H.; Vogt, U.; Buerger, H.; Korsching, E.; Liedtke, C.; Schlotter, C.M.; Wang, A.; Chan, S.Y.; Brandt, B.H.
Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease
Br. J. Cancer
99
774-780
2008
Homo sapiens
Manually annotated by BRENDA team
Seiki, S.; Frishman, W.H.
Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia
Cardiol. Rev.
17
70-76
2009
Canis lupus familiaris, Homo sapiens, Nicotiana sp.
Manually annotated by BRENDA team
Han, J.Y.; In, J.G.; Kwon, Y.S.; Choi, Y.E.
Regulation of ginsenoside and phytosterol biosynthesis by RNA interferences of squalene epoxidase gene in Panax ginseng
Phytochemistry
71
36-46
2009
Panax ginseng, Panax ginseng (B7TWW5), Panax ginseng (Q75W20)
Manually annotated by BRENDA team
Pose, D.; Castanedo, I.; Borsani, O.; Nieto, B.; Rosado, A.; Taconnat, L.; Ferrer, A.; Dolan, L.; Valpuesta, V.; Botella, M.A.
Identification of the Arabidopsis dry2/sqe1-5 mutant reveals a central role for sterols in drought tolerance and regulation of reactive oxygen species
Plant J.
59
63-76
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Nowosielski, M.; Hoffmann, M.; Wyrwicz, L.S.; Stepniak, P.; Plewczynski, D.M.; Lazniewski, M.; Ginalski, K.; Rychlewski, L.
Detailed mechanism of squalene epoxidase inhibition by terbinafine
J. Chem. Inf. Model.
51
455-462
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kim, Y.S.; Cho, J.H.; Park, S.; Han, J.Y.; Back, K.; Choi, Y.E.
Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum
Planta
233
343-355
2011
Bupleurum falcatum
Manually annotated by BRENDA team
Garaiova, M.; Zambojova, V.; Simova, Z.; Griac, P.; Hapala, I.
Squalene epoxidase as a target for manipulation of squalene levels in the yeast Saccharomyces cerevisiae
FEMS Yeast Res.
14
310-323
2014
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Stevenson, J.; Luu, W.; Kristiana, I.; Brown, A.J.
Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids
Biochem. J.
461
435-442
2014
Homo sapiens
Manually annotated by BRENDA team
Howe, V.; Chua, N.K.; Stevenson, J.; Brown, A.J.
The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change
J. Biol. Chem.
290
27533-27544
2015
Homo sapiens
Manually annotated by BRENDA team
Drozdikova, E.; Garaiova, M.; Csaky, Z.; Obernauerova, M.; Hapala, I.
Production of squalene by lactose-fermenting yeast Kluyveromyces lactis with reduced squalene epoxidase activity
Lett. Appl. Microbiol.
61
77-84
2015
Kluyveromyces lactis
Manually annotated by BRENDA team
Laranjeira, S.; Amorim-Silva, V.; Esteban, A.; Arro, M.; Ferrer, A.; Tavares, R.M.; Botella, M.A.; Rosado, A.; Azevedo, H.
Arabidopsis squalene epoxidase 3 (SQE3) complements SQE1 and is important for embryo development and bulk squalene epoxidase activity
Mol. Plant
8
1090-1102
2015
Arabidopsis thaliana
Manually annotated by BRENDA team
Chugh, A.; Ray, A.; Gupta, J.B.
Squalene epoxidase as hypocholesterolemic drug target revisited
Prog. Lipid Res.
42
37-50
2003
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Sui, Z.; Zhou, J.; Cheng, Z.; Lu, P.
Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells
Tumour Biol.
36
6173-6179
2015
Homo sapiens
Manually annotated by BRENDA team
Zare, B.; Sepehrizadeh, Z.; Faramarzi, M.; Soltany-Rezaee-Rad, M.; Rezaie, S.; Shahverdi, A.
Antifungal activity of biogenic tellurium nanoparticles against Candida albicans and its effects on squalene monooxygenase gene expression
Biotechnol. Appl. Biochem.
61
395-400
2014
Candida albicans, Candida albicans ATCC14053
-
Manually annotated by BRENDA team
Zhang, D.H.; Jiang, L.X.; Li, N.; Yu, X.; Zhao, P.; Li, T.; Xu, J.W.
Overexpression of the squalene epoxidase gene alone and in combination with the 3-hydroxy-3-methylglutaryl coenzyme A gene increases ganoderic acid production in Ganoderma lingzhi
J. Agric. Food Chem.
65
4683-4690
2017
Ganoderma lucidum (A0A1Y0JYI5)
Manually annotated by BRENDA team
Chua, N.K.; Howe, V.; Jatana, N.; Thukral, L.; Brown, A.J.
A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis
J. Biol. Chem.
292
19959-19973
2017
Homo sapiens (Q9UNR6), Homo sapiens
Manually annotated by BRENDA team
Ma, C.; Jiang, N.; Deng, M.; Chen, J.; Yang, S.; Long, G.; Zhang, G.
Cloning and characterization of three squalene epoxidase genes in Panax vietnamensis var. fuscidicus, a rare medicinal plant with high content of ocotillol-type ginsenosides
Pak. J. Bot.
48
2453-2465
2016
Panax vietnamensis var. fuscidiscus (A0A076VA95), Panax vietnamensis var. fuscidiscus (A0A076VCG0)
-
Manually annotated by BRENDA team
Guo, H.; Li, R.; Liu, S.; Zhao, N.; Han, S.; Lu, M.; Liu, X.; Xia, X.
Molecular characterization, expression, and regulation of Gynostemma pentaphyllum squalene epoxidase gene 1
Plant Physiol. Biochem.
109
230-239
2016
Gynostemma pentaphyllum
Manually annotated by BRENDA team
Uchida, H.; Sumimoto, K.; Ferriols, V.M.; Imou, K.; Saga, K.; Furuhashi, K.; Matsunaga, S.; Okada, S.
Isolation and characterization of two squalene epoxidase genes from Botryococcus braunii, race B
PLoS ONE
10
e0122649
2015
Botryococcus braunii (A0A0E4B8N8), Botryococcus braunii (A0A0E4FJ73), Botryococcus braunii
Manually annotated by BRENDA team
Zhang, M.; Wang, S.; Yin, J.; Li, C.; Zhan, Y.; Xiao, J.; Liang, T.; Li, X.
Molecular cloning and promoter analysis of squalene synthase and squalene epoxidase genes from Betula platyphylla
Protoplasma
253
1347-1363
2016
Betula platyphylla (A0A0K0VH94), Betula platyphylla
Manually annotated by BRENDA team
Brown, D.N.; Caffa, I.; Cirmena, G.; Piras, D.; Garuti, A.; Gallo, M.; Alberti, S.; Nencioni, A.; Ballestrero, A.; Zoppoli, G.
Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer
Sci. Rep.
6
19435
2016
Homo sapiens (Q9UNR6)
Manually annotated by BRENDA team
Ha, J.; Kwon, S.; Hwang, J.H.; Park, D.H.; Kim, T.W.; Kang, D.G.; Yu, G.E.; Park, H.C.; An, S.M.; Kim, C.W.
Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers
Sci. Rep.
7
16740
2017
Sus scrofa (A7L861), Sus scrofa
Manually annotated by BRENDA team
Zhang, H.Y.; Li, H.M.; Yu, Z.; Yu, X.Y.; Guo, K.
Expression and significance of squalene epoxidase in squamous lung cancerous tissues and pericarcinoma tissues
Thorac. Cancer
5
275-280
2014
Homo sapiens (Q9UNR6), Homo sapiens
Manually annotated by BRENDA team
Unland, K.; Puetter, K.M.; Vorwerk, K.; van Deenen, N.; Twyman, R.M.; Pruefer, D.; Schulze Gronover, C.
Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz
Plant Direct
2
e00063
2018
Taraxacum kok-saghyz (A0A3G1SVN6), Taraxacum kok-saghyz (A0A3G1SVN9), Taraxacum kok-saghyz (A0A3G1SVP8), Taraxacum kok-saghyz (A0A3G1SVQ2)
Manually annotated by BRENDA team