Information on EC 1.14.13.183 - dammarenediol 12-hydroxylase

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The expected taxonomic range for this enzyme is: Panax

EC NUMBER
COMMENTARY hide
1.14.13.183
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RECOMMENDED NAME
GeneOntology No.
dammarenediol 12-hydroxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dammarenediol-II + NADPH + H+ + O2 = protopanaxadiol + NADP+ + H2O
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydroxylation
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oxidation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
ginsenosides biosynthesis
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ginsenoside metabolism
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SYSTEMATIC NAME
IUBMB Comments
dammarenediol-II,NADPH:O2 oxidoreductase (12beta-hydroxylating)
A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from ginseng (Panax ginseng).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dammarenediol-II + NADPH + H+ + O2
protopanaxadiol + NADP+ + H2O
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dammarenediol-II + NADPH + H+ + O2
protopanaxadiol + NADP+ + H2O
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60000
x * 60000, calculated from amino acid sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 60000, calculated from amino acid sequence
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae strain BY4742
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expressed in Saccharomyces cerevisiae strain WAT21
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
methyl jasmonate treatment results in accumulation of mRNA in adventitious roots
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the gene is transcriptionally activated not only by methyl jasmonate treatment but also in transgenic ginseng that overexpresses squalene synthase and overproduces ginsenosides
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