Information on EC 1.14.13.66 - 2-hydroxycyclohexanone 2-monooxygenase

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The expected taxonomic range for this enzyme is: Acinetobacter

EC NUMBER
COMMENTARY hide
1.14.13.66
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RECOMMENDED NAME
GeneOntology No.
2-hydroxycyclohexanone 2-monooxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-hydroxycyclohexan-1-one + NADPH + H+ + O2 = 6-hydroxyhexan-6-olide + NADP+ + H2O
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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reduction
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Caprolactam degradation
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SYSTEMATIC NAME
IUBMB Comments
2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)
The product decomposes spontaneously to 6-oxohexanoic acid (adipic semialdehyde).
CAS REGISTRY NUMBER
COMMENTARY hide
62628-31-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
TD63
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Manually annotated by BRENDA team
TD63
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxycyclohexan-1-one + NADPH + O2
1-oxa-2-oxo-7-hydroxycycloheptane + NADP+ + H2O
show the reaction diagram
2-Hydroxycyclohexan-1-one + NADPH + O2
?
show the reaction diagram
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enzyme in the oxidation pathway of trans-cyclohexan-1,2-diol to adipate, enzyme activity is induced by trans-cyclohexan-1,2-diol
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2-Methylcyclohexanone + NADPH + O2
?
show the reaction diagram
3-Methylcyclohexanone + NADPH + O2
?
show the reaction diagram
4-Methylcyclohexanone + NADPH + O2
?
show the reaction diagram
Cyclohexanone + NADPH + O2
?
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-Hydroxycyclohexan-1-one + NADPH + O2
?
show the reaction diagram
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enzyme in the oxidation pathway of trans-cyclohexan-1,2-diol to adipate, enzyme activity is induced by trans-cyclohexan-1,2-diol
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0062
2-Hydroxycyclohexan-1-one
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0.0053
NADPH
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