Information on EC 1.14.13.56 - dihydrosanguinarine 10-monooxygenase

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The expected taxonomic range for this enzyme is: Eschscholzia californica

EC NUMBER
COMMENTARY hide
1.14.13.56
-
RECOMMENDED NAME
GeneOntology No.
dihydrosanguinarine 10-monooxygenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dihydrosanguinarine + NADPH + H+ + O2 = 10-hydroxydihydrosanguinarine + NADP+ + H2O
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
sanguinarine and macarpine biosynthesis
-
-
Isoquinoline alkaloid biosynthesis
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
SYSTEMATIC NAME
IUBMB Comments
dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)
A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants.
CAS REGISTRY NUMBER
COMMENTARY hide
144388-41-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dihydrosanguinarine + NADPH + O2
10-hydroxydihydrosanguinarine + NADP+
show the reaction diagram
-
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome P450
-
dependent on
-
NADPH
-
required, no activity with NADH
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CO
-
strong inhibition in the dark, effect is partly reversible by illumination
cytochrome c
-
-
ketoconazole
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
associated with
-
Manually annotated by BRENDA team